Síntese, caracterização e avaliação farmacológica de derivados N-acilhidrazônicos para a prevenção de aterotrombose

Atherosclerosis is a chronic inflammatory disease characterized by accumulation of lipid and fibrous components in arterial vessels, giving rise to atheromas. Development of Atheromatou plaques leads to arterial steatosis, triggering ischemic events. Atherotrombosis has a strong correlation with atherosclerosis, where rupture of atheromatous plaques cause release of vessel wall's pro-thrombotic components, activating platelet aggregation and thromosis. Due to the major role played by platelets on thrombus-embolic conditions, drugs that inhibit platelet aggregation demonstrate great relevance for atherothrombosis prevention, reducing patient mortality. Currently, there are a variety of drugs acting on several different targets, preventing platelet activation. However, these therapies demosntrate side effects such as thrombocytopenia, neutropenia, hemorrhage and low oral availability. Thus, the application of molecular modifications such as hybridization can produce novel, more efficient antiplatelet aggregation inhibitors. In this project we describe the synthesis and characterization of novel N-acilhydrazone compounds, acting through multiple mechanisms such as platelet calcium chelation and nitric oxide donation by furoxanic subunits. Furthermore, we demonstrate that such compounds exhibit biological activity in in vivo bleeding time, in vitro antiplatelet aggregation and in vivo antinociceptive assays. Therefore, novel N-acilhydrazone compounds demonstrate potential as antiplatelet drugs for atherothrombosis prevention.

Conselheiros tutelares na linha de frente da prevenção do abuso sexual

Sexual violence against girls under the age of eighteen, in the form of sexual abuse has been identified as an endemic phenomenon by public officials in the cities of São Paulo. Among t agents and tutelary councilors, which reveal the size of their work linked to the Social Assistance System, the Health System and the Public Security System, dialoguing with their local agents. However, prevent sexual abuse and exploitation constitutes a greater challenge, consciously or unconsciously. This paper opens a discussion on the urgency of designing social networks to prevent sexual violence, with participation of researchers and university students. It is based on surveys of public officials in the years 2011 to 2013 in five cities of São Paulo, with over 200 thousand inhabitants.

Prevalência das más oclusões em crianças na clínica de graduação da Faculdade de Odontologia de Araraquara - UNESP

The aim of this study was to evaluate in dental models the occlusal relationship of children treated or in orthodontic treatment of the Undergraduate Clinic of Araraquara Dental School – UNESP. It was analyzed the vertical, anteroposterior and transversal relationships of the casts models of 388 children by two previous calibrated examiners. The results were analyzed by descriptive statistics and it was found higher prevalence of occlusal deviations in the vertical direction, followed by the sagital dimension and in lower prevalence of the transverse direction.

Dental caries in children participating in a dentistry for infants program

To assess the impact of the "Dentistry for Infants" early dental care program run by Jacareí County (SP) by comparing the caries of individuals participating and not participating in this program. Methods: In total, 300 children between 0 and 48 months old were assessed in the following two groups: infants not participating in the program (G1, n = 100) and infants participating in the program (G2, n = 200). Each group was further divided according to age in subgroups of 0 to 24 months and 25 to 48 months. All children were clinically assessed for carious lesions using the visual-tactile method. The data were statistically analyzed using a paired Student's t-test, Mann-Whitney test, and c 2 test at a 5% significance level. Results: There was a significant difference in the prevalence (P) and mean index of deciduous teeth (deft) (C) that were decayed, indicated for extraction and filled, and the highest values were observed in G1 (p < 0.0001). The values were as follows: PG1, 73%; PG2, 22%; CG1, 3.45 ± 3.84; and CG2, 0.66 ± 1.57. Conclusion: Participating in the program positively impacted the infants' oral health.

