Villaverde Vega, Noé: Tingitana en la Antigüedad Tardía (siglos III-VII). Autoctonía y romanidad en el extremo mediterráneo. Real Academia de la Historia.

Permítasenos empezar con una afirmación contundente: este libro de Noé Villaverde es el mejor que se ha publicado en España sobre la Tingitana (Reino de Marruecos) desde los trabajos de Tarradell y Ponsich. Si nos viéramos obligados a sintetizar en una línea, que no es el caso, las bondades de la obra, diríamos que se trata sencilla y llanamente de un trabajo bien hecho. ¡Pero todos sabemos lo que cuesta que un texto llegue a esa categoría!

Una Cantimplora de fayenza egipcia procedente de la necrópolis de Les Casetes (La Vila Joiosa, Alicante)

La urbanización de unas parcelas en la ciudad de la Vila Joiosa (Alicante), puso al descubierto una interesante necrópolis con ajuares que pueden remontarse hasta finales del siglo VII a.n.e. En una de las tumbas, la número 18, formando parte de su ajuar se encontraba una cantimplora de fayenza que contiene en sus laterales dos cartelas con jeroglíficos egipcios. En este trabajo presentamos el yacimiento, así como el contexto donde se recuperó esta pieza, de la que realizamos un estudio más específico dado su carácter singular.

Grau Mira, Ignacio: La organización del territorio en el área central de la 'Contestania' Ibérica, Anejo de la revista Lucentum, 12, Publicaciones de la Universidad de Alicante, Alacant, 2002

Els estudis sobre territoris iberics -no sobre arees territorials més o menys coherents, com l'estudi classic de Llobregat (1972) sobre la Contestania o el de Lillo (1981) sobre l'area murciana, que són una altra COsa- compten ja amb una tradició relativament llarga, des deis primers treballs de F. Burillo (1982) sobre la val! mitjana de l'Ebre i els d' A. Ruiz i M. Molinos (1984) al' Alt Guadalquivir, posteriorment els de J. Bernabeu, H. Bonet, P. Guerin i C. Mata a l'Edetania (en particular, Bonet, 1995) i els que diferents autors han realitzat a les arees costaneres de Catalunya (Martín i Plana, 2001). El trebal! d'Ignacio Grau Mira s'insereix plenament dins d'aquesta tradició i, com és lógic, se'n beneficia en gran mesura.

Spatial relational learning and memory abilities do not differ between men and women in a real-world, open-field environment

This study assesses gender differences in spatial and non-spatial relational learning and memory in adult humans behaving freely in a real-world, open-field environment. In Experiment 1, we tested the use of proximal landmarks as conditional cues allowing subjects to predict the location of rewards hidden in one of two sets of three distinct locations. Subjects were tested in two different conditions: (1) when local visual cues marked the potentially-rewarded locations, and (2) when no local visual cues marked the potentially-rewarded locations. We found that only 17 of 20 adults (8 males, 9 females) used the proximal landmarks to predict the locations of the rewards. Although females exhibited higher exploratory behavior at the beginning of testing, males and females discriminated the potentially-rewarded locations similarly when local visual cues were present. Interestingly, when the spatial and local information conflicted in predicting the reward locations, males considered both spatial and local information, whereas females ignored the spatial information. However, in the absence of local visual cues females discriminated the potentially-rewarded locations as well as males. In Experiment 2, subjects (9 males, 9 females) were tested with three asymmetrically-arranged rewarded locations, which were marked by local cues on alternate trials. Again, females discriminated the rewarded locations as well as males in the presence or absence of local cues. In sum, although particular aspects of task performance might differ between genders, we found no evidence that women have poorer allocentric spatial relational learning and memory abilities than men in a real-world, open-field environment.

Development of a real-time PCR for the specific detection of Waddlia chondrophila in clinical samples.

Waddlia chondrophila is considered as an emerging human pathogen likely involved in miscarriage and lower respiratory tract infections. Given the low sensitivity of cell culture to recover such an obligate intracellular bacteria, molecular-based diagnostic approaches are warranted. We thus developed a real-time PCR that amplifies Waddlia chondrophila DNA. Specific primers and probe were selected to target the 16S rRNA gene. The PCR specifically amplified W. chondrophila but did not amplify other related-bacteria such as Parachlamydia acanthamoebae, Simkania negevensis and Chlamydia pneumoniae. The PCR exhibited a good intra-run and inter-run reproducibility and a sensitivity of less than ten copies of the positive control. This real-time PCR was then applied to 32 nasopharyngeal aspirates taken from children with bronchiolitis not due to respiratory syncytial virus (RSV). Three samples revealed to be Waddlia positive, suggesting a possible role of this Chlamydia-related bacteria in this setting.

Contributo para traçar o perfil do público leitor do Real Gabinete Português de Leitura: 1837-1847

Resultado de uma pesquisa que teve como objetivo identificar os critérios que propiciaram a política de seleção do acervo do Real Gabinete Português de Leitura e, a partir deles, estabelecer a Política de Seleção que foi praticada pelo Gabinete. Por uma abordagem exploratório-descritiva, utilizando características do acervo, este artigo busca delinear a figura do leitor no período de 1837-1847. Identifica ainda algumas classes de leitores e suas leituras.

Plantas de la Sierra de Orihuela (Alicante, SE de EspaÑa)

Como resultado de una excursión realizada el 23 de Marzo de 1980 a la Sierra de Orihuela, macizo perteneciente a la provincia corológica murciano-alménense, sector murciano, se citan 87 táxones de los que la mayor parte (cerca de un 70%) corresponden a terófitos. De entre las citas cabe destacar como nuevas para la provincia de Alicante: Crassula tillaea Lester-Garl. y Eryngium ilicifolium Lam. Plantago ovata Forsk. y Notoceras bicorne (Aitón) Amo fª. hispanicum WK. no se habían vuelto a encontrar en la zona desde que Rouy y Lagasca respectivamente lo hicieran el siglo pasado.

Using Scanning Lasers for Real-Time Pavement Thickness Measurement, TR-538, 2006

Due to limited budgets and reduced inspection staff, state departments of transportation (DOTs) are in need of innovative approaches for providing more efficient quality assurance on concrete paving projects. The goal of this research was to investigate and test new methods that can determine pavement thickness in real time. Three methods were evaluated: laser scanning, ultrasonic sensors, and eddy current sensors. Laser scanning, which scans the surface of the base prior to paving and then scans the surface after paving, can determine the thickness at any point. Also, scanning lasers provide thorough data coverage that can be used to calculate thickness variance accurately and identify any areas where the thickness is below tolerance. Ultrasonic and eddy current sensors also have the potential to measure thickness nondestructively at discrete points and may result in an easier method of obtaining thickness. There appear to be two viable approaches for measuring concrete pavement thickness during the paving operation: laser scanning and eddy current sensors. Laser scanning has proved to be a reliable technique in terms of its ability to provide virtual core thickness with low variability. Research is still required to develop a prototype system that integrates point cloud data from two scanners. Eddy current sensors have also proved to be a suitable alternative, and are probably closer to field implementation than the laser scanning approach. As a next step for this research project, it is suggested that a pavement thickness measuring device using eddy current sensors be created, which would involve both a handheld and paver-mounted version of the device.

De la burbuja teórica a la literatura real: La literatura en peligro, de Tzvetan Todorov

El objetivo de este libro es prevenirnos contra un enfoque excesivamente formalista de la literatura, que es, según el autor, uno de los factores fundamentales de debilitación de la literatura en el mundo contemporáneo. Habiendo sido Todorov uno de los principales representan tes y difusores del estructuralismo en Europa, es normal que abra este libro explicando el porqué de su apuesta inicial y los términos de su evolución posterior.

