Molecular model for the binary complex of uropepsin and pepstatin
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
20/05/2014
20/05/2014
14/09/2001
|
| Resumo |
The three-dimensional structure of human uropepsin complexed with pepstatin has been modelled using human pepsin as a template. Uropepsin is an aspartic proteinase from the urine, produced in the form of pepsinogen A in the gastric mucosa. The structure is bilobal, consisting of two predominantly beta -sheet lobes which, as observed in other aspartic proteinases, are related by a pseudo twofold axis. A structural comparison between binary complexes of pepsin:pepstatin and uropepsin:pepstatin is discussed. (C) 2001 Academic Press. |
| Formato |
277-281 |
| Identificador |
http://dx.doi.org/10.1006/bbrc.2001.5555 Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc., v. 287, n. 1, p. 277-281, 2001. 0006-291X http://hdl.handle.net/11449/35884 10.1006/bbrc.2001.5555 WOS:000171012600044 |
| Idioma(s) |
eng |
| Publicador |
Academic Press Inc. |
| Relação |
Biochemical and Biophysical Research Communications |
| Direitos |
closedAccess |
| Palavras-Chave | #aspartic proteinase #uropepsin #pepstatin #complex #model #Structure |
| Tipo |
info:eu-repo/semantics/article |
