Prevalence and clinical correlates of obsessive-compulsive disorder in schizophrenia

Obsessive compulsive symptoms frequently occur in a substantial proportion of patients with schizophrenia. The term schizoobsessive has been proposed to delineate this subgroup of schizophrenia patients who present with obsessive compulsive symptoms/disorder. However, whether this co-occurrence is more than just co-morbidity and represents a distinct subgroup remains controversial. A striking variation is noted across studies examining prevalence of obsessive compulsive symptoms/disorder in schizophrenia patients and their impact on clinical profile of schizophrenia. Hence, in this study, we examined the prevalence of obsessive compulsive symptoms/disorder in a large sample of consecutively hospitalized schizophrenia patients and compared the clinical and functional characteristics of schizophrenia patients with and without obsessive compulsive symptoms/disorder. We evaluated 200 consecutive subjects with the DSM-IV diagnosis of schizophrenia using the Structured Clinical Interview for DSM-IV Axis I disorders, Positive and Negative Syndrome Scale, Yale Brown Obsessive Compulsive Scale, Brown Assessment of Beliefs Scale, Clinical Global Impression-Severity scale, Global Assessment of Functioning Scale, Family Interview for Genetic Studies and World Health Organization Quality of Life scale. The prevalence of obsessive compulsive symptoms in patients with schizophrenia was 24% (n = 48); 37 of them had obsessive compulsive disorder (OCD) and II had obsessive compulsive symptoms not amounting to a clinical diagnosis of OCD (OCS). Schizophrenia patients with OCS/OCD had an earlier age at onset of schizophrenia symptoms, lower positive symptoms score, higher co-morbidity with Axis II disorders, higher occurrence of OCD in family and better quality of life. Findings of the study indicate a higher prevalence of OCS/OCD in schizophrenia. Schizophrenia patients with and without OCS/OCD have comparable clinical profile with few exceptions. High rates of OCD in first degree relatives suggest possible genetic contributions and differences in neurobiology. Finally, evidence to consider schizoobsessive as a distinct diagnostic entity is inconclusive and warrants further studies. (C) 2014 Elsevier Inc. All rights reserved.

Functional characterization of heat-shock protein 90 from Oryza sativa and crystal structure of its N-terminal domain

Heat-shock protein 90 (Hsp90) is an ATP-dependent molecular chaperone that is essential for the normal functioning of eukaryotic cells. It plays crucial roles in cell signalling, cell-cycle control and in maintaining proteome integrity and protein homeostasis. In plants, Hsp90s are required for normal plant growth and development. Hsp90s are observed to be upregulated in response to various abiotic and biotic stresses and are also involved in immune responses in plants. Although there are several studies elucidating the physiological role of Hsp90s in plants, their molecular mechanism of action is still unclear. In this study, biochemical characterization of an Hsp90 protein from rice (Oryza sativa; OsHsp90) has been performed and the crystal structure of its N-terminal domain (OsHsp90-NTD) was determined. The binding of OsHsp90 to its substrate ATP and the inhibitor 17-AAG was studied by fluorescence spectroscopy. The protein also exhibited a weak ATPase activity. The crystal structure of OsHsp90-NTD was solved in complex with the nonhydrolyzable ATP analogue AMPPCP at 3.1 angstrom resolution. The domain was crystallized by cross-seeding with crystals of the N-terminal domain of Hsp90 from Dictyostelium discoideum, which shares 70% sequence identity with OsHsp90-NTD. This is the second reported structure of a domain of Hsp90 from a plant source.

Trap modulated photoresponse of InGaN/Si isotype heterojunction at zero-bias

n-n isotype heterojunction of InGaN and bare Si (111) was formed by plasma assisted molecular beam epitaxy without nitridation steps or buffer layers. High resolution X-ray diffraction studies were carried out to confirm the formation of epilayers on Si (111). X-ray rocking curves revealed the presence of large number of edge threading dislocations at the interface. Room temperature photoluminescence studies were carried out to confirm the bandgap and the presence of defects. Temperature dependent I-V measurements of Al/InGaN/Si (111)/Al taken in dark confirm the rectifying nature of the device. I-V characteristics under UV illumination, showed modest rectification and was operated at zero bias making it a self-powered device. A band diagram of the heterojunction is proposed to understand the transport mechanism for self-powered functioning of the device. (c) 2015 AIP Publishing LLC.

