Time invested in the global respiratory care of cystic fibrosis paediatrics patients.

INTRODUCTION: Respiratory therapy is a keystone of the treatment for cystic fibrosis (CF) lung disease, but it is time consuming. OBJECTIVES: We aimed to assess the total time spent on respiratory therapy, including chest physiotherapy (CPT) and physical activity (PA), as well as inhalation therapy (IT) and maintenance of materials (MM) to rationalise and optimise treatment. METHODS: A cross-sectional prospective study in a paediatric CF cohort. A questionnaire was developed to look at the time spent on respiratory care over 3 months. Enrolled in this study are all CF patients aged from 6 to 16 years (the exclusion criterion was lung transplantation). RESULTS: Of the 40 enrolled patients, 22 participated (13 boys and 9 girls), with a mean age of 11 years. The patients spent approximately 19.46 h per week (standard deviation ± 7.53, 8.00-35.25 h) on therapy: CPT (30.58%), IT (15.11%), PA (50%) and MM (4.32%), without statistical significance between sexes. CONCLUSION: In our cohort, CF patients spent an average of nearly 20 h a week in respiratory therapy, within a wide range of between 8 h to almost 36 h a week. PA consumes almost half of the time. Physicians have to take into consideration the burden of the treatment, to optimise the therapy.

New, low estimate for carbon stock in global forest vegetation based on inventory data

Abstract

Statistics in science and in society: From a state-of-the-art to a new research agenda

Statistics occupies a prominent role in science and citizens' daily life. This article provides a state-of-the-art of the problems associated with statistics in science and in society, structured along the three paradigms defined by Bauer, Allum and Miller (2007). It explores in more detail medicine and public understanding of science on the one hand, and risks and surveys on the other. Statistics has received a good deal of attention; however, very often handled in terms of deficit - either of scientists or of citizens. Many tools have been proposed to improve statistical literacy, the image of and trust in statistics, but with little understanding of their roots, with little coordination among stakeholders and with few assessments of impacts. These deficiencies represent as many new and promising directions in which the PUS research agenda could be expanded.

Inclusion of soil erosion impacts in life cycle assessment on a global scale: application to energy crops in Spain

Purpose: Despite the fundamental role of ecosystem goods and services in sustaining human activities, there is no harmonized and internationally agreed method for including them in life cycle assessment (LCA). The main goal of this study was to develop a globally applicable and spatially resolved method for assessing land-use impacts on the erosion regulation ecosystem service.Methods: Soil erosion depends much on location. Thus, unlike conventional LCA, the endpoint method was regionalized at the grid-cell level (5 arc-minutes, approximately 10×10 km2) to reflect the spatial conditions of the site. Spatially explicit characterization factors were not further aggregated at broader spatial scales. Results and discussion: Life cycle inventory data of topsoil and topsoil organic carbon (SOC) losses were interpreted at the endpoint level in terms of the ultimate damage to soil resources and ecosystem quality. Human health damages were excluded from the assessment. The method was tested on a case study of five three-year agricultural rotations, two of them with energy crops, grown in several locations in Spain. A large variation in soil and SOC losses was recorded in the inventory step, depending on climatic and edaphic conditions. The importance of using a spatially explicit model and characterization factors is shown in the case study.Conclusions and outlook: The regionalized assessment takes into account the differences in soil erosion-related environmental impacts caused by the great variability of soils. Taking this regionalized framework as the starting point, further research should focus on testing the applicability of the method trough the complete life cycle of a product and on determining an appropriate spatial scale at which to aggregate characterization factors, in order to deal with data gaps on location of processes, especially in the background system. Additional research should also focus on improving reliability of the method by quantifying and, insofar as it is possible, reducing uncertainty.

Contribution of the Global Regulator Gene gacA to Persistence and Dissemination of Pseudomonas fluorescens Biocontrol Strain CHA0 Introduced into Soil Microcosms.

