930 resultados para heavy-ion cancer therapy


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The hadronic correlation among particle-antiparticle pairs was highlighted in the late 1990's, culminating with the demonstration that it should exist if the masses of the hadrons were modified in the hot and dense medium formed in high energy heavy ion collisions. They were called Back-to-Back Correlations (BBC) of particle-antiparticle pairs, also known as squeezed correlations. However, even though they are well-established theoretically, such hadronic correlations have not yet been experimentally discovered. Expecting to compel the experimentalists to search for this effect, we suggest here a clear way to look for the BBC signal, by constructing the squeezed correlation function of phi phi and K(+)K(-) pairs at RHIC energies, plotted in terms of the average momentum of the pair, K(12)=1/2(k(1) + k(2)), inspired by procedures adopted in Hanbury-Brown & Twiss (HBT) correlations.

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A novel type of correlation involving particle-antiparticle pairs was found out in the 1990's. Currently known as squeezed or Back-to-Back Correlations (BBC), they should be present if the hadronic masses are modified in the hot and dense medium formed in high energy heavy ion collisions. Although well-established theoretically, such hadronic correlations have not yet been observed experimentally. In this phenomenological study we suggest a promising way to search for the BBC signal, by looking into the squeezed correlation function of phi phi and K(+)K(-) pairs at RHIC energies, as function of the pair average momentum, K(12) = (k(1) + k(2))/2. The effects of in-medium mass-shift on the identical particle correlations (Hanbury-Brown and Twiss effect) are also discussed.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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The time evolution of the matter produced in high energy heavy-ion collisions seems to be well described by relativistic viscous hydrodynamics. In addition to the hydrodynamic degrees of freedom related to energy-momentum conservation, degrees of freedom associated with order parameters of broken continuous symmetries must be considered because they are all coupled to each other. of particular interest is the coupling of degrees of freedom associated with the chiral symmetry of QCD. Quantum and thermal fluctuations of the chiral fields act as noise sources in the classical equations of motion, turning them into stochastic differential equations in the form of Ginzburg-Landau-Langevin (GLL) equations. Analytic solutions of GLL equations are attainable only in very special circumstances and extensive numerical simulations are necessary, usually by discretizing the equations on a spatial lattice. However, a not much appreciated issue in the numerical simulations of GLL equations is that ultraviolet divergences in the form of lattice-spacing dependence plague the solutions. The divergences are related to the well-known Rayleigh-Jeans catastrophe in classical field theory. In the present communication we present a systematic lattice renormalization method to control the catastrophe. We discuss the implementation of the method for a GLL equation derived in the context of a model for the QCD chiral phase transition and consider the nonequilibrium evolution of the chiral condensate during the hydrodynamic flow of the quark-gluon plasma.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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We consider the modification of the Cahn-Hilliard equation when a time delay process through a memory function is taken into account. We then study the process of spinodal decomposition in fast phase transitions associated with a conserved order parameter. The introduced memory effect plays an important role to obtain a finite group velocity. Then, we discuss the constraint for the parameters to satisfy causality. The memory effect is seen to affect the dynamics of phase transition at short times and have the effect of delaying, in a significant way, the process of rapid growth of the order parameter that follows a quench into the spinodal region.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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We briefly discuss four different possible types of transitions from quark to hadronic matter and their characteristic signatures in terms of correlations. We also highlight the effects arising from mass modification of hadrons in hot and dense hadronic matter, as well as their quantum statistical consequences: the appearance of squeezed quantum states and the associated experimental signatures, i.e., the back-to-back correlations of particle-antiparticle pairs. We briefly review the theoretical results of these squeezed quanta, generated by in-medium modified masses, starting from the first indication of the existence of surprising particle-antiparticle correlations, and ending by considering the effects of chiral dynamics on these correlation patterns. Nevertheless, a prerequisite for such a signature is the experimental verification of its observability. Therefore, the experimental observation of back-to-back correlations in high energy heavy ion reactions would be a unique signature, proving the existence of in-medium mass modification of hadronic states. on the other hand, their disappearance at some threshold centrality or collision energy would indicate that the hadron formation mechanism would have qualitatively changed: asymptotic hadrons above such a threshold are not formed from medium modified hadrons anymore, but rather by new degrees of freedom characterizing the medium. Furthermore, the disappearance of the squeezed BBC could also serve as a signature of a sudden, non-equilibrium hadronization scenario from a supercooled quark-gluon plasma phase.

