922 resultados para Erik Satie
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New opportunities for social stratification research in Sweden: International occupational classifications and stratification measures over time The Swedish occupational classifications have in recent years been changed to a version of the international standard ISCO-88(COM), i.e. SSYK 96. As a consequence, a wide variety of internationally well-known stratification measures can be applied to Swedish data sets. In this article some tests of the validity of translation keys between the older national classifications and SSYK 96 are presented. The keys seem to work satisfactorily. Thus, it is possible to create long time-series with ISCO/SSYK and use these well-known stratification measures over time. Hence, the international interest in Swedish data sets, and empirical results based on these data sets, could rise. Moreover, in the article an empirical regularity, which is quite astonishing, is paid attention to; stratification measures based on different theoretical rationales indicate very similar hierarchies of occupations.
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Sociologisk Forsknings digitala arkiv
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Objectives: To translate and evaluate the psychometric properties of the Swedish version of the Fear of Complications Questionnaire. Design: Cross-sectional study design and scale development. Settings: Totally, 469 adults (response rate 63.5%) with Type 1 diabetes completed the questionnaires. Participants were recruited from two university hospitals in Sweden. Participants: Eligible patients were those who met the following inclusion criteria: diagnosed with Type 1 diabetes, diabetes duration of at least 1 year and aged at least 18 years. Methods: The Fear of Complications Questionnaire was translated using the forward-backward translation method. Factor analyses of the questionnaire were performed in two steps using both exploratory and confirmatory factor analysis. Convergent validity was examined using the Hospital Anxiety and Depression Scale and the Fear of Hypoglycaemia Fear Survey. Internal consistency was estimated using Cronbach’s alpha.Results: Exploratory factor analysis supported a two-factor solution. One factor contained three items having to do with fear of kidney-related complications and one factor included the rest of items concerning fear of other diabetes-related complications, as well as fear of complications in general. Internal consistency was high Cronbach’s alpha 0.96. The findings also gave support for convergent validity, with significant positive correlations between measures (r = 0.51 to 0.54). Conclusion: The clinical relevance of the identified two-factor model with a structure of one dominant subdomain may be considered. We suggest, however a one-factor model covering all the items as a relevant basis to assess fear of complications among people with Type 1 diabetes.
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Analyses of circulating metabolites in large prospective epidemiological studies could lead to improved prediction and better biological understanding of coronary heart disease (CHD). We performed a mass spectrometry-based non-targeted metabolomics study for association with incident CHD events in 1,028 individuals (131 events; 10 y. median follow-up) with validation in 1,670 individuals (282 events; 3.9 y. median follow-up). Four metabolites were replicated and independent of main cardiovascular risk factors [lysophosphatidylcholine 18∶1 (hazard ratio [HR] per standard deviation [SD] increment = 0.77, P-value<0.001), lysophosphatidylcholine 18∶2 (HR = 0.81, P-value<0.001), monoglyceride 18∶2 (MG 18∶2; HR = 1.18, P-value = 0.011) and sphingomyelin 28∶1 (HR = 0.85, P-value = 0.015)]. Together they contributed to moderate improvements in discrimination and re-classification in addition to traditional risk factors (C-statistic: 0.76 vs. 0.75; NRI: 9.2%). MG 18∶2 was associated with CHD independently of triglycerides. Lysophosphatidylcholines were negatively associated with body mass index, C-reactive protein and with less evidence of subclinical cardiovascular disease in additional 970 participants; a reverse pattern was observed for MG 18∶2. MG 18∶2 showed an enrichment (P-value = 0.002) of significant associations with CHD-associated SNPs (P-value = 1.2×10-7 for association with rs964184 in the ZNF259/APOA5 region) and a weak, but positive causal effect (odds ratio = 1.05 per SD increment in MG 18∶2, P-value = 0.05) on CHD, as suggested by Mendelian randomization analysis. In conclusion, we identified four lipid-related metabolites with evidence for clinical utility, as well as a causal role in CHD development.
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Syftet med uppgiften är att få kunskap om hur pedagoger uppfattar och ser på teknik i förskolan. För att undersöka detta har jag formulerat följande övergripande frågeställningar: Hur resonerar, uppfattar och ser pedagoger på begreppet teknik?, samt Hur arbetar pedagogerna med teknik i förskolan? Som metod har jag valt semistrukturerade kvalitativa intervjuer som tolkas utifrån fenomenologisk teori och sex pedagoger vid sex olika verksamheter i en kommun har intervjuats. Pedagogerna i studien ser teknikämnet som något positivt och tycker det är kul, men framför att många i deras arbetslag finner en viss rädsla för ämnet. Teknik behöver inte vara svårt och går att fånga i vardagen på förskolan, men det svåra är att medvetandegöra för barnen att de arbetar med teknik. Av studiens resultat framkommer att teknik på förskolorna framför allt är bygg- och konstruktion med olika strukturerade och ostrukturerade material, och att aktiviteter sker främst spontant och äger rum året runt både inomhus och utomhus.
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In present study interviews with five officials and the gathering of documentation carried out in a reception center for newly arrived refugees located in a medium-sized municipality in central Sweden. The aim has been on the basis of the collected empirical data to evaluate how the municipality worked to promote the integration of newcomers, what measures were available, whether there were existing goals, and how they were formulated, and the extent to which they were implemented. This constituted, together with earlier research and systems theory based framework for the study's conclusions. The study showed that communication between and within the investigated unit was partly flawed. It has also showed that there was a degree of conflict in organizational approaches within the examined entity which could cause bottlenecks in the activity. The current study also showed the difficulty in estimating the resources currently needed to cover the need of, among others, Swedish for immigrants.
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Studiens syfte är att undersöka hur omsorgspersonal inom äldreomsorgen upplever äldres behov av samtalsstöd. Metoden som har använts är kvalitativ i form av individuella semistrukturerade intervjuer med sex informanter som arbetar som omsorgspersonal inom den kommunala äldreomsorgen. De teoretiska utgångspunkter som har tillämpats är socialkonstruktionism samt Erik Homburger Eriksons teori om människans livsstadier. Resultatet av studien visar att det enligt omsorgspersonalen finns ett samtalsbehov hos brukare inom äldreomsorgen som inte alltid kan tillgodoses idag på grund av omsorgspersonalens tidsbrist samt avsaknad av kompetens i att möta djupa frågor. Kuratorer inom äldreomsorgen skulle kunna bidra med samtalsstöd för äldre samt vara ett stöd för anhöriga och personal. Resultatet antyder till att behovet av kuratorer inom äldreomsorgen kommer att öka. Framtidens äldre förmodas ställa mer krav än de gör idag på att få samtalsstöd eftersom denna insats blir högre och mer accepterad i samhället.
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Self-help and self-censorship: A self-help cultural perspective on organizational silence This paper seeks to explain silence in the workplace through an analytical perspective derived from Judith Butlers work on censorship, and in this way suggest an alternative to explanations in the existing literature on employee silence, which are often tied to the actions and motivations of the individual subject. It is thus argued that self-help books can be seen as indicative of a pervasive culture of self-improvement, which among other things promotes the absence of criticism in the workplace. The empirical point of departure for this argument is the two bestselling self-help books The secret by Rhonda Byrne and The 7 habits of highly effective people by Stephen Covey. Theoretically, the paper applies Butlers notion of ”implicit censorship” where censorship is understood as productive in the sense of being constitutive of language. Hence, in the analysis it is shown how discursive regimes in self-help literature tend to be constructed in such a way, that explicit criticism cannot emerge as a meaningful activity, and is thus implicitly censored.
