Caracterização sócio-ambiental do bairro de Felipe Camarão- Natal/ RN

The rapid growth of the Brazilian cities in the latest years has brought a series of problems regarding housing policies and, therefore, the provision of dwellings for the low-income class people. Following the pattern of other capital cities, Natal has repeated the pattern of urbanization practiced in the country, which concentrates the low-income class inhabitants in specific zones of the city known as peripheries or even in a dwelling place for less-favored classes such as Felipe Camarão, which is one of ten boroughs belonging to the western administrative zone, a region which has historically received less attention from the public administrators towards infrastructure investments. Based on those aspects, the general objective of this work is to investigate which main social-environmental alterations have resulted from the processes of urbanization and field occupation in that area. The specific objectives are concerned with verifying 1) the process of urbanization and the process of dividing urban soil from the 1960s; 2) the current configuration of the public spaces in the borough; 3) the process of the deprivation of the original landscape characteristics of Environmental Protection Zones; 4) the dynamics of land occupation which are predominant in dune areas; 5) the dynamics of land occupation which are predominant in mangrove areas; 6) and the destruction of green covering on the land with its consequent alteration of the local floristic pattern. The methodology consisted of in-loco visits; the application of questionnaires as community research; a survey of bibliography published by the organisms and institutions in charge of carrying out the city hall s environmental and housing policies; and descriptive statistics of the collected data. Concerning the pattern of occupation which is predominant in the borough, the treatment of space dispensed by the local dwellers has culminated in the emergence and consolidation of environmental alterations which are clearly different from common occurrence in both the building area represented by housing complexes and in the green areas represented by dunes and mangroves. The data show that there was the predominance of the irregular land occupation process over the official housing policy during the population settlement which contributed with a series of frequent and foreseeable problems in the dynamics of urbanization of poverty such as invasions and appropriations of land parcels, the beginning of irregular arrangement of streets, the formation of villages and slums, which are full of self-constructed housing units, and the occupation and degradation of susceptibly fragile environmental areas such as the dune slopes and the mangroves

Identification of Staphylococcus saprophyticus isolated from patients with urinary tract infection using a simple set of biochemical tests correlating with 16S-23S interspace region molecular weight patterns

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A utilização da modelagem física no estudo do desenvolvimento, geometria e cinemática de falhas distensionais

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Estudo geológico e geofísico da falha de carnaubais, Bacia Potiguar-RN, e implicações neotectônicas

The segment of Carnaubais Fault located in the southeasthern portion of Guamaré Graben (Potiguar Basin) was studied. Several structures were detected and some of them strongly suggest that the last movements in Carnaubais Fault are of Neotectonic age. The study comprises an integrated interpretation of geologic, geomorphologic and geophysical data (gravimetry, magnetometry, resistivity, and self potential methods). According to the size of the studied areas, two approaches were used in this research. The first approach is of a regional nature and was conducted in an area, hereafter named Regional Area, having approximately 6,000 km2 and localized in the northern portion of Rio Grande do Norte state, around Macau city. The second approach comprises detailled studies of two small areas inside the Regional Area: the Camurupim and São Bento areas. Gravimetric and topographic data were used in the Regional Area. A separation into regional and residual components were conducted both on gravimetric and topographic data. The interpretation of the residual component of the gravimetric data allows a precise mapping of the borders of the Guamaré Graben. The regional component features of the topographic data are controlled by the pair of conjugate faults composed by the Carnaubais Fault (NE direction) and the Afonso Bezerra Fault (NW direction). On the other hand, the residual component of the topographic data shows that river valleis of NW direction are sharply interrupted where they intersect Carnaubais Fault. This fact is interpreted as an evidency that the last significant moviments occured in the Carnaubais Fault. Geologic, geomorphologic and geophysical data (magnetometry, resistivity, and self potential methods) were used in the Camurupim Area. The geologic mapping allows to identify five lithophacies unities. The first two unities (from base to top) were interpreted as composing a marine (or transitional) depositional sequency while the other were interpreted is composing a continental depositional sequence. The two sequences are clearly separated of an erosional discordance. The unities grouped in the marine sequence are composed by calcarenites (Unity A) and mudstones (Unity B). Unity A was deposited in a shalow plataform while Unity B, in a tidal flat. The unities grouped in the continental sequence are composed of conglomerate (Unity C) and sandstones (Unities D and E). Unities C and D are fluvial deposits while unity E is an eolian deposit. Unities A and B can be stratigraphycally correlated with Guamaré Formation. Unities C and D present three possible correlations. They may be correlated with Tibau Formation; or with Barreiras Formation; or with a clastic sediment deposit, commonly found in some rivers of Rio Grande do Norte state, and statigraphycally positioned above Barreiras Formation. Based on the decrease of the grain sizes from base to top both on unities C and D, it is proposed that these unities are correlated with the clastic sediment above mentioned. In this case, these unities would have, at least, Pleistocenic age. Finally, it is proposed that Unity E represent an eolian deposit that sufferred recent changes (at least in the Quaternary). The integrated interpretation of hydrographic, morphologic and geophysical data from Camurupim Area shows that Carnaubais Fault is locally composed by a system of several paralel subvertical faults. The fault presenting the larger vertical slip controls the valley of Camurupim river and separates the area in two blocks; in the nothern block the top of the Jandaira limestone is deeper than in the southern block. In addition, at least one of the faults in the northern block is cutting the whole sedimentary section. Because unities C , D, and/or E may be of Quaternary age, tectonic moviments possibly occured in Carnaubais Fault during this period. Detailled geologic mapping were conducted in beachrocks found in São Bento Area. This area is located at the intersection of the coast line with the Carnaubais Fault. The detected structures in the beachrocks are very similar to those caused by fragile deformations. The structures mapped in the beachrocks are consistent with a stress field with maximun compressional stress in E-W direction and extensional stress in the N-S direction. Since the Carnaubais Fault has a NE direction, it is optimally positioned to suffer tectonic movements under the action of such stress field. In addition, the shape of the coastal line appear to be controlled by the Carnaubais Fault. Furthemore, the observed structures in Camurupim Área are consistent with this stress field. These facts are interpreted as evidences that Carnaubais Fault and beachrocks suffered coupled tectonic movements. These moviments are of Neotectonic age because the beachrocks present ages less than 16,000 years

Cidades pequenas, grandes problemas :perfil urbano do Agreste Potiguar

In view of the diversity and the heterogeneity of the existing cities in Brazil, our approach refers to the urban and non-metropolitan areas. Aiming to foment the studies on small cities e to apprehend the sociospatial configuration of the urban environment in such cities, this piece of work elaborates and analyzes the urban profile of the small cities of the Agreste Potiguar region, using as a theoretical reference landmark the production of the urban and regional space, from the decade of 1970 to 2000. Starting from this reference, this piece of work presents an urban sociospatial characterization of the small cities of the Agreste Potiguar region, with emphasis on the economic framework, on the population dynamics, on the main social data, culminating in the main characteristics of the local daily life. The study of the small cities of the Agreste Potiguar region makes it possible the comprehension of the problems that involve the cities of this size, above all, those inserted in economically fragile regions. In the analyzed period, the changes occurred in the productive structure of the State of Rio Grande do Norte triggered a great crisis in the economy of the Agreste Potiguar region. This aspect, allied to the insufficient performance of the public power, contributed to the sprouting of some sociospatial problems, amongst which may be distinguished: the economic fragility, the generalized unemployment, the lack of security and the urban infrastructure absence sufficient to take care of the social demand. Even facing the existing problems, the small cities must be seen as potential spaces, capable to promote the regional development. To do so, it is necessary a process of democratization of the public administration, an ample popular participation and the establishment of a new urban policy, that aims at the social promotion of the individuals, the guarantee of basic necessities and the access to the necessary services to a dignified life

Praia de Ponta Negra: uma abordagem da paisagem costeira de 1970 a 2010, Natal/RN

With process urbanization process the Brazilian cities have been goin through, Natal/RN does not differ from the other ones, it has had a fast, inordinate and planned urbanization, but not applied, it has caused a high increase of social environmental problems. One of the worrying problems observed is the change in the coastal landscape, which has caused serious damage to the city‟s population, more specifically, of Ponta Negra beach neighborhood. For the geographical studies, the issue, concerning the occupation of the beaches that has been getting higher and higher in the last decades is extremely important because these, in addition to being used as homes in the new urban configuration, have incorporated new ways of environmental interference, without a simultaneous advance of knowledge which would be necessary for a more suitable and rational use of litoral spaces. Thus, the current assignment aimed to focus the coastal landscape of Ponta Negra Beach, in the city of Natal/RN, checking and analyzing the effects caused by anthropic and natural action, and the way it reflects in the quality of life of the resident, working population and of the frequenters as well as the landscape transformations in the area which is object of study, from 1970 through 2010. The methodology used followed to stages, the first concerned the theoretical work bibliographic surveying and composition; and second one the empirical work marking of the environmental characterization and application of the questionnaires. So, we can measure that Ponta Negra, is very susceptible to environmental changes, the ones caused by the natural dynamics of the beach, as well as the human actions (society) in this really fragile and mutable space, so it needs, a more profound systematic study about the coastal landscape. In order to reach a minimization of the change of the landscapes in the coastal zones there must be an integrated management of the environments, based on the planning of actions and territorial reordination of the occupations of these so important spaces, environmentally, as well as socioeconomically. Whereas, only this way, we will have a sustentable development and a suitable use of that space

