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Doctorado en Islas Atlánticas: historia, patrimonio y marco jurídico institucional

Multiscale variability in the North Atlantic Ocean

Programa de doctorado, Oceanografía ; 2004-2006

177Lu-AMBA: Synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer

Gastrin-releasing peptide receptors (GRP-R) are upregulated in many cancers, including prostate, breast, and lung. We describe a new radiolabeled bombesin (BBN) analog for imaging and systemic radiotherapy that has improved pharmacokinetics (PK) and better retention of radioactivity in the tumor. METHODS: DO3A-CH2CO-G-4-aminobenzoyl-Q-W-A-V-G-H-L-M-NH2 (AMBA) was synthesized and radiolabeled. The human prostate cancer cell line PC-3 was used to determine the binding (Kd), retention, and efflux of 177Lu-AMBA. Receptor specificity was determined by in vitro autoradiography in human tissues. PK and radiotherapy studies were performed in PC-3 tumor-bearing male nude mice. RESULTS: 177Lu-AMBA has a high affinity for the GRP-R (Kd, 1.02 nmol/L), with a maximum binding capacity (Bmax) of 414 fmol/10(6) cells (2.5 x 10(5) GRP-R/cell). Internalization was similar for 177Lu-AMBA (76.8%), 177Lu-BBN8 (72.9%), and 125I-[Tyr4]-BBN (74.9%). Efflux was markedly lower for 177Lu-AMBA (2.9%) compared with 177Lu-BBN8 (15.9%) and 125I-[Tyr4]-BBN (46.1%). By receptor autoradiography, Lu-AMBA binds specifically to GRP-R (0.8 nmol/L) and to the neuromedin B receptor (NMB-R) (0.9 nmol/L), with no affinity for the bb3 receptor (>1,000 nmol/L). 177Lu-AMBA was renally excreted (55 %ID 1 h [percentage injected dose at 1 h]); tumor uptake at 1 and 24 h was 6.35 %ID/g and 3.39 %ID/g, respectively. One or 2 doses of 177Lu-AMBA (27.75 MBq/dose) significantly prolonged the life span of PC-3 tumor-bearing mice (P < 0.001 and P < 0.0001, respectively) and decreased PC-3 tumor growth rate over controls. When compared using World Health Organization criteria, mice receiving 2 doses versus 1 dose of 177Lu-AMBA demonstrated a shift away from stable/progressive disease toward complete/partial response; by RECIST (Response Evaluation Criteria in Solid Tumors), median survival increased by 36% and time to progression/progression-free survival increased by 65%. CONCLUSION: 177Lu-AMBA binds with nanomolar affinity to GRP-R and NMB-R, has low retention of radioactivity in kidney, demonstrates a very favorable risk-benefit profile, and is in phase I clinical trials.

Outbreak of Morel's disease in a Swiss goat flock

Staphylococcus aureus subsp. anaerobius is the causative agent of Morel’s disease in goats and sheep. We report the first outbreak of Morel’s disease in a Swiss goat flock. Multilocus sequence typing revealed that the Swiss isolates belong to sequence type (ST)1464, which is the ST responsible for outbreaks worldwide.

Demostracion legal de que se apresó injustamente el bergantin sueco, llamado La Libertad mas dulce que el oro : y conuencimiento de que el armador del corsario apresador debe reintegrar "a los napolitanos" dueños de la carga que conducia, todo su valor, y "al capitan sueco Juan Sundahl" en todo acontecimiento los fletes, estarías, daños y perjuicios, sin embargo : de la sentencia de vista del Supremo Consejo de la Guerra, cuya correccion y enmienda se solicita

Ejemplar gillotinado afectando al pie de imprenta

Does the Common Agricultural Policy Reduce Farm Labour Migration? Panel data analysis across EU regions. Factor Markets Working Paper No. 28, July 2012

This paper deals with the determinants of labour out-migration from agriculture across 149 EU regions over the 1990–2008 period. The central aim is to shed light on the role played by payments from the common agricultural policy (CAP) on this important adjustment process. Using static and dynamic panel data estimators, we show that standard neoclassical drivers, like relative income and the relative labour share, represent significant determinants of the intersectoral migration of agricultural labour. Overall, CAP payments contributed significantly to job creation in agriculture, although the magnitude of the economic effect was rather moderate. We also find that pillar I subsidies exerted an effect approximately two times greater than that of pillar II payments.

