Precision medicine in patients with allergic diseases: Airway diseases and atopic dermatitis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology

In this consensus document we summarize the current knowledge on major asthma, rhinitis, and atopic dermatitis endotypes under the auspices of the PRACTALL collaboration platform. PRACTALL is an initiative of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology aiming to harmonize the European and American approaches to best allergy practice and science. Precision medicine is of broad relevance for the management of asthma, rhinitis, and atopic dermatitis in the context of a better selection of treatment responders, risk prediction, and design of disease-modifying strategies. Progress has been made in profiling the type 2 immune response-driven asthma. The endotype driven approach for non-type 2 immune response asthma, rhinitis, and atopic dermatitis is lagging behind. Validation and qualification of biomarkers are needed to facilitate their translation into pathway-specific diagnostic tests. Wide consensus between academia, governmental regulators, and industry for further development and application of precision medicine in management of allergic diseases is of utmost importance. Improved knowledge of disease pathogenesis together with defining validated and qualified biomarkers are key approaches to precision medicine.

Contribution of Genetic Background and Clinical Risk Factors to Low-Trauma Fractures in Human Immunodeficiency Virus (HIV)-Positive Persons: The Swiss HIV Cohort Study.

Background.  The impact of human genetic background on low-trauma fracture (LTF) risk has not been evaluated in the context of human immunodeficiency virus (HIV) and clinical LTF risk factors. Methods.  In the general population, 6 common single-nucleotide polymorphisms (SNPs) associate with LTF through genome-wide association study. Using genome-wide SNP arrays and imputation, we genotyped these SNPs in HIV-positive, white Swiss HIV Cohort Study participants. We included 103 individuals with a first, physician-validated LTF and 206 controls matched on gender, whose duration of observation and whose antiretroviral therapy start dates were similar using incidence density sampling. Analyses of nongenetic LTF risk factors were based on 158 cases and 788 controls. Results.  A genetic risk score built from the 6 LTF-associated SNPs did not associate with LTF risk, in both models including and not including parental hip fracture history. The contribution of clinical LTF risk factors was limited in our dataset. Conclusions.  Genetic LTF markers with a modest effect size in the general population do not improve fracture prediction in persons with HIV, in whom clinical LTF risk factors are prevalent in both cases and controls.

The Topolovampo Pacific railway : a commercial and statistical review, showing its local, transcontinental, international and interoceanic features and advantages /

Bound in a vol. with supplied title: [Austin-Topolovampo railroad documents]

Motor vehicle accidents in relation to geometric and traffic features of highway intersections. Volume III - appendices. Final report.

Federal Highway Administration, Washington, D.C.

Motor vehicle accidents in relation to geometric and traffic features of highway intersections. Volume I - executive summary. Final report.

Federal Highway Administration, Washington, D.C.

Heparin: metabolism, physiology and clinical application.

Mode of access: Internet.

The maze test and clinical psychology.

Includes bibliography.

Motor vehicle accidents in relation to geometric and traffic features of highway intersections. Volume II - research report. Final report.

Federal Highway Administration, Washington, D.C.

Statistical and clinical report on 600 cases of gunshot wound to the chest /

Mode of access: Internet.

Androgens: biochemistry, physiology, and clinical significance

Includes bibliography.

Hydrologic and limnologic features of Quitobaquito Pond and springs, Organ Pipe Cactus National Monument /

"June 1989."

History of the Typographical union, its beginnings, progress and development, its beneficial and educational features together with a chapter on the early organization of printers.

Plate "Philadelphia typographical society," facing pl 56, accompanied by leaf with descriptive letterpress.

Handbook of systematic urinary analysis, chemical and microscopical. For the use of physicians, medical students, and clinical assistants,

Microfilmed for preservation

The climatology and physical features of Maryland.

At head of title: U.S. Department of Agriculture, Weather Bureau.