Profiling invasiveness in head and neck cancer: recent contributions of genomic and transcriptomic approaches.
Data(s) |
31/03/2015
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Resumo |
High-throughput molecular profiling approaches have emerged as precious research tools in the field of head and neck translational oncology. Such approaches have identified and/or confirmed the role of several genes or pathways in the acquisition/maintenance of an invasive phenotype and the execution of cellular programs related to cell invasion. Recently published new-generation sequencing studies in head and neck squamous cell carcinoma (HNSCC) have unveiled prominent roles in carcinogenesis and cell invasion of mutations involving NOTCH1 and PI3K-patwhay components. Gene-expression profiling studies combined with systems biology approaches have allowed identifying and gaining further mechanistic understanding into pathways commonly enriched in invasive HNSCC. These pathways include antigen-presenting and leucocyte adhesion molecules, as well as genes involved in cell-extracellular matrix interactions. Here we review the major insights into invasiveness in head and neck cancer provided by high-throughput molecular profiling approaches. |
Formato |
application/pdf |
Identificador |
http://boris.unibe.ch/75349/1/cancers-07-00585.pdf Nisa Hernandez, Lluis; Aebersold, Daniel; Giger, Roland; Caversaccio, Marco; Borner, Urs; Medova, Michaela; Zimmer, Yitzhak (2015). Profiling invasiveness in head and neck cancer: recent contributions of genomic and transcriptomic approaches. Cancers, 7(2), pp. 585-597. MDPI AG 10.3390/cancers7020585 <http://dx.doi.org/10.3390/cancers7020585> doi:10.7892/boris.75349 info:doi:10.3390/cancers7020585 info:pmid:25836654 urn:issn:2072-6694 |
Idioma(s) |
eng |
Publicador |
MDPI AG |
Relação |
http://boris.unibe.ch/75349/ |
Direitos |
info:eu-repo/semantics/openAccess |
Fonte |
Nisa Hernandez, Lluis; Aebersold, Daniel; Giger, Roland; Caversaccio, Marco; Borner, Urs; Medova, Michaela; Zimmer, Yitzhak (2015). Profiling invasiveness in head and neck cancer: recent contributions of genomic and transcriptomic approaches. Cancers, 7(2), pp. 585-597. MDPI AG 10.3390/cancers7020585 <http://dx.doi.org/10.3390/cancers7020585> |
Palavras-Chave | #610 Medicine & health |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |