Inflammatory response of endothelial cells to hepatitis C virus recombinant envelope glycoprotein 2 protein exposure

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Disseminação da informação em empresas de capital aberto e os processos de mediação da informação

Corporate governance can be understood as management mechanisms that through external and internal controls are going to reduce the distance between minority stakeholders and the control power of the company. In that context, the information management, the information mediation and the information dissemination is very necessary, because the establishment of the good communication, quick, clear and voluntary, in order to establish a confidence climate in the relation of the company with the society, creditors, and collaborators especially with investors. In Brazil, the model created by the stock exchange of São Paulo called of new market , brings in his additional conduct rules purpose to them required by the Brazilian legislation and possessed like base the equity in the handling between part, the transparency in the disclosure of information and responsibility in the installment count. This article presents some considerations about the model of information management and accountability based on legal criteria, in additional standards of information disclosure, and the information mediation process relationship the corporate governança in the business environment.

O papel da mediação da informação nas universidades

The information process should be understood as essential to the success of any institution, mainly those that produce knowledge. Information mediation being part of this process must be understood as an action capable of directing the knowledge construction of individuals. The information mediation in universities is a way of mediating the knowledge generated within and outside the university environment, including its specialized audience and to society. Thus the concept of information mediation is discussed in this work and its role within universities and the role of information professionals as information mediators. The social responsibility of universities needs to be reaffirmed into the society and the information is a possible way for the success of this action.

Mediação da informação orgânica sob a perspectiva do processo decisório empresarial: análise do papel do arquivista

This paper addresses the issue of mediation in the process of information decision-making, more specifically, organic information, seeking to deepen its determinants in an attempt to understand the mechanisms on which supports. It also examines the role of the archivist as an information professional in this process. Conceptually, it is understood that the information Organic is produced within the organization as a result of the implementation of activities and tasks undertaken. The national literature that addresses this issue is poor and therefore needs further examination. Weaving relations organic information and mediation in the context of decision making is rare in literature. Thus, this study seeks to contribute to discussions in regarding this matter and also adds to this the importance of standing up issues that may contribute to the development of studies Information Science.

Preparation, thermal characterization, and DFT study of the bacterial cellulose

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Synthesis, characterization, thermal behavior, and DFT calculation of solid 1,4-bis(3-carboxy-3-oxo-prop-1-enyl) benzene of some trivalent lanthanides

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Bacterial and chemical leaching of chalcopyrite concentrates as affected by the redox potential and ferric/ferrous iron ratio at 22 degrees C

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

A anatomia e o ensino de anatomia no Brasil: a escola boveriana

There is little scholarly research on the history, teaching and research of human anatomy in Brazil. A broader vision of the progress of anatomy under different circumstances in the country is virtually non-existent, leaving researchers keen to study the subject insecure. This is compounded by the fact that the data available are not always reliable. This text retraces the development of the discipline of anatomy and its research and education in Brazil in general and São Paulo state in particular, which can largely be reduced to the action of the self-proclaimed Boverian school of anatomy, founded by Italian physician Alfonso Bovero at the same time as the Medical Faculty of the University of São Paulo.

Chitosan-collagen scaffolds can regulate the biological activities of adipose mesenchymal stem cells for tissue engineering

Scaffolds of chitosan and collagen can offer a biological niche for the growth of adipose derived stem cells (ADSC). The objective of this work was to characterize the physico-chemical properties of the scaffolds and the ADSC, as well as their interactions to direct influences of the scaffolds on the behavior of ADSC. The methodology included an enzymatic treatment of fat obtained by liposuction by collagenase, ASDC immunophenotyping, cell growth kinetics, biocompatibility studies of the scaffolds analyzed by the activity of alkaline phosphatase (AP), nitric oxide (NO) determination by the Griess-Saltzman reaction, and images of both optical and scanning electron microscopy of the matrices. The extent of the crosslinking of genipin and glutaraldehyde was evaluated by ninhydrin assays, solubility tests and degradation of the matrices. The results showed that the matrices are biocompatible, exhibit physical and chemical properties needed to house cells in vivo and are strong stimulators of signaling proteins (AP) and other molecules (NO) which are important in tissue healing. Therefore, the matrices provide a biological niche for ADSC adhesion, proliferation and cells activities.

