Efeitos hemodinâmicos da anestesia em plano profundo com infusão intravenosa contínua de propofol ou propofol associado à lidocaína em cães

The hemodynamic effects of total intravenous anesthesia with propofol or propofol in combination with lidocaine were investigated in 12 dogs. In the P group (n=6), the dogs received a loading dose (LD) of 6mg kg-1 of propofol followed by a constant rate infusion (CRI) of 1.25mg kg-1 min-1. In the PL group (n=6), dogs received a LD of 6mg kg-1 of propofol and 1.5mg kg-1 of lidocaine followed by CRIs of 1.0mg kg-1 min-1 and 0.25mg kg-1 min-1 of propofol and lidocaine, respectively. The animals were instrumented for measurement of hemodynamic variables and bispectral index (BIS), recorded at 75, 90, 105 and 120 minutes during anesthesia. Cardiac index, stroke index, systolic, diastolic and mean arterial blood pressures were lower in the P group compared to the PL group (P<0.05). There were no significant differences between groups in heart rate, systemic vascular resistance index and BIS. Plasma concentrations of propofol were lower in group PL than in group P (medians of 5.7 to 6.1mg mL-1 in the P group versus 3.1 to 3.7mg mL-1 in the PL group). Measured lidocaine plasma concentrations (medians of 2.27 to 2.51mg mL-1) were in the range that result in analgesia and were below values that result in toxicity in dogs. The BIS values observed in the two groups of dogs were compatible with deep anesthesia (mean values of 43-46 and 45-49 in groups P and PL, respectively). Maintenance of deep anesthesia with lidocaine-propofol causes less cardiovascular depression than equipotent doses of propofol alone.

Efeito do exercício prévio no ciclismo de curta duração

INTRODUÇÃO:O exercício prévio tem importantes implicações na preparação de atletas antes de competições.OBJETIVO:Analisar o efeito de um exercício prévio realizado no domínio pesado no pico de torque (PTORQUE) medido após exercício severo.MÉTODOS:Participaram deste estudo 14 homens ativos (idade: 26 ± 4 anos, VO2max: 44 ± 6 mLO2.min-1.kg-1) que realizaram sete testes em dias diferentes: a) teste progressivo de rampa para determinação do VO2max e da potência pico; b) quatro testes de carga constante para determinação da potência crítica, capacidade de trabalho anaeróbio e potência correspondente ao tempo de exaustão de 3 min (PTLim3min) e; c) dois testes de carga constante de 2 min na PTLim3min seguidos por um sprint all out de 10 s, a fim de medir o PTORQUE. Este último protocolo foi realizado com (EP) e sem (CON) a realização de um exercício prévio pesado.RESULTADOS:O PTORQUE foi significantemente maior após o EP (101 ± 30 Nm) em relação à condição CON (95 ± 23 Nm). O tempo da resposta médio (TRM) do VO2 foi significantemente menor após o EP (24 ± 7 s) em relação à condição CON (32 ± 10 s). A amplitude primária do VO2 aumentou significantemente após o EP (2598 ± 421 mLO2.min-1) em relação à condição CON (2184 ± 246 mLO2.min-1). O déficit de O2 foi significantemente menor após o exercício prévio (980 ± 432 mLO2) em relação à condição CON (1273 ± 398 mLO2). Houve correlação significante entre a variação do déficit de O2 com a do PTORQUE (r = 0,53) e da variação do TRM com a do PTORQUE (r = 0,53).CONCLUSÃO:Pode-se concluir que o PTORQUE é maior após exercício aeróbio de curta duração precedido do EP. Deste modo, esta estratégia pode ser interessante como preparação para algumas competições esportivas.

Conversor para pulsos elétricos de alta tensão, de curta duração, para processos de geração de ozônio

Pós-graduação em Engenharia Elétrica - FEIS

Determination of the top-quark pole mass and strong coupling constant from the t(t)over-bar production cross section in pp collisions at root s=7 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Measurement of the ratio of the inclusive 3-jet cross section to the inclusive 2-jet cross section in pp collisions at root s=7 TeV and first determination of the strong coupling constant in the TeV range

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Extended ionospheric amplitude scintillation model for GPS receivers

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Rehabilitation of the Maxillary Arch After Bone Graft Using Immediate Loading With Implant-Supported Fixed Restoration

