High prevalence of herpes simplex virus (HSV)- type 2 co-infection among HIV-positive women in Ukraine, but no increased HIV mother-to-child transmission risk.


Autoria(s): Aebi-Popp, Karoline; Bailey, Heather; Malyuta, Ruslan; Volokha, Alla; Thorne, Claire
Data(s)

2016

Resumo

BACKGROUND Over 3500 HIV-positive women give birth annually in Ukraine, a setting with high prevalence of sexually transmitted infections. Herpes simplex virus Type 2 (HSV-2) co-infection may increase HIV mother-to-child transmission (MTCT) risk. We explored factors associated with HSV-2 seropositivity among HIV-positive women in Ukraine, and its impact on HIV MTCT. METHODS Data on 1513 HIV-positive women enrolled in the Ukraine European Collaborative Study from 2007 to 2012 were analysed. Poisson and logistic regression models respectively were fit to investigate factors associated with HSV-2 seropositivity and HIV MTCT. RESULTS Median maternal age was 27 years (IQR 24-31), 53% (796/1513) had been diagnosed with HIV during their most recent pregnancy and 20% had a history of injecting drugs. Median antenatal CD4 count was 430 cells/mm(3) (IQR 290-580). Ninety-six percent had received antiretroviral therapy antenatally. HSV-2 seroprevalence was 68% (1026/1513). In adjusted analyses, factors associated with HSV-2 antibodies were history of pregnancy termination (APR 1.30 (95% CI 1.18-1.43) for ≥ 2 vs. 0), having an HIV-positive partner (APR 1.15 (95% CI 1.05-1.26) vs partner's HIV status unknown) and HCV seropositivity (APR 1.23 (95 % CI 1.13-1.35)). The overall HIV MTCT rate was 2.80% (95% CI 1.98-3.84); no increased HIV MTCT risk was detected among HSV-2 seropositive women after adjusting for known risk factors (AOR 1.43 (95% CI 0.54-3.77). CONCLUSION No increased risk of HIV MTCT was detected among the 68% of HIV-positive women with antibodies to HSV-2, in this population with an overall HIV MTCT rate of 2.8%. Markers of ongoing sexual risk among HIV-positive HSV-2 seronegative women indicate the importance of interventions to prevent primary HSV-2 infection during pregnancy in this high-risk group.

Formato

application/pdf

Identificador

http://boris.unibe.ch/84477/1/art%253A10.1186%252Fs12884-016-0887-y.pdf

Aebi-Popp, Karoline; Bailey, Heather; Malyuta, Ruslan; Volokha, Alla; Thorne, Claire (2016). High prevalence of herpes simplex virus (HSV)- type 2 co-infection among HIV-positive women in Ukraine, but no increased HIV mother-to-child transmission risk. BMC pregnancy and childbirth, 16(94), p. 94. BioMed Central 10.1186/s12884-016-0887-y <http://dx.doi.org/10.1186/s12884-016-0887-y>

doi:10.7892/boris.84477

info:doi:10.1186/s12884-016-0887-y

info:pmid:27121953

urn:issn:1471-2393

Idioma(s)

eng

Publicador

BioMed Central

Relação

http://boris.unibe.ch/84477/

Direitos

info:eu-repo/semantics/openAccess

Fonte

Aebi-Popp, Karoline; Bailey, Heather; Malyuta, Ruslan; Volokha, Alla; Thorne, Claire (2016). High prevalence of herpes simplex virus (HSV)- type 2 co-infection among HIV-positive women in Ukraine, but no increased HIV mother-to-child transmission risk. BMC pregnancy and childbirth, 16(94), p. 94. BioMed Central 10.1186/s12884-016-0887-y <http://dx.doi.org/10.1186/s12884-016-0887-y>

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed