Crystal structure and physical properties of the new linear chain compound [Cu(1,2-bis(tetrazol-1-yl)ethane)3](ClO4)2

The synthesis and crystal structure of a novel one-dimensional Cu(II) compound [Cu(1,2-bis(tetrazol-1-yl)ethane)3](ClO4)2 are described. The single-crystal X-ray structure determination was carried out at 298 K. The molecular structure consists of a linear chain in which the Cu(II) ions are linked by three N4,N4' coordinating bis(tetrazole) ligands in syn conformation. The Cu(II) ions are in a Jahn-Teller distorted octahedral environment (Cu(1)-N(11)=2.034(2) Å, Cu(1)-N(21)=2.041(2) Å and Cu(1)-N(31)=2.391(2) Å). The Cu⋯Cu separations are 7.420(3) Å.

A puha költségvetési korlát szindrómája a kórházi szektorban = The soft budget constraint syndrome in the hospital sector

A kutatások eddig főképpen azt vizsgálták, hogyan jelenik meg a puha költségvetési korlát szindrómája a vállalati szférában és a hitelrendszerben. A jelen cikk a kórházi szektorra összpontosítja a figyelmet. Leírja az események öt főszereplőjének, a betegnek, az orvosnak, a kórházigazgatónak, a politikusnak és a kórház tulajdonosának motivációit és magatartásuk ellentmondásos jellegét. A motivációk magyarázzák, miért olyan erőteljes a túlköltési hajlam és a költségvetési korlát felpuhulásának tendenciája. A döntési és finanszírozási folyamatok minden szintjén felfelé hárítják a túlköltés és eladósodás terheit. A cikk kitér a különböző tulajdonformák (állami, nonprofit és forprofit nem állami tulajdonformák) és a puha költségvetési korlát szindrómájának kapcsolatára. Végül normatív szempontból vizsgálja a jelenséget: melyek a költségvetési korlát megkeményítésének kedvező és kedvezőtlen következményei, és hogyan tükröződnek a normatív dilemmák az események résztvevőinek tudatában. ___________ Researches so far have examined mainly how the soft budget constraint syndrome appears in the corporate sphere and the credit system. This article concentrates on the hospital sector. It describes the motivations and the contradictory behaviour of the five main types of participant in the events: patients, doctors, hospital managers, politicians, and hospital owners. The motivations explain why the propensity to overspend and the tendency to soften the budget constraint are so strong. The burdens of overspending and indebtedness are pushed upwards at every level of the decision-making and funding processes. The article considers the connection between the soft budget constraint syn-drome and the various forms of ownership (state ownership and the non-profit and for-profit forms of non-state ownership). Finally, the phenomenon is examined from the normative point of view: what are the favourable and unfavourable consequences of hardening the budget constraint and how these are reflected in the consciousness of the participants in the normative dilemmas and events.

Seasonality and geographical occurrence of West Nile fever and distribution of Asian tiger mosquito

The importance and risk of emerging mosquito borne diseases is going to increase in the European temperate areas due to climate change. The present and upcoming climates of Transdanubia seem to be suitable for the main vector of Chikungunya virus, the Asian tiger mosquito, Aedes albopictus Skuse (syn. Stegomyia albopicta). West Nile fever is recently endemic in Hungary. We used climate envelope modeling to predict the recent and future potential distribution/occurrence areas of the vector and the disease. We found that climate can be sufficient to explain the recently observed area of A. albopictus, while in the case of West Nile fever, the migration routes of reservoir birds, the run of the floodplains, and the position of lakes are also important determinants of the observed occurrence.