Inferência geográfica para delimitação de corredores ecológicos: um estudo de caso para a Mata Atlântica do município de Tibau do Sul/RN

The Atlantic Forest biome occupies much of the Atlantic coast of Brazil, in addition to portions of Paraguay and Argentina. Due mainly to its biodiversity which falls in the group of global hotspots, i.e., areas that have high priority for conservation. Although currently there are some available devices that assist in their protection in the course of the history of occupation and exploitation of the Brazilian territory, this biome has gone, and is still going through, an intense process of devastation, caused mainly by the pressure from economic activities, culminating in a significant reduction of its area and consequent fragmentation of the landscape, which brings with hosts a series of problems at various scales and aspects. As in most municipalities included in the reach area of the biome, the situation of forest fragmentation in Tibau do Sul / RN is quite critical, reflecting on a truly diverse landscape with broad typology of land uses. Among the alternatives aimed at the conservation of this biome include the creation of protected areas and the creation of ecological corridors, the latter being more efficient by connecting the remaining forests, increasing landscape connectivity, providing significant gains in relation to biodiversity. However, a major problem on implementation of Ecological Corridors projects is related to the selection of areas for this purpose, in this sense Geography can provide important contributions through the integrated study of landscape in the light of the geosystemic approach and the use of Geographical Information System (GIS) in order to permit assessment of reality having as a base the integration of ecological, biological and man-made aspects. Thus, this research aims to indicate potential areas and propose scenarios delimitation of Ecological Corridors in the municipality of Tibau do Sul / RN through Geographic Inference techniques in GIS platform. Therefore, the methodology adopted is based on the Geosystemic approach. From these elements were created 4 models to indicate potential areas for implementation of Ecological Corridors from the environmental perspective (potential erosion), socioeconomic (cover and land prices), legislative (areas protected by environmental legislation) and integrated (combination of environmental factors, socioeconomic and legislative), which in turn served as a basis for proposing scenarios aimed at this purpose. The results showed that all models can be quite useful in indicating potential areas for the establishment of ecological corridors, especially when based on an integrated approach between environmental and anthropogenic. The Corridors delimitation proposes shown may perform duties beyond the establishment of connectivity between fragments, since they also may have usefulness in controlling erosion and protecting fragile environments. Among the models developed, the integrated constituted itself as the best option because it enabled the interconnection of a larger number of fragments from a better use of the potentialities present in the landscape

Análise e monitoramento geoambiental da praia de Genipabu/RN

Issues concerning coastal regions, especially the beaches have sparked quite complex because studies are there that most people in the world has secured housing, mainly from the half of the last century, without concern for the natural dynamics of these environments, which have complex interactions of continental and oceanic, coastal responsible for changes in locations that can be perceived in a few years and sometimes even a few days or hours. The search took as main goal, analyze the Genipabu Beach, in the municipality of Extremoz/RN, fragile environment and rapid momentum, which has been occupied in a disorderly and unplanned. Carried out a beach monitoring through profiles beach environments: defined stages morphodynamics; realization of characterize hydrodynamic processes; identification of changes in the landscape. To this end, made necessary a survey from the bibliographic collection for theoretical and conceptual rationale. An empirical step for conducting the environmental characterization of hydrodynamics, leveling and topographic analysis of sediments (in laboratory), for observation of changes in features, influenced, and natural dynamics, anthropic action that increasingly comes taking the characteristics from the natural landscape. Underlines therefore the importance of academic studies in several areas in these environments, for setting up a coastal zoning giving public subsidies for managers for managing and planning the use and occupation of the coast in their areas

Fragilidade ambiental da bacia hidrográfica do Rio Punaú (RN) e área litorânea adjacente

