O desassossego goês. Cultura e política em Goa do liberalismo ao . Acto Colonial

Tese apresentada para cumprimento dos requisitos necessários à obtenção do grau de Doutor em História e Teoria das Ideias, especialidade Pensamento, Cultura e Política

Pombalismo, Jesuítas e a Terra nas Velhas Conquistas: Confisco e Redistribuição de Propriedade Fundiária na Goa Setecentista

Dissertação apresentada para cumprimento dos requisitos necessários à obtenção do grau de Mestre em História Moderna e dos Descobrimentos

Segurança e Governação Climáticas: o Brasil na Cena Internacional

Tese apresentada para cumprimento dos requisitos necessários à obtenção do grau de Doutor em Relações Internacionais, na especialidade de Globalização e Ambiente

Estágio no Observatório Político: Compreender o Funcionamento de uma Associação Científica

Relatório de Estágio apresentado para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Ciência Política e Relações Internacionais – Área de Especialização: Estudos Políticos de Área

A Casa de Atouguia, os Últimos Avis e o Império. Dinâmicas entrecruzadas na carreira de D. Luís de Ataíde (1516-1581)

Tese apresentada para cumprimento dos requisitos necessários à obtenção do grau de Doutor em História

Análise dos padrões de consumo de famílias portuguesas

Um dos grandes desafios dos atuais modelos de produção e consumo sustentável é estimular mudanças de atitude e comportamento na sociedade mundial, uma vez que as nossas capacidades intelectuais, morais e culturais impõem responsabilidades para com todos os atores intervenientes. O objetivo principal deste trabalho é avaliar os comportamentos e hábitos de consumo das famílias e saber qual é a motivação das decisões tomadas, umas vez que estas e as escolhas do dia-a-dia das famílias e seus impactes têm um peso muito significativo na produção e consumo de produtos e serviços. Os resultados permitiram concluir que as diferenças que se fazem sentir entre os agregados familiares, a nível de rendimento, idade e escolaridade, influenciam os comportamentos relacionados com o consumo. Foi ainda inferido nesta dissertação, que muitas práticas sustentáveis feitas pelas famílias, têm por base o fator económico e não necessariamente fatores relacionados com a sensibilização e/ou formação em relação aos efeitos na sustentabilidade do consumo. De forma a inverter os atuais padrões negativos do consumo das famílias, considera-se fundamental a implementação de políticas e ações de formação. Havendo um maior acompanhamento às famílias e ações de sensibilização, ficam mais sensibilizadas e motivadas para criar hábitos de consumo sustentável.

Cooperação e conflito entre britânicos e portugueses na Ásia. Dos primeiros contactos em Bombaim (c.1600-1740)

A aquisição da ilha de Bombaim pela coroa inglesa e a consequente convivência fronteiriça com o Estado da Índia constituiu uma novidade relacional e diplomática entre os poderes português e britânico, não só no Índico como em todo o espaço ultramarino. Esta nova situação projectou a recentemente forjada e renovada aliança anglo-portuguesa para um diferente plano, até então não experienciado. De facto, o acordo de 1661 estipulou que o Estado da Índia entregasse parte do seu território a uma coroa europeia, o que significava uma mudança no seu paradigma de actuação e a partilha de fronteiras comuns com um vizinho europeu, “consentido” e aliado. A isto adicionava-se o facto da população residente em Bombaim, constituída por uma forte comunidade de grandes foreiros portugueses e jesuítas, passar a estar sujeita aos dictames da coroa inglesa. Todos estes pressupostos constituíram uma novidade para o Estado da Índia e para os seus súbditos e exigiram, necessariamente, uma adaptação no modo de interacção com tão próximo vizinho. O mesmo se terá passado com os oficiais britânicos, numa primeira fase da coroa (1665-1668) e doravante da East India Company, para quem o domínio territorial no espaço asiático constituía uma experiência nova. Esta realidade tão próxima entre as duas potências europeias originou, necessariamente, a eclosão de problemas e tensões entre as duas estruturas de poder. Será a partir desta conjuntura sugestiva que procuraremos compreender como o entendimento anglo-português na Europa foi transposto e gerido na esfera ultramarina, através da análise do caso paradigmático de Bombaim. A gestão da aliança naquele espaço assumiu contornos específicos e de difícil administração, pois a distância ditava uma maior autonomia decisória das autoridades de Goa e Bombaim, nem sempre em consonância com as directrizes europeias. A interacção na região de Bombaim e espaços adjacentes foi pautada pela flexibilidade e, por isso, caracterizou-se por momentos de antagonismo, cooperação e conflito aberto. Nestes “encontros de (in)conveniência”, ambos os lados procuraram tirar partido das dinâmicas conjunturais da política indiana, o mesmo aplicando-se no sentido inverso, adaptando-se alinhamentos e rupturas consoante os interesses imediatos. Bombaim foi, assim, singular no relacionamento anglo-português na Ásia, o que não implica que não se procure compreender as ressonâncias da interação entre portugueses e britânicos noutros espaços do subcontinente indiano (como Madrasta) ou contrapor os modos de actuação da EIC noutros locais (como Cochim). Na dissertação em curso, propomos efectuar um estudo de longo tempo, que analise de forma sistemática a transversal as dinâmicas relacionais entre britânicos e portugueses desde a introdução britânica na Ásia até à perda portuguesa da Província

