Ampliació de les funcionalitats de l’ACME

L’ACME és una plataforma d’e-learning orientada a la correcció automàtica d’exercicis. Cada alumne té un dossier personalitzat d’exercicis, on cada exercici pot tenir una forma particular de correcció amb un nucli corrector diferent. Actualment l’ACME té diversos tipus d’exercicis entre ells hi ha: els matemàtics, els de programació, els de bases de dades relacionals, tipus tests, cert o fals, etc. Tot i tenir molts tipus d’exercicis de correcció automàtica, l’ACME no disposa de gaires exercicis de correcció manual, ni de treball en grup ni tampoc sistemes per avaluar de forma correcta els exercicis d’aquesta tipologia. Altres mancances del sistema les trobem en que no disposa de cap sistema d’importació i exportació de les assignatures i és per això que quan s'acaba un curs, si el professor vol repetir el mateix l'any següent ho ha de tornar a introduir tot.El que es pretén amb aquest és incorporar un conjunt de nous mòduls a l’ACME que permetin als usuaris facilitar les seves tasques i la interacció entre ells intentant cobrir les diferents mancances que hi ha.

Use of the Kala-Azar Detect® and IT-LEISH® rapid tests for the diagnosis of visceral leishmaniasis in Brazil

The performances of two rapid tests and a standard serological test for the diagnosis of visceral leishmaniasis (VL) were compared using sera from 193 patients with VL and 85 controls. The Kala-Azar Detect®, IT-LEISH® and IFI-LH® assays showed sensitivities of 88.1%, 93.3% and 88.6%, respectively, and specificities of 90.6%, 96.5% and 80%, respectively. The sensitivity values were similar for both rapid tests, but the specificity and positive predictive values of IT-LEISH® were higher than the corresponding values for IFI-LH®. Both rapid tests showed satisfactory performances and can be used in primary health care settings; however, IT-LEISH® permits the use of whole blood, making this assay more suitable for bedside diagnosis.

Comparison of two rapid tests for anti-phenolic glycolipid-I serology in Brazil and Nepal

The diagnosis of leprosy continues to be based on clinical symptoms and early diagnosis and treatment are critical to preventing disability and transmission. Sensitive and specific laboratory tests are not available for diagnosing leprosy. Despite the limited applicability of anti-phenolic glycolipid-I (PGL-I) serology for diagnosis, it has been suggested as an additional tool to classify leprosy patients (LPs) for treatment purposes. Two formats of rapid tests to detect anti-PGL-I antibodies [ML immunochromatography assay (ICA) and ML Flow] were compared in different groups, multibacillary patients, paucibacillary patients, household contacts and healthy controls in Brazil and Nepal. High ML Flow intra-test concordance was observed and low to moderate agreement between the results of ML ICA and ML Flow tests on the serum of LPs was observed. LPs were "seroclassified" according to the results of these tests and the seroclassification was compared to other currently used classification systems: the World Health Organization operational classification, the bacilloscopic index and the Ridley-Jopling classification. When analysing the usefulness of these tests in the operational classification of PB and MB leprosy for treatment and follow-up purposes, the ML Flow test was the best point-of-care test for subjects in Nepal and despite the need for sample dilution, the ML ICA test yielded better performance among Brazilian subjects. Our results identified possible ways to improve the performance of both tests.

Androgen dependence of hirsutism, acne, and alopecia in women: retrospective analysis of 228 patients investigated for hyperandrogenism.