Role of metalliferous mudstones and graphitic shales in the location, genesis, and paleoenvironment

The Cambrian Tally Pond volcanic belt in central Newfoundland contains numerous volcanogenic massive sulphide (VMS) deposits, prospects, and showings that are locally associated with metalliferous mudstones and/or graphitic shales. Deposits in the belt are bimodal felsic-type VMS that are both base metal- (e.g., Duck Pond, Boundary) and precious metal-enriched (e.g., Lemarchant). At the Lemarchant deposit metalliferous mudstones are genetically and spatially associated with mineralization, whereas the relationship of other mudstones and shales to massive sulphide mineralization is more intricate and remains not fully understood. Metalliferous mudstones represent a hiatus in the volcanic activity where the deposition of hydrothermal products dominated over the abiogenic background sedimentation and/or dilution by volcaniclastic-epiclastic material. Lithogeochemical signatures allow one to distinguish between predominantly hydrothermally or detritally (i.e., non-hydrothermal) derived material. Metalliferous mudstones with a significant hydrothermal component, like those at Lemarchant, have elevated Fe/Al and base-metal contents, compared to detrital shales, and shale-normalized negative Ce and positive Eu anomalies, indicative of deposition from high temperature (>250°C) hydrothermal fluids within an oxygenated water column. Mudstones and shales sampled from other locations in the Tally Pond volcanic belt have more variable signatures ranging from hydrothermal (signatures as above) to non-hydrothermal (no positive Eu-anomalies, flat REE patterns), with some that have mixed (hydrothermal and detrital) signatures. Both S and Pb isotopic compositions indicate that proximal sulphides hosted in mudstones immediately associated with massive sulphide mineralization within the Lemarchant deposit contain a higher proportion of sulphur derived from hydrothermal sources and processes, and have more juvenile lead contributions, when compared to sulphides distal (not associated with massive sulphides) from mineralization. Lead and Nd isotopic compositions of both whole rock and minerals in the Lemarchant mudstones indicate involvement of underlying crustal basement during massive sulphide formation and throughout the evolution of the Tally Pond belt. Metalliferous mudstones precipitated early in the massive sulphide depositional history, but also have undergone syn- and post-ore-forming processes and have a larger lateral extent than the mineralization. Using lithogeochemistry, whole rock and in situ stable and radiogenic isotopes it is possible to distinguish prospective vent proximal (immediately associated with massive sulphide mineralization) from less prospective distal (not associated with massive sulphides) depositional environments and to reconstruct the paleotectonic setting on a deposit- to regional-scale for the Lemarchant deposit and other mudstone-associated prospects in the Tally Pond volcanic belt.

Desenvolvimento do capim-marandu com altura fixa ou variável durante as estações do ano

Aimed to identify, for assessing the tillering dynamics and morphogenesis , strategy (s ) suitable ( s) defoliation management to optimize the appearance of tillers and biomass of Urochloa Brizantha syn. Brachiaria brizantha cv. Marandu ( marandugrass ) throughout the year. The experiment was conducted from January 2013 to May 2014 were studied three strategies defoliation: Marandugrass with 30 cm throughout the experimental period (constant height); Marandugrass 15 cm in winter, the spring 30 cm and 45 cm in summer (increasing height); and Marandugrass 45 cm in winter, the spring 30 cm and 15 cm in summer (descending height). The experimental design was completely randomized in a split plot in time, with four replications. In winter, in the spring and summer, the following variables were calculated: appearance rate (TApP), mortality (TMoP) and survival (TSoP) of tillers, balance (BAL) between TApP and TMoP, stability index (IE) numbers of tillers and leaf elongation rates and stem, length of leaf blade and stem, leaf senescence rate, phyllochron and duration of life of the sheet. The TAPP was higher in the early spring and summer. For TMoP, the highest values were in the late spring and summer. The balance between TApP and TMoP was negative in winter and late spring, regardless of defoliation strategy. There was no difference in IE between the heights of the canopy during winter and late spring .. The number of tillers was higher in early spring and summer and lower in winter and late spring. The defoliation strategies have not changed phyllochron, leaf elongation rate. In spring and summer, there were increases in the rates of appearance, elongation and leaf senescence and, furthermore, decreased life span and phyllochron sheet. The plant height with increasing showed a lower rate of senescence and lower culm length in the spring. To increase the number of tillers marandu, it is advantageous to handle the plant with increasing height, ie, 15 cm in autumn and winter, the spring 30 cm and 45 cm in summer.The maintaining of B. brizantha cv. Marandu with fixed height of 30 cm or with variations between 15 and 45cm from the fall/winter to summer, does not influence the appearance and the growth of leaves per tiller, which indicates great flexibility on management defoliation in this forage plant.