Primates, Provisioning and Plants: Impacts of Human Cultural Behaviours on Primate Ecological Functions

Human provisioning of wildlife with food is a widespread global practice that occurs in multiple socio-cultural circumstances. Provisioning may indirectly alter ecosystem functioning through changes in the eco-ethology of animals, but few studies have quantified this aspect. Provisioning of primates by humans is known to impact their activity budgets, diets and ranging patterns. Primates are also keystone species in tropical forests through their role as seed dispersers; yet there is no information on how provisioning might affect primate ecological functions. The rhesus macaque is a major human-commensal species but is also an important seed disperser in the wild. In this study, we investigated the potential impacts of provisioning on the role of rhesus macaques as seed dispersers in the Buxa Tiger Reserve, India. We studied a troop of macaques which were provisioned for a part of the year and were dependent on natural resources for the rest. We observed feeding behaviour, seed handling techniques and ranging patterns of the macaques and monitored availability of wild fruits. Irrespective of fruit availability, frugivory and seed dispersal activities decreased when the macaques were provisioned. Provisioned macaques also had shortened daily ranges implying shorter dispersal distances. Finally, during provisioning periods, seeds were deposited on tarmac roads that were unconducive for germination. Provisioning promotes human-primate conflict, as commensal primates are often involved in aggressive encounters with humans over resources, leading to negative consequences for both parties involved. Preventing or curbing provisioning is not an easy task as feeding wild animals is a socio-cultural tradition across much of South and South-East Asia, including India. We recommend the initiation of literacy programmes that educate lay citizens about the ill-effects of provisioning and strongly caution them against the practice.

Protection of Digital Telecom Exchanges Against Lightning Surges and Earth Faults

Low-power electronic devices used in digital telecom exchanges are vulnerable to surge voltages and currents primarily originating from natural lightning or due to the direct interactions between electric power and telecommunication lines, etc., causing the earth/ground potential rise, neutral potential rise, and faults in the system. The fault currents may flow directly to telecom lines or through the equipment to the customer's premises, causing adequate damage to the equipment and personnel safety. In wireline applications, analog or digital, central office, exchanges, and subscriber sides have to be protected. Decisive protection and protective methods have to be employed for proper functioning of the equipment under overvoltage/overcurrent conditions. Current investigation reports some interesting results obtained on the recently developed high-voltage high-current protection cards used in digital telecom exchanges. The performances of protection cards both for the ring wave and hybrid wave surges are evaluated and presented. The surge generators required for the investigation are developed and fabricated in house as per the relevant telecom standards.

Ab Initio MD Simulations of the Bronsted Acidity of Glutathione in Aqueous Solutions: Predicting pK(a) Shifts of the Cysteine Residue

The tripeptide glutathione (GSH) is one of the most abundant peptides and the major repository for nonprotein sulfur in both animal and plant cells. It plays a critical role in intracellular oxidative stress management by the reversible formation of glutathione disulfide with the thiol-disulfide pair acting as a redox buffer. The state of charge of the ionizable groups of GSH can influence the redox couple, and hence the pK(a) value of the cysteine residue of GSH is critical to its functioning. Here we report ab initio Car-Parrinello molecular dynamics simulations of glutathione solvated by 200 water molecules, all of which are considered in the simulation. We show that the free-energy landscape for the protonation-deprotonation reaction of the cysteine residue of GSH computed using metadynamics sampling provides shift in the dissociation constant values as compared with the isolated accurate estimates of the pK(a) and correctly predicts the cysteine amino acid.

