Contributo da utilização dos recursos educativos digitais no 1.º Ciclo do Ensino Básico

O estudo foi concretizado numa turma do 1.º ano de escolaridade do 1.º CEB, constituída por 27 alunos, numa Escola EB1, onde se realizou a Prática de Ensino Supervisionada (PES), no âmbito do Mestrado em Educação Pré-Escolar e Ensino do 1.º CEB.. O objetivo da investigação pretendeu averiguar quais os potenciais contributos que a utilização complementar de um recurso em formato digital pode contribuir para melhorar a motivação e o envolvimento dos alunos no sentido de promover mais e melhores aprendizagens. Relativamente ao tipo de investigação, optou-se por uma metodologia de natureza qualitativa que recaiu numa investigação-ação. Como técnicas de recolha de dados foram utilizadas as notas de campo, a observação participante, a entrevista semiestruturada, o inquérito por questionário e os registos fotográficos. Nesta recolha de dados houve a participação direta dos alunos da turma, da Orientadora Cooperante, do «Par Pedagógico» e dos professores titulares de turma da Escola EB1 Quinta da Granja. Os resultados obtidos após a análise e tratamento dos dados, permitiram concluir que ao utilizar este RED os alunos demonstraram terem adquirido aprendizagens mais significativas, pelo facto de se terem potenciado níveis de maior interesse, empenho, motivação, envolvimento e espírito de iniciativa no decorrer das atividades propostas.

Estudo das implicações de um software educativo – EdiLim – no processo de ensino e de aprendizagem no 1.º ciclo do ensino básico : relatório de estágio

Relatório de Estágio apresentado à Escola Superior de Educação do Instituto Politécnico de Castelo Branco para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Educação Pré-escolar e Ensino do 1.º Ciclo do Ensino Básico.

Contributo dos recursos educativos digitais - RED - no 1º Ciclo do Ensino Básico

O estudo foi realizado numa turma do 1.º ano de escolaridade do 1.º CEB, envolvendo 27 alunos, onde se realizou a Prática de Ensino Supervisionada. O objetivo da investigação pretendeu averiguar quais os potenciais contributos que a utilização complementar de um recurso em formato digital, com a utilização de um recurso em formato papel, pode contribuir para melhorar a motivação e o envolvimento dos alunos no sentido de promover mais e melhores aprendizagens. Optou-se por uma metodologia de natureza qualitativa que recaiu numa investigação-ação. Na recolha de dados houve a participação direta dos alunos da turma, da Orientadora Cooperante, do «Par Pedagógico” e dos professores titulares de turma. Os resultados obtidos permitiram concluir que ao utilizar este RED os alunos demonstraram terem adquirido aprendizagens mais significativas, pelo facto de se terem potenciado níveis de maior interesse, empenho, motivação, envolvimento e espírito de iniciativa no decorrer das atividades propostas.

O contributo da utilização do EdiLim, como recurso educativo na prática de ensino supervisionada, através da conceção de atividades no 1º ciclo do ensino básico

Relatório de Estágio apresentado à Escola Superior de Educação do Instituto Politécnico de Castelo Branco para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Educação Pré-Escolar e Ensino do 1º Ciclo do Ensino Básico.

Are iron oxide nanoparticles safe? Current knowledge and future perspectives

Due to their unique physicochemical properties, including superparamagnetism, iron oxide nanoparticles (ION) have a number of interesting applications, especially in the biomedical field, that make them one of the most fascinating nanomaterials. They are used as contrast agents for magnetic resonance imaging, in targeted drug delivery, and for induced hyperthermia cancer treatments. Together with these valuable uses, concerns regarding the onset of unexpected adverse health effects following exposure have been also raised. Nevertheless, despite the numerous ION purposes being explored, currently available information on their potential toxicity is still scarce and controversial data have been reported. Although ION have traditionally been considered as biocompatible - mainly on the basis of viability tests results - influence of nanoparticle surface coating, size, or dose, and of other experimental factors such as treatment time or cell type, has been demonstrated to be important for ION in vitro toxicity manifestation. In vivo studies have shown distribution of ION to different tissues and organs, including brain after passing the blood-brain barrier; nevertheless results from acute toxicity, genotoxicity, immunotoxicity, neurotoxicity and reproductive toxicity investigations in different animal models do not provide a clear overview on ION safety yet, and epidemiological studies are almost inexistent. Much work has still to be done to fully understand how these nanomaterials interact with cellular systems and what, if any, potential adverse health consequences can derive from ION exposure.