Occurrence and Function of Hoogsteen Base Pairs in Nucleic Acids

Nucleic acids (DNA and RNA) play essential roles in the central dogma of biology for the storage and transfer of genetic information. The unique chemical and conformational structures of nucleic acids – the double helix composed of complementary Watson-Crick base pairs, provide the structural basis to carry out their biological functions. DNA double helix can dynamically accommodate Watson-Crick and Hoogsteen base-pairing, in which the purine base is flipped by ~180° degrees to adopt syn rather than anti conformation as in Watson-Crick base pairs. There is growing evidence that Hoogsteen base pairs play important roles in DNA replication, recognition, damage or mispair accommodation and repair. Here, we constructed a database for existing Hoogsteen base pairs in DNA duplexes by a structure-based survey from the Protein Data Bank, and structural analyses based on the resulted Hoogsteen structures revealed that Hoogsteen base pairs occur in a wide variety of biological contexts and can induce DNA kinking towards the major groove. As there were documented difficulties in modeling Hoogsteen or Watson-Crick by crystallography, we collaborated with the Richardsons’ lab and identified potential Hoogsteen base pairs that were mis-modeled as Watson-Crick base pairs which suggested that Hoogsteen can be more prevalent than it was thought to be. We developed solution NMR method combined with the site-specific isotope labeling to characterize the formation of, or conformational exchange with Hoogsteen base pairs in large DNA-protein complexes under solution conditions, in the absence of the crystal packing force. We showed that there are enhanced chemical exchange, potentially between Watson-Crick and Hoogsteen, at a sharp kink site in the complex formed by DNA and the Integration Host Factor protein. In stark contrast to B-form DNA, we found that Hoogsteen base pairs are strongly disfavored in A-form RNA duplex. Chemical modifications N1-methyl adenosine and N1-methyl guanosine that block Watson-Crick base-pairing, can be absorbed as Hoogsteen base pairs in DNA, but rather potently destabilized A-form RNA and caused helix melting. The intrinsic instability of Hoogsteen base pairs in A-form RNA endows the N1-methylation as a functioning post-transcriptional modification that was known to facilitate RNA folding, translation and potentially play roles in the epitranscriptome. On the other hand, the dynamic property of DNA that can accommodate Hoogsteen base pairs could be critical to maintaining the genome stability.

Multi-proxy records of Two-Yurts Lake

Within the scope of Russian-German palaeoenvironmental research, Two-Yurts Lake (TYL, Dvuh-Yurtochnoe in Russian) was chosen as the main scientific target area to decipher Holocene climate variability on Kamchatka. The 5x2 km large and 26 m deep lake is of proglacial origin and situated on the eastern flank of Sredinny Ridge at the northwestern end of the Central Kamchatka Valley, outside the direct influence of active volcanism. Here, we present results of a multi-proxy study on sediment cores, spanning about the last 7000 years. The general tenor of the TYL record is an increase in continentality and winter snow cover in conjunction with a decrease in temperature, humidity, and biological productivity after 5000-4500 cal yrs BP, inferred from pollen and diatom data and the isotopic composition of organic carbon. The TYL proxy data also show that the late Holocene was punctuated by two colder spells, roughly between 4500 and 3500 cal yrs BP and between 1000 and 200 cal yrs BP, as local expressions of the Neoglacial and Little Ice Age, respectively. These environmental changes can be regarded as direct and indirect responses to climate change, as also demonstrated by other records in the regional terrestrial and marine realm. Long-term climate deterioration was driven by decreasing insolation, while the short-term climate excursions are best explained by local climatic processes. The latter affect the configuration of atmospheric pressure systems that control the sources as well as the temperature and moisture of air masses reaching Kamchatka.

