Coev-web: a web platform designed to simulate and evaluate coevolving positions along a phylogenetic tree.

BACKGROUND: Available methods to simulate nucleotide or amino acid data typically use Markov models to simulate each position independently. These approaches are not appropriate to assess the performance of combinatorial and probabilistic methods that look for coevolving positions in nucleotide or amino acid sequences. RESULTS: We have developed a web-based platform that gives a user-friendly access to two phylogenetic-based methods implementing the Coev model: the evaluation of coevolving scores and the simulation of coevolving positions. We have also extended the capabilities of the Coev model to allow for the generalization of the alphabet used in the Markov model, which can now analyse both nucleotide and amino acid data sets. The simulation of coevolving positions is novel and builds upon the developments of the Coev model. It allows user to simulate pairs of dependent nucleotide or amino acid positions. CONCLUSIONS: The main focus of our paper is the new simulation method we present for coevolving positions. The implementation of this method is embedded within the web platform Coev-web that is freely accessible at http://coev.vital-it.ch/, and was tested in most modern web browsers.

L'informatique: un outil remarquable pour l'enseignement de la médecine interne générale [The informatics: a remarkable tool for teaching general internal medicine].

INTERMED training implies a three week course, integrated in the "primary care module" for medical students in the first master year at the school of medicine in Lausanne. INTERMED uses an innovative teaching method based on repetitive sequences of e-learning-based individual learning followed by collaborative learning activities in teams, named Team-based learning (TBL). The e-learning takes place in a web-based virtual learning environment using a series of interactive multimedia virtual patients. By using INTERMED students go through a complete medical encounter applying clinical reasoning and choosing the diagnostic and therapeutic approach. INTERMED offers an authentic experience in an engaging and safe environment where errors are allowed and without consequences.

A web-based tool to aid the identification of chemicals potentially posing a health risk through percutaneous exposure

Occupational hygiene practitioners typically assess the risk posed by occupational exposure by comparing exposure measurements to regulatory occupational exposure limits (OELs). In most jurisdictions, OELs are only available for exposure by the inhalation pathway. Skin notations are used to indicate substances for which dermal exposure may lead to health effects. However, these notations are either present or absent and provide no indication of acceptable levels of exposure. Furthermore, the methodology and framework for assigning skin notation differ widely across jurisdictions resulting in inconsistencies in the substances that carry notations. The UPERCUT tool was developed in response to these limitations. It helps occupational health stakeholders to assess the hazard associated with dermal exposure to chemicals. UPERCUT integrates dermal quantitative structure-activity relationships (QSARs) and toxicological data to provide users with a skin hazard index called the dermal hazard ratio (DHR) for the substance and scenario of interest. The DHR is the ratio between the estimated 'received' dose and the 'acceptable' dose. The 'received' dose is estimated using physico-chemical data and information on the exposure scenario provided by the user (body parts exposure and exposure duration), and the 'acceptable' dose is estimated using inhalation OELs and toxicological data. The uncertainty surrounding the DHR is estimated with Monte Carlo simulation. Additional information on the selected substances includes intrinsic skin permeation potential of the substance and the existence of skin notations. UPERCUT is the only available tool that estimates the absorbed dose and compares this to an acceptable dose. In the absence of dermal OELs it provides a systematic and simple approach for screening dermal exposure scenarios for 1686 substances.

Capturing user behavior in e-learning environments

Peer-reviewed

Telemedicina aplicada a la dismenorrea

En aquest projecte s’ha creat una aplicació d’ús mèdic que permet veure l’eficàcia dels tractament aplicats a pacient que pateixen de dismenorrea. Aquesta aplicació està dissenyada per a ser utilitzada per a dos tipus d’usuaris, el pacient que és l’encarregat d’introduir la informació sobre els seus símptomes en els moments que aquests apareixen, i l’investigador que analitza aquesta informació per a avaluar els tractaments utilitzats. L’aplicació consta d’un entorn amigable que facilita l’ús per part dels usuaris. La seva interfície web permet a l’investigador visualitzar les dades i exportar-les per a ser utilitzades en aplicacions estadístiques, i per altra banda, també ofereix la possibilitat al pacient de fer un seguiment de l’evolució dels seus símptomes a través de gràfiques.