CIL I(2): 2.1, 2662 – Elegaic epigram celebrating the hauling of a Roman fleet across the Isthmus of Corinth by M. Antonius (grandfather of the triumvir) and Hirrus in 102 BC

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A utilização dos recursos educativos digitais : o contributo de uma investigação na prática de ensino supervisionada no 1º CEB

O presente artigo tem como objetivo refletir sobre o impacto das Tecnologias da informação e da Comunicação (TIC) em contexto educativo, focando os potenciais contributos da utilização dos Recursos Educativos Digitais (RED)) no processo de ensino e de aprendizagem. Para o efeito, serão apresentados os resultados da utilização do RED: Aula Digital - O Mundo da Carochinha 1.º Ano, O estudo foi concretizado numa turma do 1.º ano de escolaridade do 1.º CEB, constituída por 27 alunos, com idades compreendidas entre os 6-7 anos, num Agrupamento de Escolas da Cidade de Castelo Branco, no âmbito da Prática de Ensino Supervisionada. Os resultados obtidos após a análise e tratamento dos dados permitiram concluir que ao utilizar este RED os alunos demonstraram terem adquirido os conteúdos abordados, pelo facto de se terem potenciado níveis de maior interesse, empenho, motivação, envolvimento e espírito de Iniciativa no decorrer das atividades propostas. Porém, talvez pelo facto de serem alunos de 1 º ano do 1 º CEB, não descuram a presença e o acompanhamento da professora e a utilização de recursos em suporte papel. Quer isto dizer que deve haver uma complementaridade que concilie o fator humano (professora), com a utilização de recursos em suporte digital e recursos em suporte papel (Manual).

Planta (No. 4)

Órgano de difusión del departamento y cuerpo académico de Botánica, FCB-UANL

A valorização dos alunos de uma escola do 1º CEB sobre os valores em contexto de sala de aula

Relatório de Estágio apresentado à Escola Superior de Educação dp Instituto Politécnico de Castelo Branco para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Educação Pré-escolar e Ensino do 1º ciclo do Ensino Básico.

Comparison of 1-year outcome in patients with severe aorta stenosis treated conservatively or by aortic valve replacement or by percutaneous transcatheter aortic valve implantation (data from a multicenter Spanish registry)

The factors that influence decision making in severe aortic stenosis (AS) are unknown. Our aim was to assess, in patients with severe AS, the determinants of management and prognosis in a multicenter registry that enrolled all consecutive adults with severe AS during a 1-month period. One-year follow-up was obtained in all patients and included vital status and aortic valve intervention (aortic valve replacement [AVR] and transcatheter aortic valve implantation [TAVI]). A total of 726 patients were included, mean age was 77.3 ± 10.6 years, and 377 were women (51.8%). The most common management was conservative therapy in 468 (64.5%) followed by AVR in 199 (27.4%) and TAVI in 59 (8.1%). The strongest association with aortic valve intervention was patient management in a tertiary hospital with cardiac surgery (odds ratio 2.7, 95% confidence interval 1.8 to 4.1, p <0.001). The 2 main reasons to choose conservative management were the absence of significant symptoms (136% to 29.1%) and the presence of co-morbidity (128% to 27.4%). During 1-year follow-up, 132 patients died (18.2%). The main causes of death were heart failure (60% to 45.5%) and noncardiac diseases (46% to 34.9%). One-year survival for patients treated conservatively, with TAVI, and with AVR was 76.3%, 94.9%, and 92.5%, respectively, p <0.001. One-year survival of patients treated conservatively in the absence of significant symptoms was 97.1%. In conclusion, most patients with severe AS are treated conservatively. The outcome in asymptomatic patients managed conservatively was acceptable. Management in tertiary hospitals is associated with valve intervention. One-year survival was similar with both interventional strategies.

