慢性海洛因成瘾者的冲动性和行为抑制缺陷脑机制

In recent years, the deficit of inhibition has become an important reason for explaining addiction. Response inhibition resembles the compulsive drug seeking behavior and it is the basement of addiction inhibition deficits. However, there were no enough evidence for the relationship between addiction and response inhibition deficits and the results of the neuro mechanisms studies remains unclear. Few studies has focused on the exploring the heroin users. Among those paradigms for study response inhibition deficits, stop signal is a very suitable model for the representation of compulsive drug seeking, but only a few researches has worked on this paradigm. In this study, we selected about 100 heroin abusers and had behaviour and neuro imaging scannings for investigating the response inhibition deficits. The behaviour researches found: first, the chronic heroin users had longer reaction time than control group and this reaction time were not affected by stop signals in heroin users. Second, heroin users had less waiting time than control group and they were more impulsive but less flexibility. Their erro monitoring and flexibale adjustment ability decreased. Third, the SSRT of heroin users was significantly longer than control group. These results suggested that the inhibition of heroin users were impaired. Further investigation showed that the SSRT of heroin users had positive correlation of four factor scores of ASI and the macro correlation coefficient was factor three of drug use. This correlation suggested that drug use was the main reason of inhibition deficits. fMRI results mainly focused on the ANOVA analysis for group difference. First, there was no intensity difference in M1 and SMA brain areas between the two groups. Second, heroin users had less activation in right dorsalateral prefrontal cortex, right inferior prefrontal cortex and anterior cingulated cortex, while in bilateral striatum and amygdala, heroin users had more activation than control group. The right prefrontal cortex was indentified as the main inhibition brain area. The anterior cingulated cortex has relationship with erro monitoring and amygdale was an important brain area for impulsivity and emotion control. The network of these brain areas was envovled in impulsivity and inhibition and it was suggested the mainly damaged network for heroin users’ disinhibition. We also investigated the gray matter changes of heroin users and found that chonic heroin use made their gray matter density decreased in prefrontal cortex (including bilateral dorsalateral prefrontal cortex, obital frontal cortex, inferior prefrontal cortex) and anterior cingulated cortex. The gray matter density in these brain regions had negative correlation with drug use duration. In conclusion, we indentified the disinhibition of heroin users and its neuro mechanism. Their compulsivity brain areas had more activation than control group and their inhibition brain areas had less activation than normal control. On the other side, the biological mechanism of this activation changes was the gray matter density decrease in these brain areas.

汉语发展性阅读障碍儿童的视觉大细胞通路特点

Developmental dyslexia (DD) is a common kind of learning disorder, which affects 5-18% of people. It seems important to explore the deficit in visual magnocellular pathway in Chinese developmental dyslexia, for many researches demonstrated that one of the core deficits of Chinese developmental dyslexia was orthographic deficit which was associated with the deficit in visual magnocellular pathway. Two studies were done to detect the differences among Chinese developmental dyslexics, average readers of the same chronological age (CA controls) and average readers of the same reading level (RL controls) in reaction time, accuracy and visual mismatch negativity (vMMN) elicited by the moving gratings responded by visual magnocellular pathway. There were two grating-conditions which were low contrast/low spatial frequency condition and high contrast/high spatial frequency condition respectively. In ERP study, a modified “cross-modal delayed response” paradigm was used to elicit the vMMN. The results showed that the developmental dyslexics responded slower than CA controls, had more errors than RL controls, and had smaller amplitudes of vMMNs than the two controls in visual magnocellular pathway condition, but not in control condition. That is to say, Chinese developmental dyslexics had deficits in visual magnocellular pathway.

联想启动效应及其脑机制研究

By now, there are still many unsolved questions about associative priming. This study used process dissociation paradigm, perceptual identification task and speeded naming task,together with near infrared spectroscopy, to investigate priming for new associations and its brain mechanisms systematically. The results showed there was interaction between level of processing and unitization in affecting associative priming. When comparing with shallow encoding unrelated word pairs, the activation of both sides of prefrontal lobe was stronger, which suggested prefrontal lobe had relations with memory for new associations. Medial temporal lobe and frontal lobe lesioned patients were tested respectively using methods of perceptual identification task and speeded naming task. Both brain regions participated in associative priming. Medial temporal lobe mediated unitization between unrelated items. Frontal lobe contributed to priming for new associations by elaborative processing, inhibiting irrelevant information, selective attending to tasks, and establishing some effective strategies. In addition, normal subjects needed to aware the relationship between study and test to form associative priming and densely memory deficit patients could not form memory for new associations. In conclusion, the results further demonstrated that perceptual representation system could not support priming for new associations alone. Medial temporal lobe and frontal lobe played roles in priming for new associations, and there was some relation between associative priming and conscious retrieval processing.

电视广告作品评价的消费行为学研究

The quality of advertising copy is an important component of advertising service. An advertising system with only copy design and production but without evaluation is imperfect. Establishing an evaluation system of television advertising copy is the principal purpose of the present work. In terms of consumer behavior, the work focused on consumers' evaluation-in-general of T commercials. The research consisted of three subprograms. The first subprogrom was associated with the basic factors in the evaluation of television advertising copy. The second one was related to the relative importance of those basic factors. The last one was related to the way in which the consumers' synthetic evaluation of copy under multidimensions. These subprogram composed the evaluation system of television advertising copy. In the study of the first subprogram, by the use of a variaty of "multistage evaluation scale", a survey into consumers' evaluation-in-general of television ads was made, which obtained five factors, namely, credibility, attractiveness, suitability, cognition and affect impact, through factor analysis (Cum.Pct. = 56.2%, α = 0.84). The study of second subprogram acquired their relative weights by a popular method of weight in the area of decision analysis, the result was as followings: credibility-0.27, attractiveness-0.24, suitability-0.18, affect impact-0.16, cognition-0.15; and fanally, under the condition of quasi-experiment, the third studyestablished a mathematical model of the synthetic evaluation of television ad copy, which was expressed as O = ΣF * W, through a "synthetical" method of multidimensional decision making.