Fx swaps and outright forward validation

UNL - NSBE

How to improve urban mobility in Lisbon: intermodality and information and ticketing systems

Urban mobility is one of the main challenges facing urban areas due to the growing population and to traffic congestion, resulting in environmental pressures. The pathway to urban sustainable mobility involves strengthening of intermodal mobility. The integrated use of different transport modes is getting more and more important and intermodality has been mentioned as a way for public transport compete with private cars. The aim of the current dissertation is to define a set of strategies to improve urban mobility in Lisbon and by consequence reduce the environmental impacts of transports. In order to do that several intermodal practices over Europe were analysed and the transport systems of Brussels and Lisbon were studied and compared, giving special attention to intermodal systems. In the case study was gathered data from both cities in the field, by using and observing the different transport modes, and two surveys were done to the cities users. As concluded by the study, Brussels and Lisbon present significant differences. In Brussels the measures to promote intermodality are evident, while in Lisbon a lot still needs to be done. It also made clear the necessity for improvements in Lisbon’s public transports to a more intermodal passenger transport system, through integration of different transport modes and better information and ticketing system. Some of the points requiring developments are: interchanges’ waiting areas; integration of bicycle in public transport; information about correspondences with other transport modes; real-time information to passengers pre-trip and on-trip, especially in buses and trams. After the identification of the best practices in Brussels and the weaknesses in Lisbon the possibility of applying some of the practices in Brussels to Lisbon was evaluated. Brussels demonstrated to be a good example of intermodality and for that reason some of the recommendations to improve intermodal mobility in Lisbon can follow the practices in place in Brussels.

Long-term follow-up of high-dose chemotherapy with autologous stem-cell transplantation and response-adapted whole-brain radiotherapy for newly diagnosed primary CNS lymphoma: results of the multicenter Ostdeutsche Studiengruppe Hamato-Onkologie OSHO-53 phase II study

Introduction: We previously reported the results of a phase II study for patients with newly diagnosed primary CNS lymphoma (PCNSL) treated with autologous peripheral blood stem-cell transplantation (aPBSCT) and responseadapted whole brain radiotherapy (WBRT). The purpose of this report is to update the initial results and provide long-term data regarding overall survival, prognostic factors, and the risk of treatment-related neurotoxicity.Methods: A long-term follow-up was conducted on surviving primary central nervous system lymphoma patients having been treated according to the ,,OSHO-53 study", which was initiated by the Ostdeutsche Studiengruppe Hamatologie-Onkologie. Between August 1999 and October 2004 twentythree patients with an average age of 55 and median Karnofsky performance score of 70% were enrolled and received high-dose mthotrexate (HD-MTX) on days 1 and 10. In case of at least a partial remission (PR), high-dose busulfan/ thiotepa (HD-BuTT) followed by aPBSCT was performed. Patients without response to induction or without complete remission (CR) after HD-BuTT received WBRT. All patients (n=8), who are alive in 2011, were contacted and Mini Mental State examination (MMSE) and the EORTC QLQ-C30 were performed.Results: Eight patients are still alive with a median follow-up of 116,9 months (79 - 141, range). One of them suffered from a late relapse eight and a half years after initial diagnosis of PCNSL, another one suffers from a gall bladder carcinoma. Both patients are alive, the one with the relapse of PCNSL has finished rescue therapy and is further observed, the one with gall baldder carcinoma is still under therapy. MMSE and QlQ-C30 showed impressive results in the patients, who were not irradiated. Only one of the irradiated patients is still alive with a clear neurologic deficit but acceptable quality of life.Conclusions: Long-term follow-up of our patients, who were included in the OSHO-53 study show an overall survival of 30 percent. If WBRT can be avoided no long-term neurotoxicity has been observed and the patients benefit from excellent Quality of Life. Induction chemotherapy with two cycles of HD-MTX should be intensified to improve the unsatisfactory OAS of 30 percent.