Hydrographic basins always exercised a big fascination over humankind that attracted for its scenery beauty or for its richness in natural resources, had been acting in order to modify these important ecosystems without, therefore, considering the possible consequences of these changes. The attributed importance to the coast ecosystems, in eminence to the hydrographic basin of Punaú river and adjacent areas, is had when it s verified the diversity of the ecosystems that contemplate it. Hydrographic basin in evidence in Rio Grande do Norte state, occupies an area of nearly 652.71 km², being it sited in the homogeneous micro-region Litoral Nordeste, with a regional population estimated in nearly 75,188 inhabitants, according to the Anuário Estatístico do Rio Grande do Norte 2004. The region of the researched basin is formed by seven municipal districts related as it follows: Maxaranguape, Pedra Grande, Pureza, Rio do Fogo, São Miguel de Touros, Taipu and Touros, but Maxaranguape, Rio do Fogo, Touros and Pureza have a direct participation in the basin. Basin in study have it lands evaluated according to the agriculturist aptitude by the conventionally methodology practiced in the country, having as objective, then, a compara-tive analysis between the ambient unities, Aeolian littoral and coast tray, identified in the researched area. From the characterization of the physic way of the area in study and owning the kept data, it was proceeded the integrated analysis of the structural elements of the landscape which were evidenced that the fragile areas are associated with the areas of agriculture cultivation, such as the ones of irregular occupation. About the degradation, the ambient diagnostic of the basin indicated that the equivalent to the Aeolian Littoral Ambient Unit correspond to the bigger pledging of the ambient quality, in other words, high ambient fragility, being this result due to the use and occupation of the soil, propitiating this way, vulnerability in the vegetal cover of the area, despite it disposes of a low agriculture cultivation percentage. Already in the Coast Ambient Tray, is emphasized the medium ambient fragility, despite of the high index of cultivated area. In a general way, the total area of the hydrographic basin of Punaú river and adjacent areas presented ambient impacts over the tolerance limit, indicating the necessity of a review of the practices of use and handling of the soil, reforesting of the water courses edges, control of erosion and contamination of the aqueous in the perspective to reduce the effects of the impacts due to the use and occupation of the basin in regard. The present search evaluated the ambient impacts diagnosised in the hydrographic basin of Punaú river and adjacent areas, pointing the causes and the probable consequences of the damages caused by these impacts to the basin ambient. From the analysis of these data, if was possible to become explicit how they are fundamental as key elements in the process of decision taking in the ambient questions

Brazilian natural dietary components (annatto, propolis and mushrooms) protecting against mutation and cancer

Considering the high number of new cancer cases in Brazil (approximately 470 000 cases in 2005) and the remarkable differences in the incidence of this disease around the world, the development of chemopreventive strategies using foods widely consumed would have a huge impact, both medically and economically. This review summarizes some of our studies conducted to verify the anti-mutagenic and anti-carcinogenic potential of some Brazilian natural dietary constituents (annatto, mushrooms, and propolis). Overall data have shown a clear role for these compounds in preventing mutation and specific preneoplastic lesions. Taken together, these agents indicate a favorable side-effect profile and may prove to be a promising alternative for cancer prevention strategies, although more investigation is needed to fully explore this issue.

International Recommendations for Training Future Toxicologic Pathologists Participating in Regulatory-Type, Nonclinical Toxicity Studies

The International Federation of Societies of Toxicologic Pathologists (IFSTP) proposes a common global framework for training future toxicologic pathologists who will support regulatory-type nonclinical toxicology studies. Trainees optimally should undertake a scientific curriculum of at least 5 years at an accredited institution leading to a clinical degree (veterinary medicine or medicine). Trainees should then obtain 4 or more years of intensive pathology practice during a residency and/or on-the-job "apprenticeship," at least 2 years of which must be focused on regulatory-type toxicologic pathology topics. Possession of a recognized pathology qualification (i.e., certification) is highly recommended. A non-clinical pathway (e.g., a graduate degree in medical biology or pathology) may be possible if medically trained pathologists are scarce, but this option is not optimal. Regular, lifelong continuing education (peer review of nonclinical studies, professional meetings, reading, short courses) will be necessary to maintain and enhance one's understanding of current toxicologic pathology knowledge, skills, and tools. This framework should provide a rigorous yet flexible way to reliably train future toxicologic pathologists to generate, interpret, integrate, and communicate data in regulatory-type, nonclinical toxicology studies. (J Toxicol Pathol 2010; 23: 171-181)

Population size and survivorship for juvenile lemon sharks (Negaprion brevirostris) on their nursery grounds at a marine protected area in Brazil

