890 resultados para HLA-DRB1 Chains


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Az elmúlt évtizedekben a gazdálkodástudomány kitüntetett figyelemmel kísért két - mind a makrogazdaság, mind az egyes vállalatok működésének sikere szempontjából meghatározó fontosságú - jelenséget, egyrészt a szolgáltatásoknak a hagyományos termeléssel szembeni egyre erőteljesebb térnyerését, másrészt a fogyasztói érték teremtése szempontjából növekvő jelentőségű ellátási láncoknak, illetve azok menedzsmentjének kérdéskörét. Ugyanakkor igen kevés elemzés, de kevés leíró jellegű munka is született a két jelenséget és menedzsment problémát összekapcsoló területről, azaz a szolgáltatások ellátási láncáról, ezen ellátási láncok kezelésének speciális problémáiról. Jelen műhelytanulmányban a szolgáltatások ellátási láncának és menedzsmentjének jellegzetességeit, a klasszikus terméket előállító ellátási láncokhoz viszonyított sajátosságait foglaltuk össze a nemzetközi szakirodalom alapján. Ennek során bemutattuk, hogy az ún. tiszta szolgáltatások széles körben ismert jellemzői hatással vannak a szolgáltatások előállítását és értékesítését végző ellátási láncok működésére is. Ezek a hatások és a specialitások megjelennek az ellátási lánc menedzsment irodalomban megjelenő mindhárom problémakörre, rányomják tehát bélyegüket mind az ellátási lánc felépítésére, struktúrájára, mind az ellátási láncban együttműködő partnerek kapcsolatának = In the last decades scholars have paid a lot of attention to both service operation and supply chain management. There is still limited research on the overlapping field of theses two management areas, on service supply chain specialties. This working paper gives a structured overview on the latest research results published in English. Doing so the paper would like to draw attention of the Hungarian researchers to this field and facilitate these empirical researches. As described in the paper traditional service specialties (intangibility, perishability, inseparability, heterogeneity and the importance of human capital) create special management problems concerning (i) the structure of these supply chains, (ii) their relationship management and (iii) the management of supply chain processes.

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A tanulmány célja, hogy azonosítsa azokat a tényezőket, amelyek befolyásolják az élelmiszer-gazdasági kis- és közepes vállalkozások szerződéseinek teljesülését a Közép-magyarországi régióban. Számításaink megerősítik Guo-Jolly [2008] eredményeit, amely szerint a szerződések tartalmi elemeinek kulcsszerepük van a szerződések teljesülésében. Továbbá a vállalatvezetői képességek, a vállalati és tranzakciós jellemzők szintén jelentős hatást gyakorolnak a szerződések teljesülésére. Érdekes módon az ágazatspecifikus jellemzőknek csak korlátozott szerepük van a szerződések teljesülésének magyarázatában. / === / The paper analyses the contractual relations and contract fulfilment of small and medium-sized firms along the food chain, in the central region of Hungary, using survey data. The estimates also reveal that contract fulfilment is significantly affected by the design of the contract. They confirm that an important role in contract fulfilment is played by corporate and managerial attributes and transaction characteristics. Interestingly, branch-specific characteristics play only a limited role in explaining contract fulfilment.

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Megközelítésemben az "innovációs lánc" olyan társadalmi kapcsolathálót jelent, ahol a kapcsolat tartalma egy gazdasági újítás átadása. Dolgozatom fõ kérdése az, hogy egy településen kialakult társadalmi hálózat szerkezete hogyan befolyásolja az innovációk átvételének útját és terjedési sebességét. __________ A chain of innovation is a social network, defined by offering or adopting an economic innovation. The main hypothesis is that the diffusion of rural innovations and the changes of life-style of the peasants (generally: the growth of market economy) do not necessarily restructure or destroy local networks, but in some cases they will be reinforceed.

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The role of retail chains is signifi cant, not only in the European but also in the Hungarian market. Major changes can be seen in the food trade, and hypermarkets and supermarkets are becoming more widespread, which has an international tendency. We are able to see the transformation of trade structure and changes in customer behaviour. On the customers’ side, this means newer demands on retail chains, which fact greatly determines the location and shape of stores. In Hungary, the presence of small shops is still signifi cant, in accordance with European and international trends; yet on the basis of turnover, the increasing dominance of larger sales centres can be seen.