Hirsutism, acne, alopecia, and oligo-amenorrhea are clinical expressions of hyperandrogenism, one of the most frequent endocrine disorders in women of reproductive age. Women referred to our endocrine clinics for skin symptoms of hyperandrogenism underwent a laboratory workup to evaluate hormone measurements and received antiandrogen therapy. We retrospectively analyzed the outcome of 228 consecutive patients investigated over 6 years.Patients with hirsutism had higher levels of androstenedione, dehydroepiandrosterone sulfate (DHEAS), and salivary testosterone; lower levels of sex hormone-binding globulin (SHBG); and a higher prevalence of oligo-amenorrhea than patients with alopecia, while patients with acne showed intermediate values. Hirsutism score correlated positively with androstenedione, DHEAS, and salivary testosterone, and correlated negatively with SHBG; salivary testosterone showed the highest correlation coefficient. Total testosterone was not significantly different among patients with hirsutism, alopecia, or acne, and did not significantly correlate with hirsutism score. Hirsutism and oligo-amenorrhea were the most sensitive symptoms of hyperandrogenism, and no androgenic parameter alone allowed us to identify all cases of hyperandrogenism.Patients of central European origin sought consultation with milder hirsutism scores than patients of southern European origin. There was, however, no difference in the clinical-biological correlation between these groups, arguing against differences in skin sensitivity to androgens.Polycystic ovary syndrome, defined as hyperandrogenism (hirsutism or elevated androgens) and oligo-amenorrhea, was diagnosed in 63 patients (27.6%), an underestimate compared with other reports that include systematic ovarian ultrasound studies. Neither pelvic ultrasound, used in a limited number of cases, nor the luteinizing hormone/follicle-stimulating hormone ratio helped to distinguish patients with polycystic ovary syndrome from the other diagnostic groups. These included hyperandrogenism (hirsutism or elevated androgens) and eumenorrhea (101 patients; 44.3%); normal androgens (acne or alopecia and eumenorrhea) (51 patients; 22.4%); isolated low SHBG (7 patients; 3.1%); nonclassical congenital adrenal hyperplasia (4 patients; 1.8% of total, 4.9% of patients undergoing cosyntropin stimulation tests); and ovarian tumor (2 patients; 0.9%).Ethinylestradiol and high-dose cyproterone acetate treatment lowered the hirsutism score to 53.5% of baseline at 1 year, and was also effective in treating acne and alopecia. The clinical benefit is ascribed to the peripheral antiandrogenic effect of cyproterone acetate as well as the hormone-suppressive effect of this combination. Salivary testosterone showed the most marked proportional decrease of all the androgens under treatment. Cost-effectiveness and tolerance of ethinylestradiol and high-dose cyproterone acetate compared well with other antiandrogenic drug therapies for hirsutism. The less potent therapy with spironolactone only, a peripheral antiandrogen without hormone-suppressive effect, was effective in treating isolated alopecia in patients with normal androgens.

Allergy to betalactam antibiotics in children: a prospective follow-up study in retreated children after negative responses in skin and challenge tests.

BACKGROUND: Up to 10% of the patients in whom suspected betalactam hypersensitivity (HS) has been excluded by skin and challenge tests report suspected allergic reactions during subsequent treatments with the same or very similar betalactams. It has been suggested that the reactions may result from a resensitization induced by the challenge performed at the time of the allergological work-up. However, most patients did not undergo a second allergological work-up, to determine if the reactions resulted from betalactam HS or not. OBJECTIVES: We aimed to determine if children diagnosed nonallergic to betalactams have tolerated subsequent treatments with the initially suspected and/or other betalactams, and, in case of a reaction, if the reaction resulted from betalactam HS. Methods: We sent a questionnaire concerning the clinical history of their children to the parents of 256 children previously diagnosed nonallergic to betalactams. A second allergological work-up was performed in the children reporting suspected allergic reactions during subsequent treatments with the same and/or other betalactams. Skin tests were performed with the soluble form of the suspected (or very similar) betalactams and other betalactams from the same and other classes. Skin test responses were assessed at 15-20 min (immediate), 6-8 h (semi-late) and 48-72 h (late). Oral challenge (OC) was performed in children with negative skin tests, either at the hospital (immediate and accelerated reactions), or at home (delayed reactions). RESULTS: A response was obtained from 141 children (55.3%). Forty-eight (34%) of those children had not been treated with the betalactams for whom a diagnosis of allergy had been ruled out previously. Seven (7.5%) of the 93 children who had been treated again reported suspected allergic reactions. Skin tests and OC were performed in six of those children, and gave negative results in five children. In one child previously diagnosed nonallergic to amoxicillin associated with clavulanic acid, we diagnosed a delayed HS to clavulanic acid and a serum sickness-like disease to cefaclor. Thus, the frequency of reactions resulting from betalactam HS in children with negative skin and challenge tests is very low, and does not exceed 2.1% (2/93) if we consider that the child which refused a second allergological work-up is really allergic to betalactams. CONCLUSION: Our results in a very large number of children show that reactions presumed to result from betalactam HS are rare in children in whom the diagnosis of betalactam allergy has been ruled out previously. Moreover, they suggest that, as shown for the initial reactions, most of the reactions during subsequent treatments are rather a consequence of the infectious diseases for whom betalactams have been prescribed than a result of betalactam HS. Finally, they suggest that the risk of resensitization by OC is very low, and do not support the notion that skin testing should be repeated in children diagnosed nonallergic to betalactams.

