New drugs with antiprotozoal activity from marine algae: a review

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Incidência de parada cardíaca e mortalidade durante anestesia em hospital universitário de atendimento terciário no período de 2005 a 2012

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Hancornia speciosa latex for biomedical applications: physical and chemical properties, biocompatibility assessment and angiogenic activity

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Desenvolvimento de um protocolo de dosimetria para o tratamento de total skin irradiation (TSI)

A técnica radioterápica Total Skin Irradiation (TSI), utilizada para tratamento de Micose Fungóide e doenças similares, apresenta grande complexidade na sua dosimetria e implementação nos Serviços de Radioterapia. No SUS – Sistema Único de Saúde - do Brasil, só há esse tratamento no Serviço de Radioterapia do Hospital das Clínicas da UNICAMP (Campinas) e no Instituto Nacional do Câncer (INCA) (Rio de Janeiro). O objetivo deste trabalho é o estudo e o desenvolvimento de um protocolo de controle de qualidade e dosimetria a ser implementado na técnica utilizada no Serviço de Radioterapia do Hospital de Clínicas da Universidade Estadual de Campinas (HC - UNICAMP). Todos os estudos e análises para a elaboração do protocolo foram baseados no Report 23[1] da AAPM – American Association of Physicists in Medicine - e no TRS-398[3] da IAEA – International Atomic Energy Agency. A metodologia e os resultados obtidos apresentam-se descritos neste relatório

Principais aplicações terapêuticas da ozonioterapia

The ozone therapy is the therapeutic administration of ozone, which can be: subcutaneous (SC), intramuscular (IM) Intradiscal; intracavitary (pleural and peritoneal spaces); intravaginal, intrauretral, in the bladder; ozonated autohemotherapy. This therapy is being increasingly studied in order to help in some treatments and is being proven to be very effective in most cases, especially in acting on disinfection and healing of extensive wounds. There are over 6000 articles on the medical use of ozone in the literature, but the concentration used varies with each author. Most diseases have a positive response because ozone increases tissue oxygenation and metabolism. Discovered in Germany in the nineteenth century, ozone therapy still needs further study to clarify its mode of action and demonstrate its benefits. The objective of this review is to discuss some of the studies in the literature and try to clarify the main directions and forms of action of ozone therapy in medicine, showing the possibilities of getting good results including in veterinary medicine

Análise de algoritmos computacionais utilizados em sistemas de planejamento de braquiterapia de alta taxa de dose: estudo comparativo com o Código MCNP-5C

In radiotherapy, computational systems are used for radiation dose determination in the treatment’s volume and radiometric parameters quality analysis of equipment and field irradiated. Due to the increasing technological advancement, several research has been performed in brachytherapy for different computational algorithms development which may be incorporated to treatment planning systems, providing greater accuracy and confidence in the dose calculation. Informatics and information technology fields undergo constant updating and refinement, allowing the use Monte Carlo Method to simulate brachytherapy source dose distribution. The methodology formalization employed to dosimetric analysis is based mainly in the American Association of Physicists in Medicine (AAPM) studies, by Task Group nº 43 (TG-43) and protocols aimed at dosimetry of these radiation sources types. This work aims to analyze the feasibility of using the MCNP-5C (Monte Carlo N-Particle) code to obtain radiometric parameters of brachytherapy sources and so to study the radiation dose variation in the treatment planning. Simulations were performed for the radiation dose variation in the source plan and determined the dosimetric parameters required by TG-43 formalism for the characterization of the two high dose rate iridium-192 sources. The calculated values were compared with the presents in the literature, which were obtained with different Monte Carlo simulations codes. The results showed excellent consistency with the compared codes, enhancing MCNP-5C code the capacity and viability in the sources dosimetry employed in HDR brachytherapy. The method employed may suggest a possible incorporation of this code in the treatment planning systems provided by manufactures together with the equipment, since besides reducing acquisition cost, it can also make the used computational routines more comprehensive, facilitating the brachytherapy ...