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A tanulmánykötet a globális értékláncok névvel fémjelezett jelenséget veszi górcső alá. A fókuszban a multinacionális vállalatcsoportok ill. a nemzetközi cégek állnak. A tíz tanulmány különböző megközelítések alapján betekintést ad abba, hogy hogyan ragadhatják meg és vizsgálhatják a kutatók a globális értékláncokat a vállalatok, ill. vezetőik nézőpontjából, mi következik a kutatási eredményekből a vállalatok vezetői számára, és milyen következményei vannak a globális értékláncok karakteres és terjedő jelenlétének a nemzetgazdaságok gazdasági politikáit formálókra. A tanulmánykötet szerzői a 2012/2013.tanév tavaszi félévében a Nemzetközi üzleti gazdaságtan c. PhD kurzus hallgatói voltak. ______ The working paper is to provide a Hungarian language overview on the research finding s on Global Value Chain and global factory. The phenomenon behind them is recognized but under researched in Hungary. The chapters of the working paper are to cover as many angles and perspectives of Global Value Chain as many it is possible. Each chapter is based on a published English language paper. Theoretical and conceptual issues, considerations of MNEs and small- and medium sized enterprises and that of national policies are discussed. Authors of the working paper attended the International Business PhD course in the spring semester of 2012/2013.

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A kereskedelmi láncok különböző stratégiákat választhatnak, illetve alkalmazhatnak a társadalmi, gazdasági és környezeti kihívások kezelésére, a társadalmi normákhoz és elvárásokhoz való igazodáshoz. A tanulmányban a szerző azt vizsgálja, hogy milyen összefüggés van a társadalmi felelősségvállalásuk és a versenyképességük között, s a felelős magatartásuk javítja-e versenypozíciójukat. Bemutatja, hogy hazai viszonylatban a nagyobb forgalmat lebonyolító kereskedelmi láncok milyen CSR-tevékenységet végeznek, ez beépült-e hosszabb távú üzleti stratégiájukba, és mennyiben járul/járulhat hozzá versenyképességük fokozásához. Elemzi több kereskedelmi láncnál, hogy miképpen sikerült összeegyeztetni társadalmi felelősségvállalásukat a profitérdekeltségükkel, továbbá megteremthető-e a felelős működésük és a költséghatékony gazdálkodásuk összhangja. Többek között rámutat arra, hogy a gazdasági és külső szociális felelősségvállalásuk, továbbá a versenyképességük közötti pozitív korreláció megkérdőjelezhetetlen, ami win-win szituációt alakít ki. ______ Commercial companies can embark on and apply different strategies to tackle social, economic and environmental challenges and to comply with the standards and expectations of the community. In the study the author analyses the relationship between corporate social responsibility activities and competitiveness, and whether or not the responsible attitude of these companies improves their competitive position. She outlines the CSR activities of high turnover commercial chains in Hungary, examining their incorporation into the company’s longer term business strategy, and how these activities may contribute to their enhanced competitiveness. She will analyse several commercial chains from the point of view of their success in harmonizing their CSR with their profit making, and whether they can create the harmony of an environmentally friendly attitude and cost-effective operations. Among other findings, the author concludes that there is an unquestionable correlation between corporate economic and outside social responsibility and profitability, which creates a definite win-win situation.

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This dissertation delivers a framework to diagnose the Bull-Whip Effect (BWE) in supply chains and then identify methods to minimize it. Such a framework is needed because in spite of the significant amount of literature discussing the bull-whip effect, many companies continue to experience the wide variations in demand that are indicative of the bull-whip effect. While the theory and knowledge of the bull-whip effect is well established, there still is the lack of an engineering framework and method to systematically identify the problem, diagnose its causes, and identify remedies. ^ The present work seeks to fill this gap by providing a holistic, systems perspective to bull-whip identification and diagnosis. The framework employs the SCOR reference model to examine the supply chain processes with a baseline measure of demand amplification. Then, research of the supply chain structural and behavioral features is conducted by means of the system dynamics modeling method. ^ The contribution of the diagnostic framework, is called Demand Amplification Protocol (DAMP), relies not only on the improvement of existent methods but also contributes with original developments introduced to accomplish successful diagnosis. DAMP contributes a comprehensive methodology that captures the dynamic complexities of supply chain processes. The method also contributes a BWE measurement method that is suitable for actual supply chains because of its low data requirements, and introduces a BWE scorecard for relating established causes to a central BWE metric. In addition, the dissertation makes a methodological contribution to the analysis of system dynamic models with a technique for statistical screening called SS-Opt, which determines the inputs with the greatest impact on the bull-whip effect by means of perturbation analysis and subsequent multivariate optimization. The dissertation describes the implementation of the DAMP framework in an actual case study that exposes the approach, analysis, results and conclusions. The case study suggests a balanced solution between costs and demand amplification can better serve both firms and supply chain interests. Insights pinpoint to supplier network redesign, postponement in manufacturing operations and collaborative forecasting agreements with main distributors.^

