Arquitectura d'Elx. Dossier per a la salvació del patrimoni arquitectònic

Arquitectura d'Elx. Dossier per a la salvació del patrimoni arquitectònic, catàleg de l'exposició homònima, Elx, Caja de Ahorros de Alicante y Murcia, 1978.

A ductile damage criterion at various stress triaxialities

The paper discusses the effect of stress triaxiality on the onset and evolution of damage in ductile metals. A series of tests including shear tests and experiments oil smooth and pre-notched tension specimens wits carried Out for it wide range of stress triaxialities. The underlying continuum damage model is based oil kinematic definition of damage tensors. The modular structure of the approach is accomplished by the decomposition of strain rates into elastic, plastic and damage parts. Free energy functions with respect to fictitious undamaged configurations as well as damaged ones are introduced separately leading to elastic material laws which are affected by increasing damage. In addition, a macroscopic yield condition and a flow rule are used to adequately describe the plastic behavior. Numerical simulations of the experiments are performed and good correlation of tests and numerical results is achieved. Based oil experimental and numerical data the damage criterion formulated in stress space is quantified. Different branches of this function are taken into account corresponding to different damage modes depending oil stress triaxiality and Lode parameter. In addition, identification of material parameters is discussed ill detail. (C) 2007 Elsevier Ltd. All rights reserved.

Double generalized linear model for tissue culture proportion data: a Bayesian perspective

Joint generalized linear models and double generalized linear models (DGLMs) were designed to model outcomes for which the variability can be explained using factors and/or covariates. When such factors operate, the usual normal regression models, which inherently exhibit constant variance, will under-represent variation in the data and hence may lead to erroneous inferences. For count and proportion data, such noise factors can generate a so-called overdispersion effect, and the use of binomial and Poisson models underestimates the variability and, consequently, incorrectly indicate significant effects. In this manuscript, we propose a DGLM from a Bayesian perspective, focusing on the case of proportion data, where the overdispersion can be modeled using a random effect that depends on some noise factors. The posterior joint density function was sampled using Monte Carlo Markov Chain algorithms, allowing inferences over the model parameters. An application to a data set on apple tissue culture is presented, for which it is shown that the Bayesian approach is quite feasible, even when limited prior information is available, thereby generating valuable insight for the researcher about its experimental results.

Paracoccin from Paracoccidioides brasiliensis; purification through affinity with chitin and identification of N-acetyl-beta-D-glucosaminidase activity

The dimorphic fungus Paracoccidioides brasiliensis is the causative agent of paracoccidioidomycosis, the most frequent systemic mycosis in Latin America. Our group has been working with paracoccin, a P. brasiliensis lectin with MM 70 kDa. which is purified by affinity, with immobilized N-acetylglucosamine (GlcNAc). Paracoccin has been described to play a role in fungal adhesion to extracellular matrix components and to induce high and persistent levels or TNF alpha. and nitric oxide production by macrophages. In the cell wall, paracoccin colocalizes with the beta-1,4-homopolymer of GlcNAc into the budding sites of the P. brasiliensis yeast cell. In this paper we present a protocol for the chitin-affinity purification or paracoccin. This procedure provided higher yields than those achieved by means of the technique based oil the affinity of this lectin with GlcNAc and had an impact on downstream assays. SDS-PAGE and Western blot analysis revealed similarities between the N-acetylglucosamine- and chitin-bound fractions, confirmed by MALDI-TOF-MS of trypsinic peptides. Western blot of two-dimensional gel electrophoresis of the yeast extract showed a major spot with M(r) 70000 and pl approximately 5.63. Moreover, an N-acetyl-beta-D-glucosaminidase activity was reported for paracoccin, thereby providing new insights into the mechanisms that lead to cell wall remodelling and opening new perspectives for its structural characterization. Copyright (C) 2009 John Wiley & Sons. Ltd.