Chemical and isotopic composition of carbonate veins from ODP Leg 209

Carbonate veins hosted in ultramafic basement drilled at two sites in the Mid Atlantic Ridge 15°N area record two different stages of fluid-basement interaction. A first generation of carbonate veins consists of calcite and dolomite that formed syn- to postkinematically in tremolite-chlorite schists and serpentine schists that represent gently dipping large-offset faults. These veins formed at temperatures between 90 and 170 °C (oxygen isotope thermometry) and from fluids that show intense exchange of Sr and Li with the basement (87Sr/86Sr = 0.70387 to 0.70641, d7Li L-SVEC = + 3.3 to + 8.6 per mil). Carbon isotopic compositions range to high d13C PDB values (+ 8.7 per mil), indicating that methanogenesis took place at depth. The Sr-Li-C isotopic composition suggests temperatures of fluid-rock interaction that are much higher (T > 350-400 °C) than the temperatures of vein mineral precipitation inferred from oxygen isotopes. A possible explanation for this discrepancy is that fluids cooled conductively during upflow within the presumed detachment fault. Aragonite veins were formed during the last 130 kyrs at low-temperatures within the uplifted serpentinized peridotites. Chemical and isotopic data suggest that the aragonites precipitated from cold seawater, which underwent overall little exchange with the basement. Oxygen isotope compositions indicate an increase in formation temperature of the veins by 8-12 °C within the uppermost ~ 80 m of the subseafloor. This increase corresponds to a high regional geothermal gradient of 100-150 °C/km, characteristic of young lithosphere undergoing rapid uplift.

Foraminiferal assemblage and statistical analysis of surface sediment samples from the Golfe d'Arguin, Mauritania

With the growing pressure of eutrophication in tropical regions, the Mauritian shelf provides a natural situation to understand the variability in mesotrophic assemblages. Site-specific dynamics occur throughout the 1200 m depth gradient. The shallow assemblages divide into three types of warm-water mesotrophic foraminiferal assemblages, which is not only a consequence of high primary productivity restricting light to the benthos but due to low pore water oxygenation, shelf geomorphology, and sediment partitioning. In the intermediate depth (approx. 500 m), the increase in foraminiferal diversity is due to the cold-water coral habitat providing a greater range of micro niches. Planktonic species characterise the lower bathyal zone, which emphasizes the reduced benthic carbonate production at depth. Although, due to the strong hydrodynamics within the Golf, planktonic species occur in notable abundances through out the whole depth gradient. Overall, this study can easily be compared to other tropical marine settings investigating the long-term effects of tropical eutrophication and the biogeographic distribution of carbonate producing organisms.

Sedimentology of a Middle Jurassic Base-of-Slope environment, Cutri Formation, Mallorca

The Cutri Formation’s, type location, exposed in the NW of Mallorca, Spain has previously been described by Álvaro et al., (1989) and further interpreted by Abbots (1989) unpublished PhD thesis as a base-of-slope carbonate apron. Incorporating new field and laboratory analysis this paper enhances this interpretation. From this analysis, it can be shown without reasonable doubt that the Cutri Formation was deposited in a carbonate base-of-slope environment on the palaeowindward side of a Mid-Jurassic Tethyan platform. Key evidence such as laterally extensive exposures, abundant deposits of calciturbidtes and debris flows amongst hemipelagic deposits strongly support this interpretation.

Systematic review of Late Jurassic sauropods from the Museu Geológico collections (Lisboa, Portugal)

The Museu Geológico collections house some of the first sauropod references of the Lusitanian Basin Upper Jurassic record, including the Lourinhasaurus alenquerensis and Lusotitan atalaiensis lectotypes, previously considered as new species of the Apatosaurus and Brachiosaurus genera, respectively. Several fragmentary specimens have been classical referred to those taxa, but the most part of these systematic attributions are not supported herein, excluding a caudal vertebra from Maceira (MG 8804) considered as cf. Lusotitan atalaiensis. From the material housed in the Museu Geológico were identified basal eusauropods (indeterminate eusauropods and turiasaurs) and neosauropods (indeterminate neosauropods, diplodods and camarasaurids and basal titanosauriforms). Middle caudal vertebrae with lateral fossae, ventral hollow border by pronounced ventrolateral crests and quadrangular cross-section suggest for the presence of diplodocine diplodocids in north area of the Lusitanian Basin Central Sector during the Late Jurassic. A humerus collected from Praia dos Frades (MG 4976) is attributed to cf. Duriatitan humerocristatus suggesting the presence of shared sauropod forms between the Portugal and United Kingdom during the Late Jurassic. Duriatitan is an indeterminate member of Eusauropoda and the discovery of new material in both territories is necessary to confirm this systematic approach. The studied material is in according with the previous recorded paleobiodiversity for the sauropod clade during the Portuguese Late Jurassic, which includes basal eusauropods (including turiasaurs), diplodocids and macronarians (including camarasaurids and basal titanosauriforms).

Problematiken med estimering i projekt inom agil systemutveckling : Analys och undersökning av agil systemutveckling hos SDC

In today’s society, IT-Companies often have a hard time estimating changed requirements. This leads to that the clients’ confidence is negatively affected and is one of the main reasons why this has to be improved. The goal with this study was to find out what the most common problems regarding this issue are in IT-companies that works with agile software development. By analyzing one IT-company through a SWOT- and pareto-analysis the most common problems have been ascertained. The SWOT analysis have been created through interviews with selected employees to get a better understanding of the problems that the IT-company is facing. Furthermore was the pareto-analysis based on a survey that was sent out to many different employees to prioritize the problems. The reason why the survey was sent to different employees was to get a more objective input. The study showed that there was many different problems that needed attention. The most important problems was that the communication towards the client regarding requirements needed to be improved, better communication internally between different departments needed to be established, a method to quickly adapt and estimate change in requirements needed to be implemented and finally a method regarding witch key employees whom need to attend the planning of the program backlog. These problems have then been studied through interviews with other IT-companies and through a literature study. The conclusions that where drawn was that the client needs to be involved and updated through the whole project. Constant monitoring and communication regarding changed requirements needs to be processed and mediated. High standards needs to be set early towards the client in order to obtain as clear an image of the requirements as possible. Many different parties need to attend to the planning process for the program backlog before the start of the project. The client needs to be aware of that changed requirements will arise and that this will lead to that the first estimation may not necessarily be absolute. As long as the client is held up to date as well as participant through the whole project and problems are detected and mediated early, change in requirements should not be a huge problem. This is after all the purpose of being agile.

Nationella prov som didaktiskt verktyg : En intervjustudie om lärares syfte och attityder till nationella prov i matematik för årskurs 3

Bedömningsforskningen har de senaste decennierna fokuserat allt mer på formativ bedömning, som ett verktyg för lärande, snarare än en summativ avstämning av elevers kunskaper och förmågor. 2016 skriver elever i årkurs 3 nationella prov i matematik under vårterminen. Skolverket har formulerat ett huvudsakligt syfte med proven och jag vill med detta självständiga arbete undersöka hur lärares syften stämmer överens med dessa och hur väl pedagogerna upplever att proven synliggör och stöttar eleverna mot måluppfyllelse. Arbetet syftar också till att undersöka lärares attityder till och arbetssätt med de nationella proven i matematik i årskurs 3 samt vilka för- och nackdelar lärarna upplever med proven. Studien är av kvalitativ karaktär och bygger på semistrukturerade intervjuer av fyra yrkesverksamma lärare inom både kommunala skolor och friskolor. Resultatet visade att dessa lärare uttryckte en överlag positiv attityd till de nationella proven. De angav att de genomförde proven delvis för att det var obligatoriskt men också för att synliggöra elevernas måluppfyllelse, detta i enighet med Skolverkets uttalade syfte. Lärarna angav att de aktivt arbetade med proven för att dessutom stötta eleverna mot vidare kunskapsutveckling samt för att utvärdera sin undervisning men upplevde att detta är upp till den enskilda läraren att genomföra. Två av lärarna ansåg att proven dessutom hjälpte till att konkretisera styrdokumenten. Lärarna uttryckte de nationella provens möjligheter till att synliggöra och nå måluppfyllelse samt att utvärdera och utveckla den egna undervisningen som fördelar. Den mest framträdande nackdelen var bland informanterna den tid som proven tar i anspråk, både i fråga om genomförande och bedömning.  Studien visade vidare att två av lärarna sambedömde proven inom arbetslaget och att samtliga medverkande tog stöd från specialpedagoger vid behov. 