Conference scene: Immune signatures in the tumor and beyond.

Led by key opinion leaders in the field, the Cancer Immunotherapy Consortium of the Cancer Research Institute 2012 Scientific Colloquium included 179 participants who exchanged cutting-edge information on basic, clinical and translational cancer immunology and immunotherapy. The meeting revealed how rapidly this field is advancing. The keynote talk was given by Wolf H Fridman and it described the microenvironment of primary and metastatic human tumors. Participants interacted through oral presentations and panel discussions on topics that included host reactions in tumors, advances in imaging, monitoring therapeutic immune modulation, the benefit and risk of immunotherapy, and immune monitoring activities. In summary, the annual meeting gathered clinicians and scientists from academia, industry and regulatory agencies from around the globe to interact and exchange important scientific advances related to tumor immunobiology and cancer immunotherapy.

Cohort profile: Antiretroviral Therapy Cohort Collaboration (ART-CC).

The advent of effective combination antiretroviral therapy (ART) in 1996 resulted in fewer patients experiencing clinical events, so that some prognostic analyses of individual cohort studies of human immunodeficiency virus-infected individuals had low statistical power. Because of this, the Antiretroviral Therapy Cohort Collaboration (ART-CC) of HIV cohort studies in Europe and North America was established in 2000, with the aim of studying the prognosis for clinical events in acquired immune deficiency syndrome (AIDS) and the mortality of adult patients treated for HIV-1 infection. In 2002, the ART-CC collected data on more than 12,000 patients in 13 cohorts who had begun combination ART between 1995 and 2001. Subsequent updates took place in 2004, 2006, 2008, and 2010. The ART-CC data base now includes data on more than 70,000 patients participating in 19 cohorts who began treatment before the end of 2009. Data are collected on patient demographics (e.g. sex, age, assumed transmission group, race/ethnicity, geographical origin), HIV biomarkers (e.g. CD4 cell count, plasma viral load of HIV-1), ART regimen, dates and types of AIDS events, and dates and causes of death. In recent years, additional data on co-infections such as hepatitis C; risk factors such as smoking, alcohol and drug use; non-HIV biomarkers such as haemoglobin and liver enzymes; and adherence to ART have been collected whenever available. The data remain the property of the contributing cohorts, whose representatives manage the ART-CC via the steering committee of the Collaboration. External collaboration is welcomed. Details of contacts are given on the ART-CC website (www.art-cohort-collaboration.org).

The relation of body mass index and abdominal adiposity with dyslipidemia in 27 general populations of the WHO MONICA Project.

The association between adiposity measures and dyslipidemia has seldom been assessed in a multipopulational setting. 27 populations from Europe, Australia, New Zealand and Canada (WHO MONICA project) using health surveys conducted between 1990 and 1997 in adults aged 35-64 years (n = 40,480). Dyslipidemia was defined as the total/HDL cholesterol ratio >6 (men) and >5 (women). Overall prevalence of dyslipidemia was 25% in men and 23% in women. Logistic regression showed that dyslipidemia was strongly associated with body mass index (BMI) in men and with waist circumference (WC) in women, after adjusting for region, age and smoking. Among normal-weight men and women (BMI<25 kg/m(2)), an increase in the odds for being dyslipidemic was observed between lowest and highest WC quartiles (OR = 3.6, p < 0.001). Among obese men (BMI ≥ 30), the corresponding increase was smaller (OR = 1.2, p = 0.036). A similar weakening was observed among women. Classification tree analysis was performed to assign subjects into classes of risk for dyslipidemia. BMI thresholds (25.4 and 29.2 kg/m(2)) in men and WC thresholds (81.7 and 92.6 cm) in women came out at first stages. High WC (>84.8 cm) in normal-weight men, menopause in women and regular smoking further defined subgroups at increased risk. standard categories of BMI and WC, or their combinations, do not lead to optimal risk stratification for dyslipidemia in middle-age adults. Sex-specific adaptations are necessary, in particular by taking into account abdominal obesity in normal-weight men, post-menopausal age in women and regular smoking in both sexes.

Repartición de los recursos alimenticios entre tres peces bentófagos frente al Perú antes, durante y después de El Niño 1982-83.

Se revisa la utilización de recursos alimenticios de tres peces bentófagos en los fondos arenosos someros de la Bahía de Ancón: Menticirrhus ophicephalus, stellifer minos y Paralichthys adspersus.