983 resultados para Desenvolvimento fetal - Efeitos de drogas


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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Introduction: The growth of the aged population in developing countries is fast. Cognitive, motion, metabolic and social injuries are associated to aging, which are potentially able to impair the quality of life of the elder population. A physical activity that provides a mental and physical welfare besides its importance to the good aging, therefore, the Tai Chi Chuan is considered an effi cient and cheap way to improve the quality of life and to reduce the physical alterations unchained by aging. Objective: To verify the effect of the Tai Chi Chuan of the quality of life, fl exibility and balance in elderly. Methods: Nine volunteers, three men (66.33 ± 13.32 years) and six women (68.67 ± 11.34 years) participated in the study. They performed the training of Tai Chi Chuan during 12 weeks, two times per week, with duration of one hour each session. The volunteers were evaluated at the beginning of the study and after the 12 weeks of training by means of the application of the questionnaire of quality of life SF-36, a scale of balance and the test to seat and to reach was applied to evaluate the fl exibility. Results: It was observed in the Tai Chi Chuan training improvement of the balance and fl exibility; however, the quality of life did not present signifi cant difference. Conclusion: These fi ndings allow us to conclude that the Tai Chi Chuan was effi cient in the improvement of the equilibrium and the fl exibility of elder people; however, it did not modify the Quality of Life of the studied population.

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Programas educacionais de prevenção são mecanismos utilizados para suprir necessidades, sendo importante conhecer peculiaridades de sua aplicação e resultados obtidos. O objetivo deste estudo foi identificar e analisar o método e os resultados de publicações sobre o Programa Educacional de Resistência às Drogas e à Violência (PROERD), tanto no Brasil quanto no exterior. A pesquisa foi realizada nas bases de dados Scielo, Lilacs, Medline, Cohrane e Eric, utilizando-se como descritores os termos Proerd, Dare, Programa Proerd, Dare program e Dare Project. Verificou-se que são escassas as publicações, sobretudo no Brasil, não há padronização de instrumentos de pesquisa e há divergências entre os resultados que avaliaram o PROERD. Conclui-se que é preciso ampliar a realização e a divulgação de pesquisas que investigam o desenvolvimento e os resultados do programa.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Pós-graduação em Biociências - FCLAS

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Speech has been regarded as a social communicative modality required for building relationships in different contexts and cultures. Nevertheless, this is not always a readily available resource, especially for those who have developmental disorders. In this sense, Augmentative and Alternative Communication resources and strategies have been used by nonspeaking students with disabilities as useful tools to achieve greater social participation in different environments. Therefore, the present study examined the interaction between teachers and a student with cerebral palsy before and after the use of Alternative Communication strategies in the classroom. The study had a quantitative and qualitative nature and was designed as an intervention study. There were four main stages: 1) filming before the introduction of the resources in the classroom, 2) training the school teachers 3) providing technical assistance regarding the use of alternative communication to the child's teacher 4) filming teacher-student interactions using these technological resources. The interactions were transcribed and grouped into links. In this research, a link means the initiator's behavior directed to the exchange partner and the response in sequence from the interlocutor back to the initiator. It was found that the established interactions presented a maximum of four links, with greater frequency for episodes of 1st and 2nd links. After the intervention, there were different contexts with the presence of interactions up to the 6th link, often greater frequency for episodes of 1st, 2nd and 3rd links. In addition, the teacher showed a tendency to use symbols only as a tool for evaluating and teaching concepts. This perception changed as the teacher became familiarized with the Augmentative and Alternative Communication technology resources.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Silicosis, a common type of pneumoconiosis, is an occupational lung disease caused by inhalation of silica dust often with mining activity and thus reaches the miners. The fine and ultrafine silica particles deposited in the alveolar epithelium may lead to the development of progressive massive fibrosis. An increased reactive oxygen species (ROS) production has been proposed to explain the mechanism for induction of pulmonary fibrosis in silicosis. In this situation, alveolar macrophages are activated to phagocytes silica particles deposited in the alveoli. The activated macrophages secrete large amounts of ROS that in turn induce synthesis of fibrotic factors. In addition, the activity of antioxidant enzymes is impaired, which results in increased lipid peroxidation, as well as generating a local inflammatory process. Diffuse pulmonary fibrosis progresses with interstitial collagen deposition. Interstitial collagen overlies small pulmonary arteries and arterioles and thus it is associated with pulmonary hypertension in pulmonary fibrotic diseases. In addition, cytokines and silica particles passing through the respiratory membrane can reach the bloodstream. In this context, the increase in the generation of ROS in the circulation may lead to a reduction in the bioavailability of nitric oxide, an important endothelium-derived relaxing factor. A deficiency in the nitric oxide bioavailability can result in vascular endothelial dysfunction. Moreover, pro-inflammatory cytokines could contribute to the impairment of endothelial function. In the airways, pro-inflammatory cytokines can reduce the smooth muscle responsiveness to β- adrenergic agonists as isoproterenol. Thus, the aim of this study was to evaluate the effect of silica dust instillation in the function of the pulmonary artery, aorta and trachea of rats with acute silicosis. For this purpose, male Wistar rats were anesthetized... (Complete abstract click electronic access below)