Ein Mann der Tat : zu Lag-boomer

M. Henes

Erlebnis und Tat : ein Wort über jüdische Mystik

Max Dienemann

Arthur Schnitzler [Rezension] : Der Geist im Wort und der Geist in der Tat

Heinrich York-Steiner

Wort und Tat : (Gedicht)

Jakob Loewenberg

Der Geist im Wort und der Geist in der Tat : Vorläufige Bemerkungen zu zwei Diagrammen

Arthur Schnitzler

Tat und Arbeit : (zum 10jährigen Bestehen des "Hapoel Hazair")

Israel Reichert

Guide de la section de l'état indépendant du Congo à l'exposition de Bruxelles-Tervueren en 1897

publ. sous la dir. de Liebrechts. Par les soins du Th. Masui

La civilisation africaine 1876 - 1888 : étude historique et critique de l'œuvre africaine, l'organisation intérieure et de l'économie politique de l'État indépendant du Congo

par Pierre Kassai͏̈

La fondation de l'état indépendant du Congo au point de vue juridique

par Gustave Moynier

Notice sur l'État Indépendant du Congo

par H. Droogmans

Les juifs d'Occident, où Recherches sur l'état civil, le commerce, et la littérature des Juifs en France, en Espagne et en Italie pendant la durée du moyen âge

par Arthur Beugnot

Félicien David, Buste Marbre, Commandé par l'État pour l'Opéra-Comique

Signatur des Originals: S 36/F12056

Traduction annotée d’un poème québécois

Emprender la traducción de un poema constituye un desafío que se revela apasionante pues nos exige construir un puente intercultural que nos permite acceder al universo profundo del otro. Esto es lo que nos proponemos hacer al abordar la traducción anotada de un poema que consideramos muy representativo del espíritu quebequense contemporáneo.

HIV-1 Tat protein mimicry of chemokines

The HIV-1 Tat protein is a potent chemoattractant for monocytes. We observed that Tat shows conserved amino acids corresponding to critical sequences of the chemokines, a family of molecules known for their potent ability to attract monocytes. Synthetic Tat and a peptide (CysL24–51) encompassing the “chemokine-like” region of Tat induced a rapid and transient Ca2+ influx in monocytes and macrophages, analogous to β-chemokines. Both monocyte migration and Ca2+ mobilization were pertussis toxin sensitive and cholera toxin insensitive. Cross-desensitization studies indicated that Tat shares receptors with MCP-1, MCP-3, and eotaxin. Tat was able to displace binding of β-chemokines from the β-chemokine receptors CCR2 and CCR3, but not CCR1, CCR4, and CCR5. Direct receptor binding experiments with the CysL24–51 peptide confirmed binding to cells transfected with CCR2 and CCR3. HIV-1 Tat appears to mimic β-chemokine features, which may serve to locally recruit chemokine receptor-expressing monocytes/macrophages toward HIV producing cells and facilitate activation and infection.

HIV-1 Tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter

In cells infected with HIV type 1 (HIV-1), the integrated viral promoter is present in a chromatin-bound conformation and is transcriptionally silent in the absence of stimulation. The HIV-1 Tat protein binds to a stem-loop structure at the 5′ end of viral mRNA and relieves this inhibition by inducing a remodeling of the nucleosome arrangement downstream of the transcription-initiation site. Here we show that Tat performs this activity by recruiting to the viral long terminal repeat (LTR) the transcriptional coactivator p300 and the closely related CREB-binding protein (CBP), having histone acetyltransferase (HAT) activity. Tat associates with HAT activity in human nuclear extracts and binds to p300 and CBP both in vitro and in vivo. Integrity of the basic domain of Tat is essential for this interaction. By a quantitative chromatin immunoprecipitation assay we show that the delivery of recombinant Tat induces the association of p300 and CBP with the chromosomally integrated LTR promoter. Expression of human p300 in both human and rodent cells increases the levels of Tat transactivation of the integrated LTR. These results reinforce the evidence that p300 and CBP have a pivotal function at both cellular and viral promoters and demonstrate that they also can be recruited by an RNA-targeted activator. Additionally, these findings have important implications for the understanding of the mechanisms of HIV-1 latency and reactivation.