967 resultados para Combined virtual screening
Resumo:
The divergence of properties from one location to another within a soil mass is termed spatial variability, which traditionally includes three parameters the mean, the standard deviation, and the scale of fluctuation, in order to stochastically describe a soil property. Among them, determining the scale of fluctuation in the evaluation of spatial variability of soil profiles is not easy due to soil condition complexity. A simplified procedure is presented in the paper to determine the scale of fluctuation combined recurrence averaging and weighted linear regression. The alternative approach utilizes widely usable spreadsheet to solve the problem more directly and efficiently.
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[ES] El Castillo se encuentra coronando, junto a la iglesia de San Pedro, el cerro sobre el que se asienta el caserío de Cornago. Actualmente está formado por un patio interior de forma rectangular y rematado por cuatro torres en las esquinas, de las cuales tres son circulares de diferentes radios y una cuarta (NE) cuadrada, la superficie total ocupada es de unos 50 x 30 metros al exterior.
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[ES] Una de las aplicaciones más interesantes de las nuevas tecnologías en la docencia, es la utilización de plataformas virtuales accesibles por el alumno a través de Internet. eKASI es una plataforma informática para el apoyo a la docencia presencial desarrollada en la Universidad del Pais Vasco, que permite la gestión de los documentos y la gestión de los estudiantes de un curso, a la vez que facilita el aprendizaje del alumno. Es una herramienta de distribución gratuita y de fácil manejo. Durante el curso 2005/2006, se ha utilizado esta plataforma como apoyo a la docencia de la asignatura Tecnología Farmacéutica I de 4º curso de la Licenciatura en Farmacia de la Universidad del País Vasco. La plataforma está accesible en la dirección de Internet http://ekasi.ehu.es mediante la introducción de una clave facilitada por el administrador del sistema. En la sección correspondiente al aula virtual de la plataforma, el alumno tiene a su disposición la información y documentos relacionados con la asignatura (plan docente, presentaciones utilizadas en las clases, cuestionarios de autoevaluación, enlaces de interés a paginas web, materiales multimedia, etc.). Por otra parte, esta plataforma permite la colaboración y discusión on line de los materiales estudiados, a través del foro y del correo electrónico y posibilita al profesor tutorizar y realizar un seguimiento del progreso de los estudiantes, mediante la realización de tests y de las diferentes tareas propuestas al grupo de alumnos. La plataforma eKASI ha supuesto un instrumento de gran utilidad como apoyo a la docencia presencial tal como se deduce de los resultados de la encuesta realizada a los alumnos al finalizar el curso académico.
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Processing simulation is at the bottom of the coral technology of VM and is also difficult due to the complexity of mechanism and diversity of parameters. Previously much research has been mainly carried out on the geometrical simulation or physical simulation respectively. The aim of this paper is to study the processing simulation in laser surface treatment based on the mechanism, put forward the architecture of the whole processing simulation and give the models of the processing. As a result the data structure layers in the whole simulation is presented.
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An assessment of the status of the Atlantic stock of red drum is conducted using recreational and commercial data from 1986 through 1998. This assessment updates data and analyses from the 1989, 1991, 1992 and 1995 stock assessments on Atlantic coast red drum (Vaughan and Helser, 1990; Vaughan 1992; 1993; 1996). Since 1981, coastwide recreational catches ranged between 762,300 pounds in 1980 and 2,623,900 pounds in 1984, while commercial landings ranged between 60,900 pounds in 1997 and 422,500 pounds in 1984. In weight of fish caught, Atlantic red drum constitute predominantly a recreational fishery (ranging between 85 and 95% during the 1990s). Commercially, red drum continue to be harvested as part of mixed species fisheries. Using available length-frequency distributions and age-length keys, recreational and commercial catches are converted to catch in numbers at age. Separable and tuned virtual population analyses are conducted on the catch in numbers at age to obtain estimates of fishing mortality rates and population size (including recruitment to age 1). In tum, these estimates of fishing mortality rates combined with estimates of growth (length and weight), sex ratios, sexual maturity and fecundity are used to estimate yield per recruit, escapement to age 4, and static (or equilibrium) spawning potential ratio (static SPR, based on both female biomass and egg production). Three virtual analysis approaches (separable, spreadsheet, and FADAPT) were applied to catch matrices for two time periods (early: 1986-1991, and late: 1992-1998) and two regions (Northern: North Carolina and north, and Southern: South Carolina through east coast of Florida). Additional catch matrices were developed based on different treatments for the catch-and-release recreationally-caught red drum (B2-type). These approaches included assuming 0% mortality (BASEO) versus 10% mortality for B2 fish. For the 10% mortality on B2 fish, sizes were assumed the same as caught fish (BASEl), or positive difference in size distribution between the early period and the later period (DELTA), or intermediate (PROP). Hence, a total of 8 catch matrices were developed (2 regions, and 4 B2 assumptions for 1986-1998) to which the three VPA approaches were applied. The question of when offshore emigration or reduced availability begins (during or after age 3) continues to be a source of bias that tends to result in