Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin.

A number of factors both stimulating and inhibiting angiogenesis have been described. In the current work, we demonstrate that the angiogenic factor vascular endothelial growth factor (VEGF) activates mitogen-activated protein kinase (MAPK) as has been previously shown for basic fibroblast growth factor. The antiagiogenic factor 16-kDa N-terminal fragment of human prolactin inhibits activation of MAPK distal to autophosphorylation of the putative VEGF receptor, Flk-1, and phospholipase C-gamma. These data show that activation and inhibition of MAPK may play a central role in the control of angiogenesis.

Simple tandem DNA repeats and human genetic disease.

The human genome contains many repeated DNA sequences that vary in complexity of repeating unit from a single nucleotide to a whole gene. The repeat sequences can be widely dispersed or in simple tandem arrays. Arrays of up to 5 or 6 nt are known as simple tandem repeats, and these are widely dispersed and highly polymorphic. Members of one group of the simple tandem repeats, the trinucleotide repeats, can undergo an increase in copy number by a process of dynamic mutation. Dynamic mutations of the CCG trinucleotide give rise to one group of fragile sites on human chromosomes, the rare folate-sensitive group. One member of this group, the fragile X (FRAXA) is responsible for the most common familial form of mental retardation. Another member of the group FRAXE is responsible for a rarer mild form of mental retardation. Similar mutations of AGC repeats give rise to a number of neurological disorders. The expanded repeats are unstable between generations and somatically. The intergenerational instability gives rise to unusual patterns of inheritance--particularly anticipation, the increasing severity and/or earlier age of onset of the disorder in successive generations. Dynamic mutations have been found only in the human species, and possible reasons for this are considered. The mechanism of dynamic mutation is discussed, and a number of observations of simple tandem repeat mutation that could assist in understanding this phenomenon are commented on.

Nuevos medios y empresas innovadoras. El caso de las agencias de medios

Los medios digitales abren nuevos horizontes para la investigación y la planificación publicitaria. Las agencias de medios deben adaptar su actividad a esta nueva realidad con el propósito de seguir llegando a los públicos y aprovechar las oportunidades de negocio. Este artículo plantea que este proceso de asimilación de los nuevos medios en las campañas publicitarias amplía los servicios ofrecidos por las agencias, construyendo los pilares para que las mismas sean consideradas empresas innovadoras. Para ello, se observan las diez agencias de medios españolas que más inversi��n publicitaria gestionan, de acuerdo con el ranking de Infoadex. Estas empresas contribuyen a la iniciativa “Unión por la innovación” de la Estrategia Europea 2020.

Triennial Catalogue annotated by Jeremy Belknap, 1791

The collection holds a heavily interleaved 1791 Triennial Catalogue annotated, in part, by Jeremy Belknap. A note by Harvard Librarian John Langdon Sibley, on the verso of the flyleaf, indicates a second annotator: "It should be observed that this catalogue is in the handwriting of two persons, Dr. Belknap & probably interlineations & additions by Rev. Dr. [John] Eliot. The interlineing part should not be too confidently relied on for accuracy. J. L. Sibley, April 14, 1848." The volume contains biographical notes, newspaper clippings, excerpts from manuscript and printed sources such as New England's First Fruits, the manuscript memoirs of Charles Chauncey, and John Winthrop's Journal, and a 1795 letter from Isaac Mansfield. In the letter, Mansfield references an item he believed to be written by his grandfather, Ames Cheever (Harvard AB 1707), and briefly describes his grandfather. A list of election sermon orators with dates is also pasted into the inside back cover, along with an obituary of the Rev. John Wales (Harvard AB 1728) from the Boston Post-Boy, March 4, 1765.

Papers of William Merchant Richardson, 1797-1806

The collection contains a four-page handwritten poem titled "Invention" composed by graduate William Richardson for the 1797 Harvard College Commencement, and an 1806 letter of introduction written by Richardson. The rhyming poem begins, “Long had creations anthem peal been rung…” and contains classical references, and mentions scientists and philosophers including Voltaire, Franklin and Newton. The poem is accompanied by a one-page handwritten letter of introduction for lawyer Benjamin Ames (Harvard AB 1803) written by William M. Richardson to Reverend William Jenks (Harvard AB 1797). The letter is dated November 10, 1806.

