A Novel Breast Tissue Density Classification Methodology

It has been shown that the accuracy of mammographic abnormality detection methods is strongly dependent on the breast tissue characteristics, where a dense breast drastically reduces detection sensitivity. In addition, breast tissue density is widely accepted to be an important risk indicator for the development of breast cancer. Here, we describe the development of an automatic breast tissue classification methodology, which can be summarized in a number of distinct steps: 1) the segmentation of the breast area into fatty versus dense mammographic tissue; 2) the extraction of morphological and texture features from the segmented breast areas; and 3) the use of a Bayesian combination of a number of classifiers. The evaluation, based on a large number of cases from two different mammographic data sets, shows a strong correlation ( and 0.67 for the two data sets) between automatic and expert-based Breast Imaging Reporting and Data System mammographic density assessment

An integrated approach for the assessment of HAB dynamics in two NW Mediterranean bays from a GEOHAB perspective

Alfacs and Fangar Bay in the Ebro Delta, NW Mediterranean are the major sites in Catalonia for shellfish cultivation. These bays are subject to occasional closures in shellfish harvesting due to the presence of phycotoxins. Fish kills have also been associated with harmful algal blooms. The comparison of phytoplankton dynamics in both bays offers the opportunity to reveal differences in bloom patterns of species known to be harmful for the ecosystem and aquaculture activities. Field research is underway under the GEOHAB framework within the Core Research Project on HABs in Fjords and Coastal Embayments. The overall objective of this study is to improve our understanding of HAB biogeographical patterns, and key elements driving bloom dynamics in time and space within these semi-constrained embayments. Via the comparative approach we aim to improve the prediction for monitoring purposes, with a focus on Karlodinium spp. associated with massive kills of aquaculture species. This objective is addressed by incorporating long-term time series of phytoplankton identification and enumeration with the first results of recent field work in both bays. The latter includes the application of optical sensors, to yield a complementary view with enhanced spatial and temporal resolution of bloom phenomena.

Managing diabetes in Switzerland : a systemic approach

Executive summaryThe increasing prevalence of chronic diseases is one of the major causes of rising health expenditure, as stated by the WHO. Not only chronic diseases are very costly, but they are by far the leading cause of mortality in the world, representing 60% of all deaths. Diabetes in particular is becoming a major burden of disease. In Switzerland around 5% of the population suffer of type 2 diabetes and 5 to 10% of the annual health care budget is attributable to diabetes. If the predictions of WHO do realise, the prevalence of diabetes will double until 2030 and so is expected the attributable health expenditure.The objective of this thesis is to provide policy recommendations as to slow down the disease progression and its costly complication. We study the factors that influence diabetes dynamics and the interventions that improve health outcomes while decreasing costs according to different time horizon and use systems thinking and system dynamic.Our results show that managing diabetes requires using integrated care interventions that are effective on three fronts: (1) delaying the onset of complications, (2) slowing down the disease progression and (3) accelerating the time to diagnosis of diabetes and its complications. We recommend firstly the implementation of those interventions targeted at changing patients' behaviour which are also less expensive, but require a change in the delivery of care and medical practices. Then policies targeted at an earlier diagnosis of diabetes, its prevention and the diagnosis of complications are to be considered. This sequence of interventions allows saving money, as total costs decrease, even including the costs of interventions and result in longer life expectancy of diabetics in the long term.In diabetes management there is therefore a trade-off between medical costs and patients' benefits on the one hand and between the objectives of obtaining results in the short or long term on the other hand. Decision makers need to deliver acceptable outcomes in the short term. Considering this criterion, the preferred policy may be to focus only on diagnosed diabetics, thus attempting to slow down the progression of their disease, compared to an integrated care approach addressing all the aspects of the disease. Such a policy also yields desirable results in terms of costs and patients' benefits.

Portafoli virtual

El propòsit que es vol assolir amb aquest projecte és la possibilitat de tenir un portafoli virtual de les feines realitzades durant les diverses assignatures, amb una connotació temporal per poder veure l'evolució, millores i aprenentatge que han tingut els alumnes.

Object and Scene Classification: what does a Supervised Approach Provide us?

Given a set of images of scenes containing different object categories (e.g. grass, roads) our objective is to discover these objects in each image, and to use this object occurrences to perform a scene classification (e.g. beach scene, mountain scene). We achieve this by using a supervised learning algorithm able to learn with few images to facilitate the user task. We use a probabilistic model to recognise the objects and further we classify the scene based on their object occurrences. Experimental results are shown and evaluated to prove the validity of our proposal. Object recognition performance is compared to the approaches of He et al. (2004) and Marti et al. (2001) using their own datasets. Furthermore an unsupervised method is implemented in order to evaluate the advantages and disadvantages of our supervised classification approach versus an unsupervised one

Estudi de les pressions antròpiques de s’Estany des Peix i cartografia de l’escull-barrera de posidònia de Sa Boca

Realització per primera vegada de la cartografia de l’escull de Posidònia oceànica per tal d’observar la seva evolució, i estudi de s’Estany des Peix, concretament de les fortes pressions antròpiques que rep i posterior elaboració d’una proposta el més sostenible possible. S’estudia també la relació entre aquests dos espais

Guidelines for the use and interpretation of assays for monitoring autophagy.

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.

Pla de gestió dels senders ecoturístics del la zona d’interès etnològic de les Gavarres

El massís de les Gavarres és un espai que forma part del Pla d’Espais Naturals d’Interès Natural de Catalunya i es caracteritza per ser un espai molt ric en patrimoni cultural, sobretot etnològic. És per això que des de l’entitat del Consorci de les Gavarres sorgeix la proposta d’elaborar un conjunt de senders ecoturístics sobra la Zona d’Interès Etnològic de la Gavarres. L’objectiu principal és impulsar la posta en valor i crear instruments de gestió dels principals elements del patrimoni cultural que es troben presents arreu del massís de les Gavarres, a partir del disseny d’un conjunt de senders ecoturístics que, de manera respectuosa amb el medi ambient, serveixin d’instruments de dinamització i de gestió per a la conservació de l’espai i els seu elements patrimonials.

Algorismes per a la resolució de problemes de proximitat en terrenys

El modelatge, visualització i anàlisi de terrenys és de gran importància en els Sistemes d’Informació Geogràfica (GIS). Actualment és de gran interès per a aquesta comunitat disposar de software que permeti analitzar terrenys. L’objectiu principal del projecte és desenvolupar una aplicació per a la resolució de diversos problemes de proximitat en terrenys. Una part important ha d’ésser la de poder generar, visualitzar i modificar un model 3D d’un terreny a partir de dades introduïdes per l’usuari o obtingudes des d’un fitxer. Per tal de poder construir l’aplicació desitjada ha calgut dissenyar una interfície gràfica d’usuari que permetés realitzar de forma interactiva la introducció, modificació i esborrat de les diferents seus (punts, segments, polígons, poligonals...) o restriccions del terreny, així com la seva visualització

The legal and ethical framework governing Body Donation in Europe - A review of current practice and recommendations for good practice

Discussions at the inaugural meeting of a Trans-European Pedagogic Research Group for Anatomical Sciences highlighted the fact that there exist considerable variations in the legal and ethical frameworks throughout Europe concerning body bequests for anatomical examination. Such differences appear to reflect cultural and religious variations as well as different legal and constitutional frameworks. For example, there are different views concerning the "ownership" of cadavers and concerning the need (perceived by different societies and national politicians) for legislation specifically related to anatomical dissection. Furthermore, there are different views concerning the acceptability of using unclaimed bodies that have not given informed consent. Given that in Europe there have been a series of controversial anatomical exhibitions and also a public (televised) dissection/autopsy, and given that the commercial sale or transport of anatomical material across national boundaries is strongly debated, it would seem appropriate to "harmonise" the situation (at least in the European Union). This paper summarises the legal situation in a variety of European countries and suggests examples of good practice. In particular, it recommends that all countries should adopt clear legal frameworks to regulate the acceptance of donations for medical education and research. It stresses the need for informed consent, with donors being given clear information upon which to base their decision, intentions to bequest being made by the donor before death and encourages donors to discuss their wishes to bequeath with relatives prior to death. Departments are encouraged, where they feel it appropriate, to hold Services of Thanksgiving and Commemoration for those who have donated their bodies. Finally, there needs to be legislation to regulate transport of bodies or body parts across national borders and a discouragement of any moves towards commercialisation in relation to bequests.

Oxygen isotope compositions of iron oxides from high-grade BIF-hosted iron ore deposits of the Central Hamersley Province, Western Australia: Constraints on the evolution of hydrothermal fluids