Conceitos de fertilidade do solo e manejo adequado para as regiões tropicais.

A Organização das Nações Unidas para Alimentação e Agricultura (FAO, 2009) alertou para a necessidade de ampliar a produção mundial de alimentos em 70% até 2050 por conta do crescimento da população. No ano em questão, haverá 2,3 bilhões de pessoas a mais do que hoje para se alimentar. A FAO estima que mais de 120 milhões de hectares de terra serão necessários para suprir as necessidades, mas acredita que boa parte da produção de alimentos deverá ser por meio do aumento da produtividade das áreas já cultivadas, principalmente das regiões tropicais. Solos cultivados são limitantes para a produção de alimentos, pois os cultivos seguidos tendem a diminuir a fertilidade. Nos trópicos, onde a pressão populacional é maior, a expansão agrícola dependerá essencialmente do cultivo de solos ?velhos? (solos que ficaram muito tempo expostos à ação das chuvas e do sol e consequentemente são mais pobres em nutrientes), ácidos, de baixa fertilidade nutricional ou com problemas de deficit hídrico. Ante as peculiaridades da agricultura nas regiões tropicais, onde se insere o Brasil, torna-se necessário o conhecimento detalhado das características e propriedades químicas e físicas dos solos, objetivando seu manejo adequado, o uso mais apropriado de insumos e produções mais rentáveis. A avaliação da fertilidade química dos solos é de utilidade para a definição das quantidades e tipos de fertilizantes, corretivos e manejo geral que devem ser aplicados ao solo visando à manutenção ou à recuperação de sua produtividade. Sendo assim, o objetivo deste trabalho foi apresentar os principais conceitos da fertilidade dos solos e relacioná-los às formas de manejo mais adequadas para as regiões tropicais. Este trabalho compreende conceitos de fertilidade do solo e representa um texto básico para compreensão da relação entre produtividade agropecuária e aplicações de geotecnologias, tal como o uso de sensoriamento remoto e técnicas de geoprocessamento.

Recuperação do sorgo apos um período de déficit hídrico.

1991

Avaliação de acessos da coleção núcleo de milho quanto a tolerância ao déficit hídrico.

Material e metódos; Materiais genéticos; Delineamento experimental e caracteres avaliados; Caracterização dos ambientes com e sem estresse; Resultados e discussão.

Modelling random fuzzy renewal reward processes

Shen, Q., Zhao, R., Tang, W. (2008). Modelling random fuzzy renewal reward processes. IEEE Transactions on Fuzzy Systems, 16 (5),1379-1385

Wpływ wyciągu nart wodnych na wybrane elementy środowiska przyrodniczego i aktywność turystyczno-rekreacyjną na przykładzie Augustowa

Wydział Nauk Geograficznych i Geologicznych: Zakład Centrum Turystyki i Rekreacji

Palaeontology of the Middle Turonian limestones of the Nysa Kłodzka Graben (Sudetes, SW Poland): biostratigraphical and palaeogeographical implications

The ammonites Lewesiceras peramplum Mantell and ?Lewesiceras sp. are reported from the Upper Cretaceous in the Nysa Kłodzka Graben; they date from the Middle Turonian and ?Coniacian, respectively. The Middle Turonian limestones of the Stara Bystrzyca quarry contain an abundant assemblage of inoceramids (Inoceramus cuvieri Sowerby and I. lamarcki Parkinson) and other bivalves, including oysters, as well as brachiopods and trace fossils. Micropalaeontological data show the presence of foraminifers and siliceous sponge spiculae, bryozoans, ostracods and fragments of bivalves and gastropods. The Middle Turonian calcareous deposits belongs to the upper part of the Inoceramus lamarcki Zone (late Middle Turonian) and were deposited on a shallow, subtidal offshore shelf. They overlie the Middle Turonian Bystrzyca and Długopole Sandstones, which represent foreshore-shoreface delta deposits. The fossil assemblage suggests a moderate- to low-energy, normal-salinity environment with occasionally an oxygen deficit.

Metody zwiększania frekwencji wyborczej. Polska a doświadczenia innych państw

Numerous reports and analyses of voter turnout levels have recorded the global trend of declining participation by citizens in national elections. One of the most important results of poor participation of citizens in electoral processes is the serious legitimization deficit. Governments in many countries try to prevent that by taking various measures to solve the problem of falling turnout and to increase the level of the electorate’s involvement. In Poland, the low turnout level has been the subject of many scholarly discussions aimed at finding solutions to the problem of poor civic participation. The main goal of this study is to assess the various methods of increasing voter turnout which are used in different countries, including Poland.

A Fitoterapia como tratamento complementar na Diabetes mellitus

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas

Suplementação com Vitamina D e seus derivados na prevenção e tratamento do cancro da próstata

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas

Os recetores da melatonina como novos alvos de fármacos antidepressivos

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas

Gestão construtiva de conflitos em contexto de saúde

Dissertação apresentada à Universidade Fernando Pessoa como parte dos requisitos para a obtenção do grau de Mestre em Psicologia, ramo de Psicologia Clínica e da Saúde