A real-time coherent dedispersion pipeline for the giant metrewave radio telescope

A fully real-time coherent dedispersion system has been developed for the pulsar back-end at the Giant Metrewave Radio Telescope (GMRT). The dedispersion pipeline uses the single phased array voltage beam produced by the existing GMRT software back-end (GSB) to produce coherently dedispersed intensity output in real time, for the currently operational bandwidths of 16 MHz and 32 MHz. Provision has also been made to coherently dedisperse voltage beam data from observations recorded on disk. We discuss the design and implementation of the real-time coherent dedispersion system, describing the steps carried out to optimise the performance of the pipeline. Presently functioning on an Intel Xeon X5550 CPU equipped with a NVIDIA Tesla C2075 GPU, the pipeline allows dispersion free, high time resolution data to be obtained in real-time. We illustrate the significant improvements over the existing incoherent dedispersion system at the GMRT, and present some preliminary results obtained from studies of pulsars using this system, demonstrating its potential as a useful tool for low frequency pulsar observations. We describe the salient features of our implementation, comparing it with other recently developed real-time coherent dedispersion systems. This implementation of a real-time coherent dedispersion pipeline for a large, low frequency array instrument like the GMRT, will enable long-term observing programs using coherent dedispersion to be carried out routinely at the observatory. We also outline the possible improvements for such a pipeline, including prospects for the upgraded GMRT which will have bandwidths about ten times larger than at present.

Density functional theory based study of chlorine doped WS2-metal interface

Investigation of a transition metal dichalcogenide (TMD)-metal interface is essential for the effective functioning of monolayer TMD based field effect transistors. In this work, we employ the Density Functional Theory calculations to analyze the modulation of the electronic structure of monolayer WS2 with chlorine doping and the relative changes in the contact properties when interfaced with gold and palladium. We initially examine the atomic and electronic structures of pure and doped monolayer WS2 supercell and explore the formation of midgap states with band splitting near the conduction band edge. Further, we analyze the contact nature of the pure supercell with Au and Pd. We find that while Au is physiosorbed and forms n-type contact, Pd is chemisorped and forms p-type contact with a higher valence electron density. Next, we study the interface formed between the Cl-doped supercell and metals and observe a reduction in the Schottky barrier height (SBH) in comparison to the pure supercell. This reduction found is higher for Pd in comparison to Au, which is further validated by examining the charge transfer occurring at the interface. Our study confirms that Cl doping is an efficient mechanism to reduce the n-SBH for both Au and Pd, which form different types of contact with WS2. (C) 2016 AIP Publishing LLC.

El redescubrimiento de la filosofía personalista de Jacques Maritain

Resumen: El autor sostiene que la búsqueda de nuevos modelos empresariales y de política económica nos invita a redescubrir la filosofía personalista de Maritain. En el núcleo de la obra Humanismo integral (1936) del filósofo francés aparece la idea de que el hombre es una persona "de naturaleza espiritual, dotada de libre albedrío, y por lo tanto autónoma en relación con el mundo". El artículo estudia la naturaleza del bien común temporal, que para Maritain se relaciona con la vida buena de la toda la comunidad –el bien común o bonum commune– tanto en el sentido material como moral. Este bonum commune no es el objetivo final del orden temporal, sino que está subordinado a lo que trasciende el bienestar temporal de la persona humana –la realización de la libertad y la perfección espiritual. En última instancia, el orden nunca se completa. El balance definitivo o telos nunca se obtiene ya que el hombre está siempre en camino.

Moralidad, ética y ciencias

El panorama científico contemporáneo se nos manifiesta con una pronunciada asepsia con respecto a toda relación axiológica y una carencia notable de regulación ético-normativa, preocupando, en especial, el funcionamiento de las ciencias que tienen al hombre, directa o indirectamente, como sujeto de tratamiento. Una vez más, como en las épocas más puras de mecanicismo científico, el dato sensible, la reducción matemática (o lógico-matemática) y la expresión sólo teórica del pensamiento, se presentan como ingredientes necesarios y suficientes para alcanzar la verdad y la certeza. En este contexto, tanto a la Ética como a la Filosofía Moral le significa un gran esfuerzo obtener un lugar y ostentar alguna función propiamente científica en el cuadro de los saberes, hasta el extremo de sufrir el desprestigio o acusaciones de ilegitimidad, con la lógica consecuencia de no poder brindar bases sólidas a un ethos del científico, es decir, al proceder moralmente digno en la vida del científico.

