Considerações sobre o câncer localmente avançado de mama (CLAM) acrescidas de identificação dos receptores de estrogênios usando anticorpos monoclonais.
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
27/05/2014
27/05/2014
01/01/1993
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Resumo |
The effects of therapy in locally advanced breast cancer submitted to combined conventional telecobalt therapy plus chemotherapy with cyclophosphamide and 5-fluorouracil were studied in 49 patients. Associated to radical mastectomy in operable cases. Local tumor control was achieved in 86.7%. There were no local recurrences in those submitted to surgery but they reached 21.7% in inoperable patients who received only radiation therapy and chemotherapy. The median follow-up time for dead patients was 29.5 months and for living patients 79.3 months. The index of complete responses was 24.5% and the median disease free interval was 22.9 months. The overall survival rate, between three and five years, was 32.7%. Estrogen receptors were identified by using immunohistochemical assay ER-ICA and monoclonal antibody H222-SP gamma, Abbott. There were no differences in the complete response index, disease free interval and survival rates, among ER-positive and ER-negative patients, explained by the far advanced stage of the disease. ER-positivity was significantly correlated with histological features of the tumors: cell differentiation, presence of elastosis, absence of lymphocytic infiltration and absence of tumor necrosis. |
Formato |
17-32 |
Identificador |
Revista da Associacao Medica Brasileira (1992), v. 39, n. 1, p. 17-32, 1993. 0104-4230 http://hdl.handle.net/11449/64345 2-s2.0-0027356193 |
Idioma(s) |
por |
Relação |
Revista da Associação Médica Brasileira (1992) |
Direitos |
closedAccess |
Palavras-Chave | #estrogen receptor #monoclonal antibody #adult #aged #breast tumor #cancer staging #chemistry #comparative study #female #human #mortality #multimodality cancer therapy #pathology #prognosis #retrospective study #review #tumor recurrence #Adult #Aged #Aged, 80 and over #Antibodies, Monoclonal #Breast Neoplasms #Combined Modality Therapy #Comparative Study #English Abstract #Female #Human #Middle Age #Neoplasm Recurrence, Local #Neoplasm Staging #Prognosis #Receptors, Estrogen #Retrospective Studies |
Tipo |
info:eu-repo/semantics/review |