Laborativt arbete i skolans naturorienterade ämnen i årskurs 4-6 : En observations- och intervjustudie om lärares arbete och uppfattningar om laborativt arbete

Föreliggande studie har sin grund i PISA:s och TIMSS resultat där det pekas på att kunskapsutveckligen mellan årskurs 4 och årskurs 8 är svag. Laborativt arbete har visat sig ha effekt på elevers lärande, varför denna studies syfte är att undersöka hur några mellanstadie­lärare använder sig av ett laborativt arbetssätt i undervisningen i de naturorienterade ämnena, och vad de har för uppfattningar och erfarenheter av det från sin yrkesutövning. För att besvara studiens syfte, formulerades följande frågeställningar: I vilka sammanhang används ett laborativt arbetssätt, hur använder sig lärarna av ett laborativt arbetssätt i undervisningen och vad uppger lärarna att de har för syfte med det laborativa arbetet? En kvalitativ metod har använts i denna studie, där lärares arbete med laborativt arbete har observerats, varpå en intervju med var och en av dem har gjorts. Studien visar att laborativt arbete är ett inslag i samtliga deltagande lärares undervisning, och alla anser att arbetssättet är viktigt. Vad som skiljer deras arbeten åt är hur laborationerna går till och sedan bearbetas.  Syftena de uppger att de har med det laborativa arbetet är att eleverna lär sig saker genom laborationer som de inte kan lära sig på annat vis, att variera undervisningen, perceptuella preferenser och att elever lär på olika vis, att det är viktigt för elever att kunna ställa hypoteser, att följa läroplanen, att arbeta för elevers livslånga lust att lära, att konkretisera undervisningen, att eleverna själva ska få pröva och inte enbart ha undervisning om någonting som inte inkluderar någonting konkret, för att få större förståelse och för att komma fram till hur saker fungerar.  Alla lärare uppgav att de berättar om syftet med laborationerna för sina elever, men mina observationer visade att alla utom en gjorde det.

Språkinlärning i en Ur och Skur praktik : En studie om platsens betydelse för språklärande

Denna uppsats har till syfte att öka kunskap om mellanrummet mellan platsens betydelse och motorikens inverkan på barns språkinlärning i en Ur och Skur verksamhet. Den valda metoden för att försöka få syn på detta mellanrum har varit observationer med fältanteckningar och ljudinspelningar. Sedan har materialet analyserats med hjälp av sociokulturellt perspektiv. Det resultat som framkommit ur mitt empiriska material är att barnens lekar har möjligheten att utvecklas åt många olika håll. Att vara utomhus leder till att de i mindre utsträckning är påverkade av normstyrda artefakter jämfört med en förskola som vistas till större delar inomhus. Dock finns det en social praktik som pedagogerna har skapat som gynnar barns språkinlärning. Strukturen och kulturen av att ställa frågor och ha möjligheten att ge ordentliga svar, i både lek och vardag. Ytterligare ett resultat som framkommit är att både barn och pedagoger är vana vid att använda sin omgivning för att utvidga sitt lärande så att även en skylt i tunnelbanan blev ett medierande redskap för språkinlärning och intresse. Slutsatsen blev att platsen och då främst skogen gav förutsättningarna till rörelse och fantasilek där barnen själva kunde utforska sina intressen. Samtidigt som pedagogerna gav möjligheterna till barnens lekar genom att visa att de tyckte de var viktiga och gav möjligheter för samtal genom bland annat frågelekar.