Diocesan Episcopacy: as Founded on the supposed Episcopacy of Timothy & Titus, subverted in a sermon preached at Harvard College May 9, 1770 at the Lecture founded by Paul Dudley

Two handwritten drafts of the Dudleian lecture delivered by Amos Adams on May 9, 1770 at Harvard College written in the same hand. The sermon begins with the Biblical text Titus 1:5. The first copy (HUC 5340.70) is bound between black paper covers and includes edits and citations written on interleaved pages. The second copy (HUC 5340.70.2) appears to be a subsequent draft of the address with additional edits.

Sermon at the annual Dudleian lecture, May 13th, 1772

The hand-sewn notebook contains a 108-page manuscript draft of the Dudleian lecture delivered by Benjamin Stevens on May 13, 1772 at Harvard College. The sermon begins with the Biblical text Heb. 1:1, 2. The copy includes a small number of edits and struck-out words. The cover page is no longer attached.

Newport, Rhode Island, ca. 1892 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of Newport, R.I., surveyed by N.W. Eayrs, c.e. ; under the direction of J.P. Cotton, c.e. ; J. Bergner, del. It was published ca. 1892 by Simon Hart. Scale [ca. 1:13,000]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Rhode Island State Plane Coordinate System (Feet) (FIPS 3800). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, city ward boundaries, selected property boundaries, buildings, and names of property owners, and more. Includes inset: Road map of island of Rhode Island and Conanicut Island, surveyed by C.E. Hammett, Jr. Scale [ca. 1:85,000]. Also includes index to points of interest (churches, schools, hotels, libraries, mills, etc.), tables of elevation and distances, and shows radial distances. This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and map purposes.

Tiverton, Rhode Island, 1854 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of the town of Tiverton, Newport County, R.I., by Wm. G. Borden, civil engineer. It was published in 1854 by Friend & Aub. Scale [ca. 1:21,200]. Covers Tiverton, Rhode Island and a portion of Fall River, Massachusetts. "Note: this map is partly from note furnished by H.F. Walling, civil engineer, and partly from original surveys." The image inside the map neatline is georeferenced to the surface of the earth and fit to the Rhode Island State Plane Coordinate System (Feet) (FIPS 3800). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as roads, drainage, selected private buildings labeled with owners' names, public buildings, churches, schools, industry locations (e.g. mills, factories, mines, etc.), cemeteries, town and school district boundaries, and more. Relief shown by hachures. Includes table and view of Oliver Chace's Thread Mill. This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and map purposes.

Kyōto-shi, Japan, ca. 1732 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Plan de Miaco résidence de l'empereur ecclésiastique : copié d'après l'original japonnois ... qui se trouve dans le Cabinet du Chevalier Hans Sloane = Platte grondt van de stad Miaco, zetel van den geestelyken erf-keyzer van Japan : na een origineele japansche kaart ... onder den Ridder Hans Sloane berustende door J. G. Scheuchser. It was published by chez R. & I. Ottens in ca. 1732. Scale [ca. 1:14,000]. Covers Kyōto-shi, Japan. Map in French and Dutch.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Tokyo Universal Transverse Mercator (UTM) Zone 53N projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, streets, mountains, selected buildings, and more. Relief shown pictorially.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

[ Fetâvâ] : manuscript, 1132 [ca. 1720 C.E.]

A typical fatwa collection covering almost all aspects of law: prayers, ablution, alms, fasting, divorce, capital punishment, etc.

Ratos de ocio (escritos literarios)

At head of title: Alberto Arias Sánchez (A. S. Alberto)

An investigation of truck size and weight limits - technical supplement. Volume 2: truck and rail cost effects of truck size and weight limits. Final report.

Transportation Department, Office of the Assistant Secretary for Policy and International Affairs, Washington, D.C.