The Hamersley province of northwest Australia is one of the world's premier iron ore regions with high-grade martite-microplaty hematite iron ore deposits mostly hosted within banded iron formation (BIF) sequences of the Brockman Iron Formations of the Hamersley Group. These high-grade iron ores contain between 60 and 68 wt percent Fe, and formed by the multistage interaction of hydrothermal fluids with the host BIF formation. The oxygen isotope compositions of magnetite and hematite from BIF, hydrothermal alteration assemblages, and high-grade iron Ore were analyzed from the Mount Tom Price, Paraburdoo, and Charmar iron ore deposits. The delta(18)O values of magnetite and hematite from hydrothermal alteration assemblages and high-grade iron ore range from -9.0 to -2.9 per mil, a depletion of 5 to 15 per mil relative to the host BIF. The delta(18)O values are spatially controlled by faults within the deposits, a response to higher fluid flux and larger influence the isotopic compositions by the hydrothermal fluids. The oxygen isotope composition of hydrothermal fluids (delta(18)O(fluid)) indicates that the decrease in the (18)O content of iron oxides was due to the interaction of both basinal brines and meteoric fluids with the original BIF. Late-stage talc-bearing ore at the Mount Tom Price deposit formed in the presence of a pulse of delta(18)O-enriched basinal brine, indicating that hydrothermal fluids may have repeatedly interacted with the BIFs during the Paleoproterozoic.

Els apareguts i el culte de les ànimes del Purgatori (segles XIV-XVII). Estudi i edició de textos catalans

Report for the scientific sojourn carried out at the Institut National d'Histoire de l'Art (INHA), France, from 2010 to 2012. It has focused on the analysis and editing of tales of human apparitions from the other world belonging to the Catalan culture or referring to it. We have studied and edited different versions of the process of Esperança Alegre (Lleida, 1500) and the Peregrinació del Venturós Pelegrí. These medieval works have been preserved in sources of the late sixteenth century or later. We have located a manuscript of the Esperança Alegre's tale, unknown to us at the beginning of this research (Biblioteca Nacional de España, ms. 1701), which differs from the version of ms. Baluze 238 of the Bibliothèque Nationale de France. The scribe of the ms. 1701 adds several paragraphs where considers the case as a diabolical phantasmagoria. About the Venturós Pelegrí, we have tried to establish firm criteria for the classification of many editions from the seventeenth to nineteenth centuries. We have been looking for printed books in the libràries of the world and we have made several requests for photographic reproductions, in order to classify undated editions by comparing woodcuts and other decorative elements. In the legend of Prince Charles of Viana (1421-1461), the appearances of his ghost are accompanied by rumors of his poisoning and of his sanctity. In addition, we have studied the cycles of masses for the souls in Purgatory linked to the hagiographies of St. Amadour and St. Vincent Ferrer, as well as the appearances described in L'Ànima d’Oliver of Francesc Moner, in the Carmelite chronicles of Father John of St. Joseph (1642-1718) and in some folktales collected from the eighteenth to the twentieth century. All this have allowed us to verify the evolution of certain cultural paradigms since the Middle Ages to the present.

Detecció de quadres des d'un dispositiu mòbil

En aquest treball es presenta una aplicació mòbil que, mitjançant l'ús de classificadors prèviament entrenats a un ordinador emprant l'algorisme Random Ferns, és capaç de detectar en temps real, i mitjançant la càmera del dispositiu mòbil, quadres i diferents parts dels quadres detectats. La informació dels elements detectats es presenta per pantalla, identificant el nom i autor de l'obra d'art, i assenyalant quines parts s'han detectat. L'usuari pot polsar sobre una de les parts assenyalades per tal de veure la informació relacionada.

Anàlisi de la comunicació família-escola-serveis socio-educatius com a eina per a millorar l'èxit escolar. La situació de les famílies migrades a Catalunya: determinació de necessitats i propostes d'actuació

L’èxit escolar i personal dels nens i nenes escolaritzats en les primeres etapes de l’ensenyament obligatori passa per l’entesa de les seves famílies amb el professorat de les escoles a les que van i pel suport que els ofereixi l’entorn social en que estan immersos. Per entendre’s uns i altres els cal establir vies de comunicació eficients que permetin arribar al coneixement i al treball mutu. El projecte ACOFES (Anàlisi de la Comunicació Família-Escola-Serveis socio-educatius) ha buscat respostes a aquesta qüestió al voltant de cinc eixos: 1.Com es comuniquen els tres agents educatius que intervenen en l’èxit escolar: famílies, professorat i serveis socioeducatius municipals; 2.Quines són les vies de comunicació que fan servir i quina la seva eficàcia; 3.Què pensen les famílies, què necessiten a què es poden o volen comprometre’s respecte a l’escola i a l’educació dels seus fills i filles; 4.Què pensa el professorat de la comunicació amb les famílies, què necessiten com a professionals i a què pot o vol comprometre’s; 5.Quins són aquells factors que poden influir de forma més rellevant en la millora de les possibilitats d’èxit de tot l’alumnat fent, en darrer lloc, noves propostes d’intervenció en particular per ajudar a solventar les necessitats específiques de l’alumnat procedent d’altres cultures que s’escolaritzen a Catalunya.