A crónica no panorama literário cultural cabo-verdiano : da crítica social a uma preocupação humanitária : Salústio e Medina : dois casos paradigmático

Esta dissertação visou compreender o caráter temático e discursivo de algumas crónicas literárias de dois autores cabo-verdianos, Dina Salústio e Daniel Medina, e provar o carácter pedagógico e humanitário das composições. Fez-se, num primeiro momento, um estudo de conteúdos teóricos sobre a cronística portuguesa, visando recensear aspetos relacionados com a evolução do género ao longo dos tempos, desde a Idade Média até à Contemporaneidade, sempre numa perspetiva pragmática, e discutiram-se as características enformadoras do género, sendo assinaláveis a subjetividade, versatilidade, objetividade, estilo entre o oral e o literário, quotidianidade e dialogismo. De seguida, em termos metodológicos, optou-se por convocar o ethos de Amossy e Maingueneau para o estudo das composições. Num segundo momento, através de dez crónicas literárias cabo-verdianas, sendo cinco de cada autor, procedeu-se à análise crítica das quais se confirmou, a partir da análise temática, uma preocupação pedagógica e humanitária uma vez que se notou uma certa inquietação com problemas que envolvem a idiossincrasia do homem cabo-verdiano, como a perda de valores em termos educacionais e instrucionais, quer no seio familiar como escolar, a preocupação com os mais desfavorecidos materialmente, onde se destacam crianças órfãs de pais vivos, o descaso com os doentes mentais e as crianças de rua, a gravidez precoce, a prostituição infantil, entre outros. O modo, como os cronistas se posicionam face à abordagem dos temas, permitiu-nos projetar o ethos discursivo de duas personalidades sensíveis, sérias e comprometidas com os valores mais nobres que enformam o ser humano. Do mesmo modo, pôde constatar como características relevantes das composições a subjetividade e pessoalidade discursivas, a brevidade, o diálogo no estilo indirecto livre, a quotidianidade e literariedade aliados a alguns recursos retóricos que nos permitiram apurar os tons sério e irónico do sujeito enunciador ao tratar as questões temáticas.

Els dissenys curriculars per competències en els títols de grau i postgrau: possibilitats i limitacions

L'Espai Europeu d'Educació Superior planteja reptes ineludibles que caldrà abordar a mig i llarg termini en tant que impliquen un canvi cultural difícil d'incorporar sobtadament per bona part de la comunitat acadèmica. El debat sobre el tipus de plans d'estudis (el seu contingut i estructura) i sobre les formes organitzatives i de treball que hi haurien de portar aparellades no és un debat sobre el format o l'aparença en què organitzem el treball sinó sobre el propi sentit del treball, de la missió de les institucions universitàries i del nostre rol com a professors i professores.