Contaminação radioativa: aspectos fundamentais associados à poluição nuclear

Since its discovery, radioactivity has brought numerous benefits to human societies. It has many applications in medicine, serving as a tool for non-invasive methods for diagnosis and therapies against diseases such as cancer. It also applies to technologies for energy in nuclear power plants with relatively low impacts on terms of perfect security. All applications, however, have risks, requiring maximum caution to drive processes and operations involving radioactive elements because, once released into the environment, they have extremely harmful effects on organisms affected. This paper presents fundamental concepts and principles of nuclear physics in order to understand the effects of radioactive elements released into the environment, culminating on the issue of radioactive contamination. Literature review allowed us to understand the radioactive contamination problem on living beings. Three major nuclear accidents have happened in the last thirty years, two of them in consecutive years. The nuclear accident at Chernobyl, Ukraine, in 1986, polluted large areas, condemning hundreds of thousands of people to live with consequences of the accident and effects of radiation, killing thousands of people throughout the years. In 1987, a major radiological accident occurred in Goiania (GO) when a source of radioactive cesium was violated, leading to the death of those who had direct or indirect contact with cesium. The most recent accident, in March, 2011, was located at the nuclear power plant in Fukushima Prefecture, Japan, after an earthquake and tsunami hit the region. There is no extensive and accurate knowledge about the consequences of the contamination entailed in that accident, although it is possible to verify signals on a global scale. An analysis of reports of contamination of large areas generated by nuclear plants with release of hazardous wastes suggests it is necessary to rethink the energy matrix of the various countries...

Estudo da técnica de ressonância magnética para algumas aplicações voltadas à neurologia e à neurociência

Magnetic resonance imaging (MRI), which is studied since 1938, is a technique used in medicine to produce high quality images from inside the human body. These images are produced non-invasively and without ionizing radiation. In addition, MRI is an extremely flexible technique, with which it is possible to produce images with different contrasts that provide different information about the anatomy, structure and function of the human body, and it is therefore one of the techniques preferred by radiologists. The phenomenon of MRI is based on the interaction of magnetic fields with the nuclear spins of the scanned sample. In this work a detailed study of the technique of magnetic resonance imaging is presented, with a description of the main features of the images produced by the technique and an analysis of its application to the fields of applications Neurology and Neuroscience

Mensuração do volume atrial esquerdo pelo método biplanar de Simpson em cães portadores da doença mixomatosa da válvula mitral

Pós-graduação em Medicina Veterinária - FCAV

Desenvolvimento de imunossensor baseado na imobilização de anticorpo monoclonal em fibroína da seda para diagnóstico rápido da cisticercose bovina

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Transtorno mental comum e lazer entre estudantes da área da saúde do campus de Botucatu-UNESP: um estudo transversal

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Aneurysm and neurocysticercosis: casual or causal relationship? Case report and review of the literature

Four cases of suggestive inflammatory aneurysms in patients with neurocysticercosis have been described. We report a case of a 49-year-old woman who presented with subarachnoid haemorrhage from a right middle cerebral artery bifurcation aneurysm and had a casual relationship with neurocysticercosis. At surgery, a viable cysticercus without signs of inflammation or thickened leptomeninges was found in the distal position of the aneurysm. Postoperatively, the patient received albendazole and dextrochlorpheniramine. In the subsequent three years, the patient was asymptomatic and took drugs to prevent convulsion and arterial hypertension. The relationship between NCC and the presence of cerebral aneurysm is discussed.

Ferramenta computacional para identificação de micro-organismos com base em assinaturas genômicas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Nanocompósitos multifuncionas de fibroína reforçados com biocelulose

This work shows the preparation and characterization of the new nanocomposites based on fibroin and biocellulose. Bacterial cellulose (BC) is an exopolysaccharide produced by bacteria of the genus Gluconacetobacter, which it has identical chemical structure of the cellulose from plants and it has gained attention in the field of research for its unique properties as excellent mechanical properties when dry and hydrated , higher capacity of water retention, moldability , biodegradability and excellent biological affinity . Silk fibroin (SF) is a structural protein present in the cocoon of the silkworm, Bombyx mori, has been identified as suitable for developing optical devices, tissue engineering application, enzyme immobilization, controlled release drug agent biopolymer. Silk fibroin/bacterial cellulose nanocomposite films were prepared impregnating different cellulose charges (0.5 %, 1.0 %, 1.5 %, 2.5 %, 5.0 % and 10.0 %) weight/weight. According mechanical tests and water and Paynes's cup permeability showed that SF/BC 1% nanocomposite has the most relevant results. Poliethylenoglicol (PEG) containing SF films improved optical and mechanical properties when compared to pristine SF film. New SF/BC nanocomposites could be applied in Medicine, as biodegradable packaging and flexible substrates for OLEDs.