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I denna artikel redogörs för två delstudier i projektet Musikfolkhögskolans utbildningsideologier. Dels behandlas utbildningsideologier bland svenska folkmusiker under 1920-talet (von Wachenfeldt, Brändström & Liljas, 2012a) och dels ges en bild av hur undervisningen av folkmusiker kan gestalta sig i en samtidskontext (von Wachenfeldt, Brändström & Liljas, 2012b).I projektet som helhet anknyts till ett ideologibegrepp som utvecklats av Sven-Erik Liedman. Han menar att det för varje tid fnns två identiferbara grundformer av ideologi: manifesta och latenta (1997; 2006). Manifesta ide-ologier avser explicita och medvetet formulerade utsagor med ideologiskt innehåll som binder samman verklighetspåståenden, värderingar och nor-mer. Latenta eller frusna ideologier är sådant som fnns under ytan och som tas för givet av fältets aktörer.
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Vinylen har lyckats överleva trots att både CD:n och det digitala formatet gett oss nya och lättare sätt att lyssna på musiken. Vinylen tilltalar personer i yngre åldrar som inte växte upp med vinylen som det vardagliga formatet. Det tydligaste resultat som kommit att visa sig i undersökning för denna uppsats är att vinyler fortfarande upplevs tilltalande av intervjupersonerna, även om det digitala formatet fortfarande används dagligen. Intervjupersonerna tilltalas av olika aspekter av vinylen som gör det värt att gå och köpa en skiva, även om vi lever i en tid där vi näst intill har obegränsad tillgång till musik digitalt. Vinylen lockar personer på olika sätt när det kommer till användningen av skivorna och på samma sätt när det kommer till det materiella och det estetiska. Detta är dock inte tillräckligt för att personerna ska ändra sina lyssningsvanor och byta format från det digitala till analogt. För det är fortfarande det digitala formatet som används mest av intervjupersonerna.
Chloroquine is grossly under dosed in young children with malaria : implications for drug resistance
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Background: Plasmodium falciparum malaria is treated with 25 mg/kg of chloroquine (CQ) irrespective of age. Theoretically, CQ should be dosed according to body surface area (BSA). The effect of dosing CQ according to BSA has not been determined but doubling the dose per kg doubled the efficacy of CQ in children aged <15 years infected with P. falciparum carrying CQ resistance causing genes typical for Africa. The study aim was to determine the effect of age on CQ concentrations. Methods and Findings: Day 7 whole blood CQ concentrations were determined in 150 and 302 children treated with 25 and 50 mg/kg, respectively, in previously conducted clinical trials. CQ concentrations normalised for the dose taken in mg/kg of CQ decreased with decreasing age (p<0.001). CQ concentrations normalised for dose taken in mg/m(2) were unaffected by age. The median CQ concentration in children aged <2 years taking 50 mg/kg and in children aged 10-14 years taking 25 mg/kg were 825 (95% confidence interval [CI] 662-988) and 758 (95% CI 640-876) nmol/l, respectively (p = 0.67). The median CQ concentration in children aged 10-14 taking 50 mg/kg and children aged 0-2 taking 25 mg/kg were 1521 and 549 nmol/l. Adverse events were not age/concentration dependent. Conclusions: CQ is under-dosed in children and should ideally be dosed according to BSA. Children aged <2 years need approximately double the dose per kg to attain CQ concentrations found in children aged 10-14 years. Clinical trials assessing the efficacy of CQ in Africa are typically performed in children aged <5 years. Thus the efficacy of CQ is typically assessed in children in whom CQ is under dosed. Approximately 3 fold higher drug concentrations can probably be safely given to the youngest children. As CQ resistance is concentration dependent an alternative dosing of CQ may overcome resistance in Africa.