Cardiomyopathy and cell therapy: ejection fraction improvement and cardiac muscle mass increasing, after a year of bone marrow stem cells transplantation, by magnetic resonance image

The idiopathic dilated cardiomyopathy (IDC) is one of the major public health problems in the western world. Patients with IDC in functional class IV (New York Health Association - NYHA), even after therapeutic optimization, have high mortality. Stem cell therapy has emerged as a potential therapeutic option for cell death-related heart diseases and several positive effects were assigned to cell therapy in cardiomyopathy. The aim of this study was identify short-term result of cell transplantation in idiopathic dilated cardiomyopathy patients (IDC) who were treated by transplantation of autologous bone marrow mononuclear cells (BMMC). Intracoronary injections of autologous BMMC were performed in eight patients with severe ventricle dysfunction (mean of left ventricle ejection fraction – LEVF=20.03%), cardiac mass muscle around 156.2 g and NYHA between III and IV grades, other 8 IDC patients received placebo. The IDCs were followed - up for one and two years, by magnetic resonance imaging (MRI). The results after one year showed significant improvement in LVEF (mean=181.4) and muscle mass increasing (mean=181.4 g), after two years the LVEF continued improving, reaching a mean of 32.69% and the cardiac muscle mass kept stable (mean=179.4 g). Excepted for one patient, all the other had improvement in the NYHA functional class. The placebo group did not show any improvement. We believe that BMMC implant may be a beneficial therapeutic option for IDC patients.

Entre nativos e exóticos: a mestiçagem na construção de uma nova identidade na caprinovinocultura dos sertões

In the Northeastern Semiarid of Brazil, dynamic among creators of goats and sheep native and exotic bring a range of meanings. In addition to actual trade disputes, conflicts are waged in the realm of ideas, revealing different values and interests around the racial origin of these animals. Between these two segments lies most of the small farmers and the traditional Semiarid sheep and goat raising, based on the use of animals breed, arising from the dynamics of spontaneous crossings, own extensive creations characterized by reduced control over the herds, state which shows a marked contrast to the first two segments. Given that their influence on a traditional creations can result in improved production of small farmers, linked to different social sector research and extension have turned their efforts to construct possible arrangements that are satisfactory to the reversal of historical problems of the region, especially the use of animal miscegenation as a strategy for change. It focuses on the work of these actors, the forms of interaction between them, fulfill the role that ideas, values and attitudes in the face of the possibilities for sheep and goat raising that region.

Iniciativa privada e educação pública: contribuições metodológicas para a análise de objetos de pesquisa difusos na área de política e gestão educacional

Provides elements for a reflection on methodological strategies in the face of objects of study that prove difficult to approach. Through a case study in education, seeks to show that difficulties in obtaining information and data have been overcome by using an analytical model developed. It is shown that its use allowed inferences broader and reveal hidden inconsistencies in discussions on public and private education. Intended to assist reflection on qualitative research methods for those who deal with such studies. Concludes that the current expectations of management efficiency and transfer of resources sufficient quantity and quality have not materialized with a private enterprise under public education, even if we have succeeded in building a positive image by the promoters of this action with the sectors of public opinion. Prevailing trade policy interests at the expense of the motivations declared the initiative of aid to education, and even can not be said that the initiative has resulted in a private redefined the public character of the systems affected, there is evidence that its implementation represents a unique chapter focused "education", compared to a scenario in which stand out historically mutual aid agreements of a politicaleconomic development between state and private enterprise.

Interações entre universidade e sociedade em Axixá do Tocantins: uma proposta de ação educativa como passo inicial para enfrentamento de problemas socioambientais

Contextualiza e descreve o trabalho desenvolvido pela equipe da UNESP de Araraquara no município de Axixá do Tocantins durante o Projeto Rondon. Apresenta proposta multidisciplinar desenvolvida e voltada para os anos finais do Ensino Fundamental e Ensino Médio, entendendo-se que a rede municipal de ensino constitui-se num espaço estratégico para desencadear processos formativos que possam atingir, direta ou indiretamente, o público escolar e população em contato com esta. Focando a Serra do Estrondo, patrimônio natural local, a proposta objetiva a articulação de conhecimentos teóricos e práticos a partir de conteúdos relacionados à temática ambiental para enfrentamento de problemas socioambientais.

Mudança de fronteiras étnicas e participação política de descendentes de imigrantes em São Paulo

This paper analyzes patterns of political mobility of a specific social stratum - immigrants and their descendants - in the western region of São Paulo, where coffee economy prevailed since the last quarter of the XIXth century. We investigate the main agents of local politics in seven cities: from the traditional oligarchic regime characteristic of the Old Republic to the processes of political transformation in the thirties that resulted in the post-war re-democratization, when a recomposition of local political elites takes place.

Entre bois e cabras: uma visão histórica sobre mentalidades e valores nos sertões

A culture of resistance in the semi-arid, expressed by mentalities and values, goes against the economic potential of sheep and goat raising, considered as an inferior activity when compared to the cattle raising, historically linked to social status and prestige. This paper attempts to shed light on aspects that make possible to clarify the roots of the cognitive apparatus that supports this view, resorting to it to the production of relevant authors dealing with the issue of displacement of colonizer and livestock in the hinterlands. Ultimately, it seeks evidence of the influence of the historical process of economic and social organization of space on the present.