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For producers motivated by their new status as self-employed, landowning, capitalist coffee growers, specialty coffee presents an opportunity to proactively change the way they participate in the international market. Now responsible for determining their own path, many producers have jumped at the chance to enhance the value of their product and participate in the new "fair trade" market. But recent trends in the international coffee price have led many producers to wonder why their efforts to produce a certified Fair Trade and organic product are not generating the price advantage they had anticipated. My study incorporates data collected in eighteen months of fieldwork, including more than 45 interviews with coffee producers and fair trade roasters, 90 surveys of coffee growers, and ongoing participant observation to understand how fair trade certification, as both a market system and development program, meets the expectations of the coffee growers. By comparing three coffee cooperatives that have engaged the Fair Trade system to disparate ends, the results of this investigation are three case studies that demonstrate how global processes of certification, commodity trade, market interaction, and development aid effect social and cultural change within communities. This study frames several lessons learned in terms of (1) socioeconomic impacts of fair trade, (2) characteristics associated with positive development encounters, and (3) potential for commodity producers to capture value further along their global value chain. Commodity chain comparisons indicate the Fair Trade certified cooperative receives the highest per-pound price, though these findings are complicated by costs associate with certification and producers' perceptions of an "unjust" system. Fair trade-supported projects are demonstrated as more "successful" in the eyes of recipients, though their attention to detail can just as easily result in "failure". Finally, survey results reveal just how limited is the market knowledge of producers in each cooperative, though fair trade does, in fact, provide a rare opportunity for producers to learn about consumer demand for coffee quality. Though bittersweet, the fair trade experiences described here present a learning opportunity for a wide range of audiences, from the certified to the certifiers to the concerned public and conscientious consumer.

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The long-term performance of the lodging chain is highly dependent on the use of the most effective techniques for evaluating capital projects. This study provides information on the critical aspects of lodging chains' capital budgeting practices and compares current ones with those used by chains in 1980 and 1990.

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Little research has been done to measure brand equity of hospitality companies. It is important for food service organizations to measure accurately their brand equity in order to manage and leverage it properly. This study attempts to measure the brand equity of casual dining restaurant chains in monetary terms using conjoint analysis.

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In the latest phase of globalization, transnational corporations based in the U.S. have worked closely with U.S. foreign policymakers to secure favorable foreign direct investment provisions within U.S. domestic legislation and within U.S. trade agreements. These interactions between transnational firms and the U.S. state have provided many of the preconditions for an expansion of foreign direct investment connected to capital liberalization and the growth of global supply chains from the 1980s to the present. This relationship is best conceptualized as representing a “transnational interest bloc,” whose policy objectives are incorporated within investment provisions in US-backed trade and investment agreements.

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The human leukocyte antigen (HLA) complex is an extensively studied cluster of genes with immunoregulatory function. Pseudomonas aeruginosa is capable of infecting individuals with weakened immune systems, and is associated with a high mortality rate. Previous genetic studies of the HLA region have found correlations between bacterial infection and its effect on regulating HLA gene expressions to establish their infection. This project analyzes the expression of classical HLA loci (A, B, C, DR, DQ, DP) in human B cells and macrophage cells during the infection of virulent strains of P. aeruginosa. Cells were cultured and infected with different virulent live, and heat-killed strains of P. aeruginosa for different time periods. The mRNA was extracted and converted into cDNA followed by real-time quantitative PCR and data analysis. The Western Blot technique was used to identify the targeted protein’s cell surface expression. Infection with P. aeruginosa was found to inhibit the expression of HLA proteins. The PA14 strain inhibited expression of all targeted genes in all experiments. Infections with PA01 and PA103 showed different patterns depending on the incubation time and the targeted gene. These differences suggest that the three strains use various mechanisms to inhibit HLA protein expression.