overestimates of fishing mortality. Additionally, the continued assumption (Vaughan and Helser, 1990; Vaughan 1992; 1993; 1996) of no fishing mortality on adults (ages 6 and older), causes a bias that results in underestimates of fishing mortality for adult ages (0 versus some positive value). Because of emigration and the effect of the slot limit for the later period, a range in relative exploitations of age 3 to age 2 red drum was considered. Tuning indices were developed from the MRFSS, and state indices for use in the spreadsheet and FADAPT VPAs. The SAFMC Red Drum Assessment Group (Appendix A) favored the FADAPT approach with catch matrix based on DELTA and a selectivity for age 3 relative to age 2 of 0.70 for the northern region and 0.87 for the southern region. In the northern region, estimates of static SPR increased from about 1.3% for the period 1987-1991 to approximately 18% (15% and 20%) for the period 1992-1998. For the southern region, estimates of static SPR increased from about 0.5% for the period 1988-1991 to approximately 15% for the period 1992-1998. Population models used in this assessment (specifically yield per recruit and static spawning potential ratio) are based on equilibrium assumptions: because no direct estimates are available as to the current status of the adult stock, model results imply potential longer term, equilibrium effects. Because current status of the adult stock is unknown, a specific rebuilding schedule cannot be determined. However, the duration of a rebuilding schedule should reflect, in part, a measure of the generation time of the fish species under consideration. For a long-lived, but relatively early spawning, species as red drum, mean generation time would be on the order of 15 to 20 years based on age-specific egg production. Maximum age is 50 to 60 years for the northern region, and about 40 years for the southern region. The ASMFC Red Drum Board's first phase recovery goal of increasing %SPR to at least 10% appears to have been met. (PDF contains 79 pages)
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Brickwork Lecturer Chris Holland has created a resource that allows students to lay bricks on a computer screen. The former bricklayer has used the ActivInspire suite on the Promethean interactive whiteboard to draw various types of bricks, as well as other interactive tools from the building site. Students are now more engaged in the classroom as they can practise cavity walling, block work, and setting walls on foundation before they get out in the workplace. Learners using the resource range from 14–16-year-old school students and full-time 16–19-year-olds completing Diplomas in brickwork to apprentices completing NVQs.
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[ENG]Aiming at an integrated and mechanistic view of the early biological effects of selected metals in the marine sentinel organism Mytilus galloprovincialis, we exposed mussels for 48 hours to 50, 100 and 200 nM solutions of equimolar Cd, Cu and Hg salts and measured cytological and molecular biomarkers in parallel. Focusing on the mussel gills, first target of toxic water contaminants and actively proliferating tissue, we detected significant dose-related increases of cells with micronuclei and other nuclear abnormalities in the treated mussels, with differences in the bioconcentration of the three metals determined in the mussel flesh by atomic absorption spectrometry. Gene expression profiles, determined in the same individual gills in parallel, revealed some transcriptional changes at the 50 nM dose, and substantial increases of differentially expressed genes at the 100 and 200 nM doses, with roughly similar amounts of up- and down-regulated genes. The functional annotation of gill transcripts with consistent expression trends and significantly altered at least in one dose point disclosed the complexity of the induced cell response. The most evident transcriptional changes concerned protein synthesis and turnover, ion homeostasis, cell cycle regulation and apoptosis, and intracellular trafficking (transcript sequences denoting heat shock proteins, metal binding thioneins, sequestosome 1 and proteasome subunits, and GADD45 exemplify up-regulated genes while transcript sequences denoting actin, tubulins and the apoptosis inhibitor 1 exemplify down-regulated genes). Overall, nanomolar doses of co-occurring free metal ions have induced significant structural and functional changes in the mussel gills: the intensity of response to the stimulus measured in laboratory supports the additional validation of molecular markers of metal exposure to be used in Mussel Watch programs
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Chromosome territories constitute the most conspicuous feature of nuclear architecture, and they exhibit non-random distribution patterns in the interphase nucleus. We observed that in cell nuclei from humans with Down Syndrome two chromosomes 21 frequently localize proximal to one another and distant from the third chromosome. To systematically investigate whether the proximally positioned chromosomes were always the same in all cells, we developed an approach consisting of sequential FISH and CISH combined with laser-microdissection of chromosomes from the interphase nucleus and followed by subsequent chromosome identification by microsatellite allele genotyping. This approach identified proximally positioned chromosomes from cultured cells, and the analysis showed that the identity of the chromosomes proximally positioned varies. However, the data suggest that there may be a tendency of the same chromosomes to be positioned close to each other in the interphase nucleus of trisomic cells. The protocol described here represents a powerful new method for genome analysis
Resumo:
Analisa a ferramenta Delegacia Virtual da Polícia do Senado Federal, disponibilizada por meio da Intranet da Instituição, com vistas a possibilitar o registro de ocorrências de maneira remota ao público interno.