Profiling invasiveness in head and neck cancer: recent contributions of genomic and transcriptomic approaches.

High-throughput molecular profiling approaches have emerged as precious research tools in the field of head and neck translational oncology. Such approaches have identified and/or confirmed the role of several genes or pathways in the acquisition/maintenance of an invasive phenotype and the execution of cellular programs related to cell invasion. Recently published new-generation sequencing studies in head and neck squamous cell carcinoma (HNSCC) have unveiled prominent roles in carcinogenesis and cell invasion of mutations involving NOTCH1 and PI3K-patwhay components. Gene-expression profiling studies combined with systems biology approaches have allowed identifying and gaining further mechanistic understanding into pathways commonly enriched in invasive HNSCC. These pathways include antigen-presenting and leucocyte adhesion molecules, as well as genes involved in cell-extracellular matrix interactions. Here we review the major insights into invasiveness in head and neck cancer provided by high-throughput molecular profiling approaches.

Refractions of Canada in European Literature and Culture

Ever since the first exploratory expeditions in the early modern period, North America has epitomized to Europeans a promise and the hope for the fulfilment of great expectations, be it of more freedom, greater wealth, social liberation or religious tolerance. While numerous features in this dialogic intercontinental relationship will hold true for North America in its entirety, the vast northern territories which we know as Canada today began to emerge early on as a specific iconic location in European mind-maps, and they definitely acquired a distinctive profile after the formation of the USA. As a rich source of cultural exchange and an important partner in political and economic cooperation Canada has come to occupy an important position in the cultural discourses of many European nations. It is these refractions and images of Canada which this volume thoroughly explores in European literature and culture. The contributions include literature, philosophy, language, life-writing and the concept of 'Heimat' (homeland) as well as the cultural impact of the World Wars. While there is an emphasis on literary texts, other fields of cultural representation are also included.

Significance of the Philosophy of Family-Centered Care in the

The philosophy of family-centered care is “an approach to the planning, delivery, and evaluation of healthcare that is grounded in mutually beneficial partnerships among patients, families and healthcare practitioners” (Children’s Hospital of Philadelphia, 1996-2008). The word “family” refers to “two or more persons who are related in any way-biologically, legally, or emotionally” (Institute for Family-Centered Care). It is patients and families, who define those included in their families, which usually in pediatrics includes parents or guardians.

Ein Symposium der Forschung [Rezension] : Occident and Orient. Being Studies in Semitic Philology and Literature, Jewish History, Philosophy and Folklore in the widest sense. In Honour of Haham Dr. Gasters 80. Birthday ed. by Bruno Schindler and A. Marmorstein. Taylors Foreign Press, London 1937

-ss.

Philosophia Britannica: or, a new and comprehensive system of the Newtonian philosophy, astronomy, and geography, in a course of twelve lectures, with notes

by B. Martin

Charlotte Wolter als Martha Didier, Rollenbild, in: Victorien Sardou: Eine Familie nach der Mode, Wien: Burgtheater

Signatur des Originals: S 36/F02231

Charlotte Wolter als Martha Didier, Rollenbild, in: Victorien Sardou: Eine Familie nach der Mode, Wien: Burgtheater

Signatur des Originals: S 36/F02233

Martha Bommer als Carmen, Rollenbild, in: Georges Bizet: Carmen

Signatur des Originals: S 36/F03104

Ludwig Ermold , Rollenbild, Hüftbild, in: Friedrich von Flotow: Martha

Signatur des Originals: S 36/F03578

Else Gentner-Fischer als Martha, Rollenbild, Kniestück, in: Eugen d'Albert: Tiefland

Signatur des Originals: S 36/F04011

Else Gentner-Fischer als Martha, Rollenbild, Kniestück, in: Eugen d'Albert: Tiefland

Signatur des Originals: S 36/F04015

Else Gentner-Fischer als Martha, Szenenfoto, in: Eugen d'Albert: Tiefland

Signatur des Originals: S 36/F04018

Else Gentner-Fischer als Martha, {[N.N.], Szenenfoto, Doppelbildnis, in: Eugen d'Albert: Tiefland

Signatur des Originals: S 36/F04019

Else Gentner-Fischer als Martha, {[N.N.], Szenenfoto, Doppelbildnis, in: Eugen d'Albert: Tiefland

Signatur des Originals: S 36/F04020

Else Gentner-Fischer als Martha, Rollenbild, Hüftbild, in: Eugen d'Albert: Tiefland

Signatur des Originals: S 36/F04021