Exercício físico no diabete transgeracional de ratas: efeito na performance reprodutiva e nos hormônios sexuais

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Padrões de dominância manual, podálica e performance motora em gêmeos

O método de gêmeos envolve a análise diferencial de gêmeos monozigóticos (MZs) e dizigóticos (DZs) a fim de determinar a proporção de variância em um determinado traço atribuível a fatores genéticos e ambientais. Sendo geneticamente idênticos, os gêmeos MZs tendem a apresentar alto índice de concordância em vários atributos comportamentais, enquanto que, os DZs, compartilham 50 % da carga genética, manifestando um reduzido grau de concordância. Todavia, pesquisadores têm investigado possíveis mecanismos genéticos subjacentes do desenvolvimento cerebral para dominância manual e, não têm encontrado utilidade no método de gêmeos, pois, desde 1924, em todos os estudos de dominância manual em gêmeos, a taxa de discordância para o canhotismo e destrimanismo têm sido similares em MZs e DZs. Além disso, frequentemente gêmeos mostram taxa mais alta de prevalência para o canhotismo que os não gêmeos. O objetivo deste estudo foi investigar as possíveis diferenças entre gêmeos destros e canhotos (MZs e DZs combinados) e não gêmeos em variáveis fenótipicas específicas relacionadas à dominância manual, incluindo dominância podálica (chute de penalty), consistência de dominância manual, canhotismo familiar (CF+), postura manual e medidas de habilidades motoras em três testes : Batidas digitais, Tabuleiro de Annett e Pontilhar Pontinhos. Foram avaliados 286 gêmeos ( 255 destros, 34 canhotos) e, 251 não gêmeos (141 destros e 110 canhotos). A análise dos dados revelou o aumento de canhotismo no sexo masculino em três vezes mais do que no feminino. Além disto, destros e canhotos gêmeos foram mais mistos em suas dominâncias manuais e apontaram alta incidência de CF+ entre parentes de primeiro grau que não gêmeos canhotos e destros. Em concordância com estudos anteriores, a frequência de chute contralateral foi mais alta nos mistos do que nos que apresentaram consistência na dominância manual, especialmente entre os canhotos. No que diz respeito à habilidade manual, não foram encontradas diferenças significativas nos três testes de habilidade manual. Conforme as expectativas, destros e canhotos foram mais proficientes na manipulação do estímulo com suas mãos dominantes. Em todas as três medidas, em contraste com os destros, os canhotos (gêmeos e não gêmeos) apresentaram redução entre as assimetrias manuais. Por extensão, o aumento da prevalência de canhotismo entre gêmeos não poderia ser atribuída a influências patológicas, inversão de assimetria ou ordem de nascimento. É possível, levar em consideração, observando a diferença robusta em dominância manual mista que, o padrão de lateralização neuromotora, pode ser mais difusamente organizado nos hemisférios dos gêmeos que em não gêmeos, mas, esta sugestão requer evidência direta, pelo menos a partir de testes de neuro-imagem.

Modelo de gerenciamento da logística reversa integrado às questões estratégicas das organizações

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Assesment of the TEI index of myocardial performance in dogs with doxorubicin-induced cardiomiopathy

The development of a dose-dependent cardiomyopathy is the main limitation for the use of doxorubicin in chemotherapy protocols in both humans and animals. In this setting, the global myocardial function may be compromised resulting in signs of congestive heart failure. In this study, we investigated the ability of the Tei index of myocardial performance to identify myocardial dysfunction in healthy dogs receiving doxorubicin to a cumulative dose of 210 mg/m(2) over 147 days, comparing it with other standard echocardiographic indicators of systolic and diastolic function. Our results indicated that the Tei index, the isovolumic relaxation time, pre-ejection period and the pre-ejection period-to-left ventricular ejection time ratio were able to identify the cardiotoxic effects of doxorubicin on cardiac function when only 60 mg/m(2) had been administered, while the standard systolic and diastolic parameters, including left ventricular diameter at systole, ejection fraction, and fractional shortening needed at least 120 mg/mg(2) to deteriorate. We concluded that prolonged anthracycline therapy compromises both systolic and diastolic functions, which may be documented earlier by including the Tel index evaluation to the standard echocardiographic assessment of animals receiving doxorubicin.

Improvement of the physical performance is associated with activation of NO/PGC-l alpha/mtTFA signaling pathway and increased protein expressions of electron transport chain in gastrocnemius muscle from rats supplemented with L-arginine

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Anthropometric indicators predict metabolic syndrome diagnosis in maintenance hemodialysis patients

Obesity has been considered the key in metabolic syndrome (MetS) development, and fat accumulation may be responsible for the occurrence of metabolic abnormalities in hemodialysis patients. The use of gold-standard methods to evaluate obesity is limited, and anthropometric measures may be the simplest methods. However, no study has investigated the association between anthropometric indexes and MetS in these patients. Therefore, the aim was to determine which anthropometric indexes had the best association and prediction for MetS in patients undergoing hemodialysis. Cross-sectional study that included patients older than 18 years, undergoing hemodialysis for at least 3 months. Patients with liver disease and cancer or those receiving corticosteroids or antiretroviral therapy were excluded. Diagnostic criteria from Harmonizing Metabolic Syndrome were used for the diagnosis of MetS. Anthropometric indexes evaluated were body mass index (BMI); percent standard of triceps skinfold thickness and of middle arm muscle circumference; waist circumference (WC); sagittal abdominal diameter; neck circumference; waist-to-hip, waist-to-thigh, and waist-to-height ratios; sagittal index; conicity index; and body fat percentage. Ninety-eight patients were included, 54.1% male, and mean age was 57.8 ± 12.9 years. The prevalence of MetS was 74.5%. Individuals with MetS had increased accumulation of abdominal fat and general obesity. Waist-to-height ratio was the variable independently associated with MetS diagnosis (odds ratio, 1.21; 95% confidence interval, 1.09-1.34; P < .01) and that better predicts MetS, followed by WC and BMI (area under the curve of 0.840, 0.836, and 0.798, respectively, P < .01). Waist-to-height ratio was the best anthropometric predictor of MetS in maintenance hemodialysis patients.

