Périartérite noueuse et hépatite C: association fortuite [Periarteritis nodosa and hepatitis C: a fortuitous association?]

Polyarteritis nodosa is a vasculitis of unknown origin which can be rarely associated with hepatitis B. A exceptional clinical situation of a polyarteritis nodosa associated with hepatitis C is described. This case is also the occasion to review the clinical manifestations, the diagnostic strategy und the therapeutic options of this rare vasculitis.

Sistema de auto localización a partir de una red WIFI

El objetivo de este trabajo es la localización de una persona u objeto mediante la tecnología inalámbrica. Para realizarlo se ha hecho un estudio sobre las ondas wifi observando su comportamiento en distintas situaciones, así como sus problemas y factores que pueden ser relevantes en el proceso, para dar lugar a un posicionamiento acertado.

The association of aldosterone with obesity-related hypertension and the metabolic syndrome.

Overweight and obesity are associated with arterial hypertension. Given the large increase in the obesity prevalence worldwide, the number of obese patients with hypertension is likely to increase substantially in the near future. Overweight and obese patients are exposed to an important metabolic and cardiovascular risk. The understanding of the mechanisms linking obesity to hypertension is important for specific prevention and therapy in this population. There is some evidence that obesity is associated with an increased aldosterone level. To date, 2 mechanisms may explain the interaction of fat tissue with the renin-angiotensin-aldosterone system, and therefore explain, in part, obesity-related hypertension. First, human adipose tissue produces several components of the renin-angiotensin-aldosterone system, mainly adipose tissue-derived angiotensinogen. Second, increased fatty acid production in the obese patient, especially nonesterified fatty acids, might stimulate aldosterone production, independent of renin. A better understanding of these mechanisms might have implications for the management of hypertension in overweight and obese patients. Because aldosterone also is associated with blood glucose and blood lipids, selective aldosterone blockade may represent a particularly attractive therapeutic strategy in obese patients with a clustering of cardiovascular risk factors.

Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls.

Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure have been interrogated using GWAS, although in generally small samples. Under the auspices of the International Collaboration for the Genomics of HIV, we have combined the genome-wide single nucleotide polymorphism (SNP) data collected by 25 cohorts, studies, or institutions on HIV-1 infected individuals and compared them to carefully matched population-level data sets (a list of all collaborators appears in Note S1 in Text S1). After imputation using the 1,000 Genomes Project reference panel, we tested approximately 8 million common DNA variants (SNPs and indels) for association with HIV-1 acquisition in 6,334 infected patients and 7,247 population samples of European ancestry. Initial association testing identified the SNP rs4418214, the C allele of which is known to tag the HLA-B*57:01 and B*27:05 alleles, as genome-wide significant (p = 3.6×10(-11)). However, restricting analysis to individuals with a known date of seroconversion suggested that this association was due to the frailty bias in studies of lethal diseases. Further analyses including testing recessive genetic models, testing for bulk effects of non-genome-wide significant variants, stratifying by sexual or parenteral transmission risk and testing previously reported associations showed no evidence for genetic influence on HIV-1 acquisition (with the exception of CCR5Δ32 homozygosity). Thus, these data suggest that genetic influences on HIV acquisition are either rare or have smaller effects than can be detected by this sample size.

Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: A genome-wide association and polygenic scoring study.

Epidemiological studies have recognized a genetic diathesis for suicidal behavior, which is independent of other psychiatric disorders. Genome-wide association studies (GWAS) on suicide attempt (SA) and ideation have failed to identify specific genetic variants. Here, we conduct further GWAS and for the first time, use polygenic score analysis in cohorts of patients with mood disorders, to test for common genetic variants for mood disorders and suicide phenotypes. Genome-wide studies for SA were conducted in the RADIANT and GSK-Munich recurrent depression samples and London Bipolar Affective Disorder Case-Control Study (BACCs) then meta-analysis was performed. A GWAS on suicidal ideation during antidepressant treatment had previously been conducted in the Genome Based Therapeutic Drugs for Depression (GENDEP) study. We derived polygenic scores from each sample and tested their ability to predict SA in the mood disorder cohorts or ideation status in the GENDEP study. Polygenic scores for major depressive disorder, bipolar disorder and schizophrenia from the Psychiatric Genomics Consortium were used to investigate pleiotropy between psychiatric disorders and suicide phenotypes. No significant evidence for association was detected at any SNP in GWAS or meta-analysis. Polygenic scores for major depressive disorder significantly predicted suicidal ideation in the GENDEP pharmacogenetics study and also predicted SA in a combined validation dataset. Polygenic scores for SA showed no predictive ability for suicidal ideation. Polygenic score analysis suggests pleiotropy between psychiatric disorders and suicidal ideation whereas the tendency to act on such thoughts may have a partially independent genetic diathesis. © 2014 Wiley Periodicals, Inc.

Crawford County Fair Association, September 30, 2002

County Audit Report - Fair Association

A auto-estima e o não-verbal dos pacientes com queimaduras

Esta pesquisa teve como objetivos identificar o grau de auto-estima dos pacientes do Ambulatório de Seqüelas de Queimaduras do HC-FMUSP e identificar os sinais não-verbais emitidos pelos pacientes, quando questionados sobre sua auto-estima. Realizado com 80 pacientes (54 mulheres e 26 homens) atendidos na unidade durante o mês de fevereiro de 2002, o projeto foi aprovado pelas Comissões de Ética em Pesquisa da EEUSP e do HC-FMUSP e as entrevistas individuais com os pacientes baseadas em uma escala para avaliação de auto-estima validada no Brasil e na classificação de sinais não-verbais proposta por Silva. Dentre os resultados, verificamos que 18,75% pacientes apresentam baixa auto-estima, 32,50% média auto-estima e 48,75% pacientes alta auto-estima. O complemento foi a função dos sinais não-verbais mais freqüente entre os pacientes.

Asnières, [Football] Association, 31-11-19 [i.e. 1er décembre 1919], équipe U.S.A. [Union sportive et amicale] de Clichy : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57095

Asnières, [Football] Association, 31-11-19 [i. e. 1er décembre 1919], équipe du F.E.C. [Football étoile club] de Levallois : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57094

31-11-19 [i.e. 1er décembre], rue Olivier de Serres, [Football] Association, équipe Red star : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57087

A auto-estima de indivíduos que foram submetidos à cirurgia de revascularização do miocárdio

Estudo descritivo e correlacional com objetivos de medir a auto-estima de indivíduos submetidos à cirurgia de revascularização do miocárdio e correlacionar a auto-estima com variáveis sócio-demográficas e clínicas. Uma amostra de 97 pacientes ambulatoriais foi entrevistada. Os dados foram analisados através de estatística descritiva, teste de Correlação de Pearson, testes Mann-Whitney e Kruskal Wallis. A confiabilidade da escala foi verificada (alfa de Cronbach de 0,79) e a média encontrada para auto-estima foi 32,22 (intervalo possível de 10 a 40). Encontramos correlação, estatisticamente significante, apenas para auto-estima e sexo. Concluímos que os participantes apresentavam elevada auto-estima a qual não estava correlacionada com outras variáveis.

[Stade] R[ue] Olivier de Serres [Paris, 15e arrondissement], 1-2-20, [football] association, équipe [de] l'Olympique Lillois : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57846

Page County Landfill Association, June 30, 2001 & June 30, 2002

Other Audit Reports

Page County Landfill Association, June 30, 2003

Other Audit Report