Population pharmacokinetics and pharmacodynamics: An underutilized resource

A meeting was convened in Canberra, Australia, at the request of the Australian Drug Evaluation Committee (ADEC), on December 3-4, 1997 to discuss the role of population pharmacokinetics and pharmacodynamics in drug evaluation and development. The ADEC was particularly concerned about registration of drugs in the pediatric age group. The population approach could be used more often than is currently the case in pharmacokinetic and pharmacodynamic studies to provide valuable information for the safe and effective use of drugs in neonates, infants, and children. The meeting ultimately broadened to include discussion about other subgroups. The main conclusions of the meeting were: 1. The population approach, pharmacokinetic and pharmacodynamic analysis, is a valuable tool both for drug registration purposes and for optimal dosing of drugs in specific groups of patients, 2. Population pharmacokinetic and pharmacodynamic studies are able to fill in the gaps' in registration of drugs, for example, to provide information on optimal pediatric dosing. Such studies provide a basis for enhancing product information to improve rational prescribing, 3. Expertise is required to perform the population studies and expertise, with a clinical perspective, is also required to evaluate such studies if they are to be submitted as part of a drug registration dossier Such expertise is available in the Australasian region and is increasing. Centers of excellence with the appropriate expertise to advise and assist should be encouraged to develop and grow in the region, 4. The use of the population approach by the pharmaceutical industry needs to be encouraged to provide valuable information not obtainable by other techniques. The acceptance of population pharmacokinetic and pharmacodynamic analyses by regulatory agencies also needs to be encouraged, and 5. Development of the population approach to pharmacokinetics and pharmacodynamics is needed from a public health perspective to ensure that all available information is collected and used to improve the way drugs are used. This important endeavor needs funding and support at the local and international levels.

Wide Dispersal and Possible Multiple Origins of Low-Copy-Number Plasmids in Rickettsia Species Associated with Blood-Feeding Arthropods

Plasmids are mobile genetic elements of bacteria that can impart important adaptive traits, such as increased virulence or antibiotic resistance. We report the existence of plasmids in Rickettsia (Rickettsiales; Rickettsiaceae) species, including Rickettsia akari, ""Candidatus Rickettsia amblyommii,"" R. bellii, R. rhipicephali, and REIS, the rickettsial endosymbiont of Ixodes scapularis. All of the rickettsiae were isolated from humans or North and South American ticks. R. parkeri isolates from both continents did not possess plasmids. We have now demonstrated plasmids in nearly all Rickettsia species that we have surveyed from three continents, which represent three of the four major proposed phylogenetic groups associated with blood-feeding arthropods. Gel-based evidence consistent with the existence of multiple plasmids in some species was confirmed by cloning plasmids with very different sequences from each of two ""Ca. Rickettsia amblyommii"" isolates. Phylogenetic analysis of rickettsial ParA plasmid partitioning proteins indicated multiple parA gene origins and plasmid incompatibility groups, consistent with possible multiple plasmid origins. Phylogenetic analysis of potentially host-adaptive rickettsial small heat shock proteins showed that hsp2 genes were plasmid specific and that hsp1 genes, found only on plasmids of ""Ca. Rickettsia amblyommii,"" R. felis, R. monacensis, and R. peacockii, were probably acquired independently of the hsp2 genes. Plasmid copy numbers in seven Rickettsia species ranged from 2.4 to 9.2 per chromosomal equivalent, as determined by real-time quantitative PCR. Plasmids may be of significance in rickettsial evolution and epidemiology by conferring genetic plasticity and host-adaptive traits via horizontal gene transfer that counteracts the reductive genome evolution typical of obligate intracellular bacteria.

Resenha: Burocracia e elites burocr??ticas no Brasil

Resenha do livro: GOUV??A, Gilda Portugal. Burocracia e Elites Burocr??ticas no Brasil. S??o Paulo: Editora Paullc??ia, 1994, 320 p. Elaborado a partir de ura vasto levantamento de informa????es hist??ricas e de in??meras entrevistas realizadas com protagonistas que partici??param e conduziram um processo de mudan??a, apresenta uma an??lise valiosa de um segm ento burocr??tico que conseguiu modificar a forma de organiza????o e compet??ncias dos ??rg??o respons??veis pela con??du????o da pol??tica econ??mica no Brasil, revelando o quanto pode ser efetiva uma burocracia com prometida com a neces??sidade de produzir formas mais racionalizadoras e transparentes de gest??o para a administra????o das finan??as p??blicas.