Análise do desempenho térmico de habitações populares da microrregião de Guaratinguetá - SP

Pós-graduação em Engenharia Mecânica - FEG

Carimbó do Santo Preto: a presença negra na performance musical da festividade do Glorioso São Benedito em Santarém Novo (PA)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

The Performance of Elliptic Curve Based Group Diffie-Hellman Protocols for Secure Group Communication over Ad Hoc Networks

The security of the two party Diffie-Hellman key exchange protocol is currently based on the discrete logarithm problem (DLP). However, it can also be built upon the elliptic curve discrete logarithm problem (ECDLP). Most proposed secure group communication schemes employ the DLP-based Diffie-Hellman protocol. This paper proposes the ECDLP-based Diffie-Hellman protocols for secure group communication and evaluates their performance on wireless ad hoc networks. The proposed schemes are compared at the same security level with DLP-based group protocols under different channel conditions. Our experiments and analysis show that the Tree-based Group Elliptic Curve Diffie-Hellman (TGECDH) protocol is the best in overall performance for secure group communication among the four schemes discussed in the paper. Low communication overhead, relatively low computation load and short packets are the main reasons for the good performance of the TGECDH protocol.

Carimbó do Santo Preto: a presença negra na performance musical da festividade do Glorioso São Benedito em Santarém Novo (PA)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A comparison of time-motion performance between age groups in judo matches

The aim of this study was to compare time-motion indicators during judo matches performed by athletes from different age groups. The following age groups were analysed: Pre-Juvenile (13-14 years, n=522), Juvenile (15-16 years, n 353); Junior (19 years, n = 349) and Senior (>20 years, n = 587). The time-motion indicators included: Total Combat Time, Standing Combat Time, Displacement Without Contact, Gripping Time, Groundwork Combat Time and Pause Time. Analysis of variance (ANOVA) one-way and the Tukey test, as well as the Kruskal-Wallis test and Mann-Whitney (for non-parametric data), were conducted, using P < 0.05 as significance level. The results showed that all analysed groups obtained a median of 7 (first quantile - 3, third quantile - 12) sequences of combat/pause cycles. In total time of combat, the result was: for Total Combat Time, Standing Combat Time and Gripping Time: Pre-Juvenile and Senior were significantly longer than Juvenile and Junior. Considering Displacement Without Contact, Junior was significantly longer than all other age groups. For Groundwork Combat Time, Senior was significantly longer than all other age groups and Pre-Juvenile was longer than Junior. These results can be used to improve the physiological performance in intermittent practices, as well as technicaltactical training during judo sessions.

Performance of electronic devices submitted to X-rays and high energy proton beams

In this work we have studied the radiation effects on MOSFET electronic devices. The integrated circuits were exposed to 10 key X-ray radiation and 2.6 MeV energy proton beam. We have irradiated MOSFET devices with two different geometries: rectangular-gate transistor and circular-gate transistor. We have observed the cumulative dose provokes shifts on the threshold voltage and increases or decreases the transistor's off-state and leakage current. The position of the trapped charges in modern CMOS technology devices depends on radiation type, dose rate, total dose, applied bias and is a function of device geometry. We concluded the circular-gate transistor is more tolerant to radiation than the rectangular-gate transistor. (C) 2011 Elsevier B.V. All rights reserved.

Performance tests of two small trigeneration pilot plants

Trigeneration systems have been used with advantage in the last years in distributed electricity generation systems as a function of a growth of natural gas pipeline network distribution system, tax incentives, and energy regulation policies. Typically, a trigeneration system is used to produce electrical power simultaneously with supplying heating and cooling load by recovering the combustion products thermal power content that otherwise would be driven to atmosphere. Concerning that, two small scale trigeneration plants have been tested for overall efficiency evaluation and operational comparison. The first system is based on a 30 kW (ISO) natural gas powered microturbine, and the second one uses a 26 kW natural gas powered internal combustion engine coupled to an electrical generator as a prime mover. The stack gases from both machines were directed to a 17.6 kW ammonia-water absorption refrigeration chiller for producing chilled water first and next to a water heat recovery boiler in order to produce hot water. Experimental results are presented along with relevant system operational parameters for appropriate operation including natural gas consumption, net electrical and thermal power production, i.e., hot and cold water production rates, primary energy saving index, and the energy utilization factor over total and partial electrical load operational conditions. (c) 2011 Elsevier Ltd. All rights reserved.

Organization Performance Evaluation Using System Thinking: A Study in Brazilian Chemical Organizations Models

System thinking allows companies to use subjective constructs indicators like recursiveness, cause-effect relationships and autonomy to performance evaluation. Thus, the question that motivates this paper is: Are Brazilian companies searching new performance measurement and evaluation models based on system thinking? The study investigates models looking for system thinking roots in their framework. It was both exploratory and descriptive based on a multiple four case studies strategy in chemical sector. The findings showed organizational models have some characteristics that can be related to system thinking as system control and communication. Complexity and autonomy are deficiently formalized by the companies. All data suggest, inside its context, that system thinking seems to be adequate to organizational performance evaluation but remains distant from the management proceedings.

Automatic (data-based) learning of expressive indicators for machine failure detection : a proposal

Máster Universitario en Sistemas Inteligentes y Aplicaciones Numéricas en Ingeniería (SIANI)