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Sharp transitions are perhaps absent in QCD, so that one looks for physical quantities which may reflect the phase change. One such quantity is the sound velocity which was shown in lattice theory to become zero at the transition point for pure glue. We show that even in a simple bag model the sound velocity goes to zero at temperature T = T(v) not-equal 0 and that the numerical value of this T(v) depends on the nature of the meson. The average thermal energy of mesons goes linearly with T near T(v), with much smaller slope for the pion. The T(v) - s can be connected with the Boltzmann temperatures obtained from transverse momentum spectrum of these mesons in heavy-ion collision at mid-rapidity. It would be interesting to check the presence of different T(v) - s in present day finite T lattice theory.

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Extensive systematizations of theoretical and experimental nuclear densities and of optical potential strengths extracted from heavy-ion elastic scattering data analyses at low and intermediate energies are presented. The energy dependence of the nuclear potential is accounted for within a model based on the nonlocal nature of the interaction. The systematics indicates that the heavy-ion nuclear potential can be described in a simple global way through a double-folding shape, which basically depends only on the density of nucleons of the partners in the collision. The possibility of extracting information about the nucleon-nucleon interaction from the heavy-ion potential is investigated.

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A new platinum(II) complex with deoxyalliin was synthesized and characterized by chemical and spectroscopic techniques. Elemental and mass spectrometry analyses of the solid complex fit to the composition [Pt(C6H11NO2S)Cl-2] center dot H2O. C-13 NMR, N-15 NMR and infrared spectra of the complex are consistent with coordination of deoxyalliin to Pt( II) through the nitrogen and sulfur atoms forming a square-planar geometry. The complex is soluble in dimethylsulfoxide. Biological analysis for evaluation of a potential cytotoxic effect of the complex was performed using HeLa cells, a human cervix adenocarcinoma-derived cell line. The results were compared with those of a palladium( II) complex previously described.

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The effects of therapy in locally advanced breast cancer submitted to combined conventional telecobalt therapy plus chemotherapy with cyclophosphamide and 5-fluorouracil were studied in 49 patients. Associated to radical mastectomy in operable cases. Local tumor control was achieved in 86.7%. There were no local recurrences in those submitted to surgery but they reached 21.7% in inoperable patients who received only radiation therapy and chemotherapy. The median follow-up time for dead patients was 29.5 months and for living patients 79.3 months. The index of complete responses was 24.5% and the median disease free interval was 22.9 months. The overall survival rate, between three and five years, was 32.7%. Estrogen receptors were identified by using immunohistochemical assay ER-ICA and monoclonal antibody H222-SP gamma, Abbott. There were no differences in the complete response index, disease free interval and survival rates, among ER-positive and ER-negative patients, explained by the far advanced stage of the disease. ER-positivity was significantly correlated with histological features of the tumors: cell differentiation, presence of elastosis, absence of lymphocytic infiltration and absence of tumor necrosis.

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We derive simple and physically transparent expressions for the contribution of the strong interaction to one-nucleon-removal processes in peripheral relativistic heavy-ion collisions. The coherent contribution, i.e., the excitation of a giant dipole resonance via meson exchange, is shown to be negligible as well as the interference between Coulomb and nuclear excitation. The incoherent nucleon-knockout contribution is also derived suggesting the nature of the nuclear interaction in this class of processes. We also justify the simple formulae used to fit the data of the E814 Collaboration. © 1995 Elseier Science B.V. All rights reserved.

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The usual particle emission scenario used in hydrodynamics presupposes that particles instantaneously stop interacting (freeze-out) once they reach some three dimensional surface. Another formalism has been developed recently where particle emission occurs continuously during the whole expansion of thermalized matter. Here we compare both mechanisms in a simplified hydrodynamical framework and show that they lead to a drastically different interpretation of data.

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The effect of the continuous emission hypothesis on the two-pion Bose-Einstein correlation function is discussed and compared with the corresponding results based on the usual freeze-out. Sizable differences in the correlation function appear in these different descriptions of the decoupling process. This means that, when extracting properties of the hot matter formed in high-energy heavy-ion collisions from the data, completely different conclusions may be reached according to the description of the particle emission process adopted.