A compilation of traffic regulations in thirteen Iowa cities / by Laurence W. Murray [and] Alfred B. Bowman, 1936

This questionnaire was circulated in order to discover traffic problems. No preparation was made to meet the problem with the tools of science, and as a result traffic ordinances have grown like traffic problems, without design.

Alfred Schäfer: Irritierende Fremdheit, Bildungsforschung als Diskursanalyse. Paderborn: Schöningh 2011 [Rezension]

Rezension von: Alfred Schäfer: Irritierende Fremdheit, Bildungsforschung als Diskursanalyse, Paderborn: Schöningh 2011 (326 S.; ISBN 978-3-5067-7103-2)

Ensino da sistematização da assistência de enfermagem na formação em nível técnico: típico ideal de docentes

Introdução: A Sistematização da Assistência de Enfermagem (SAE) é reconhecida enquanto metodologia organizadora do trabalho da enfermagem. Todavia, apesar de ter sua obrigatoriedade no Brasil instituída pelo Conselho Federal de Enfermagem, sua consolidação ainda é inconsistente. Nesse contexto se reconhece que uma possibilidade de avanço para a implementação da SAE constitui o aspecto formativo da equipe de enfermagem, sobretudo dos técnicos de enfermagem, classe que costuma ser esquecida quando se aborda a SAE (Cruz & Almeida, 2010; Salvador & Santos, 2013). Objetivos: Desvelar a tipificação de docentes sobre o ensino da sistematização da assistência de enfermagem em nível técnico. Metodologia: Estudo descritivo, de abordagem qualitativa. Participaram sete docentes do Curso Técnico em Enfermagem de uma universidade pública do Nordeste do Brasil. A coleta de dados ocorreu em fevereiro de 2015, a partir da técnica do grupo focal. As falas foram transcritas e o conteúdo textual decorrente das entrevistas foi submetido à análise lexicográfica, com auxílio do software Interface de R pour Analyses Multidimensionnelles de Textes et de Questionneires (IRAMUTEQ). A análise dos dados foi realizada a partir do referencial teórico de Alfred Schutz (2012). Os preceitos éticos foram atendidos. Resultados: Participaram sete docentes com formação mínima de mestrado, experientes no ensino técnico. Por meio da Classificação Hierárquica Descendente, cinco classes advieram das três partições de conteúdo. As classes 1 e 2 denotaram por um lado experiências e possibilidades que afirmam a necessidade de inserir a SAE no nível técnico e por outro dúvidas quanto ao momento certo para este ensino. As classes 3 e 4 elucidaram os motivos-porque ensinar a SAE aos técnicos de enfermagem, ao destacar que os docentes devem enfrentar os receios em busca de alternativas para que o ensino da SAE em nível técnico se consolide, a partir da reflexão acerca do papel da universidade na mudança da prática e na superação da cisão entre o fazer e o pensar no mundo da vida da enfermagem. A classe 5 possibilitou a compreensão dos motivos-para ensinar a SAE em nível técnico, com destaque para as contribuições que o técnico de enfermagem pode efetivar ao se integrar à SAE. Conclusões: Os docentes do curso técnico de enfermagem tipificam a importância de efetivar o ensino da SAE aos técnicos de enfermagem. Para tanto, enfatizam a necessidade de incluir tal temática na formação em nível técnico. Assim, ao mesmo tempo em que denotam dúvidas e receios em não saber como e quando efetivar o ensino da SAE aos técnicos de enfermagem, refletem acerca das possibilidades e necessidade de consolidar tal ensino.

The works of Alfred Lord Tennyson.

vol. II. Idylls of the king. To the queen.- vol. III. The princess. Maud. Enoch Arden. In memoriam.- vol. IV. Queen Mary. Harold. The lover's tale. Ballads and other poems. Sonnets. Translations, etc.- Vol. V. Tiresias and other poems. The promise of May. Demeter and other poems.- vol. VI. Becket. The cup. The falcon. The foresters. Balin and Balan. The death of Oenone, and other poems. Complete indexes.

A plan of Alfred, Maine /

Shows buildings pictorially.

The importance of being Alfred -- from the king of West Saxons to Nobel

The article appeared in a Festschrift devoted to a distinguished Polish linguist Professor Alfred F. Majewicz. It discusses the Christian name Alfred born by the Jubilarian in its various aspects: its Anglo-Saxon origins, etymology and popularity (past and present) in various European countries, with particular emphasis on Poland. It also presents some famous people, literary characters and pop culture heroes bearing this name.

Ensinar sistematização da assistência de enfermagem em nível técnico: percepção de docentes

Objetivo: Descrever a percepção de docentes sobre o ensino da sistematização da assistência de enfermagem em nível técnico. Métodos: Estudo descritivo, de abordagem mista. Participaram do grupo focal sete docentes do Curso Técnico em Enfermagem de uma universidade pública do Nordeste brasileiro. O conteúdo textual foi tratado com auxílio do IRAMUTEQ e a análise dos dados foi realizada a partir do referencial teórico de Alfred Schutz. Resultados: Os docentes do curso técnico de enfermagem tipificam a importância de integrar o técnico de enfermagem na sistematização da assistência e para tanto realçam a necessidade de incluir tal temática na formação em nível técnico. Conclusão: os docentes denotam dúvidas e receios em não saber como e quando efetivar o ensino da SAE em nível técnico, mas refletem sobre as possibilidades e necessidades de consolidar esta temática.

Cyclic strain disrupts endothelial network formation on Matrigel

Most forms of tissue healing depend critically on revascularisation. In soft tissues and in vitro, mechanical stimuli have been shown to promote vessel-forming activity. However, in bone defects, increased interfragmentary motion impairs vascular regeneration. Because these effects seem contradictory, we aimed to determine whether a range of mechanical stimuli exists in which angiogenesis is favoured. A series of cyclic strain magnitudes were applied to a Matrigel-based “tube formation” assay and the total lengths of networks formed by human microvascular endothelial cells measured at 24 h. Network lengths were reduced at all strain levels, compared to unstretched controls. However, the levels of pro-angiogenic matrix metalloproteases-2 and -9 in the corresponding conditioned media were unchanged by strain, and vascular endothelial growth factor was uniformly elevated in stretched conditions. By repeating the assay with the addition of conditioned media from mesenchymal stem cells cultivated in similar conditions, paracrine stimuli were shown to increase network lengths, but not to alter the negative effect of cyclic stretching. Together, these results demonstrate that directly applied periodic strains can inhibit endothelial organisation in vitro, and suggest that this may be due to physical disruption rather than biochemical modulation. Most importantly, the results indicate that the straining of endothelial cells and their assembly into vascular-like structures must be studied simultaneously to adequately characterise the mechanical influence on vessel formation.

Establishment of a preclinical ovine model for tibial segmental bone defect repair by applying bone tissue engineering strategies

Currently, well-established clinical therapeutic approaches for bone reconstruction are restricted to the transplantation of autografts and allografts, and the implantation of metal devices or ceramic-based implants to assist bone regeneration. Bone grafts possess osteoconductive and osteoinductive properties, however they are limited in access and availability and associated with donor site morbidity, haemorrhage, risk of infection, insufficient transplant integration, graft devitalisation, and subsequent resorption resulting in decreased mechanical stability. As a result, recent research focuses on the development of alternative therapeutic concepts. The field of tissue engineering has emerged as an important approach to bone regeneration. However, bench to bedside translations are still infrequent as the process towards approval by regulatory bodies is protracted and costly, requiring both comprehensive in vitro and in vivo studies. The subsequent gap between research and clinical translation, hence commercialization, is referred to as the ‘Valley of Death’ and describes a large number of projects and/or ventures that are ceased due to a lack of funding during the transition from product/technology development to regulatory approval and subsequently commercialization. One of the greatest difficulties in bridging the Valley of Death is to develop good manufacturing processes (GMP) and scalable designs and to apply these in pre-clinical studies. In this article, we describe part of the rationale and road map of how our multidisciplinary research team has approached the first steps to translate orthopaedic bone engineering from bench to bedside byestablishing a pre-clinical ovine critical-sized tibial segmental bone defect model and discuss our preliminary data relating to this decisive step.

Asynchronicity and the ‘time envelope’ of online annotation : the case of the photosharing website, Flickr

This paper examines a sequence of asynchronous interaction on the photosharing website, Flickr. In responding to a call for a focus on the performative aspects of online annotation (Wolff & Neuwirth, 2001), we outline and apply an interaction order approach to identify temporal and cultural aspects of the setting that provide for commonality and sharing. In particular, we study the interaction as a feature of a synthetic situation (Knorr Cetina, 2009) focusing on the requirements of maintaining a sense of an ongoing discussion online. Our analysis suggests that the rhetorical system of the Flickr environment, its appropriation by participants as a context for bounded activities, and displays of commonality, affiliation, and shared access provide for a common sense of participation in a time envelope. This, in turn, is argued to be central to new processes of consociation (Schutz, 1967; Zhao, 2004) occurring in the life world of Web 2.0 environments.

