Analysis of successful modes for the implementation and use of open course ware (OCW) & open educational resources (OER) in higher education : the virtual mobility case

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Conformations of poly{G}-poly{C} π stacks with high hole mobility

Charge transfer properties of DNA depend strongly on the π stack conformation. In the present paper, we identify conformations of homogeneous poly-{G}-poly-{C} stacks that should exhibit high charge mobility. Two different computational approaches were applied. First, we calculated the electronic coupling squared, V2, between adjacent base pairs for all 1 ps snapshots extracted from 15 ns molecular dynamics trajectory of the duplex G15. The average value of the coupling squared 〈 V2 〉 is found to be 0.0065 eV2. Then we analyze the base-pair and step parameters of the configurations in which V2 is at least an order of magnitude larger than 〈 V2 〉. To obtain more consistent data, ∼65 000 configurations of the (G:C)2 stack were built using systematic screening of the step parameters shift, slide, and twist. We show that undertwisted structures (twist<20°) are of special interest, because the π stack conformations with strong electronic couplings are found for a wide range of slide and shift. Although effective hole transfer can also occur in configurations with twist=30° and 35°, large mutual displacements of neighboring base pairs are required for that. Overtwisted conformation (twist38°) seems to be of limited interest in the context of effective hole transfer. The results may be helpful in the search for DNA based elements for nanoelectronics

Measuring sustained superior performance at the firm level

This paper proposes a two-dimensional Strategic Performance Measure (SPM) to evaluate the achievement of sustained superior performance. This proposal builds primarily on the fact that, under the strategic management perspective, a firm's prevalent objective is the pursuit of sustained superior performance. Three basic conceptual dimensions stem from this objective: relativity, sign dependence, and dynamism. These are the foundations of the SPM, which carries out a separate evaluation of the attained superior performance and of its sustainability over time. In contrast to existing measures of performance, the SPM provides: (i) a dynamic approach by considering the progress or regress in performance over time, and (ii) a cardinal measurement of performance differences and its changes over time. The paper also proposes an axiomatic framework that a measure of strategic performance should comply with to be theoretically and managerially sound. Finally, an empirical illustration of the Spanish banking sector during 1987-1999 is herein provided by discussing some relevant case

Prediction of postprandial blood glucose under intra-patient variability and uncertainty and its use in the design of insulin dosing strategies for type 1 diabetic patients

In this thesis I propose a novel method to estimate the dose and injection-to-meal time for low-risk intensive insulin therapy. This dosage-aid system uses an optimization algorithm to determine the insulin dose and injection-to-meal time that minimizes the risk of postprandial hyper- and hypoglycaemia in type 1 diabetic patients. To this end, the algorithm applies a methodology that quantifies the risk of experiencing different grades of hypo- or hyperglycaemia in the postprandial state induced by insulin therapy according to an individual patient’s parameters. This methodology is based on modal interval analysis (MIA). Applying MIA, the postprandial glucose level is predicted with consideration of intra-patient variability and other sources of uncertainty. A worst-case approach is then used to calculate the risk index. In this way, a safer prediction of possible hyper- and hypoglycaemic episodes induced by the insulin therapy tested can be calculated in terms of these uncertainties.

Igarapés de Manaus – uma oportunidade de ação intra-urbana

Este trabalho toma como base para reflexão uma intervenção na área dos Igarapés de Manaus desenvolvido pelo Governo do Estado com co-financiamento e apoio do Banco Interamericano de Desenvolvimento. Sem mecanismos adequados para atender ao crescimento urbano e habitacional para uma população que quintuplicou de 1970 a 2003, passando de 300.000 habitantes para quase 1,5 milhões (50% da população do Estado), a cidade sofreu com sistemáticas invasões de terras, originando situações de grande vulnerabilidade ambiental. A ocupação dessas áreas sem aptidão para ocupação urbana, representa um grave problema ambiental, urbanístico e social para a cidade. O Plano Diretor Municipal, recentemente concluído em 2002, prevê Áreas de Especial Interesse Social, e abre caminho para o desenvolvimento de legislação apropriada. O projeto em questão oferece uma boa oportunidade para testar uma abordagem inovadora no tratamento da problemática . Pretende-se fazer uma reflexão que se centra basicamente no desafio de promover uma ação ambientalmente adequada e socialmente integradora, com ênfase na promoção da regularidade jurídica e urbanística. Dessa forma o trabalho abordará as seguintes questões: como compatibilizar necessidades territoriais locais com as do conjunto da cidade, que oportunidades existem para a regularização fundiária e urbanística; e como mediar a preservação ambiental com equidade e justiça social.

Castes, Social Mobility and Politics in Goa

While the colonial policies and the missionary activities dented the caste system by playing upon the caste rivalries to divide and rule, the post-independence Indian democracy transformed the traditional castes into valuable vote-banks that have permitted non-brahmin castes to achieve political leadership in several States, particularly following the politics of reservation recommended by the Mandal Commission in 1980s.

Las fronteras intra-andinas: avances y retrocesos (Otros Temas)

El artículo analiza el proceso de integración fronteriza en la CAN partiendo de sus antecedentes y señalando las fortalezas y debilidades que lo han acompañado. La autora realiza un análisis de la importancia que el tema tiene para Colombia debido a que es este país el que más fronteras andinas comparte y el que presenta un intenso conflicto cuyos efectos se sienten en los países vecinos. Finalmente formula algunas sugerencias para el manejo de los asuntos fronterizos en la CAN a corto, mediano y largo plazo.

spotlight europe #2012/04, June 2012: Can mobility offset unemployment?

Almost a quarter of the young people in the EU are unemployed. And once again it is the crisis-ridden states that have been hit hardest. But in other countries such as France, Sweden, and Luxembourg, younger members of the workforce, far more than their older counterparts, are also finding it difficult to get a job. Freedom of movement within the EU could help to provide them with new opportunities. All that is needed is the right kind of support.

spotlight europe #2012/04, Juni 2012: Mobil statt arbeitslos? = Can mobility offset unemployment?

No abstract.