Loss of Outer Retinal Neurons and Circuitry Alterations in the DBA/2J Mouse

Purpose. The DBA/2J mouse line develops essential iris atrophy, pigment dispersion, and glaucomatous age-related changes, including an increase of IOP, optic nerve atrophy, and retinal ganglion cell (RGC) death. The aim of this study was to evaluate possible morphological changes in the outer retina of the DBA/2J mouse concomitant with disease progression and aging, based on the reduction of both the a- and b-waves and photopic flicker ERGs in this mouse line. Methods. Vertically sectioned DBA/2J mice retinas were evaluated at 3, 8, and 16 months of age using photoreceptor, horizontal, and bipolar cell markers. Sixteen-month-old C57BL/6 mice retinas were used as controls. Results. The DBA/2J mice had outer retinal degeneration at all ages, with the most severe degeneration in the oldest retinas. At 3 months of age, the number of photoreceptor cells and the thickness of the OPL were reduced. In addition, there was a loss of horizontal and ON-bipolar cell processes. At 8 months of age, RGC degeneration occurred in patches, and in the outer retina overlying these patches, cone morphology was impaired with a reduction in size as well as loss of outer segments and growth of horizontal and bipolar cell processes into the outer nuclear layer. At 16 months of age, connectivity between photoreceptors and horizontal and bipolar cell processes overlying these patches was lost. Conclusions. Retinal degeneration in DBA/2J mice includes photoreceptor death, loss of bipolar and horizontal cell processes, and loss of synaptic contacts in an aging-dependent manner.

A note on the real projection of the zeros of partial sums of Riemann zeta function

This paper proves that the real projection of each simple zero of any partial sum of the Riemann zeta function ζn(s):=∑nk=11ks,n>2 , is an accumulation point of the set {Res : ζ n (s) = 0}.

Motion picture projection and sound pictures.

"12th edition."--Dust jacket.

Photographic illustrations for projection, plain or colored ... : photographic views from nature in all parts of the world : extensive collection : astronomy, light and optics, anatomy, crystallography, physics, botany, geology, geography.

Cover title.

Digital-simulation and projection of head changes in the Potomac-Raritan-Magothy aquifer system, coastal plain, New Jersey /

"May 1980."

Map projection applications /

"Speech notes only, does not reflect NOS policy." -- p. i.

Forecasting models for air freight demand and projection of cargo activity at U.S. air hubs /

Mode of access: Internet.

A ready reference projection manual for educational institutions and industrial training departments.

Mode of access: Internet.

Sound equipment, motion picture projection, public address systems,

"This new book constitutes the sixth edition of Motion picture projection, the second edition of Public address systems and the second edtion of Questions and answers on sound projection."--p. [1]

Optic projection : principles, installation, and use of the magic lantern, projection microscope, reflection lantern moving picture machine, fully illustrated with plates and with over 400 text-figures /

Bibliography: p. 693-703.

Plane coordinate projection tables : Michigan.

Mode of access: Internet.

Plane coordinate projection tables : Mississippi.

Mode of access: Internet.

Linear perspective projection, &c. A text-book for the use of the Royal military academy, Woolwich. In two parts.

Part I: Text (82 p.) Part II: Plates.