Os tubarões enfrentam muitos obstáculos para sobreviver nos primeiros anos de vida e muitas espécies ocupam áreas de berçário. Embora estimativas de sobrevivência, particularmente para jovens, sejam essenciais para acessar, monitorar e manejar efetivamente populações animais, existem poucos cálculos destas estimativas para populações de tubarões e poucas estimativas baseadas em métodos diretos para estes animais em suas áreas de berçário. Métodos de marcação e recaptura foram utilizados no presente estudo para estimar o tamanho populacional e a sobrevivência de jovens tubarões-limão (Negaprion brevirostris) em uma área de berçário na Reserva Biológica do Atol das Rocas, Brasil. Os indivíduos foram amostrados entre 1999 e 2003 e as estimativas de tamanho populacional variaram entre 12 a 100 indivíduos jovens e a taxa de sobrevivência entre 24 e 54%, com média de 44,6% durante o período de amostragem mais robusto. A população destes tubarões jovens diminuiu ao longo de nosso estudo, ainda que as taxas de sobrevivência tenham aumentado durante o mesmo período. Mesmo um nível moderado de pesca e a remoção de fêmeas maduras em áreas adjacentes podem afetar dramaticamente pequenas populações de tubarões num berçário pequeno e isolado como o Atol das Rocas. As taxas de sobrevivência e tamanho populacional relativamente mais baixos em Rocas podem ser resultado das diferenças nas características físicas deste berçário, comparadas a outros utilizados pela espécie no Atlântico norte-ocidental. Tais parâmetros comparativamente mais baixos no Atol das Rocas sugerem a fragilidade da população jovem de tubarões-limão neste berçário.

LaTBP1: A Leishmania amazonensis DNA-binding protein that associates in vivo with telomeres and GT-rich DNA using a Myb-like domain

Different species of Leishmania can cause a variety of medically important diseases, whose control and treatment are still health problems. Telomere binding proteins (TBPs) have potential as targets for anti-parasitic chemotherapy because of their importance for genome stability and cell viability. Here, we describe LaTBP1 a protein that has a Myb-like DNA-binding domain, a feature shared by most double-stranded telomeric proteins. Binding assays using full-length and truncated LaTBP1 combined with spectroscopy analysis were used to map the boundaries of the Myb-like domain near to the protein only tryptophan residue. The Myb-like domain of LaTBP1 contains a conserved hydrophobic cavity implicated in DNA-binding activity. A hypothetical model helped to visualize that it shares structural homology with domains of other Myb-containing proteins. Competition assays and chromatin immunoprecipitation confirmed the specificity of LaTBP1 for telomeric and GT-rich DNAs, suggesting that LaTBP1 is a new TBP. (C) 2007 Elsevier B.V. All rights reserved.

Mass spectrometric characterization of two novel inflammatory peptides from the venom of the social wasp Polybia paulista

The social wasp P. paulista is relatively common in southeast Brazil causing many medically important stinging incidents. The seriousness of these incidents is dependent on the amount of venom inoculated by the wasps into the victims, and the characteristic envenomation symptoms are strongly dependent on the types of peptides present in the venom. In order to identify some of these naturally occurring peptides available in very low amounts, an analytical protocol was developed that uses a combination of reversed-phase and normal-phase high-performance liquid chromatography (HPLC) of wasp venom for peptide purification, with matrix-assisted laser desorption/ionization time-of-flight post-source decay mass spectrometry (MALDI-Tof-PSD-MS) and low-energy collision-induced dissociation (CID) in a quadrupole time-of-flight tandem mass spectrometry (QTof-MS/MS) instrument for peptide sequencing at the sub-picomole level. The distinction between Leu and Ile was achieved both by observing d-type fragment ions obtained under CID conditions and by comparison of retention times of the natural peptides and their synthetic counterparts (with different combinations of I and/or L at N- and C-terminal positions). To distinguish the isobaric residues K and Q, acetylation of peptides was followed by Q-Tof-MS analysis. The primary sequences obtained were INWLKLGKMVIDAL-NH2 (MW 1611.98Da) and IDWLKLGKMVMDVL-NH2 (MW 1658.98Da). Micro-scale bioassay protocols characterized both peptides as presenting potent hemolytic action, mast cell degranulation, and chemotaxis of poly-morphonucleated leukocyte (PMNL) cells. The primary sequences and the bioassay results suggest that these toxins constitute members of a new sub-class of mastoparan toxins, directly involved in the occurrence of inflammatory processes after wasp stinging. Copyright (C) 2004 John Wiley Sons, Ltd.

Gene Mutations and Polymorphisms of TP53 and FHIT in Chronic Esophagitis and Esophageal Carcinoma

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)