Structural and regulatory genes involved in the synthesis of antimicrobial metabolites are essential for the biocontrol activity of fluorescent pseudomonads and, in principle, amenable to genetic engineering for strain improvement. An eventual large-scale release of such bacteria raises the question of whether such genes also contribute to the persistence and dissemination of the bacteria in soil ecosystems. Pseudomonas fluorescens wild-type strain CHA0 protects plants against a variety of fungal diseases and produces several antimicrobial metabolites. The regulatory gene gacA globally controls antibiotic production and is crucial for disease suppression in CHA0. This gene also regulates the production of extracellular protease and phospholipase. The contribution of gacA to survival and vertical translocation of CHA0 in soil microcosms of increasing complexity was studied in coinoculation experiments with the wild type and a gacA mutant which lacks antibiotics and some exoenzymes. Both strains were marked with spontaneous resistance to rifampin. In a closed system with sterile soil, strain CHA0 and the gacA mutant multiplied for several weeks, whereas these strains declined exponentially in nonsterile soil of different Swiss origins. The gacA mutant was less persistent in nonrhizosphere raw soil than was the wild type, but no competitive disadvantage when colonizing the rhizosphere and roots of wheat was found in the particular soil type and during the period studied. Vertical translocation was assessed after strains had been applied to undisturbed, long (60-cm) or short (20-cm) soil columns, both planted with wheat. A smaller number of cells of the gacA mutant than of the wild type were detected in the percolated water and in different depths of the soil column. Single-strain inoculation gave similar results in all microcosms tested. We conclude that mutation in a single regulatory gene involved in antibiotic and exoenzyme synthesis can affect the survival of P. fluorescens more profoundly in unplanted soil than in the rhizosphere.

La Economía del Cuidado en la Agenda de la Cooperación Internacional para el Desarrollo. Estudio de caso: Las políticas de los cuidados en América Latina. Una aproximación a Panamá y Uruguay.

El cuidado es una actividad indispensable en todos los hogares para la reproducción social y el bienestar en la vida diaria de las personas. La economía del cuidado hace referencia al espacio de actividades, bienes y servicios necesarios para la reproducción cotidiana de los individuos, siendo de suma importancia para el desarrollo económico de los países y el bienestar de sus poblaciones. Sin embargo, sigue siendo subvalorada por las sociedades y gobiernos de todo el mundo. El trabajo de cuidados o doméstico remunerado alcanza índices bajísimos de salarios mínimos, precarias condiciones laborales o se realiza desde la economía informal. El trabajo doméstico no remunerado es concebido por la sociedad como improductivo y vinculado a la mujer por razones de habilidades naturales de clara concepción machista. El resultado es la marginación de la mujer en las sociedades que la impide o le resta posibilidades de acceder a formación, empleo digno, ser parte de la esfera pública e incluso al sufragio.

Bioética intercultural para la salud global

Hoy las enfermedades no tienen fronteras,por lo tanto no pueden ser concebidas en términos locales, sino como problemas conectados con la pobreza y la marginalidad en todos los países del mundo. Esta consideración de la salud global e integral obliga, por una parte, a detectar los impedimentos que dificultan crear condiciones de salud mundial y, por otra parte, buscar las vías y diseñar las estrategias necesariaspara superar los obstáculos y alcanzar las cotas de salud que se entiende constituyen la calidad de vida.

Global Bioethics and Cultural Anthropology

Análisis del Protocolo de 1995 sobre reclamaciones colectivas como instrumento quasijurisdiccional de control sobre el cumplimiento de la Carta Social Europea.

Bioética intercultural para la salud global

Hoy las enfermedades no tienen fronteras,por lo tanto no pueden ser concebidas en términos locales, sino como problemas conectados con la pobreza y la marginalidad en todos los países del mundo. Esta consideración de la salud global e integral obliga, por una parte, a detectar los impedimentos que dificultan crear condiciones de salud mundial y, por otra parte, buscar las vías y diseñar las estrategias necesariaspara superar los obstáculos y alcanzar las cotas de salud que se entiende constituyen la calidad de vida.

Global Bioethics and Cultural Anthropology

Análisis del Protocolo de 1995 sobre reclamaciones colectivas como instrumento quasijurisdiccional de control sobre el cumplimiento de la Carta Social Europea.