998 resultados para Ballerina,Cloud Native,API,Linguaggio di Programmazione
Resumo:
v.8 (1910)
Resumo:
v.5 (1907)
Resumo:
v.1 (1904)
Resumo:
v. 1
Resumo:
v. 2
Resumo:
v. 3
Resumo:
La legge costituzionale 1/1999 per le Regioni ordinarie (e la successiva 2/2001 per le Speciali) ha rappresentato un punto di svolta fondamentale del regionalismo italiano. Essa ha stabilito il principio dell’elezione popolare diretta del Presidente della Regione, a cui si collega un premio di maggioranza nel Consiglio regionale secondo il cosiddetto modello neo-parlamentare. Qualsiasi interruzione del rapporto fiduciario per dimissioni del Presidente o approvazione di una mozione di sfiducia porterebbe a nuove elezioni, cosa che rappresenta un serissimo deterrente alle crisi. La riforma prevedeva anche la possibilità per le Regioni di derogare col proprio Statuto a tali scelte tornando all’elezione consiliare e a sostituzioni della maggioranza. Nonostante alcuni tentativi di sfuggire alla regola del governo di legislatura utilizzando tale deroga in modo esplicito o surrettizio, seguendo vecchi retaggi assemblearisti, l’elezione diretta si è imposta ovunque, garantendo a tutte le Regioni analoghi e inediti standards di governabilità.
Resumo:
Peripheral nerve injury is a serious problem affecting significantly patients' life. Autografts are the "gold standard" used to repair the injury gap, however, only 50% of patients fully recover from the trauma. Artificial conduits are a valid alternative to repairing peripheral nerve. They aim at confining the nerve environment throughout the regeneration process, and providing guidance to axon outgrowth. Biocompatible materials have been carefully designed to reduce inflammation and scar tissue formation, but modifications of the inner lumen are still required in order to optimise the scaffolds. Biomicking the native neural tissue with extracellular matrix fillers or coatings showed great promises in repairing longer gaps and extending cell survival. In addition, extracellular matrix molecules provide a platform to further bind growth factors that can be released in the system over time. Alternatively, conduit fillers can be used for cell transplantation at the injury site, reducing the lag time required for endogenous Schwann cells to proliferate and take part in the regeneration process. This review provides an overview on the importance of extracellular matrix molecules in peripheral nerve repair.
Resumo:
ASSOCIATIVE GEOGRAPHY AND SWISS IMPERIALISM. THE EXAMPLE OF GENEVA (1858-1914) − This article is about geographical society of Geneva and its involvement in the 19th century colonial imperialism. Through this society, Swiss bourgeoisie takes part in the exploration and colonization of the world. Is this participation a sign of Swiss imperialism? This issue will be at the heart of this study.
Resumo:
Aim Niche conservatism, or the extent to which niches are conserved across space and time, is of special concern for the study of non-native species as it underlies predictions of invasion risk. Based on the occurrence of 28 non-native birds in Europe, we assess to what extent Grinnellian realized niches are conserved during invasion, formulate hypotheses to explain the variation in observed niche changes and test how well species distribution models can predict non-native bird occurrence in Europe. Location Europe. Methods To quantify niche changes, a recent method that applies kernel smoothers to densities of species occurrence in a gridded environmental space was used. This corrects for differences in the availability of environments between study areas and allows discrimination between 'niche expansion' into environments new to the species and 'niche unfilling', whereby the species only partially fills its niche in the invaded range. Predictions of non-native bird distribution in Europe were generated using several distribution modelling techniques. Results Niche overlap between native and non-native bird populations is low, but niche changes are smaller for species having a higher propagule pressure and that were introduced longer ago. Non-native birds in Europe occupy a subset of the environments they inhabit in their native ranges. Niche expansion into novel environments is rare for most species, allowing species distribution models to accurately predict invasion risk. Main conclusions Because of the recent nature of most bird introductions, species occupy only part of the suitable environments available in the invaded range. This signals that apart from purely ecological factors, patterns of niche conservatism may also be contingent on population-specific historical factors. These results also suggest that many claims of niche differences may be due to a partial filling of the native niche in the invaded range and thus do not represent true niche changes.
Resumo:
Vaccines have been used as a successful tool in medicine by way of controlling many major diseases. In spite of this, vaccines today represent only a handful of all infectious diseases. Therefore, there is a pressing demand for improvements of existing vaccines with particular reference to higher efficacy and undisputed safety profiles. To this effect, as an alternative to available vaccine technologies, there has been a drive to develop vaccine candidate polypeptides by chemical synthesis. In our laboratory, we have recently developed a technology to manufacture long synthetic peptides of up to 130 residues, which are correctly folded and biologically active. This paper discusses the advantages of the molecularly defined, long synthetic peptide approach in the context of vaccine design, development and use in human vaccination.