Intervention musicale et concept de soi chez les jeunes de la rue

Les jeunes de la rue sont reconnus comme étant fragile [i.e. fragiles] dans leur identité qui les entraînent plus souvent qu'autrement à délaisser le monde de l'éducation et par la suite celui du travail. L'adaptation à la vie scolaire et professionnelle des jeunes de la rue passe entre autres par le développement d'un sentiment identitaire. Notre étude tente de comprendre comment contribuer au développement du concept de soi des jeunes de la rue par les arts. Pour y arriver, un cadre conceptuel double est utilisé, soit le modèle du concept de soi de l'Écuyer (1990) concernant le sentiment identitaire et l'art comme moyen d'intervention à partir des écrits de Vygotsky (1971). L'objectif général est de décrire la façon dont l'intervention musicale dans le projet Artifice agit sur le concept de soi, du point de vue des jeunes et de l'équipe d'intervention.

Les caractéristiques des jeunes et des parents associées à l'évolution de l'alliance thérapeutique en contexte d'intervention brève et intensive de crise familiale

La présente étude visait à identifier les caractéristiques des jeunes et des parents (telles que la présence de troubles internalisés chez le jeune, la présence de troubles externalisés chez le jeune, l'estime de soi du jeune, la détresse psychologique des parents, les ressources interpersonnelles du parent, la qualité de la communication dans la famille, la cohésion familiale, l'intensité et la fréquence des conflits conjugaux) associées à l'évolution de l'alliance thérapeutique en contexte d'intervention brève et intensive de crise familiale. Pour atteindre cet objectif, nous avons effectué une étude corrélationnelle et descriptive avec deux temps de mesure de l'alliance thérapeutique. Notre échantillon est composé de 96 familles participantes au programme d'intervention Crise-Ado-Famille-Enfance. Selon les résultats obtenus, la perception de l'évolution de l'alliance thérapeutique des jeunes participant au programme CAFE ne semble pas être influencée significativement par aucune des caractéristiques recensées pour la présente étude. Au niveau de la perception de l'évolution de l'alliance thérapeutique des parents, les résultats révèlent qu'une seule des caractéristiques des jeunes et des familles y est associée de façon significative, soit la présence de troubles internalisés chez le jeune.

Study of influence of regulatory polymorphisms of expression in development of breast cancer

The human genome has millions of genetics variants that can affect gene expression. These variants are known as cis-regulatory variants and are responsible for intra-species phenotypic differences and individual susceptibility to disease. One of the diseases affected by cis-regulatory variants is breast cancer. Breast cancer is one of the most common cancers, with approximately 4500 new cases each year in Portugal. Breast cancer has many genes mutated and TP53 has been shown to be relevant for this disease. TP53 is one of the most commonly mutated genes in human cancer and it is involved in cell cycle regulation and apoptosis. Previous work by Maia et al has shown that TP53 has differential allelic expression (DAE), which suggests that this gene may be under the influence of cis-regulatory variants. Also, its DAE pattern is totally altered in breast tumours with normal copy number. We hypothesized that cis-regulatory variants affecting TP53 may have a role in breast cancer development and treatment. The present work aims to identify the cis-regulatory variants playing a role in TP53 expression, using in silico, in vitro and in vivo approaches. By bioinformatic tools we have identified candidate cis-regulatory variants and predicted the possible transcription factor binding sites that they affect. By EMSA we studied DNA-protein interactions in this region of TP53. The in silico analysis allowed us to identified three candidate cis-regulatory SNPs which may affect the binding of seven transcription factors. However, the EMSA experiments have not been conclusive and we have not yet confirmed whether any of the identified SNPs are associated with gene expression control of TP53. We will carry out further experiments to validate our findings.

Regulatory interactions between the metabolic sensors SIRT1 and AMPK in modulating PPARα linked functions, in obesity-dependent type 2 diabetes mellitus

Tese de doutoramento, Ciências Biomédicas (Ciências Funcionais), Universidade de Lisboa, Faculdade de Medicina, 2014

Pharmacist intervention on adherence to therapy in the elderly

Background: Non-adherence to therapy contributes to the increase in hospitalizations, admissions to nursing homes, decreased quality of life and consequent increased morbimortality in the elderly. Aim: To assess whether pharmacist intervention contributes to the adherence to medical prescription by elderly patients.

The role of reciprocal regulation between TAL1 and miRNA expression in T-cell leukemia progression

Tese de doutoramento, Ciências Biomédicas (Biologia Celular e Molecular), Universidade de Lisboa, Faculdade de Medicina, 2015

Utilização de folhas de estilo para definir a apresentação de páginas Web

Relatório da Prática de Ensino Supervisionada, Mestrado em Ensino de Informática, Universidade de Lisboa, 2014

Os processos de regulação educativa no programa alimentar : um estudo de caso na autarquia de Cascais

Relatório de estágio de mestrado, Educação (Área de especialização Administração Educacional), Universidade de Lisboa, Instituto de Educação, 2015

Towards the therapeutic use of regulatory T cells for the treatment of human autoimmune diseases

Tese de doutoramento, Medicina (Imunologia Clínica), Universidade de Lisboa, Faculdade de Medicina, 2016

Intervention Recommendations to Minimize the 30-Day Risk-of-Readmission for Heart Failure

Thesis (Master's)--University of Washington, 2015

Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

Objective: Individuals with obesity and type 2 diabetes differ from lean and healthy individuals in their abundance of certain gut microbial species and microbial gene richness. Abundance of Akkermansia muciniphila, a mucin-degrading bacterium, has been inversely associated with bodyfat mass and glucose intolerance in mice, but more evidence is needed in humans. The impact of diet and weight loss on this bacterial species is unknown. Our objective was to evaluate the association between fecal A. muciniphila abundance, fecal microbiome gene richness, diet, host characteristics, and their changes after calorie restriction (CR). Design: The intervention consisted of a 6-week CR period followed by a 6-week weight stabilization (WS) diet in overweight and obese adults (N=49, including 41 women). Fecal A. muciniphila abundance, fecal microbial gene richness, diet and bioclinical parameters were measured at baseline and after CR and WS. Results: At baseline A. muciniphila was inversely related to fasting glucose, waist-to-hip ratio, and subcutaneous adipocyte diameter. Subjects with higher gene richness and A. muciniphila abundance exhibited the healthiest metabolic status, particularly in fasting plasma glucose, plasma triglycerides and body fat distribution. Individuals with higher baseline A. muciniphila displayed greater improvement in insulin sensitivity markers and other clinical parameters after CR. A. muciniphila was associated with microbial species known to be related to health. Conclusion: A. muciniphila is associated with a healthier metabolic status and better clinicaloutcomes after CR in overweight/obese adults, however the interaction between gut microbiota ecology and A. muciniphila has to be taken into account.

The Wilderness Expedition: An effective life course intervention to improve young peoples well-being and connectedness to nature

It is well understood that wilderness expeditions improve well-being; however, there is little supporting quantitative data. The aim of this study was to measure the impact of wilderness expeditions on self-esteem (SE) and connectedness to nature (CN) and assess whether benefits varied according to participant and expedition characteristics. SE and CN were assessed pre– and post–wilderness expeditions in 130 adolescents using Rosenberg’s SE scale and the state CN scale. Two-way ANOVA revealed significant increases in SE and CN (p < .001) as a result of single expeditions. There was also an interaction effect of expedition and gender on SE (p < .05). Males had a higher SE at the start but female SE increased most. Linear regression revealed that living environment, gender, and the length and location of the expedition did not contribute to changes in SE and CN. Regular contact with natural environments will improve adolescent well-being, with the largest improvements in females.