The association of aldosterone with obesity-related hypertension and the metabolic syndrome.


Autoria(s): Vogt B.; Bochud M.; Burnier M.
Data(s)

2007

Resumo

Overweight and obesity are associated with arterial hypertension. Given the large increase in the obesity prevalence worldwide, the number of obese patients with hypertension is likely to increase substantially in the near future. Overweight and obese patients are exposed to an important metabolic and cardiovascular risk. The understanding of the mechanisms linking obesity to hypertension is important for specific prevention and therapy in this population. There is some evidence that obesity is associated with an increased aldosterone level. To date, 2 mechanisms may explain the interaction of fat tissue with the renin-angiotensin-aldosterone system, and therefore explain, in part, obesity-related hypertension. First, human adipose tissue produces several components of the renin-angiotensin-aldosterone system, mainly adipose tissue-derived angiotensinogen. Second, increased fatty acid production in the obese patient, especially nonesterified fatty acids, might stimulate aldosterone production, independent of renin. A better understanding of these mechanisms might have implications for the management of hypertension in overweight and obese patients. Because aldosterone also is associated with blood glucose and blood lipids, selective aldosterone blockade may represent a particularly attractive therapeutic strategy in obese patients with a clustering of cardiovascular risk factors.

Identificador

http://serval.unil.ch/?id=serval:BIB_5445B36DACCA

isbn:0270-9295

pmid:17868790

doi:10.1016/j.semnephrol.2007.07.009

isiid:000249836300005

Idioma(s)

en

Fonte

Seminars in nephrology, vol. 27, no. 5, pp. 529-537

Palavras-Chave #Adipose Tissue; Aldosterone; Animals; Blood Pressure; Humans; Hypertension; Metabolic Syndrome X; Obesity; Prognosis; Risk Factors
Tipo

info:eu-repo/semantics/review

article