Role of the human chymase (CMA1) in the conversion of big-endothelin-1 to endothelin-1 (1-31)

Abstract : The chymase-dependant pathway responsible for converting Big ET-1 to ET-1 was established in vitro. It has only been recently, in 2009, that our group demonstrated that the conversion of Big ET-1 to ET-1 (1-31) can occur in vivo in mice (Simard et al., 2009), knowing that ET-1 (1-31) is converted to ET-1 via NEP in vivo (Fecteau et al., 2005). In addition, our laboratory demonstrated in 2013 that mMCP-4, the murine analogue of human chymase, produces ET-1 (1-31) from the Big ET-1 precursor (Houde et al. 2013). Thus far, in the literature, there are no specific characterizations of recombinant chymases (human or murine). In fact, the group of Murakami published in 1995 a study characterizing the CMA1 (human chymase) in a chymostatin-dependent fashion, using Angiotensin I as a substrate (Murakami et al., 1995). However, chymostatin is a non-specific inhibitor of chymase. It has been shown that chymostatin can inhibit elastase, an enzyme that can convert Angiotensin I to Angiotensin II (Becari et al., 2005). Based on these observations, the proposed hypothesis in the present study suggests that recombinant as well as extracted CMA1 from LUVA (human mast cell line), in addition to soluble fractions of human aortas, convert Big ET-1 into ET-1 (1-31 ) in a TY-51469 (a chymase-specific inhibitor) sensitive manner. In a second component, we studied the enzyme kinetics of CMA1 with regard to the Big ET-1 and Ang I substrate. The affinity of CMA1 against Big ET-1 was greater compared to Ang I (KM Big ET- 1: 12.55 μM and Ang I: 37.53 μM). However, CMA1 was more effective in cleaving Ang I compared to Big ET-1 (Kcat / KM Big ET-1: 6.57 x 10-5 μM-1.s-1 and Ang I: 1.8 x 10-4 ΜM-1.s- 1). In a third component involving in vivo experiments, the pressor effects of Big ET-1, ET-1 and Ang I were tested in conscious mMCP-4 KO mice compared to wild-type mice. The increase in mean arterial pressure after administration of Big ET-1 was greater in wild-type mice compared to mMCP- 4 KO mice. This effect was not observed after administration of ET-1 and / or Ang I.

New dimeric supramolecular structure of mixed (phthalocyaninato)(porphyrinato)-europium(III) sandwiches : preparation and spectroscopic characteristics

The mixed double-decker Eu\[Pc(15C5)4](TPP) (1) was obtained by base-catalysed tetramerisation of 4,5-dicyanobenzo-15-crown-5 using the half-sandwich complex Eu(TPP)(acac) (acac = acetylacetonate), generated in situ, as the template. For comparative studies, the mixed triple-decker complexes Eu2\[Pc(15C5)4](TPP)2 (2) and Eu2\[Pc(15C5)4]2(TPP) (3) were also synthesised by the raise-by-one-story method. These mixed ring sandwich complexes were characterised by various spectroscopic methods. Up to four one-electron oxidations and two one-electron reductions were revealed by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). As shown by electronic absorption and infrared spectroscopy, supramolecular dimers (SM1 and SM3) were formed from the corresponding double-decker 1 and triple-decker 3 in the presence of potassium ions in MeOH/CHCl3.

No evidence for association of ataxia-telangiectasia mutated gene T2119C and C3161G amino acid substitution variants with risk of breast cancer

Background There is evidence that certain mutations in the double-strand break repair pathway ataxia-telangiectasia mutated gene act in a dominant-negative manner to increase the risk of breast cancer. There are also some reports to suggest that the amino acid substitution variants T2119C Ser707Pro and C3161G Pro1054Arg may be associated with breast cancer risk. We investigate the breast cancer risk associated with these two nonconservative amino acid substitution variants using a large Australian population-based case–control study. Methods The polymorphisms were genotyped in more than 1300 cases and 600 controls using 5' exonuclease assays. Case–control analyses and genotype distributions were compared by logistic regression. Results The 2119C variant was rare, occurring at frequencies of 1.4 and 1.3% in cases and controls, respectively (P = 0.8). There was no difference in genotype distribution between cases and controls (P = 0.8), and the TC genotype was not associated with increased risk of breast cancer (adjusted odds ratio = 1.08, 95% confidence interval = 0.59–1.97, P = 0.8). Similarly, the 3161G variant was no more common in cases than in controls (2.9% versus 2.2%, P = 0.2), there was no difference in genotype distribution between cases and controls (P = 0.1), and the CG genotype was not associated with an increased risk of breast cancer (adjusted odds ratio = 1.30, 95% confidence interval = 0.85–1.98, P = 0.2). This lack of evidence for an association persisted within groups defined by the family history of breast cancer or by age. Conclusion The 2119C and 3161G amino acid substitution variants are not associated with moderate or high risks of breast cancer in Australian women.