Treatment of adriamycin-induced nephropathy with erythropoietin and G-CSF

Background: Granulocyte colony-stimulating factor (G-CSF) and Erythropoietin (EPO) are known to stimulate the growth and differentiation of progenitor cells to prevent acute renal injury. This study aimed to assess the use of growth factors to mobilize stem cell in a mouse model of adriamycin-induced chronic kidney disease. Methods: All animals were injected with adriamycin for kidney injury and allocated into three treatment groups (G-CSF, EPO and G-CSF + EPO), and a control group (adriamycin alone). Results: Number of atrophic sites, glomerulosclerosis rate and interstitial fibrosis severity score were assessed in all groups. In all treatment groups, histologic parameters did not significantly differ, but were lower than in the control group (P<.001). Scal and CD34 expressions among treatment groups showed no statistically significant difference, but were higher than in the control group (P<.0001). CD105 expression was higher in EPO and G+EPO as compared to G-CSF and the control group (P<.0001), with no statistically significant difference between the latter two groups (P = NS). Conclusion: G-CSF and EPO had a histologic protective effect, while treatment with EPO + G-CSF had no additive effects in a model of adriamycin-induced chronic kidney disease. © 2013 Societá Italiana di Nefrologia.

Quasi-homologous spherically symmetric branes and their symmetry breaking

We revisit the dynamical system-based approach of spherically symmetric vacuum braneworlds, pointing out and studying the existence of a transcritical bifurcation as the dark pressure parameter changes its sign, we analyze some consequences of not discard the brane cosmological constant. For instance, it is noteworthy that the existence of an isothermal state equation between the dark fluid parameters cannot be obtained via the requirement of a quasi-homologous symmetry of the vacuum. © 2013 Springer-Verlag Berlin Heidelberg and Società Italiana di Fisica.

Modernidade, vulnerabilidade e população de rua em Presidente Prudente (SP)

Pós-graduação em Geografia - FCT

O princípio da igualdade e as obrigações constitucionais do Estado na tutela penal

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Industria y educación en El Salvador

Incluye Bibliografía

Proceso pedagógico y heterogeneidad cultural en el Ecuador

Incluye Bibliografía

Education and development in Latin America (1950-1975)

Includes bibliography

Marginalidad urbana y educación formal: planteo del problema y perspectivas de análisis

Incluye Bibliografía

Educacion e industrialización en la Argentina

Incluye Bibliografía

Escolas municipais: a busca de respostas aos desafios contemporâneos na/da escola pública, popular e democrática

Pós-graduação em Educação - FCT

A crítica da elite letrada à incorporação do homem-massa na Argentina na década de 1940: a Revista Sur em confronto com o Peronismo

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Educación y empleo industrial: un análisis a partir de datos censales 1960-1970

Incluye Bibliografía

El proceso pedagógico y aprendizaje en contextos de heterogeneidad: el caso de la sierra ecuatoriana

Incluye Bibliografía

Disputa intelectual ou impertinência de um polemista?: uma análise comparatista entre As Américas de Sílvio Romero e Manoel Bomfim

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Elementos para un diagnóstico del sistema educativo tradicional en América Latina

Incluye Bibliografía