El Rey. Muy Reverendos Arzobispos ... En vista de los que me digné resolver á consulta de mi Consejo de Indias de tres de abril de mil setecientos ochenta y nueve , ha impetrado Don Nicolás de Azara ... un Breve, en que el actual Sumo Pontífice Pio Sexto proroga por veinte años las veinte años las facultades de dispensar en los Matrimonios que os concedió por otro Breve de veinte y tres de julio de mil setecientos setenta y ocho ... Fecho en Madrid á quinze de agosto de mil setecientos y noventa.

En fin de texto consta : A los Arzobispos, y Obispos de Indias, é Islas Filipinas, sobre el Breve expedido por Su Santidad, prorogándoles por veinte años las facultades que les concedió en otro de veinte y tres de julio de mil setecientos setenta y ocho para dispensas matrimoniales.

[Commentariorum Aeneae Sylvii Piccolominei Senensis, de Concilio Basileae celebrato libri duo, olim quidem scripti, nunc vero primum impressi, in quibus sic illam synodum depingit, sic quicquid illic actum est, bona fide refert ... cum multis aliis nunquam antehac impressis ...]

Incluye: Vita Henrici quarti Caesaris Augusti ... ; Oratio excusatoria ... regi Vladislao ad Ungariam missa ; Articuli Johannis Wiclephi Angli, impugnati a Wilhelmus Widefordus ; Articuli Johannis Wiclephi Angli, damnati per Concilium Constantiense ; Rationes et motiva, ac reprobationes articulorum Wiclephi, et sequacis sui Ioannis Huss, in Concilio Constantiensi damnatorum ; Quonam pacto doctrina Johannis Wiclephi in Bohemiam venerit ... ex historia Bohemorum, cuius author fuit Aeneas Sylvius ; Leonardo Areteni ... adversum hypocritas libellus ; Synodus Aribonis Archiepiscopi Moguntini, cum Coepiscopis ac Abbatibus suis, anno Domini MXXIII apud Saligunstat celebrata ; Quomodo Bohemi vocati, productique sint ad Basiliensem synodum oecumenicam ... commentariis compendio relatum ; Examen magistrale ac theologicale doctoris Ioannis de VVesalia ... ; Sententia damnationis doctrinae Johannis Wiclephi ...

Benedicti XIV Pont. Opt. Max. olim Prosperi Card. de Lambertinis... De festis Domini Nostri Jesu Christi Beatae Mariae Virginis et quorumdam sanctorum de quibus celebratur officium cum missa in civitate et dioecesi Bononiensi libri tres.

Mode of access: Internet.

Tractatus de ecclesia christi : ad usum seminariorum et sacrae theologiae alumnorum /

Mode of access: Internet.

Commentaria in Aristotelem graeca : Edita consilio et auctoritate Academiae litterarum ragiae borussicae ...

A supplement of both the edition of Aristotle's works by the Berlin Academy (1831-1870) and of the Commentaria, is the Supplementum Aristotelicum editum consilio et auctoritate Academiae litterarum regiæ Borussicae ... Berolini, 1885-1903.

Res gestæ Caroli Vesæll dicti, cum historia Regis Magni Boni cohærentes.

Text in Icelandic and Latin.

Bibliothecæ Upsaliensis historia,

Mode of access: Internet.

Commentarium anecdotum, Brandkrossa-þáttr dictum,

Text in Icelandic and Latin.