Aplicação clínica da mola T do grupo B para retração dos dentes anteriores

A TAS (Técnica do Arco Segmentado) representa uma alternativa à mecânica de deslizamento, muitas vezes dificultada pela incerteza da quantidade de força de atrito envolvida em cada sistema de forças utilizado. Nesse contexto, sabe-se que poucos cursos de Ortodontia no Brasil têm ensinado efetivamente a filosofia e o modo de trabalhar com a TAS. Portanto, este trabalho procura elucidar a forma de raciocínio das relaçÕes entre força e momento manipuladas na TAS, bem como mostrar a forma de confecção e utilização de mola "T" do grupo B, onde objetiva-se a movimentação recíproca dos segmentos posterior e anterior e, por fim, apresentar um caso clínico tratado com esse tipo de mecânica.

Hipomineralização Molar Incisivo (HMI): avaliação clínica e microscópica

This study aimed to evaluate the clinical and microscopic changes of MIH, and compare them to areas of healthy dental enamel. Methodology: epoxy resin replicas of healthy incisors and affected by MIH were evaluated qualitatively by scanning electron microscopy (SEM) photographs. Results: Clinically it was observed that MIH incisors showed changes in color and surface, with significant structural losses. By SEM, these had irregular surfaces and margins with structural losses. Conclusions: The teeth affected by HMI have clinical and morphological characteristics that are important for the definition of patient's treatment plan.

Análise clínica, tomográfica e histológica comparativa entre ha+β-tcp isolado ou associado a proteínas derivadas do esmalte utilizadas como enxertos após a elevação da membrana do seio maxilar e colocação de implantes: estudo piloto

The aim of this study was to evaluate the clinical, tomographic, and histological similarity within the use of HA+β-TCP (Boneceramic) alone or associated with enamel matrix derived (EMD) proteins in sinus lifting procedures with subsequent dental implant placement. We selected two patients with residual bony ridges between 3 mm and 5 mm in height in need of bone grafts. Six months later, eight implants were installed (two implants at each site). Biopsies were made, and the tissue was processed and stained with HE solution. Tomographic evaluation showed bone height gain up to 10.0 mm on average. Histology showed new bone formation for both groups, with similar bone density and trabecular interconnectivity. It can be concluded that the HA+β-TCP graft isolated or associated to EMD provided bone height gain in sinus lifting procedures, with similar clinical, tomographic and histological characteristics.

Caracterização clínica, demográfica e nutricional de pacientes oncológicos atendidos em um hospital público - 2008

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Conhecimento de mães sobre promoção de saúde bucal em bebês

The aim of this study was to assess the knowledge level on oral health promotion for babies of all mothers (n=60), aged 18-42 years, assisted in the Preventive Dentistry Clinic of the Faculty of Araraquara, at Universidade Estadual Paulista (UNESP), during the period 2005-2008. Methods - An interview was performed using a questionnaire with 18 open and five closed questions about knowledge and practices related to caries prevention as well as demographic information. Methods - The majority believed that breast milk does not cause caries (73,3%), that caries is not a transmissible disease (51,6%) and that anatibiotics cause caries (63,3%). Almost all mothers (93,3%) responded that brushing teeth could prevent the disease, action that should be initiated since first tooth erupts (75%). For 73,3% of the respondents, the use of dental floss should be initiated onle after all deciduous teeth erupt. Results - The majority (83,3%) knew what was fluoride, but a third of them (33,3%) did not know the best time to start using it. The dentist counseling related to oral health of babies was considered imoprtant by 96,7% of mothers. Conslusion - The mothers presented good knowledge about baby's oral hygiene, however, they did not know about other important variables for oral health promotin of babies.