Moderate and controlled loading environments support or enhance osteogenesis, and, consequently, a high degree of bone-to-implant contact can be acquired. This is because when osteoprogenitor cells are exposed to limited physical deformation, their differentiation into osteoblasts is enhanced. Then, some range of microstrain is considered advantageous for bone ingrowth and osseointegration. The primary stability has been considered one of the main clinical means of controlling micromotion between the implant and the forming interfacial tissue, which helps to establish the proper mechanical environment for osteogenesis. Based on the biological aspects of immediate loading (IL), the objective of this study is to present a clinical case of maxillary arch rehabilitation using immediate loading with implant-supported fixed restoration after bone graft. Ten dental implants were placed in the maxilla 6 months after the autogenous bone graft, removed from the mandible (bilateral oblique line and chin), followed by the installation of an immediate-load fixed cross-arch implant-supported restoration because primary stability was reached for 8 implants. In addition, instructions about masticatory function and how it is related to interfacial micromotion were addressed and emphasized to the patient. The reasons for the IL were further avoidance of an interim healing phase, a potential reduction in the number of clinical interventions for the patient, and aesthetic reasons. After monitoring the rehabilitation for 8 years, the authors can conclude that maxillary IL can be performed followed by a well-established treatment planning based on computed tomography, providing immediate esthetics and function to the patient even when autogenous bone graft was previously performed in the maxilla.

Biomechanical Loading Modulates Proinflammatory and Bone Resorptive Mediators in Bacterial-Stimulated PDL Cells

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Influence of Three Types of Abutments on Preload Values Before and After Cyclic Loading with Structural Analysis by Scanning Electron Microscopy

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Seasonal variability of a conditional stability constant and the characterization of sedimentary humic substances from typical agricultural and urban areas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Microstrain Around Dental Implants Supporting Fixed Partial Prostheses Under Axial and Non-Axial Loading Conditions, In Vitro Strain Gauge Analysis

The current study used strain gauge analysis to perform an in vitro evaluation of the effect of axial and non-axial loading on implant-supported fixed partial prostheses, varying the implant placement configurations and the loading points. Three internal hexagon implants were embedded in the center of each polyurethane block with in-line and offset placements. Microunit abutments were connected to the implants using a torque of 20 N.cm, and plastic prosthetic cylinders were screwed onto the abutments, which received standard patterns cast in Co-Cr alloy (n = 10). Four strain gauges (SGs) were bonded onto the surfaces of the blocks, tangentially to the implants: SG 01 mesially to implant 1, SG 02 and SG 03 mesially and distally to implant 2, respectively, and SG 04 distally to implant 3. Each metallic structure was screwed onto the abutments using a 10-N.cm torque, and axial and non-axial loads of 30 kg were applied at 5 predetermined points. The data obtained from the strain gauge analyses were analyzed statistically through the repeated measures analysis of variance and the Tukey test, with a conventional level of significance of P < 0.05. The results showed a statistically significant difference for the loading point (P = 0.0001), with point E (nonaxial) generating the highest microstrain (327.67 mu epsilon) and point A (axial) generating the smallest microstrain (208.93 mu epsilon). No statistically significant difference was found for implant placement configuration (P = 0.856). It was concluded that the offset implant placement did not reduce the magnitude of microstrain around the implants under axial and non-axial loading conditions, although loading location did influence this magnitude.

N-point tree-level scattering amplitude in the new Berkovits' string

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Finite time blow-up and breaking of solitary wind waves

The evolution of surface water waves in finite depth under wind forcing is reduced to an antidissipative Korteweg-de Vries-Burgers equation. We exhibit its solitary wave solution. Antidissipation accelerates and increases the amplitude of the solitary wave and leads to blow-up and breaking. Blow-up occurs in finite time for infinitely large asymptotic space so it is a nonlinear, dispersive, and antidissipative equivalent of the linear instability which occurs for infinite time. Due to antidissipation two given arbitrary and adjacent planes of constant phases of the solitary wave acquire different velocities and accelerations inducing breaking. Soliton breaking occurs in finite space in a time prior to the blow-up. We show that the theoretical growth in amplitude and the time of breaking are both testable in an existing experimental facility.

The closed-string 3-loop amplitude and S-duality

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

The intrinsic growth rate as a predictor of population viability under climate warming

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)