Fit optimisation of a distal medial tibia plate

An iterative method for the fit optimisation of a pre-contoured fracture fixation plate for a given bone data set is presented. Both plate shape optimisation and plate fit quantification are conducted in a virtual environment utilising computer graphical methods and 3D bone and plate models. Two optimised shapes of the undersurface of an existing distal medial tibia plate were generated based on a dataset of 45 3D bone models reconstructed from computed tomography image data of Japanese tibiae. The existing plate shape achieved an anatomical fit on 13% of tibiae from the dataset. Modified plate 1 achieved an anatomical fit for 42% and modified plate 2 a fit for 67% of the bones. If either modified plate 1 or plate 2 is used, then the anatomical fit can be increased to 82% for the same dataset. Issues pertaining to any further improvement in plate fit/shape are discussed.

Ovine bone and marrow derived progenitor cells : isolation, characterization, and osteogenic potential

Recently, research has focused on bone marrow derived multipotent mesenchymal precursor cells (MPC) for their potential clinical use in bone engineering. Prior to clinical application, MPC-based treatment concepts need to be evaluated in preclinical, immunocompetent, large animal models. Sheep in particular are considered a valid model for orthopaedic and trauma related research. However, ovine MPC and their osteogenic potential remain poorly characterized. In the present study, ex vivo expanded MPC isolated from ovine bone marrow proliferated at a higher rate than osteoblasts (OB) derived from tibial compact bone as assessed using standard 2D culture. MPC expressed the respective phenotypic profile typical for different mesenchymal cell populations (CD14-/CD31-/CD45- /CD29+/CD44+/CD166+) and showed a multilineage differentiation potential. When compared to OB, MPC had a higher mineralization potential under standard osteogenic culture conditions and expressed typical markers such as osteocalcin, osteonectin and type I collagen at the mRNA and protein level. After 4 weeks in 3D culture, MPC constructs demonstrated higher cell density and mineralization, whilst cell viability on the scaffolds was assessed >90%. Cells displayed a spindle-like morphology and formed an interconnected network. Implanted subcutaneously into NOD/SCID mice on type I collagen coated polycaprolactone-tricalciumphosphate (mPCL-TCP) scaffolds, MPC presented a higher developmental potential than osteoblasts. In summary, this study provides a detailed in vitro characterisation of ovine MPC from a bone engineering perspective and suggests that MPC provide promising means for future bone disease related treatment applications.

Effects of reduced contrast on the perception and control of speed when driving

Misperception of speed under low-contrast conditions has been identified as a possible contributor to motor vehicle crashes in fog. To test this hypothesis, we investigated the effects of reduced contrast on drivers’ perception and control of speed while driving under real-world conditions. Fourteen participants drove around a 2.85 km closed road course under three visual conditions: clear view and with two levels of reduced contrast created by diffusing filters on the windscreen and side windows. Three dependent measures were obtained, without view of the speedometer, on separate laps around the road course: verbal estimates of speed; adjustment of speed to instructed levels (25 to 70 km h-1); and estimation of minimum stopping distance. The results showed that drivers traveled more slowly under low-contrast conditions. Reduced contrast had little or no effect on either verbal judgments of speed or estimates of minimum stopping distance. Speed adjustments were significantly slower under low-contrast than clear conditions, indicating that, contrary to studies of object motion, drivers perceived themselves to be traveling faster under conditions of reduced contrast. Under real-world driving conditions, drivers’ ability to perceive and control their speed was not adversely affected by large variations in the contrast of their surroundings. These findings suggest that perceptions of self-motion and object motion involve neural processes that are differentially affected by variations in stimulus contrast as encountered in fog.

Correlation of the expression of human kallikrein-related peptidases 4 and 7 with the prognosis in oral squamous cell carcinoma

Background Very few articles have been written about the expression of kallikreins (KLK4 and KLK7) in oral cancers. Therefore, the purpose of this study was to examine and report on their prognostic potential. Methods Eighty archival blocks of primary oral cancers were sectioned and stained for KLK4 and KLK7 by immunohistochemistry. The percentage and the intensity of malignant keratinocyte staining were correlated with patient survival using Cox regression analysis. Results Both kallikreins were expressed strongly in the majority of tumor cells in 68 of 80 cases: these were mostly moderately or poorly differentiated neoplasms. Staining was particularly intense at the infiltrating front. Patients with intense staining had significantly shorter overall survival (p < .05). Conclusion This is the first observation on the patient survival influenced by kallikrein expression in oral carcinoma. The findings are consistent with those for carcinomas at other sites, in particular the prostate and ovary. KLK4 and/or KLK7 immunohistochemistry seems to have diagnostic and prognostic potential in this disease.