Perda endógena e absorção real de fósforo em dietas para eqüinos em crescimento

O trabalho teve por objetivo avaliar os efeitos de diferentes níveis de P na dieta de eqüinos em crescimento sobre sua perda endógena fecal, e verificar qual seja a exigência mínima diária desse elemento na sua alimentação. Foram utilizados 16 eqüinos machos em crescimento, recebendo dieta basal sem suplementação de P, e dieta basal suplementada com fosfato bicálcico, para fornecer 15, 20 e 25 g P/animal/dia. No 16º dia experimental, foram injetados 30 MBq de 32P/animal e coletaram-se amostras de sangue, fezes e urina, durante sete dias. Foram determinadas as atividades específicas do P no plasma, nas fezes e na urina, e calculou-se a perda endógena fecal e a absorção real de P. A perda endógena fecal e a absorção real de P não foram afetadas (P>0,05) pelos tratamentos, e foram estimados, em média, 10,34 mg P/kg PV/dia e 47,07%, respectivamente, o que indica que, nas condições experimentais, animais com idade média de 19 meses necessitam de 21,96 mg de P/kg PV/dia para manter o balanço da perda metabólica fecal, e a quantidade diária de P de 14,75 g.

Exposure to bioaerosols in poultry houses at different stages of fattening; use of real-time PCR for airborne bacterial quantification

Previous studies have demonstrated that poultry house workers are exposed to very high levels of organic dust and consequently have an increased prevalence of adverse respiratory symptoms. However, the influence of the age of broilers on bioaerosol concentrations has not been investigated. To evaluate the evolution of bioaerosol concentration during the fattening period, bioaerosol parameters (inhalable dust, endotoxin and bacteria) were measured in 12 poultry confinement buildings in Switzerland, at three different stages of the birds' growth; samples of air taken from within the breathing zones of individual poultry house employees as they caught the chickens ready to be transported for slaughter were also analysed. Quantitative polymerase chain reaction (Q-PCR) was used to assess the quantity of total airborne bacteria and total airborne Staphylococcus species. Bioaerosol levels increased significantly during the fattening period of the chickens. During the task of catching mature birds, the mean inhalable dust concentration for a worker was 26 +/- 1.9 mg m(-3) and endotoxin concentration was 6198 +/- 2.3 EU m(-3) air, >6-fold higher than the Swiss occupational recommended value (1000 EU m(-3)). The mean exposure level of bird catchers to total bacteria and Staphylococcus species measured by Q-PCR is also very high, respectively, reaching values of 53 (+/-2.6) x 10(7) cells m(-3) air and 62 (+/-1.9) x 10(6) m(-3) air. It was concluded that in the absence of wearing protective breathing apparatus, chicken catchers in Switzerland risk exposure beyond recommended limits for all measured bioaerosol parameters. Moreover, the use of Q-PCR to estimate total and specific numbers of airborne bacteria is a promising tool for evaluating any modifications intended to improve the safety of current working practices

Validation of real-time methylation-specific PCR to determine O6-methylguanine-DNA methyltransferase gene promoter methylation in glioma.

Epigenetic silencing of the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) by promoter methylation predicts successful alkylating agent therapy, such as with temozolomide, in glioblastoma patients. Stratified therapy assignment of patients in prospective clinical trials according to tumor MGMT status requires a standardized diagnostic test, suitable for high-throughput analysis of small amounts of formalin-fixed, paraffin-embedded tumor tissue. A direct, real-time methylation-specific PCR (MSP) assay was developed to determine methylation status of the MGMT gene promoter. Assay specificity was obtained by selective amplification of methylated DNA sequences of sodium bisulfite-modified DNA. The copy number of the methylated MGMT promoter, normalized to the beta-actin gene, provides a quantitative test result. We analyzed 134 clinical glioma samples, comparing the new test with the previously validated nested gel-based MSP assay, which yields a binary readout. A cut-off value for the MGMT methylation status was suggested by fitting a bimodal normal mixture model to the real-time results, supporting the hypothesis that there are two distinct populations within the test samples. Comparison of the tests showed high concordance of the results (82/91 [90%]; Cohen's kappa = 0.80; 95% confidence interval, 0.82-0.95). The direct, real-time MSP assay was highly reproducible (Pearson correlation 0.996) and showed valid test results for 93% (125/134) of samples compared with 75% (94/125) for the nested, gel-based MSP assay. This high-throughput test provides an important pharmacogenomic tool for individualized management of alkylating agent chemotherapy.