Measurement of the energy spectrum of cosmic rays above 10(18) eV using the Pierre Auger Observatory

We report a measurement of the flux of cosmic rays with unprecedented precision and Statistics using the Pierre Auger Observatory Based on fluorescence observations in coincidence with at least one Surface detector we derive a spectrum for energies above 10(18) eV We also update the previously published energy spectrum obtained with the surface detector array The two spectra are combined addressing the systematic uncertainties and, in particular. the influence of the energy resolution on the spectral shape The spectrum can be described by a broken power law E(-gamma) with index gamma = 3 3 below the ankle which is measured at log(10)(E(ankle)/eV) = 18 6 Above the ankle the spectrum is described by a power law with index 2 6 followed by a flux suppression, above about log(10)(E/eV) = 19 5, detected with high statistical significance (C) 2010 Elsevier B V All rights reserved

A study of the effect of molecular and aerosol conditions in the atmosphere on air fluorescence measurements at the Pierre Auger Observatory

The air fluorescence detector of the Pierre Auger Observatory is designed to perforin calorimetric measurements of extensive air showers created by Cosmic rays of above 10(18) eV. To correct these measurements for the effects introduced by atmospheric fluctuations, the Observatory contains a group Of monitoring instruments to record atmospheric conditions across the detector site, ail area exceeding 3000 km(2). The atmospheric data are used extensively in the reconstruction of air showers, and are particularly important for the correct determination of shower energies and the depths of shower maxima. This paper contains a summary of the molecular and aerosol conditions measured at the Pierre Auger Observatory since the start of regular operations in 2004, and includes a discussion of the impact of these measurements oil air shower reconstructions. Between 10(18) and 10(20) eV, the systematic Uncertainties due to all atmospheric effects increase from 4% to 8% in measurements of shower energy, and 4 g cm(-2) to 8 g cm(-2) in measurements of the shower maximum. (C) 2010 Elsevier B.V. All rights reserved.

Biflavonoids from Araucaria angustifolia protect against DNA UV-Induced damage

Ultraviolet radiation is one of the most deleterious forms of radiation to terrestrial organisms and is involved in formation of mutagenic pyrimidine dimers and oxidized nucleotides. The biflavonoid fraction (BFF), extracted from needles of Araucaria angustifolia was capable of protecting calf thymus DNA from damage induced by UV radiation. This occurred through prevention of cyclobutane thymine dimer and 8-oxo-7,8-dihydro-2`-deoxyguanosine formation, this being quantified by high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) in a multiple reaction monitoring mode (MRM) and by HPLC-coulometric detection, respectively. (C) 2009 Elsevier Ltd. All rights reserved.

Glypican-3 regulates migration, adhesion and actin cytoskeleton organization in mammary tumor cells through Wnt signaling modulation

Glypican-3 (GPC3) is a proteoglycan involved in migration, proliferation and cell survival modulation in several tissues. There are many reports demonstrating a downregulation of GPC3 expression in some human tumors, including mesothelioma, ovarian and breast cancer. Previously, we determined that GPC3 reexpression in the murine mammary adenocarcinoma LM3 cells induced an impairment of their in vivo invasive and metastatic capacities together with a higher susceptibility to in vitro apoptosis. Currently, the signaling mechanism of GPC3 is not clear. First, it was speculated that GPC3 regulates the insulin-like growth factor (IGF) signaling system. This hypothesis, however, has been strongly challenged. Recently, several reports indicated that at least in some cell types GPC3 serves as a selective regulator of Wnt signaling. Here we provide new data demonstrating that GPC3 regulates Wnt pathway in the metastatic adenocarcinoma mammary LM3 cell line. We found that GPC3 is able to inhibit canonical Wnt signals involved in cell proliferation and survival, as well as it is able to activate non canonical pathway, which directs cell morphology and migration. This is the first report indicating that breast tumor cell malignant properties can be reverted, at least in part, by GPC3 modulation of Wnt signaling. Our results are consistent with the potential role of GPC3 as a metastasis suppressor.

Schistosoma mansoni: In vitro schistosomicidal activity of piplartine

Schistosomiasis is one of the world`s greatly neglected tropical diseases, and its control is largely dependent on a single drug, praziquantel. Here, we report the in vitro effect of piplartine, an amide isolated from Piper tuberculatum (Piperaceae), on Schistosoma mansoni adult worms. A piplartine concentration of 15.8 mu M reduced the motor activity of worms and caused their death within 24 h in a RPMI 1640 medium. Similarly, the highest sub-lethal concentration of piplartine (6.3 mu M) caused a 75% reduction in egg production in spite of coupling. Additionally, piplartine induced morphological changes on the tegument, and a quantitative analysis carried out by confocal microscopy revealed an extensive tegumental destruction and damage in the tubercles. This damage was dose-dependent in the range of 15.8-630.2 mu M. At doses higher than 157.6 mu M, piplartine induced morphological changes in the oral and ventral sucker regions of the worms. It is the first time that the schistosomicidal activity has been reported for piplartine. Published by Elsevier Inc.

Från varningsklocka till säkerhetspolitiska beslutsunderlag : En beskrivande studie av relationen mellan den svenska militära underrättelsetjänsten och beslutsfattare på politisk nivå

Uppsatsen har som syfte att beskriva relationen mellan den svenska militära underrättelsetjänsten och beslutsfattare på politisk nivå. Utgående från Samuel Huntingtons och Morris Janowitz teorier om civil-militära relationer studerar jag 1974 och 1996 års underrättelseutredningar för att genom en jämförelse av dessa försöka beskriva relationen utifrån teorins etablerade begrepp imperatives och control, i denna studie översatta till fordringar och kontroll. Studien genomförs som en kvalitativ innehållsanalys och dokumentstudie. Analysen av hur utredningarna beskriver den svenska militära underrättelsetjänsten tjänar som underlag för att beskriva relationen mellan beslutsfattare och underrättelsetjänst och hur denna utvecklats. Slutsatserna visar att det sedan mitten av 1970-talet råder en uttalad och tämligen oförändrad syn på att det är de funktionella fordringarna som styr den militära underrättelsetjänsten. Med en förändrad säkerhetspolitisk situation har den militära underrättelsetjänsten fått en viktigare roll och ökat inflytande i den politiska processen samtidigt som den politiska sidans syn på behov av kontroll och insyn i underrättelsetjänsten har ökat. Underrättelsetjänstens autonomi visavi beslutsfattarna kan sägas ha minskat.

Kommunikation bortom orden : En etnografisk studie om hur lärares actio och ickeverbala kommunikation påverkar elevers motivation

Syftet med detta examensarbete är att få insikt i hur lärarens ickeverbala kommunikation och actio påverkar elevers motivation. Utifrån en etnografisk arbetsmetod observerades en svensklärare på en gymnasieskola under fyra lektionstimmar för att undersöka hur läraren kommunicerade med sina elever ickeverbalt. Parallellt med observationerna intervjuades både läraren och eleverna som deltog i undersökningen. Undersökningen visade att lärares ickeverbala kommunikation och actio har en stor påverkan på elevernas motivation, att denna påverkan sker omedelbart och att den kan förändras under en pågående lektion. När en lärare medvetandegör hur hon eller han kommunicerar med sina elever ickeverbalt kan aspekter som oavsiktlig och intuitiv kommunikation få en mindre påverkan på undervisningen. Detta bidrar i sin tur till att utveckla lärarens ickeverbala kompetens och på så sätt sin förmåga att motivera sina elever under hela lektionen.