Guia prático de medicina baseada em evidências

Neste livro são expostos, para uso de profissionais da área, os princípios básicos e conceitos fundamentais, além dos procedimentos necessários para a prática da Medicina Baseada em Evidências (MBE). A MBE é uma prática relativamente nova, criada em 1992, pelo cientista epidemiologista Gordon Guyatt, na canadense McMaster University. Trata-se da utilização e do desenvolvimento de métodos rigorosos que respondam a questões clinicas sobre efetividade, eficiência e segurança de determinado tratamento e prevenção, bem como sobre a sensibilidade e especificidade de testes diagnósticos de certa doença na área de saúde. A MBE propõe realizar pesquisas de boa qualidade metodológica e livres de vieses e conflitos de interesse, de forma que as respostas sejam adequadas para auxiliar na tomada de decisão clínica. Segundo a MBE, a melhor forma de saber se uma medicação específica é eficaz no tratamento de determinada doença é a revisão sistemática de ensaios clínicos randomizados, que mapeiam os estudos publicados e não publicados realizados mundialmente sobre o assunto. Tal revisão deve ainda contar com metodologia rigorosa que busque, por exemplo, explicar resultados contraditórios sobre a mesma questão e comparar estudos com diferentes amostras para detectar possível diferença estatística. De forma didática e detalhada, mas mantendo todo o rigor científico, esta obra tem caráter de manual. Ao longo dos capítulos, seus autores explicam conceitos e apresentam o passo a passo da utilização da MBE para os profissionais de saúde.

A clínica dos casos difíceis no imaginário de estudantes de psicologia

The conducts that occur in the context of intersubjectivity are arranged from unconscious psychological fields which influence individual and collective practices. Therefore, it becomes important to consider the collective imagination of psychology students as this may interfere about the exercise of their clinical practice. The aim of this study was to investigate the collective imaginary of psychology students about the clinical practice with patients considered difficult in the analytic setting. Based on the psychoanalytic method, this research utilized the Procedure of Drawings-Stories with Theme in group interview, for the purpose of discuss on the vicissitudes of contemporary clinical work with these patients. In the present study, participated eight undergraduates of the eighth semester of a psychology course.The resulting material of the interview constituted by drawings-stories and the narrative was psychoanalytically analyzed, in the light of the Multiple Fields Theory proposed by Herrmann and in dialogue with the winnicottian thought, allowing to apprehend the follows fields of affective-emotional meaning: “Insecurity”, “Perfect Therapist”, “Mutuality”, “Experience”, “Negation of Madness” and “Madness as tal”. In general the imaginary manifestations of psychology students constitute the analytic relationship with the difficult patients by mobilizing feelings of insecurity, distress, anxiety, incapacity and helplessness.

O objeto transicional pode ser uma pessoa? teoria e clínica

The objective of this work is to answer the question posed in the title, based on the texts of D. W. Winnicott. To this effect we addressed the origins of the concept of transitional object in the author’s work, the chronology of its first appearances, direct references to the topic and a discussion of a clinical case. Winnicott rarely referred to a person as being another person’s transitional object, and when he did so, he situated this experience in the field of pathology, and when referring to it, used such terms as “comforter object”, “fetish object” and “regressive object”. In contrast, the concept of transitional object is linked to an experience indicative of mental health, of transition between fusion and mother-baby separation, and of the personal and symbolic use of objects of the sensory field. Maintaining this conceptual specificity enables us to discriminate nuances in the evolution of the use of material objects by the child, and helps to guide anamnesis, diagnosis and the therapeutic process.

Cuidadores informais de idosos em pós-operatório de cirurgia de fêmur proximal: prevenção de novas quedas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Replantation as treatment for extrusive luxation

In the treatment of extrusive luxation cases, it is important that the repositioning of extruded tooth in the socket is done as soon as possible. If this does not occur, periapical clot becomes organized and makes replantation difficult reposition. In this article the patient referred to the Clinics for dental trauma sustaining extrusive luxation of the maxillary right central incisor. The patient reported having suffered a bicycle accident 12 days before, which caused traumatic tooth injuries. The repositioning was attempted without success and an alternative form of treatment was necessary to solve the case. Intentional tooth replantation, which is the deliberate extraction of the tooth and its replantation, was indicated. This technique allows clot removal and correct repositioning of the extruded tooth. Care should be taken as endodontic treatment is required for the prevention of subsequent infection-related resorption. Intracanal dressing with calcium hydroxide was used for 30 days before final root filling. Splint, systemic antibiotics and avoidance of further damage to the root surface is also important. After 49 months, showed clinical and radiographic characteristics of normality and demonstrates the availability of this technique to adversity in trauma.