Direct support and general support maintenance repair parts and special tools list (including depot maintenance repair parts and special tools) : radio teletypewriter set, AN/GRC-142B, (NSN 5815-00-443-5511).

Includes index.

Federal role in urban affairs : hearings ... Eighty-ninth Congress, second session [-Ninetieth Congress, second session].

Part 21 (Index) issued with separate paging (iii, 268 p.).

Praefationes, tractatus, diatribae et exegeses praeliminares atque nonnulla venerandae antiquitatis tum sacrae, cum profanae monumenta /

Mode of access: Internet.

Particle size of Saharan dust in the Atlantic Ocean, from October 2012 to November 2013

Mineral dust has a large impact on regional and global climate, depending on its particle size. Especially in the Atlantic Ocean downwind of the Sahara, the largest dust source on earth, the effects can be substantial but are poorly understood. This study focuses on seasonal and spatial variations in particle size of Saharan dust deposition across the Atlantic Ocean, using an array of submarine sediment traps moored along a transect at 12° N. We show that the particle size decreases downwind with increased distance from the Saharan source, due to higher gravitational settling velocities of coarse particles in the atmosphere. Modal grain sizes vary between 4 and 33 µm throughout the different seasons and at five locations along the transect. This is much coarser than previously suggested and incorporated into climate models. In addition, seasonal changes are prominent, with coarser dust in summer, and finer dust in winter and spring. Such seasonal changes are caused by transport at higher altitudes and at greater wind velocities during summer than in winter. Also the latitudinal migration of the dust cloud, associated with the Intertropical Convergence Zone, causes seasonal differences in deposition as the summer dust cloud is located more to the north, and more directly above the sampled transect. Furthermore, increased precipitation and more frequent dust storms in summer coincide with coarser dust deposition. Our findings contribute to understanding Saharan dust transport and deposition relevant for the interpretation of sedimentary records for climate reconstructions, as well as for global and regional models for improved prediction of future climate.

Bauliche Ausgestaltung von Bahn und Fahrzeug, Betrieb und Verkehr

Original erschien als Band 817 der "Sammlung Göschen"

An attachment perspective on adult sibling relationships

This study investigated adult sibling relationships from an attachment perspective. A total of 817 adults (253 males; 564 females) ranging in age from 16 to 90 years completed a modified version of the WHO-TO measure of attachment strength (Hazan & Zeifman, 1994). This measure records multiple attachment figures, in order of importance, across four functions of attachment. One hundred and seventy four siblings of the participants also completed the measure as part of a larger sibling study. There were 29 brother dyads, 83 sister dyads and 62 brother-sister dyads. Results revealed that siblings have the potential to fulfil attachment-related functions, with 37% of the sample judged to be attached to a sibling. Females, and those not in romantic relationships reported stronger attachment to a sibling. Furthermore, sibling dyads were generally congruent in their perception of their relationship as an attachment bond. More than half of the sister-sister dyads (54%) agreed their relationship was an attachment bond, compared to 33% of brother-brother dyads and 24% of brother-sister dyads. Taken together, the findings support the applicability of attachment theory as a framework for investigating sibling relationships in adulthood.

Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development

Background. The growth of solid tumors depends on establishing blood supply; thus, inhibiting tumor angiogenesis has been a long-term goal in cancer therapy. The SOX18 transcription factor is a key regulator of murine and human blood vessel formation. Methods: We established allograft melanoma tumors in wild-type mice, Sox18-null mice, and mice expressing a dominant-negative form of Sox18 (Sox18RaOp) (n = 4 per group) and measured tumor growth and microvessel density by immunohistochemical analysis with antibodies to the endothelial marker CD31 and the pericyte marker NG2. We also assessed the affects of disrupted SOX18 function on MCF-7 human breast cancer and human umbilical vein endothelial cell (HUVEC) proliferation by measuring BrdU incorporation and by MTS assay, cell migration using Boyden chamber assay, and capillary tube formation in vitro. All statistical tests were two-sided. Results: Allograft tumors in Sox18-null and Sox18RaOp mice grew more slowly than those in wild-type mice (tumor volume at day 14, Sox18 null, mean = 486 mm(3), 95% confidence interval [CI] = 345 mm(3) to 627 mm(3), p = .004; Sox18RaOp, mean = 233 mm(3), 95% CI = 73 mm(3) to 119 mm(3), p < .001; versus wild-type, mean = 817 mm(3), 95% CI = 643 mm(3) to 1001 mm(3)) and had fewer CD31- and NG2-expressing vessels. Expression of dominant-negative Sox18 reduced the proliferation of MCF-7 cells (BrdU incorporation: MCF-7(Ra) = 20%, 95% CI = 15% to 25% versus MCF-7 = 41%, 95% CI = 35% to 45%; P = .013) and HUVECs (optical density at 490 nm, empty vector, mean = 0.46 versus SOX18 mean = 0.29; difference = 0.17, 95% CI = 0.14 to 0.19; P = .001) compared with control subjects. Overexpression of wild-type SOX18 promoted capillary tube formation of HUVECs in vitro, whereas expression of dominant-negative SOX18 impaired tube formation of HUVECs and the migration of MCF-7 cells via the disruption of the actin cytoskeleton. Conclusions: SOX18 is a potential target for antiangiogenic therapy of human cancers.