A ilustração e o Skate

Este projecto de investigação tem como objectivo o estudo da relação entre a Cultura Urbana do Skate e a Ilustração. A partir desta premissa, é proposto um trabalho teórico-prático que reflecte sobre a aplicação da Ilustração no universo do Skate. Através da vertente teórica, procura-se fundamentar e explicar a prática, constituindo uma recolha de estudos de caso adequados aos objectivos práticos do projecto. Na vertente prática, é proposto um sistema de trabalho em rede entre os dois autores, são delineadas várias etapas de implementação repartidas entre ambos, onde cada autor desempenha o seu cargo de forma autónoma com valores e objectivos compartilhados. Posteriormente, é apresentado um relatório com os resultados práticos deste projecto que envolvem a criação de um blogue gráfico experimental, uma marca que o identifica e um evento que reúne a Cultura Urbana do Skate, a Ilustração e a Música. O presente documento é composto por dois volumes distintos. O primeiro volume destina-se à redação escrita da dissertação sobre a investigação realizada. O segundo volume destina-se à documentação de todas as etapas de implementação prática do projecto, através de um dossier de campo.

DWI: factores que influenciam a medição do coeficiente de difusão aparente (ADC) no estudo da mama

Mestrado em Radiações Aplicadas às Tecnologias da Saúde. Área de especialização: Ressonância Magnética

“To laugh in tragic joy” – a linguagem poética de W. B. Yeats em Lapis Lazuli

Artigo em texto integral no link da versão do editor

A Tradução num mundo globalizado – da arte à linha de montagem

Há muito que o tradutor, qual artista na sua torre de marfim, deixou de trabalhar à frente de uma simples máquina de escrever, rodeado de páginas e páginas de dicionários, enciclopédias, revistas especializadas, etc., que se empilhavam e acumulavam por todo o lado. Com o aparecimento da Internet o mundo ficou ao alcance de um “clique” e todos podem ter acesso a informações das mais diversas áreas e a ferramentas de trabalho preciosas. Para os tradutores, a Internet implica, sobretudo, uma revolução radical nos métodos e ferramentas de trabalho. Traduzir já não é considerado uma arte mas um produto resultante de uma linha de montagem, onde o tradutor é um operário especializado num mercado onde a tradução é, acima de tudo, um negócio. Neste contexto, e mais do que nunca, a sobrevivência dos tradutores passa por uma actualização permanente e pelo conhecimento e utilização dos vários recursos disponíveis em rede, de aplicações informáticas e até do seu concorrente mais temido: a tradução automática. Neste artigo, pretendemos referir algumas das ferramentas electrónicas disponíveis e mostrar como estas podem facilitar e melhorar a qualidade do trabalho de um tradutor num mundo onde o mercado é global.

Redes (des)conexas de intervenção local na violência infanto-juvenil

O objectivo deste estudo é apresentar os resultados de uma análise diagnóstica da atuação institucional relativamente às situações de violência infanto-juvenil em três territórios de um concelho da períferia de Lisboa(Portugal)

Futures of automobile industry and challenges on sustainable development and mobility

Portugal had only very few foresight exercises on the automobile sector, and the most recent one was a survey held in a project on work organisation systems in the automobile industry, its recent historical paths and the special strategies of location of companies (the WorTiS project). This involved several teams with different disciplinary backgrounds and from two Portuguese universities. The provisional main results of the first round of a Delphi survey held in Portugal on the automotive sector were already published, but a further analysis was not yet done. This foresight survey was done under the WorTiS project, developed in 2004 by IET – Research Centre on Enterprise and Work Innovation (at FCT-UNL), and financed by the Portuguese Ministry of Science and Technology. Some of this experience on foresight analysis is also been transferred to other projects, namely the WORKS project on work organisation restructuring in the knowledge society that received the support from EC and still is running. The majority of experts considered having an average of less knowledge in almost all the scenario topics presented. This means that information on the automotive industry is not spread enough among academics or experts in related fields (regional scientists, innovation economists, engineers, sociologists). Some have a good knowledge but in very specialised fields. Others have expertise on foresight, or macroeconomics, or management sciences, but feel insecure on issues related with futures of automobile sector. Nevertheless, we considered specially the topics where the experts considered themselves to have some knowledge. There were no “irrelevant” topics considered as such by the expert panel. There are also no topics that are not considered a need for co-operation. The lack of technological infrastructures was not considered as a hindered factor for the accomplishment of any scenario. The experts’ panel considered no other international competence besides US, Japan or Germany in these topics. Special focus will be made in this paper on the topic 2. Public policy and automobile industries, and more specifically on the technological and/or research policies issues, where one can specify the automobile’s role in transport policies with further implications like environment, safety, energy, mobility.