Innovative Solutions for Slope Stability Reinforcement and Characterization: Vol. I, TR-489, 2005

Soil slope instability concerning highway infrastructure is an ongoing problem in Iowa, as slope failures endanger public safety and continue to result in costly repair work. Characterization of slope failures is complicated, because the factors affecting slope stability can be difficult to discern and measure, particularly soil shear strength parameters. While in the past extensive research has been conducted on slope stability investigations and analysis, this research consists of field investigations addressing both the characterization and reinforcement of such slope failures. The current research focuses on applying an infrequently-used testing technique comprised of the Borehole Shear Test (BST). This in-situ test rapidly provides effective (i.e., drained) shear strength parameter values of soil. Using the BST device, fifteen Iowa slopes (fourteen failures and one proposed slope) were investigated and documented. Particular attention was paid to highly weathered shale and glacial till soil deposits, which have both been associated with slope failures in the southern Iowa drift region. Conventional laboratory tests including direct shear tests, triaxial compression tests, and ring shear tests were also performed on undisturbed and reconstituted soil samples to supplement BST results. The shear strength measurements were incorporated into complete evaluations of slope stability using both limit equilibrium and probabilistic analyses. The research methods and findings of these investigations are summarized in Volume 1 of this report. Research details of the independent characterization and reinforcement investigations are provided in Volumes 2 and 3, respectively. Combined, the field investigations offer guidance on identifying the factors that affect slope stability at a particular location and also on designing slope reinforcement using pile elements for cases where remedial measures are necessary. The research findings are expected to benefit civil and geotechnical engineers of government transportation agencies, consultants, and contractors dealing with slope stability, slope remediation, and geotechnical testing in Iowa.

Innovative Solutions for Slope Stability Reinforcement and Characterization: Vol. II, TR-489, 2005

Soil slope instability concerning highway infrastructure is an ongoing problem in Iowa, as slope failures endanger public safety and continue to result in costly repair work. While in the past extensive research has been conducted on slope stability investigations and analysis, this current research study consists of field investigations addressing both the characterization and reinforcement of such slope failures. While Volume I summarizes the research methods and findings of this study, Volume II provides procedural details for incorporating an infrequently-used testing technique, borehole shear tests, into practice. Fifteen slopes along Iowa highways were investigated, including thirteen slides (failed slopes), one unfailed slope, and one proposed embankment slope (the Sugar Creek Project). The slopes are mainly comprised of either clay shale or glacial till, and are generally gentle and of small scale, with slope angle ranging from 11 deg to 23 deg and height ranging from 6 to 23 m. Extensive field investigations and laboratory tests were performed for each slope. Field investigations included survey of slope geometry, borehole drilling, soil sampling, in-situ Borehole Shear Testing (BST) and ground water table measurement. Laboratory investigations mainly comprised of ring shear tests, soil basic property tests (grain size analysis and Atterberg limits test), mineralogy analyses, soil classifications, and natural water contents and density measurements on the representative soil samples from each slope. Extensive direct shear tests and a few triaxial compression tests and unconfined compression tests were also performed on undisturbed soil samples for the Sugar Creek Project. Based on the results of field and lab investigations, slope stability analysis was performed on each of the slopes to determine the possible factors resulting in the slope failures or to evaluate the potential slope instabilities using limit equilibrium methods. Deterministic slope analyses were performed for all the slopes. Probabilistic slope analysis and sensitivity study were also performed for the slope of the Sugar Creek Project. Results indicate that while the in-situ test rapidly provides effective shear strength parameters of soils, some training may be required for effective and appropriate use of the BST. Also, it is primarily intended to test cohesive soils and can produce erroneous results in gravelly soils. Additionally, the quality of boreholes affects test results, and disturbance to borehole walls should be minimized before test performance. A final limitation of widespread borehole shear testing may be its limited availability, as only about four to six test devices are currently being used in Iowa. Based on the data gathered in the field testing, reinforcement investigations are continued in Volume III.

Exigències i problemes de l'avaluació en l'Espai Europeu d'Educació Superior

Aquest estudi es proposa mostrar les condicions i les exigències de l'avaluació en l'EEES a partir del seu marc regulador. La primera conclusió és que aquestes condicions no venen imposades per aquest marc sinó que deriven de la relació de coherència entre l'avaluació i l'aprenentatge, del qual en forma part. Només si entenem l'avaluació com un problema de disseny del programa educatiu, com proposen els nous enfocaments educatius, serem capaços d'oferir propostes que tendeixin cap a una avaluació més qualitativa i més personalitzada. En aquest context, el repte consisteix a trobar instruments que atenguin aquestes necessitats i alhora siguin prou fiables tot intentant evitar la trivialització. Ateses les limitacions d'espai, però, no és possible entrar en el detall de cadascuna d'aquestes propostes.