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In this study wave propagation, dispersion relations, and energy relations for linear elastic periodic systems are analyzed. In particular, the dispersion relations for monoatomic chain of infinite dimension are obtained analytically by writing the Block-type wave equation for a unit cell in order to capture the dynamic behavior for chains under prescribed vibration. By comparing the discretized model (mass-spring chain) with the solid bar system, the nonlinearity of the dispersion relation for chain indicates that the periodic lattice is dispersive in contrast to the continuous rod, which is non dispersive. Further investigations have been performed considering one-dimensional diatomic linear elastic mass-spring chain. The dispersion relations, energy velocity, and group velocity have been derived. At certain range of frequencies harmonic plane waves do not propagate in contrast with monoatomic chain. Also, since the diatomic chain considered is a linear elastic chain, both of the energy velocity and the group velocity are identical. As long as the linear elastic condition is considered the results show zero flux condition without residual energy. In addition, this paper shows that the diatomic chain dispersion relations are independent on the unit cell scheme. Finally, an extension for the study covers the dispersion and energy relations for 2D- grid system. The 2x2 grid system show a periodicity of the dispersion surface in the wavenumber domain. In addition, the symmetry of the surface can be exploited to identify an Irreducible Brillouin Zone (IBZ). Compact representations of the dispersion properties of multidimensional periodic systems are obtained by plotting frequency as the wave vector’s components vary along the boundary of the IBZ, which leads to a widely accepted and effective visualization of bandgaps and overall dispersion properties.

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From the 12th until the 17th of July 2016, research vessel Maria S. Merian entered the Nordvestfjord of Scorsby Sound (East Greenland) as part of research cruise MSM56, "Ecological chemistry in Arctic fjords". A large variety of chemical and biological parameters of fjord and meltwater were measured during this cruise to characterize biogeochemical fluxes in arctic fjords. The photo documentation described here was a side project. It was started when we were close to the Daugaard-Jensen glacier at the end of the Nordvestfjord and realized that not many people have seen this area before and photos available for scientists are probably rare. These pictures shall help to document climate and landscape changes in a remote area of East Greenland. Pictures were taken with a Panasonic Lumix G6 equipped with either a 14-42 or 45-150 objective (zoom factor available in jpg metadata). Polarizer filters were used on both objectives. The time between taking the pictures and writing down the coordinates was maximally one minute but usually shorter. The uncertainty in position is therefore small as we were steaming slowly most of the time the pictures were taken (i.e. below 5 knots). I assume the uncertainty is in most cases below 200 m radius of the noted position. I did not check the direction I directed the camera to with a compass at the beginning. Hence, the direction that was noted is an approximation based on the navigation map and the positioning of the ship. The uncertainty was probably around +/- 40° but initially (pictures 1-17) perhaps even higher as this documentation was a spontaneous idea and it took some time to get the orientation right. It should be easy, however, to find the location of the mountains and glaciers when being on the respective positions because the mountains have a quite characteristic shape. In a later stage of this documentation, I took pictures from the bridge and used the gyros to approximate the direction the camera was pointed at. Here the uncertainty was much lower (i.e. +/- 20° or better). Directions approximated with the help of gyros have degree values in the overview table. The ship data provided in the MSM56 cruise report will contain all kinds of sensor data from Maria S. Merian sensor setup. This data can also be used to further constrain the position the pictures were taken because the exact time a photo was shot is noted in the metadata of the .jpg photo file. The shipboard clock was set on UTC. It was 57 minutes and 45 seconds behind the time in the camera. For example 12:57:45 on the camera was 12:00:00 UTC on the ship. All pictures provided here can be used for scientific purposes. In case of usage in presentations etc. please acknowledge RV Maria S. Merian (MSM56) and Lennart T. Bach as author. Please inform me and ask for reprint permission in case you want to use the pictures for scientific publications. I would like to thank all participants and the crew of Maria S. Merian Cruise 56 (MSM56, Ecological chemistry in Arctic fjords).

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OBJETIVOS El objetivo principal de esta tesis doctoral consiste en determinar la presencia de la proteína HLA-G en la superficie celular de células madre CD34/CD133, células dendríticas mieloides y plasmacitoides, células dendríticas derivadas de células CD34/CD133 y derivadas de monocitos de sangre de cordón umbilical y sangre periférica materna, por técnicas de citometría de flujo y la expresión de la proteína HLA-G soluble en plasma de sangre de cordón umbilical por técnicas de ELISA. MATERIALES Y METODOS Se obtuvo un total de 35 unidades de sangre de cordón umbilical y 35 muestras de sangre periférica de gestantes a término que acudieron al Servicio de Ginecología y Obstetricia del Hospital Clínico Universitario San Carlos con cesáreas programadas, según aprobación de Comité Ético. Se realizaron técnicas de cultivo celular, citometría de flujo, Elisa y anticuerpos monoclonales, según protocolo, para la obtención de las células madre CD34+, células dendríticas mieloides y plasmacitoides del cordón umbilical y células dendríticas derivadas de células madre CD34+, y determinación de la molécula HLA-G, isoformas, nuevos alelos y polimorfismos...