COMUNICAÇAO INTEGRADA DE MARKETING E AÇÕES DE PATROCÍNIO A EVENTOS: O EFEITO SINÉRGICO

Este trabalho enfoca a ação de patrocínio a eventos como ferramenta comunicacional, incorporada ao composto da comunicação de marketing. O principal objetivo é analisar e apresentar como as empresas usam e articulam as ferramentas da comunicação integrada de marketing às ações de patrocínio para se criar um efeito sinérgico de comunicação. A metodologia constitui-se em pesquisa bibliográfica e documental e o estudo de casos envolvendo as empresas Ambev, Petrobras e Bradesco com o patrocínio aos respectivos eventos: Skol Beats; Jogos Pan-americanos 2007 e o Espetáculo Saltimbanco do Cirque du Soleil, verificando como os aspectos teóricos foram apropriados em cada caso. As conclusões apontam, principalmente, que as empresas vêm buscando utilizar o potencial máximo de comunicação dos eventos não só ao promoverem, mas também na condição de patrocinadoras, e que o patrocínio deve ser parte de um plano integrado, no qual as ações estratégicas de comunicação de marketing, através das várias ferramentas que as constituem, podem e devem ser conjugadas para alcançar sinergia e valorizar as ações comunicacionais dos patrocinadores.(AU)

Politik och romantik : Muslimsk "kvinnlighet" förkroppsligad i slöjan

Många muslimska kvinnor utsatts för ett omfattande förtryck med våld som yttersta sanktion. Somliga skulle säga att alla muslimska kvinnor utsatts för förtryck. Återigen andra skule säga att överhuvudtaget alla kvinnor i majoriteten av världens kulturer i någon form är förtryckta. Debatten om kvinnors möjligheter och rättigheter har förts upp på den samhällspolitiska agendan och attraherar allt fler deltagare. I svensk samhällsdebatt ägnas den muslimska slöjan som symbol för repression ett relativt stort utrymme och engagerar människor på såväl akademisk, politisk som vardaglig nivå. Detta innefattar svenskar utan egna erfarenheter av utövande av islamiska påbud, svenska konvertiter utan erfarenheter av att leva i muslimska samhällen och muslimer vars erfarenheter har formatt dem att aktivt ta ställning mot slojan. I denna uppsats vill jag, utan normativa förtecken, låta två muslimska kvinnor med ett till synes mer positivt eller neutralt förhållande till slöjan komma till tals. Syftet ar att undersöka deras relation till slöjan och hur denna eventuellt förändras i en svensk kontext. Genom att ge kvinnornas berättelser om deras egen praktik och erfarenhet utrymme hoppas jälva och med andra informanter hade andra perspektiv på denna komplexa frågeställning hamnat i fokus.

Reliability, normative data, and the effect of age-related macular disease on the Eger Macular Stressometer photostress recovery time

Purpose: To assess repeatability and reproducibility, to determine normative data, and to investigate the effect of age-related macular disease, compared with normals, on photostress recovery time measured using the Eger Macular Stressometer (EMS). Method: The study population comprised 49 healthy eyes of 49 participants. Four EMS measurements were taken in two sessions separated by 1 h by two practitioners, with reversal of order in the second session. EMS readings were also taken from 17 age-related maculopathy (ARM), and 12 age-related macular degeneration (AMD), affected eyes. Results: EMS readings are repeatable to within ± 7 s. There is a statistically significant difference between controls and ARM affected eyes (t = 2.169, p = 0.045), and AMD affected eyes (t = 2.817, p = 0.016). The EMS is highly specific, and demonstrates sensitivity of 29% for ARM, and 50% for AMD. Conclusions: The EMS may be a useful screening test for ARM, however, direct illumination of the macula of greater intensity and longer duration may yield less variable results. © 2004 The College of Optometrists.

The use of counterfactual scenarios as a means to assess policy deadweight:an Irish case study

The evaluation of industrial policy interventions has attracted increasing policy and academic attention in recent years. Despite the widespread consensus regarding the need for evaluation, the issue of how to evaluate, and the associated methodological considerations, continue to be issues of considerable debate. The authors develop an approach to estimate the net additionality of financial assistance from Enterprise Ireland to indigenously owned firms in Ireland for the period 2000 to 2002. With a sample of Enterprise Ireland assisted firms, an innovative, self-assessment, in-depth, face-to-face, interview methodology was adopted. The authors also explore a way of incorporating the indirect benefits of assistance into derived deadweight estimate issue which is seldom discussed in the context of deadweight estimates. They conclude by reflecting on the key methodological lessons learned from the evaluation process, and highlight some pertinent evaluation issues which should form the focus of much future discussion in this field of research.

