Prenatal testosterone exposure as a model for the study of endocrine-disrupting chemicals on the gerbil prostate

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Solutions of the bound-state Faddeev-Yakubovsky equations in three dimensions by using NN and 3N potential models

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Towards a Realization of the Condensed-Matter-Gravity Correspondence in String Theory via Consistent Abelian Truncation of the Aharony-Bergman-Jafferis-Maldacena Model

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Analysis of tectonic-controlled fluvial morphology and sedimentary processes of the western Amazon Basin: an approach using satellite images and digital elevation model

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

THE GREEN-FUNCTION IN THE BLOCH-NORDSIECK MODEL FOR QED(3)

The electron Green's function is obtained in the Bloch-Nordsieck approximation of three-dimensional QED. Dimensional regularization is used in the intermediate stages of calculation.

Molecular model for the binary complex of uropepsin and pepstatin

The three-dimensional structure of human uropepsin complexed with pepstatin has been modelled using human pepsin as a template. Uropepsin is an aspartic proteinase from the urine, produced in the form of pepsinogen A in the gastric mucosa. The structure is bilobal, consisting of two predominantly beta -sheet lobes which, as observed in other aspartic proteinases, are related by a pseudo twofold axis. A structural comparison between binary complexes of pepsin:pepstatin and uropepsin:pepstatin is discussed. (C) 2001 Academic Press.

Quantum tunneling fragmentation model

A nonthermal quantum mechanical statistical fragmentation model based on tunneling of particles through potential barriers is studied in compact two- and three-dimensional systems. It is shown that this fragmentation dynamics gives origin to several static and dynamic scaling relations. The critical exponents are found and compared with those obtained in classical statistical models of fragmentation of general interest, in particular with thermal fragmentation involving classical processes over potential barriers. Besides its general theoretical interest, the fragmentation dynamics discussed here is complementary to classical fragmentation dynamics of interest in chemical kinetics and can be useful in the study of a number of other dynamic processes such as nuclear fragmentation. ©2000 The American Physical Society.

Renormalization of the ladder light-front Bethe-Salpeter equation in the Yukawa model

The reduction of the two-fermion Bethe-Salpeter equation in the framework of light-front dynamics is studied for the Yukawa model. It yields auxiliary three-dimensional quantities for the transition matrix and the bound state. The arising effective interaction can be perturbatively expanded in powers of the coupling constant gs allowing a defined number of boson exchanges; it is divergent and needs renormalization; it also includes the instantaneous term of the Dirac propagator. One possible solution of the renormalization problem of the boson exchanges is shown to be provided by expanding the effective interaction beyond single boson exchange. The effective interaction in ladder approximation up to order g4 s is discussed in detail. It is shown that the effective interaction naturally yields the box counterterm required to be introduced ad hoc previously. The covariant results of the Bethe-Salpeter equation can be recovered from the corresponding auxiliary three-dimensional quantities.

Euclidean 4d exact solitons in a Skyrme type model

We introduce a Skyrme type, four-dimensional Euclidean field theory made of a triplet of scalar fields n→, taking values on the sphere S2, and an additional real scalar field φ, which is dynamical only on a three-dimensional surface embedded in R4. Using a special ansatz we reduce the 4d non-linear equations of motion into linear ordinary differential equations, which lead to the construction of an infinite number of exact soliton solutions with vanishing Euclidean action. The theory possesses a mass scale which fixes the size of the solitons in way which differs from Derrick's scaling arguments. The model may be relevant to the study of the low energy limit of pure SU(2) Yang-Mills theory. © 2004 Elsevier B.V. All rights reserved.

Analytical model for heterogeneous crystallization kinetics of spherical glass particles

An analytical model developed to describe the crystallization kinetics of spherical glass particles has been derived in this work. A continuous phase transition from three-dimensional (3D)-like to 1D-like crystal growth has been considered and a procedure for the quantitative evaluation of the critical time for this 3D-1D transition is proposed. This model also allows straightforward determination of the density of surface nucleation sites on glass powders using differential scanning calorimetry data obtained under different thermal conditions. © 2009 The American Ceramic Society.

A new proposed rodent model of chemically induced prostate carcinogenesis: Distinct time-course prostate cancer progression in the dorsolateral and ventral lobes

Background. Characterization of novel rodent models for prostate cancer studies requires evaluation of either spontaneous and carcinogen-induced tumors as well as tumor incidence in different prostatic lobes. We propose a new short-term rodent model of chemically induced prostate carcinogenesis in which prostate cancer progression occurs differentially in the dorsolateral and ventral lobes. Methods. Adult gerbils were treated with MNU alone or associated with testosterone for 3 or 6 months of treatment. Tumor incidence, latency, localization, and immunohistochemistry (AR, PCNA, smooth muscle α-actin, p63, MGMT, and E-cadherin) were studied in both lobes. Results. Comparisons between both lobes revealed that lesions developed first in the DL while the VL presented longer tumor latency. However, after 6 months, there was a dramatic increase in tumor multiplicity in the VL, mainly in MNU-treated groups. Lesions clearly progressed from a premalignant to a malignant phenotype over time and tumor latency was decreased by MNU + testosterone administration. Three-dimensional reconstruction of the prostatic complex showed that the DL developed tumors exclusively in the periurethral area and showed intense AR, PCNA, and MGMT immunostaining. Moreover, VL lesions emerged throughout the entire lobe. MNU-induced lesions presented markers indicative of an aggressive phenotype: lack of basal cells, rupture of the smooth muscle cell layer, loss of E-cadherin, and high MGMT staining. Conclusions. There are distinct pathways involved in tumor progression in gerbil prostate lobes. This animal provides a good model for prostate cancer since it allows the investigation of advanced steps of carcinogenesis with shorter latency periods in both lobes. Copyright © 2013 Wiley Periodicals, Inc.

