956 resultados para Corporations -- Auditing -- Handbooks, manuals, etc


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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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This collection is a valuable source on home economics history in South Carolina during the twentieth century. While there is information on the SCHEA from its beginning in 1914 to 1980, the actual records do not start until 1920. An outline of what the South Carolina Home Economics Association was doing from 1914 to 1920, is provided in the “historical file” (see Box 1, folders 1 to 4). The inclusive dates for a particular series may vary and, for most series, the records are incomplete. The collection contains all the records normally created by an organization, including constitutions, correspondence, minutes, reports, handbooks, etc. A wide variety of research topics could be developed from the records, including the SCHEA’s impact on the legislative process in South Carolina (e.g. the passage of the bill for the enrichment of cornmeal and grits in 1943), its cooperation and relationship with relief agencies in the state and its role in improving child health during the 1930s.

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The Mrs. W. E. Cochran Papers consist of histories, constitutions, bylaws, reports, memoranda, minutes, membership lists, newsletters, handbooks, brochures, manuals, newspaper clippings and photographs, relating to her involvement with the South Carolina Extension Homemakers’ Council (1936-1976), the National Home Demonstration Council (1960-1976), the Associated Country Women of the World (1947-1976), the Master Farm Homemakers’ Guild (1964-1976), and the South Carolina Council for the Common Good (1968-1972).

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Recently, a nongenomic cytotoxic component of the chemotherapeutic agent tamoxifen (TAM) has been identified that predominantly triggers mitochondrial events. The present study delineates the intracellular fate of TAM and studies its interaction with a spectrum of cell homeostasis modulators primarily relevant to mitochondria. The subcellular localization of TAM was assessed by confocal fluorescence microscopy. The effect of the modulators on TAM cytotoxicity was assessed by standard MTT assays. Our findings show that in estrogen receptor positive MCF7 breast adenocarcinoma cells and DU145 human prostate cancer cells, TAM largely accumulates in the mitochondria and endoplasmic reticulum, but not lysosomes. Our results further demonstrate that in MCF7, but not in DU145 cells, mitochondrial electron transport chain complex I and III inhibitors exacerbate TAM toxicity with an order of potency of myxothiazol = stigmatellin > rotenone > antimycin A, suggesting a cell-specific cytotoxic interplay between mitochondrial complex I and III function and TAM action.

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Esse trabalho tem por objetivo a análise de livros didáticos jurídicos na perspectiva da história dos direitos europeu e brasileiro, tendo como referencial teórico o texto de Alain Choppin sobre as funções do livro didático. Foram analisados livros didáticos jurídicos produzidos desde a Antiguidade até os dias atuais, assim como importantes mudanças legislativas ocorridas em Portugal no século XVIII e no Brasil no século XIX. Seus autores são, em sua maioria, professores universitários, para que seus textos servissem de fonte de argumentos de autoridade na prática. Ao lado dos manuais, sempre foi recorrente o uso de apostilas elaboradas pelos professores ou pelos próprios alunos, a partir das anotações das aulas. Nos últimos tempos, os manuais sofrem a concorrência dos resumos voltados para concursos públicos e dos “cadernos” distribuídos pelos alunos pela Internet. As principais conclusões foram as de que os livros didáticos jurídicos são importantes para o aprendizado do Direito.