901 resultados para behind-the-counter-lääkkeet
Resumo:
Globaalissa taloudessa yritysten rakenteet ovat kehittyneet yhteistyöverkostoiksi, joissa yritykset pyrkivät keskittymään ydinosaamiseensa ja tuottamaan muut toiminnot yhteistyökumppaneilla. Nykyisin yhä suurempi osa myös logistisista toiminnoista tuotetaan kolmansilla osapuolilla. Logistiikan piirissä saavutettavat synergiaedut ovat suuret ja monet yritykset niitä ovat myös jo saavuttaneet. Menestyksekkäät esimerkit ulkoistamisista ja toisaalta kehittyvän tietotekniikan tuomat uudet toimintamahdollisuudet johtavat ulkoistamisen, 3PL toiminnan, entistäkin suurempaan suosioon. Ongelmaksi on yrityksille muodostunut yhteistyökumppaneiden suuri määrä. Kun ydinosaamisalueen ulkopuolisia tehtäviä on jaettu useille eri yritykselle, tulee yhteistyöverkoston hallinnasta haasteellinen tehtävä, ja siihen vaaditaan kalliita tietojärjestelmiä. Kustannusten säästö saattoi kuitenkin olla ulkoistaneen yrityksen motiivi! Kaiken lisäksi toimitusketjun hallinnan periaatteiden mukaisesti tiukka toimitusketjun sisäinen koordinointi on välttämättömyys arvoprosessin tehokkuuudelle. Tutkimuksen tarkoituksena on selvittää 4PL toimintamallin logiikka, sekä kuinka sitä voidaan käyttää ratkaisemaan 3PL toiminnan ongelmakohtia. Case osuudessa esitellään kahden haastateluin selvitetyn logistiikkaintegraattorin toiminta ja tarkastellaan niiden toiminnan pohjalta teoreettista mallia. Tutkimuksen toisena päätavoitteena on selvittää toimitusketjun hallinnan periaatteet kehitettäessä toimitusketjua sekä tutkia 4PL toimintamallia näiden teorioiden valossa. Tutkielmassa esitetään toimitusketjun hallinnan integraatiofilosofian mukaiset periaatteet, jossa integroidaan toimitusketjun 8 avainprosessia. Tutkimuksen tulokset osoittavat, että joint venture yrityksenä perustettavan logistiikkaintegraattorin käyttö toimitusketjussa voi parantaa ennenkaikkea koordinointiongelmia, pienentää logistisia kustannuksia, sekä tehokkaasti vähentää niitä ongelmia, joita kolmannen osapuolen palveluntarjoajien käyttö yritykselle aiheuttaa. Tutkimuksessa esitetään myös kuinka logistiikkaintegraattorin toimintaperiaatteita voidaan laajentaa arvoketjuintegraattoriksi ja kuinka se voi auttaa toimitusketjun avainprosessien integroinnissa, synergiaetujen hyödyntämisessä ja koko toimitusketjun tehokkaassa hallinnassa.
Resumo:
Mottling is one of the key defects in offset-printing. Mottling can be defined as unwanted unevenness of print. In this work, diameter of a mottle spot is defined between 0.5-10.0 mm. There are several types of mottling, but the reason behind the problem is still not fully understood. Several commercial machine vision products for the evaluation of print unevenness have been presented. Two of these methods used in these products have been implemented in this thesis. The one is the cluster method and the other is the band-pass method. The properties of human vision system have been taken into account in the implementation of these two methods. An index produced by the cluster method is a weighted sum of the number of found spots, and an index produced by band-pass method is a weighted sum of coefficients of variations of gray-levels for each spatial band. Both methods produce larger indices for visually poor samples, so they can discern good samples from the poor ones. The difference between the indices for good and poor samples is slightly larger produced by the cluster method. 11 However, without the samples evaluated by human experts, the goodness of these results is still questionable. This comparison will be left to the next phase of the project.
Resumo:
Chemical perception is considered one of the first senses used as a communication system between living organisms. Such communication is based on the emission of signals between a sender and a receiver; if the communication is chemical, these signals are called pheromones. These signals have evolved via natural selection through a mechanism known as ritualization, which converts cues (which are not adapted to communication and which the receiver picks up regardless of the interests of the sender) into signals (information that the sender transmits as an adaptative response to its previously developed perception of the receiver). When communication has evolved between actors (sender and receiver) with common interests, the honesty of the signal is taken for granted, since both want the same thing (i.e., there is no reason to deceive). If the actors have conflicting interests, however, then the possibility of deception seeps into the possible array of adaptations. This can be observed in the case of communicative mimicry. However, in other situations natural selection imposes conditions that screen the possible signals, allowing only those that meet the requirement of honesty to stabilize. These include indices and added-cost signals. The emission of pheromones plays a variety of roles in the life processes of living beings. It facilitates encounters between individuals of the same species and is heavily involved in the mechanisms of recognition of relatives. It also fosters behaviours such as altruism (cooperation between individuals that share a percentage of their genetic inheritance). In many species, including humans, chemical communication works behind the scenes to guide the choice of a sexual partner.
Resumo:
Konepajateollisuuden suurasiakkaiden kansainvälistymisen myötä on noussut esiin uusia haasteita ja tarpeita, joihin yritysten tulisi pystyä vastaamaan kilpailukyvyn säilyttämiseksi. Konepajateollisuudessa tämä tarkoittaa entistä tiukempaa keskittymistä ydinosaamisalueisiin, kilpailuedun säilyttämistä, kustannustason sekä laadun hallintaa ja tehtävien jakoa päämiehiltä omille toimittajilleen verkostossa. Toimittajaverkostoissa toimii lukuisa määrä erikokoisia ja - tasoisia alihankkijoita, joista päämiesten lähimpinä toimittajina ovat niin kutsutut järjestelmätoimittajat. Tässä diplomityössä on tutkittu verkostoitumista ja sen perusteita lähinnä konepajateollisuuden kannalta, alan alihankintaverkostoa yleisesti sekä paikallisesti eteläisessä Kymenlaaksossa. Järjestelmätoimittajuuteen on kiinnitetty erityistä huomiota. Työssä on haettu sellaisia pk-yrityksiltä vaadittavia toimenpiteitä ja ominaisuuksia, jotta nouseminen jonkun päähankkijan komponenttitoimittajasta järjestelmätoimittajaksi olisi mahdollista. Aihetta on tarkasteltu teoreettisesti tutkimusten, julkaisujen ja kirjallisuuden avulla. Tämän lisäksi on suoritettu benchmarkkauksia muutamille menestyneille, konepajateollisuudessa toimiville ja järjestelmätoimittajiksi kehittyneille yrityksille. Näiden kerättyjen tietojen perusteella on tehty johtopäätöksiä ja niistä edelleen käytännön kehitystoimenpiteiden ja vaatimusten kartoitus sekä toimintasuunnitelma eräälle Kymenlaakson seudulta olevalle metallialan pk-yritykselle, jolla on tunnistettu olevan mahdollisuudet kehittyä järjestelmätoimittajaksi ja mitä liiketoimintamallia yrityksen johto pitää varteenotettavana vaihtoehtona ja kiinnostavana mahdollisuutena.
Resumo:
In the beginning of the year 2007 there was a change in our taxation laws, allowing the use of partial division in business restructuring without any direct taxation consequences. In this literature research thesis, partial division and transfer of assets and their similarities and differences have been examined. In addition, the concept of branch of activity, which is closely related to partial division and transfer of assets, has been defined. The concept of branch of activity has changed over the years in the Central Tax Board rulings towards more allowing, taking the taxpayer’s opinions into consideration better. The definition of branch of activity can be made relatively flexibly as long as there is a valid commercial reason behind the restructuring. Partial division can be more usable in business restructuring than division, because the transferring company does not dissolve in partial division. Compared to transfer of assets, the advantage of partial division is the transfer of losses to the receiving company and the possibility to use cash payments.
Resumo:
The objective of my thesis is to assess mechanisms of ecological community control in macroalgal communities in the Baltic Sea. In the top-down model, predatory fish feed on invertebrate mesograzers, releasing algae partly from grazing pressure. Such a reciprocal relationship is called trophic cascade. In the bottom-up model, nutrients increase biomass in the food chain. The nutrients are first assimilated by algae and, via food chain, increase also abundance of grazers and predators. Previous studies on oceanic shores have described these two regulative mechanisms in the grazer - alga link, but how they interact in the trophic cascades from fish to algae is still inadequately known. Because the top-down and bottom-up mechanisms are predicted to depend on environmental disturbances, such as wave stress and light, I have studied these models at two distinct water depths. There are five factorial field experiments behind the thesis, which were all conducted in the Finnish Archipelago Sea. In all the experiments, I studied macroalgal colonization - either density, filament length or biomass - on submerged colonization substrates. By excluding predatory fish and mesograzers from the algal communities, the studies compared the strength of the top-down control to natural algal communities. A part of the experimental units were, in addition, exposed to enriched nitrogen and phosphorus concentrations, which enabled testing of bottom-up control. These two models of community control were further investigated in shallow (<1 m) and deep (ca. 3 m) water. Moreover, the control mechanisms were also expected to depend on grazer species. Therefore different grazer species were enclosed into experimental units and their impacts on macroalgal communities were followed specifically. The community control in the Baltic rocky shores was found to follow theoretical predictions, which have not been confirmed by field studies before. Predatory fish limited grazing impact, which was seen as denser algal communities and longer algal filaments. Nutrient enrichment increased density and filament length of annual algae and, thus, changed the species composition of the algal community. The perennial alga Fucus vesiculosusA and the red alga Ceramium tenuicorne suffered from the increased nutrient availabilities. The enriched nutrient conditions led to denser grazer fauna, thereby causing strong top-down control over both the annual and perennial macroalgae. The strength of the top-down control seemed to depend on the density and diversity of grazers and predators as well as on the species composition of macroalgal assemblages. The nutrient enrichment led to, however, weaker limiting impact of predatory fish on grazer fauna, because fish stocks did not respond as quickly to enhanced resources in the environment as the invertebrate fauna. According to environmental stress model, environmental disturbances weaken the top-down control. For example, on a wave-exposed shore, wave stress causes more stress to animals close to the surface than deeper on the shore. Mesograzers were efficient consumers at both the depths, while predation by fish was weaker in shallow water. Thus, the results supported the environmental stress model, which predicts that environmental disturbance affects stronger the higher a species is in the food chain. This thesis assessed the mechanisms of community control in three-level food chains and did not take into account higher predators. Such predators in the Baltic Sea are, for example, cormorant, seals, white-tailed sea eagle, cod and salmon. All these predatory species were recently or are currently under intensive fishing, hunting and persecution, and their stocks have only recently increased in the region. Therefore, it is possible that future densities of top predators may yet alter the strengths of the controlling mechanisms in the Baltic littoral zone.
Resumo:
The fight against doping in sports has been governed since 1999 by the World Anti-Doping Agency (WADA), an independent institution behind the implementation of the World Anti-Doping Code (Code). The intent of the Code is to protect clean athletes through the harmonization of anti-doping programs at the international level with special attention to detection, deterrence and prevention of doping.1 A new version of the Code came into force on January 1st 2015, introducing, among other improvements, longer periods of sanctioning for athletes (up to four years) and measures to strengthen the role of anti-doping investigations and intelligence. To ensure optimal harmonization, five International Standards covering different technical aspects of the Code are also currently in force: the List of Prohibited Substances and Methods (List), Testing and Investigations, Laboratories, Therapeutic Use Exemptions (TUE) and Protection of Privacy and Personal Information. Adherence to these standards is mandatory for all anti-doping stakeholders to be compliant with the Code. Among these documents, the eighth version of International Standard for Laboratories (ISL), which also came into effect on January 1st 2015, includes regulations for WADA and ISO/IEC 17025 accreditations and their application for urine and blood sample analysis by anti-doping laboratories.2 Specific requirements are also described in several Technical Documents or Guidelines in which various topics are highlighted such as the identification criteria for gas chromatography (GC) and liquid chromatography (LC) coupled to mass spectrometry (MS) techniques (IDCR), measurements and reporting of endogenous androgenic anabolic agents (EAAS) and analytical requirements for the Athlete Biological Passport (ABP).
Resumo:
Ever since the inception of economics over two hundred years ago, the tools at the discipline's disposal have grown more and more more sophisticated. This book provides a historical introduction to the methodology of economics through the eyes of economists. The story begins with John Stuart Mill's seminal essay from 1836 on the definition and method of political economy, which is then followed by an examination of how the actual practices of economists changed over time to such an extent that they not only altered their methods of enquiry, but also their self-perception as economists. Beginning as intellectuals and journalists operating to a large extent in the public sphere, they then transformed into experts who developed their tools of research increasingly behind the scenes. No longer did they try to influence policy agendas through public discourse; rather they targeted policymakers directly and with instruments that showed them as independent and objective policy advisors, the tools of the trade changing all the while. In order to shed light on this evolution of economic methodology, this book takes carefully selected snapshots from the discipline's history. It tracks the process of development through the nineteenth and twentieth centuries, analysing the growth of empirical and mathematical modelling. It also looks at the emergence of the experiment in economics, in addition to the similarities and differences between modelling and experimentation. This book will be relevant reading for students and academics in the fields of economic methodology, history of economics, and history and philosophy of the social sciences.
Resumo:
When a flash is presented aligned with a moving stimulus, the former is perceived to lag behind the latter (the flash-lag effect). We study whether this mislocalization occurs when a positional judgment is not required, but a veridical spatial relationship between moving and flashed stimuli is needed to perceive a global shape. To do this, we used Glass patterns that are formed by pairs of correlated dots. One dot of each pair was presented moving and, at a given moment, the other dot of each pair was flashed in order to build the Glass pattern. If a flash-lag effect occurs between each pair of dots, we expect the best perception of the global shape to occur when the flashed dots are presented before the moving dots arrive at the position that physically builds the Glass pattern. Contrary to this, we found that the best detection of Glass patterns occurred for the situation of physical alignment. This result is not consistent with a low-level contribution to the flash-lag effect.
Resumo:
El artículo versa sobre la memoria visual de la escuela incidiendo tanto en las motivaciones que orientan la producción de imágenes como sobre el acercamiento a ellas que hoy podemos realizar. Parte así del análisis de los motivos de producción de imágenes según los períodos de la evolución escolar, prosigue una reseña de las distintas posibilidades de formación de memoria a través de las representaciones gráficas de la escuela y, finalmente, se plantean las principales características así como retos del tratamiento museológico y museográfico de la imagen escolar. El objetivo del artículo es, por lo tanto, realizar una aproximación a las imágenes concibiéndolas como bienes gráficos que requieren un avance en las formas de conservación, difusión e investigación que están desarrollando los centros de gestión del patrimonio educativo.
Resumo:
Syrjäytystilavuuspumppua käytetään kuluttavien, syövyttävien, jähmeiden ja kiteytyvien väliaineiden pumppaukseen. Sähkömoottorin pyörittämä akseli puristaa rullan välityksellä letkun tiiviisti rungon sisäpintaa vasten työntäen samalla väliainetta edellään kulkiessaan letkua pitkin. Puristuksen jälkeen letku palautuu pyöreään muotoonsa muodostaen alipaineen pumpun imupuolelle. Nykyisen konstruktion iskunsäätö on toteutettu ruuvi-epäkeskomekanismilla, jolle haetaan vaihtoehtoja. Tässä työssä on tavoitteena kehittää syrjäytystilavuuspumpun iskunsäätömekanismista nykyistä konstruktiota yksinkertaisempi ja halvempi vaihtoehto. Työssä ideoidaan koneensuunnittelun perinteisin keinoin uusia ratkaisuvaihtoehtoja, joista kaksi valitaan jatkokehitykseen. Näistä kahdesta valitaan nykyiseen konstruktioon tehdyn vertailun jälkeen toinen lopulliseksi vaihtoehdoksi.
Resumo:
There is an increasing reliance on computers to solve complex engineering problems. This is because computers, in addition to supporting the development and implementation of adequate and clear models, can especially minimize the financial support required. The ability of computers to perform complex calculations at high speed has enabled the creation of highly complex systems to model real-world phenomena. The complexity of the fluid dynamics problem makes it difficult or impossible to solve equations of an object in a flow exactly. Approximate solutions can be obtained by construction and measurement of prototypes placed in a flow, or by use of a numerical simulation. Since usage of prototypes can be prohibitively time-consuming and expensive, many have turned to simulations to provide insight during the engineering process. In this case the simulation setup and parameters can be altered much more easily than one could with a real-world experiment. The objective of this research work is to develop numerical models for different suspensions (fiber suspensions, blood flow through microvessels and branching geometries, and magnetic fluids), and also fluid flow through porous media. The models will have merit as a scientific tool and will also have practical application in industries. Most of the numerical simulations were done by the commercial software, Fluent, and user defined functions were added to apply a multiscale method and magnetic field. The results from simulation of fiber suspension can elucidate the physics behind the break up of a fiber floc, opening the possibility for developing a meaningful numerical model of the fiber flow. The simulation of blood movement from an arteriole through a venule via a capillary showed that the model based on VOF can successfully predict the deformation and flow of RBCs in an arteriole. Furthermore, the result corresponds to the experimental observation illustrates that the RBC is deformed during the movement. The concluding remarks presented, provide a correct methodology and a mathematical and numerical framework for the simulation of blood flows in branching. Analysis of ferrofluids simulations indicate that the magnetic Soret effect can be even higher than the conventional one and its strength depends on the strength of magnetic field, confirmed experimentally by Völker and Odenbach. It was also shown that when a magnetic field is perpendicular to the temperature gradient, there will be additional increase in the heat transfer compared to the cases where the magnetic field is parallel to the temperature gradient. In addition, the statistical evaluation (Taguchi technique) on magnetic fluids showed that the temperature and initial concentration of the magnetic phase exert the maximum and minimum contribution to the thermodiffusion, respectively. In the simulation of flow through porous media, dimensionless pressure drop was studied at different Reynolds numbers, based on pore permeability and interstitial fluid velocity. The obtained results agreed well with the correlation of Macdonald et al. (1979) for the range of actual flow Reynolds studied. Furthermore, calculated results for the dispersion coefficients in the cylinder geometry were found to be in agreement with those of Seymour and Callaghan.
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In nature, variation for example in herbivory, wind exposure, moisture and pollution impact often creates variation in physiological stress and plant productivity. This variation is seldom clear-cut, but rather results in clines of decreasing growth and productivity towards the high-stress end. These clines of unidirectionally changing stress are generally known as ‘stress gradients’. Through its effect on plant performance, stress has the capacity to fundamentally alter the ecological relationships between individuals, and through variation in survival and reproduction it also causes evolutionary change, i.e. local adaptations to stress and eventually speciation. In certain conditions local adaptations to environmental stress have been documented in a matter of just a few generations. In plant-plant interactions, intensities of both negative interactions (competition) and positive ones (facilitation) are expected to vary along stress gradients. The stress-gradient hypothesis (SGH) suggests that net facilitation will be strongest in conditions of high biotic and abiotic stress, while a more recent ‘humpback’ model predicts strongest net facilitation at intermediate levels of stress. Plant interactions on stress gradients, however, are affected by a multitude of confounding factors, making studies of facilitation-related theories challenging. Among these factors are plant ontogeny, spatial scale, and local adaptation to stress. The last of these has very rarely been included in facilitation studies, despite the potential co-occurrence of local adaptations and changes in net facilitation in stress gradients. Current theory would predict both competitive effects and facilitative responses to be weakest in populations locally adapted to withstand high abiotic stress. This thesis is based on six experiments, conducted both in greenhouses and in the field in Russia, Norway and Finland, with mountain birch (Betula pubescens subsp. czerepanovii) as the model species. The aims were to study potential local adaptations in multiple stress gradients (both natural and anthropogenic), changes in plant-plant interactions under conditions of varying stress (as predicted by SGH), potential mechanisms behind intraspecific facilitation, and factors confounding plant-plant facilitation, such as spatiotemporal, ontogenetic, and genetic differences. I found rapid evolutionary adaptations (occurring within a time-span of 60 to 70 years) towards heavy-metal resistance around two copper-nickel smelters, a phenomenon that has resulted in a trade-off of decreased performance in pristine conditions. Heavy-metal-adapted individuals had lowered nickel uptake, indicating a possible mechanism behind the detected resistance. Seedlings adapted to heavy-metal toxicity were not co-resistant to others forms of abiotic stress, but showed co-resistance to biotic stress by being consumed to a lesser extent by insect herbivores. Conversely, populations from conditions of high natural stress (wind, drought etc.) showed no local adaptations, despite much longer evolutionary time scales. Due to decreasing emissions, I was unable to test SGH in the pollution gradients. In natural stress gradients, however, plant performance was in accordance with SGH, with the strongest host-seedling facilitation found at the high-stress sites in two different stress gradients. Factors confounding this pattern included (1) plant size / ontogenetic status, with seedling-seedling interactions being competition dominated and host-seedling interactions potentially switching towards competition with seedling growth, and (2) spatial distance, with competition dominating at very short planting distances, and facilitation being strongest at a distance of circa ¼ benefactor height. I found no evidence for changes in facilitation with respect to the evolutionary histories of plant populations. Despite the support for SGH, it may be that the ‘humpback’ model is more relevant when the main stressor is resource-related, while what I studied were the effects of ‘non-resource’ stressors (i.e. heavy-metal pollution and wind). The results have potential practical applications: the utilisation of locally adapted seedlings and plant facilitation may increase the success of future restoration efforts in industrial barrens as well as in other wind-exposed sites. The findings also have implications with regard to the effects of global change in subarctic environments: the documented potential by mountain birch for rapid evolutionary change, together with the general lack of evolutionary ‘dead ends’, due to not (over)specialising to current natural conditions, increase the chances of this crucial forest-forming tree persisting even under the anticipated climate change.
Resumo:
The paper industry has been experiencing remarkable structural changes since paper demand growth has ceased and some markets are declining. One reason behind the declined demand is the Internet, which has partially substituted the newspaper as a source of information. Paper products alone can no longer provide livelihood, and the paper industry has to find new business areas. In this research, we studied radio frequency identification (RFID), and the market opportunities it could provide for paper industry. The research combined a quantitative industry analysis and qualitative interviews. RFID is a growing industry in the beginning of its life cycle, in which value chains and technologies still evolve significantly. The industry is going to concentrate on the future, and in the long term RFID-identifiers will probably be printed on paper substrate or directly onto products. Paper industry has the chance to enter the RFID industry, but it has to obtain the required competences, for example through acquisitions. The business potential RFID offers to paper industry is inadequate, and while reviewing new strategic options, the paper industry must consider more options, for example the entire printed intelligence.
Resumo:
The aim of this thesis was to fractionate wood extracts into pure fractions using membrane technology, to observe membrane behaviour in solvents and to study the effect of conditioning on membrane performance. Four different wood extracts were used in the performed filtrations. In the literature part, the focus was on the effect of different solvent properties on polymeric membranes, especially on their retention and flux. Solute properties, such as shape, polarity and charge, were examined. Transport models, membrane stability and ways to improve the stability, when solvents were filtered, were also discussed. The experimental part consisted of a series of filtrations, where the effect of the wood extracts and solvent concentration on solute retention was observed. Polymeric and ceramic membranes were tested under different conditions and the solute analyses were performed with GC and GC-MS. It was discovered that it is possible to fractionate wood extracts using membrane technology to some extent, but more research must be done to understand the mechanisms behind the various interactions between the solvent and the membrane. Conditioning was also considered as an important part of the membrane pre-treatment.