Análise de parâmetros da função característica de Hamilton

A análise de velocidades é um processo fundamental na sísmica de reflexão, onde as velocidades de empilhamento bem como o tempo de trânsito de afastamento nulo (onde supõe-se que a fonte e o detetor ocupam a mesma posição) são parâmetros suficientes na determinação do modelo geológico para meios com camadas horizontais. Por outro lado quando expresso através do formalismo estabelecido por Hamilton, os mesmos parâmetros (velocidade e tempo de afastamento nulo) são suficientes para determinar a função característica para este mesmo tipo de meio. Para o caso de um modelo geológico heterogêneo com interfaces arbitrariamente curvas, a função característica de Hamilton é dada a partir da estimativa de nove parâmetros, onde os mesmos parâmetros são necessários na determinação do modelo geológico em 3D. Este trabalho tem por objetivo estimar os parâmetros que determinam a função característica de Hamilton para meios 3D e estudar a influência de cada parâmetro na função, através de cortes horizontais nas seções de tempos de trânsito (conhecidos como time slices), nas configurações de ponto médio comum e afastamento nulo. Dentro desta abordagem é dado um exemplo a partir de um modelo sintético onde, aqueles resultados obtidos com estudo da influência de cada parâmetro na função característica, são aplicados como um critério de ajuste entre a função característica calculada e a função de tempos de trânsito obtida no levantamento de dados.

Métodos sísmicos de refração e eletromagnético aplicados ao estudo de um paleocanal da Ilha do Marajó, Pará

Os métodos sísmico de refração e eletromagnético foram aplicados, em caráter experimental, à prospecção de água subterrânea. A eficiência destes métodos foi testada com cerca de 1.500m de perfis de refração rasa na delimitação geométrica em três dimensões de um paleocanal na região dos campos naturais da Ilha de Marajó e com um perfil eletromagnético (técnica Slingram) para a detecção de contatos laterais de água doce-água salobra. A interpretação dos dados sísmicos foi realizada com as equações de tempo de intersecção para n camadas inclinadas com o auxílio do controle geológico de 2 (dois) poços para contornar problemas de camadas não detectadas. Obteve-se uma baixa velocidade (0,81 km/s) para os sedimentos silte-arenosos saturados que preenchem o paleocanal. Em virtude da inversão de velocidades ter sido obtida como resultado para estes sedimentos, não se aconselha o mapeamento de paleocanais pela sísmica de refração, salvo com a utilização de técnicas especiais de campo (registro digital, 'up-hole survey', registro ondas S, reflexão simultânea, ...). Os dados eletromagnéticos foram analisados semi-quantitativamente com o auxílio de um modelo reduzido construído a partir de uma seção de resistividades aparentes. Um diagrama de Argand, traçado com os dados de laboratório, fornece subsídios para a determinação da condutância em ambientes de sedimentos não consolidados análogos ao de Marajó. Recomenda-se a utilização dos métodos eletromagnéticos para o reconhecimento lateral de zonas de água doce-água-salobra, uma vez que a componente quadratura da frequência alta (2640 Hz) define, com precisão suficiente, estas zonas. A comparação dos resultados dos dois métodos mostra que apenas parte do paleocanal se comporta como um aquífero.

Bright solitons in a quasi-one-dimensional dipolar Bose-Einstein condensate

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Modelo petrofísico 3D do Arenito Namorado no Campo de Namorado - Bacia de Campos, RJ

The Namorado Oil Field represents the beginning of the oil exploration in Brazil, in the 70s, and it is still a subject of researches because the importance of this turbidite sandstone in the brazilian oil production. The Namorado’s production level was denominated “Namorado sandstone”, it is composed by turbidite sandstone deposited during the Albian-Cenomanian. In order to define the structural geometry of the main reservoir, geological and geophysical tools like RECON and Geographix (Prizm – Seisvision) softwares were used, and its application was focused on geological facies analysis, for that propose well logs, seismic interpretation and petrophysical calculations were applied. Along this work 15 vertical wells were used and the facies reservoirs were mapped of along the oil field; it is important to mentioned that the all the facies were calibrated by the correlation rock vs log profile, and 12 reservoir-levels (NA-1, NA-2, NA-3, NA-4, NA-5, NA-6, NA-7, NA-8, NA-9, NA-10, NA-11 e NA-12) were recognized and interpreted. Stratigraphic sections (NE-SW and NW-SE) were also built based on stratigraphic well correlation of each interpreted level, and seismic interpretation (pseudo-3D seismic data) on the southeastern portion of the oil field. As results it was interpreted on two- and three-dimensional maps that the deposition reservoir’s levels are hight controlled by normal faults systems. This research also shows attribute maps interpretation and its relationship with the selection of the reservoir attribute represented on it. Finally the data integration of stratigraphic, geophysical and petrophysical calculations lets us the possibility of obtain a detail geological/petrophysical 3D model of the main reservoir levels of “Namorado sandstone” inside the oil/gás field