El sistema político rionegrino frente a la desnacionalización política: 1983-2011

Resumen: Las pautas que regulan la competencia por el acceso al poder son aspectos centrales para abordar el funcionamiento del sistema político democrático, las cuales se multiplican en un sistema federal o multinivel. Tras la apertura democrática el sistema político argentino redefinió su funcionamiento frente a la mayor autoridad de las provincias en materia de implementación de políticas públicas, recursos fiscales e independencia electoral respecto de la esfera nacional. La territorialización de la política (o desnacionalización) en parte explica los cambios sufridos por el bipartidismo nacional (PJ-UCR), el surgimiento de nuevos partidos políticos y la construcción de nuevas identidades políticas. Hasta el 2011, Río Negro fue de los pocos distritos con partido predominante diferente al partido predominante a nivel nacional, y el único que gobernó la Unión Cívica Radical de forma ininterrumpida desde 1983. El presente trabajo busca explorar el funcionamiento del sistema político rionegrino en el contexto de desnacionalización a partir de los siguientes interrogantes. ¿Cuán congruente o incongruente es el sistema de partido rionegrino al nacional? ¿Qué niveles registra la competencia partidaria en ambos sistemas? ¿Qué efectos tuvieron las reformas electorales sobre el funcionamiento del sistema de partidos subnacional en Río Negro? Dando respuesta a estas preguntas, este artículo busca aportar al estudio de la interaccion del sistema de partidos nacional y un sistema de partidos subnacional, en el marco de los sistemas políticos federales o multinivel

La planificación en la Argentina del desarrollo (1955-1973)

Resumen: Entre el derrocamiento del primer peronismo y el ocaso del segundo, la política económica de los distintos gobiernos se propuso por medios distintos alcanzar una relativa certidumbre de largo plazo a través de la preparación de planes ¿Por qué esta idea tuvo éxito? La planificación fue una tendencia más o menos general en América Latina. Pero además cada gobierno fue impulsando una modalidad particular de planificación acorde a sus objetivos políticos. Nuestro trabajo pretende resumir las diversas expresiones de la planificación, mostrar algunos de los principales obstáculos para su concreción y analizar el funcionamiento del sistema estatal encargado de esa tarea, especialmente representado por el Consejo Nacional de Desarrollo.

Lo visual como construcción. Desarrollo de un modelo pictórico de representación de la imagen

903 páginas, bibliografía en páginas 854-895, glosario en páginas 896-903

O poder coercitivo do Conselho de Ética e Decoro Parlamentar da Câmara dos Deputados

Propõe reflexão sobre a atuação do Conselho de Ética e Decoro Parlamentar da Câmara dos Deputados, instituído pela Resolução nº 25 de 2001. São enumeradas e caracterizadas algumas de suas deficiências operacionais, especialmente a ausência de poder coercitivo específico para convocar testemunhas. São apresentados os conceitos de ética, moral e decoro, tanto no sentido que se aplica às relações pessoais de indivíduos em sociedade, como nas implicações inerentes à atividade política, no interior do Parlamento. São focalizados os episódios recentes da política brasileira que demandaram a primeira grande atuação do Conselho de Ética, como órgão recém-instituído no âmbito do Poder Legislativo. Como problema específico de pesquisa, destaca-se o poder testemunhal nos processos judiciais para ressaltar a importância da testemunha no processo de julgamento político, conduzido pelo Conselho de Ética. Discutem-se, finalmente, a necessidade e algumas possibilidades de aprimoramento da estrutura normativa que forma a base para o funcionamento do Conselho de Ética e Decoro Parlamentar da Câmara dos Deputados.

Frente Parlamentar Mista das Micro e Pequenas Empresas : lógica de funcionamento e resultados

Analisa o modo com que os parlamentares se organizam frente à estrutura institucional no Congresso Nacional. Tem como referências para discussão, contribuições de Barry Ames (2003) e Figueiredo e Limongi (2001) que apresentam dois modelos de funcionamento do Parlamento, o distributivista e o partidário. Analisa a atuação da Frente Parlamentar Mista das Micro e Pequenas Empresas. Enfatiza a segunda fase de funcionamento da Frente, os anos de 2008 e 2009, quando trabalhou pela regulamentação da Lei Geral das Micro e Pequenas Empresas (Lei Complementar nº 123/06) nos Estados e Municípios e seus aperfeiçoamentos por meio da aprovação de Leis Complementares nºs 127/07, 128/08 e 133/09.