Sleep-disordered breathing among acute ischemic stroke patients in Brazil.

OBJECTIVES Sleep-disordered breathing (SDB) is very common in acute stroke patients and has been related to poor outcome. However, there is a lack of data about the association between SDB and stroke in developing countries. The study aims to characterize the frequency and severity of SDB in Brazilian patients during the acute phase of ischemic stroke; to identify clinical and laboratorial data related to SDB in those patients; and to assess the relationship between sleep apnea and functional outcome after six months of stroke. METHODS Clinical data and laboratorial tests were collected at hospital admission. The polysomnography was performed on the first night after stroke symptoms onset. Functional outcome was assessed by the modified Rankin Scale (mRS). RESULTS We prospectively evaluated 69 patients with their first-ever acute ischemic stroke. The mean apnea-hypopnea index (AHI) was 37.7 ± 30.2. Fifty-three patients (76.8%) exhibited an AHI ≥ 10 with predominantly obstructive respiratory events (90.6%), and thirty-three (47.8%) had severe sleep apnea. Age (OR: 1.09; 95% CI: 1.03-1.15; p= 0.004) and hematocrit (OR: 1.18; 95% CI: 1.03-1.34; p= 0.01) were independent predictors of sleep apnea. Age (OR: 1.13; 95% CI: 1.03-1.24; p= 0.01), body mass index (OR: 1.54; 95% CI: 1.54-2.18; p= 0.01), and hematocrit (OR: 1.19; 95% CI: 1.01-1.40; p= 0.04) were independent predictors of severe sleep apnea. The National Institutes of Health Stroke Scale (NIHSS; OR: 1.30; 95% CI: 1.1-1.5; p= 0.001) and severe sleep apnea (OR: 9.7; 95% CI: 1.3-73.8; p= 0.03) were independently associated to mRS >2 at six months, after adjusting for confounders. CONCLUSION Patients with acute ischemic stroke in Brazil have a high frequency of SDB. Severe sleep apnea is associated with a poor long-term functional outcome following stroke in that population.

High prevalence of herpes simplex virus (HSV)- type 2 co-infection among HIV-positive women in Ukraine, but no increased HIV mother-to-child transmission risk.

BACKGROUND Over 3500 HIV-positive women give birth annually in Ukraine, a setting with high prevalence of sexually transmitted infections. Herpes simplex virus Type 2 (HSV-2) co-infection may increase HIV mother-to-child transmission (MTCT) risk. We explored factors associated with HSV-2 seropositivity among HIV-positive women in Ukraine, and its impact on HIV MTCT. METHODS Data on 1513 HIV-positive women enrolled in the Ukraine European Collaborative Study from 2007 to 2012 were analysed. Poisson and logistic regression models respectively were fit to investigate factors associated with HSV-2 seropositivity and HIV MTCT. RESULTS Median maternal age was 27 years (IQR 24-31), 53% (796/1513) had been diagnosed with HIV during their most recent pregnancy and 20% had a history of injecting drugs. Median antenatal CD4 count was 430 cells/mm(3) (IQR 290-580). Ninety-six percent had received antiretroviral therapy antenatally. HSV-2 seroprevalence was 68% (1026/1513). In adjusted analyses, factors associated with HSV-2 antibodies were history of pregnancy termination (APR 1.30 (95% CI 1.18-1.43) for ≥ 2 vs. 0), having an HIV-positive partner (APR 1.15 (95% CI 1.05-1.26) vs partner's HIV status unknown) and HCV seropositivity (APR 1.23 (95 % CI 1.13-1.35)). The overall HIV MTCT rate was 2.80% (95% CI 1.98-3.84); no increased HIV MTCT risk was detected among HSV-2 seropositive women after adjusting for known risk factors (AOR 1.43 (95% CI 0.54-3.77). CONCLUSION No increased risk of HIV MTCT was detected among the 68% of HIV-positive women with antibodies to HSV-2, in this population with an overall HIV MTCT rate of 2.8%. Markers of ongoing sexual risk among HIV-positive HSV-2 seronegative women indicate the importance of interventions to prevent primary HSV-2 infection during pregnancy in this high-risk group.

[Culinary ephemera : gelatin and tapioca].

Corporate contributors include: Genesee Pure Food Company; Jell-O-Co. Inc.

[Colonial records of Pennsylvania]

Collection of documents, supplemented by the companion series "Pennsylvania archives". (See preliminary reports of the committees, and of the editors, S. Hazard, and the Act providing for the publication, 1837, in Pennsylvania archives, v.1, p. 1-23, especially p. 7 and 17-23, where the present collection is officially designated as the "Colonial records", a title not used in printing, the vols. having special titles only, as given in "Contents" below)

Plate with King Hunting Rams

Metalwork, Iran, Sasanian; 1 13/16 in. x 8 5/8 in.; silver, mercury gilding, niello inlay

Cardinal Pierto Bembo

Titian; 3 ft. 1 13/64 in.x 2 ft. 6 1/8 in.; oil on canvas

Report.

Reports for 1918/19-1925/26 and 1927/28 are also in New Jersey. Agricultural Experiment Station, New Brunswick. Report.

Translations on Soviet geodesy, 1925-1940.

JPRS: R-105-N/31; R-107-N/31; R-107-N/72; R-113-N/1; R-104-N/25; R-104-N/2; R-105-N/25; R-105-N/24.

Sämmtliche Schriften des heiligen Hilarius, Bischofs von Poitiers.

In Sämtliche Werke der Kirchenväter, v.7, pp.333-386; 8-12; 13, pp.1-222.

Skrifter utgivna av K. Humanistiska vetenskapssamfundet i Uppsala.

Vols. 1-3, 8-9, 13, 20, 24, include reports on the work of the society, lists of members, etc.

Nuevo diccionario de agricultura, teórica-práctica y económica y de medicina doméstica y veterinaria /

Contiene: t. 1 - 13

La Florida del Inca : historia del adelantado Hernando de Soto, Governador y Capitán General del Reino de la Florida, y de otros heroicos caballeros españoles e indios /

Mode of access: Internet.

Bibliotheca Mexicana sive Eruditorum Historia virorum : qui in America Boreali nati, vel alibi geniti, in ipsam domicilis aut Studijs asciti, quaris linguâ scripto aliquid tradiderunt /

Mode of access: Internet.

The Oxyrhynchus papyri /

Pts. 1-13 published as Memoirs 1-2, 5-6, 8-16 of the Egypt Exploration Fund, Graeco-Roman Branch; pts. 14- as Graeco-Roman memoirs no. 17-20, 26- of the Egypt Exploration Society.

Bulletin de la Société fribourgeoise des sciences naturelles.

Includes list of members.