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BACKGROUND: The role of inflammation and oxidative stress in mild renal impairment in the elderly is not well studied. Accordingly, we aimed at investigating the associations between estimated glomerular filtration rate (eGFR), albumin/creatinine ratio (ACR), and markers of different inflammatory pathways and oxidative stress in a community based cohort of elderly men. FINDINGS: Cystatin C-based GFR, ACR, and biomarkers of cytokine-mediated inflammation (interleukin-6, high-sensitivity C-reactive protein[CRP], serum amyloid A[SAA]), cyclooxygenase-mediated inflammation (urinary prostaglandin F2alpha [PGF2alpha]), and oxidative stress (urinary F2 isoprostanes) were assessed in the Uppsala Longitudinal Study of Adult Men(n = 647, mean age 77 years). RESULTS: In linear regression models adjusting for age, BMI, smoking, blood pressure, LDL-cholesterol, HDL-cholesterol, triglycerides, and treatment with statins, ACE-inhibitors, ASA, and anti-inflammatory agents, eGFR was inversely associated with CRP, interleukin-6, and SAA (beta-coefficient -0.13 to -0.19, p < 0.001 for all), and positively associated with urinary F2-isoprostanes (beta-coefficient 0.09, p = 0.02). In line with this, ACR was positively associated with CRP, interleukin-6, and SAA (beta- coefficient 0.09-0.12, p < 0.02 for all), and negatively associated with urinary F2-isoprostanes (beta-coefficient -0.12, p = 0.002). The associations were similar but with lower regression coefficients in a sub-sample with normal eGFR (>60 ml/min/1.73 m2, n = 514), with the exception that F2-isoprostane and SAA were no longer associated with eGFR. CONCLUSION: Our data indicate that cytokine-mediated inflammation is involved in the early stages of impaired kidney function in the elderly, but that cyclooxygenase-mediated inflammation does not play a role at this stage. The unexpected association between higher eGFR/lower albuminuria and increased F2-isoprostanes in urine merits further studies.
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BACKGROUND: Increased circulating cathepsin S levels have been linked to increased risk of cardiometabolic diseases and cancer. However, whether cathepsin S is a modifiable risk factor is unclear. We aimed to investigate the effects of a prudent diet on plasma cathepsin S levels in healthy individuals. FINDINGS: Explorative analyses of a randomized study were performed in 88 normal to slightly overweight and hyperlipidemic men and women (aged 25 to 65) that were randomly assigned to ad libitum prudent diet, i.e. healthy Nordic diet (ND) or a control group (habitual Western diet) for 6 weeks. Whereas all foods in the ND were provided, the control group was advised to consume their habitual diet throughout the study. The ND was in line with dietary recommendations, e.g. low in saturated fats, sugars and salt, but high in plant-based foods rich in fibre and unsaturated fats.The ND significantly decreased cathepsin S levels (from 20.1 (+/-4.0 SD) to 19.7 μg/L (+/-4.3 SD)) compared with control group (from 18.2 (+/-2.9 SD) to 19.1 μg/L (+/-3.8 SD)). This difference remained after adjusting for sex and change in insulin sensitivity (P = 0.03), and near significant after adjusting for baseline cathepsin S levels (P = 0.06), but not for change in weight or LDL-C. Changes in cathepsin S levels were directly correlated with change in LDL-C. CONCLUSIONS: Compared with a habitual control diet, a provided ad libitum healthy Nordic diet decreased cathepsin S levels in healthy individuals, possibly mediated by weight loss or lowered LDL-C. These differences between groups in cathepsin S were however not robust and therefore need further investigation.
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In the area of campaign financing in federal elections, one of the most controversial issues is that of soft money. Soft money refers to those funds raised by the national party organizations for use on various grassroots and party-building activities. but which are not subject to the restraints of federal campaign finance law. Critics contend that these party-building activitie, such as generic television advertising, voter registration and get-out-the vote drives, provide ancillary benefits to federal candidates and should, therefore, be subject to federal contribution and expenditure limits. Critics further argue that because these funds are not subject to federal law and do benefit federal candidates, the national parties raise monies in amounts and from sources, such as corporations and unions, that are prohibited under federal law. Efforts to gain a better understanding of soft money have been hampered by a lack of data, as the national parties were not required to disclose their soft money receipts and transactions until 1991. The purpose of this study is to analyze data recently made available in an attempt to add the import of empirical evidence to the debate over soft money. The nature, size and timing of soft money contributions are investigated and national party soft money disbursements are examined. The findings suggest that any attempts to reform the soft money system must first consider its compensatory benefits. Most prominently, this includes the extent to which soft money has promoted the resurgence of the national party organizations in the context of election politics.