Effects of syllabic complexity in predicting accuracy of repetition and direction of errors in patients with articulatory and phonological difficulties

The purpose of this paper is to demonstrate the existence of a strong and significant effect of complexity in aphasia independent from other variables including length. Complexity was found to be a strong and significant predictor of accurate repetition in a group of 13 Italian aphasic patients when it was entered in a regression equation either simultaneously or after a large number of other variables. Significant effects were found both when complexity was measured in terms of number of complex onsets (as in a recent paper by Nickels & Howard, 2004) and when it was measured in a more comprehensive way. Significant complexity effects were also found with matched lists contrasting simple and complex words and in analyses of errors. Effects of complexity, however, were restricted to patients with articulatory difficulties. Reasons for this association and for the lack of significant results in Nickels and Howard (2004) are discussed. © 2005 Psychology Press Ltd.

The perceptual organization of sine-wave speech under competitive conditions

Speech comprises dynamic and heterogeneous acoustic elements, yet it is heard as a single perceptual stream even when accompanied by other sounds. The relative contributions of grouping “primitives” and of speech-specific grouping factors to the perceptual coherence of speech are unclear, and the acoustical correlates of the latter remain unspecified. The parametric manipulations possible with simplified speech signals, such as sine-wave analogues, make them attractive stimuli to explore these issues. Given that the factors governing perceptual organization are generally revealed only where competition operates, the second-formant competitor (F2C) paradigm was used, in which the listener must resist competition to optimize recognition [Remez et al., Psychol. Rev. 101, 129-156 (1994)]. Three-formant (F1+F2+F3) sine-wave analogues were derived from natural sentences and presented dichotically (one ear = F1+F2C+F3; opposite ear = F2). Different versions of F2C were derived from F2 using separate manipulations of its amplitude and frequency contours. F2Cs with time-varying frequency contours were highly effective competitors, regardless of their amplitude characteristics. In contrast, F2Cs with constant frequency contours were completely ineffective. Competitor efficacy was not due to energetic masking of F3 by F2C. These findings indicate that modulation of the frequency, but not the amplitude, contour is critical for across-formant grouping.

Systematic identification of small molecule adjuvants

Introduction: Adjuvants potentiate immune responses, reducing the amount and dosing frequency of antigen required for inducing protective immunity. Adjuvants are of special importance when considering subunit, epitope-based or more unusual vaccine formulations lacking significant innate immunogenicity. While numerous adjuvants are known, only a few are licensed for human use; principally alum, and squalene-based oil-in-water adjuvants. Alum, the most commonly used, is suboptimal. There are many varieties of adjuvant: proteins, oligonucleotides, drug-like small molecules and liposome-based delivery systems with intrinsic adjuvant activity being perhaps the most prominent. Areas covered: This article focuses on small molecules acting as adjuvants, with the author reviewing their current status while highlighting their potential for systematic discovery and rational optimisation. Known small molecule adjuvants (SMAs) can be synthetically complex natural products, small oligonucleotides or drug-like synthetic molecules. The author provides examples of each class, discussing adjuvant mechanisms relevant to SMAs, and exploring the high-throughput discovery of SMAs. Expert opinion: SMAs, particularly synthetic drug-like adjuvants, are amenable to the plethora of drug-discovery techniques able to optimise the properties of biologically active small molecules. These range from laborious synthetic modifications to modern, rational, effort-efficient computational approaches, such as QSAR and structure-based drug design. In principal, any property or characteristic can thus be designed in or out of compounds, allowing us to tailor SMAs to specific biological functions, such as targeting specific cells or pathways, in turn affording the power to tailor SMAs to better address different diseases.

30 years of retail change:where (and how) do you shop?

Purpose – The purpose of this paper is to investigate the extent of retail change in the UK grocery sector over the last 30 years. Design/methodology/approach – In 1980, a press article by Richard Milner and Patience Wheatcroft attempted to anticipate retail change by 1984. Taking that as a template, the paper examines how retail did, in fact, change over a much longer timescale: with some unanticipated innovations in place even by 1984. Reference is made to academic research on grocery retailing in progress at the time and which has recently been revisited. Findings – Although Milner and Wheatcroft tackled the modest task of looking ahead just four years, the content of their article is intriguingly reflective of the retail structure and systems of the UK at the time. Whilst some innovations were not anticipated, the broad themes of superstore power and market regulation still command attention 30 years on. Originality/value – Through reconsidering 30 years of retail change, the paper highlights that with time how do you shop has come to pose at least as interesting a question as where do you shop.