Per a sortir de la 'calma blanca' a l'escola primària

En este artículo, al tiempo que se reclama la necesidad de llevar a cabo investigaciones que permitan conocer qué está pasando en la escuela primaria, se señalan y analizan cuatro aspectos que pueden servir como indicadores de una situación que se define como de «calma blanca», es decir, de tiempo de espera en el que casi nada sucede: (a) la preeminencia de la noción de aprendiz frente a la de sujeto pedagógico; (b) el papel de los libros de texto como mediadores de aprendizaje; (c) las concepciones sobre la enseñanza y el aprendizaje y (d) la organización del curriculum por materias. Estos cuatro aspectos se consideran como ejemplos de una situación en la educación primaria, frente a la que se proponen algunas vías para repensar el estado actual de cosas y salir de él.

Therapeutic drug monitoring and pharmacogenetic tests as tools in pharmacovigilance.

Therapeutic drug monitoring (TDM) and pharmacogenetic tests play a major role in minimising adverse drug reactions and enhancing optimal therapeutic response. The response to medication varies greatly between individuals, according to genetic constitution, age, sex, co-morbidities, environmental factors including diet and lifestyle (e.g. smoking and alcohol intake), and drug-related factors such as pharmacokinetic or pharmacodynamic drug-drug interactions. Most adverse drug reactions are type A reactions, i.e. plasma-level dependent, and represent one of the major causes of hospitalisation, in some cases leading to death. However, they may be avoidable to some extent if pharmacokinetic and pharmacogenetic factors are taken into consideration. This article provides a review of the literature and describes how to apply and interpret TDM and certain pharmacogenetic tests and is illustrated by case reports. An algorithm on the use of TDM and pharmacogenetic tests to help characterise adverse drug reactions is also presented. Although, in the scientific community, differences in drug response are increasingly recognised, there is an urgent need to translate this knowledge into clinical recommendations. Databases on drug-drug interactions and the impact of pharmacogenetic polymorphisms and adverse drug reaction information systems will be helpful to guide clinicians in individualised treatment choices.

Optimització i aprofitament del temps de pràctica motriu en les classes deducació física d'un grup de 4t ESO

Amb aquest treball d‟investigació es pretén fer veure al docent la importància d‟una adequada gestió del temps de classe d‟Educació Física (E.F.), concretament, abans, durant i al final de la sessió, amb l‟objectiu d‟augmentar el temps de compromís motor dels alumnes. Tanmateix citaré autors i esmentaré estudis que demostren que un increment en el temps de compromís motor per part de l‟alumne, augmenta la probabilitat de que s‟assoleixin els objectius proposats i, per tant, el procés d‟ensenyament – aprenentatge serà més eficaç. En conseqüència, s‟analitzen les categories i variables temporals (temps d‟informació del professor, temps d‟organització dels alumnes i del material i temps d‟imprevistos) que poden restar minuts al temps de pràctica motriu i, a la vegada, es presenten una sèrie de recursos i estratègies que ajuden al professor d‟E.F a reduir les accions i variables temporals que incideixen negativament a fi i efecte d‟augmentar el temps de pràctica motriu.

A Classification of Tools for Learning Logic

A table showing a comparison and classification of tools (intelligent tutoring systems) for e-learning of Logic at a college level.

Ultimate Load Behavior of Full-Scale Highway Truss Bridges: Phase II - Service Load and Supplementary Tests, Interim Report, HR-169, 1975

As a result of the construction of the Saylorville Dam and Reservoir on the Des Moines River, six highway bridges crossing the river were scheduled for removal. Two of these were incorporated into a comprehensive test program to study the behavior of old pin-connected high-truss single-lane bridges. The test program consisted of ultimate load tests, service load tests and a supplementary test program. The results reported in this report cover the service load tests on the two bridges as well as the supplementary tests, both static and fatigue, of eyebar members removed from the two bridges. The field test results of the service loading are compared with theoretical results of the truss analysis.