Diseño de una aplicación web para la gestión de una revista científica

Este proyecto tiene como finalidad el análisis, diseño y desarrollo de una aplicación web en base a una revista científica. La mecánica de la revista consiste en la propia revisión y edición de los artículos por parte de los usuarios dados de alta en el aplicativo. Los usuarios que componen la web, puede tener diferentes perfiles: autor, editor, revisor, técnico editor y administrador. Cada usuario tiene unas tareas específicas en el flujo de revisión y edición. El proyecto se ha desarrollado sobre la plataforma ASP.NET y SQL para el diseño de la base de datos.

Usabilitat i disseny centrat en l'usuari : Pàgina web i intranet per serveis de manteniment d'equips mèdics

L'objectiu d'aquest projecte és millorar la situació actual del servei tècnic de reparació i manteniment d'equipament mèdic de l'Hospital Verge de la Cinta i dels centres d'atenció primària de Tortosa i crear unes interfícies clares, ordenades, fàcils i intuïtives per als usuaris, ja siguin els clients o els propis empleats, i que serviran de pont de comunicació amb el servidor central de l'organització on estarà tota la seva informació. Per crear les interfícies s'utilitzarà la metodologia del disseny centrat en l'usuari (DCU) i, a través d'un prototip, s'avaluaran les tasques que han de realitzar els usuaris (clients i empleats).

Disseny i implementació d'una pàgina web de subhastes

Amb la situació econòmica actual pot ser interessant poder vendre objectes que ja no s’utilitzen i també poder-ne comprar de segona mà. Amb aquesta idea sorgeix el projecte de crear una pàgina de subhastes online on la gent pugui comerciar amb les coses que ja no necessita. Tenint en compte el concepte inicial, el propietari de la pàgina no rebrà cap retribució ni percentatge de cada subhasta, tot l’import serà pel venedor. L’objectiu principal és el de poder oferir un lloc on després de registrar-se, els usuaris puguin veure i pujar per els articles que altres persones estan subhastant i també la possibilitat de crear les seves pròpies subhastes. Cada usuari disposarà d’un espai personal on veure les subhastes amb les que ha interactuat i així no perdre-les de vista i també on poder veure en cada moment l’estat de les subhastes que ha creat. La vista d’una subhasta s’actualitzarà automàticament sense haver de recarregar la pàgina i si algú puja durant l’últim minut la subhasta s’allargarà un minut més per evitar puges a l’últim moment i així maximitzar el preu final. Hi haurà un administrador que serà l’encarregat de gestionar el bon funcionament de la pàgina amb permís per afegir, editar, consultar i eliminar tota la informació disponible. Per portar a terme el projecte s’ha utilitzat PHP per la part de programació i MySQL com a sistema gestor de bases de dades.

Web-makrot ja käyttäjäautomaatio web-sovelluksessa: prototyypin suunnittelu ja toteutus

Tämän kandidaatintyön aiheena on web-sovelluksen käyttäjäautomaatio web-makrojen avulla. Työssä esitellään prototyyppitoteutus SaaS-sovellukseen kohdistetusta web-makrojärjestelmästä. Työn teoriaosa esittelee web-automaation ja web-ympäristön keskeisen teknologian. Ratkaisuosa pohjustaa ratkaisuun käytetyn lähestymistavan, esittelee työn prototyyppiratkaisun ja arvioi ratkaisun lopputulosta. Lopputuloksena havaitaan, että prototyyppiratkaisu onnistuu selvittämään makrotoiminnallisuuden toteuttamiseen liittyvät tekniset haasteet. Ratkaisun merkittävimmäksi tekniseksi haasteeksi arvioidaan selainyhteensopivuuden saavutus ja ylläpito. Ratkaisun hyödynnettävyys koko web-sovelluksen mittakaavassa todetaan kuitenkin heikoksi, koska sovelluksen liiketoimintalogiikka rajoittaa makroparadigman käyttöä.

Social media and public libraries : exploring information activities of library professionals and users

Social media has become a part of many people’s everyday lives. In the library field the adoption of social media has been widespread and discussions of the development of “Library 2.0” began at an early stage. The aim with this thesis is to study the interface between public libraries, social media, and users, focusing on information activities. The main research question is: How is the interface between public libraries and social media perceived and acted upon by its main stakeholders (library professionals and users)? The background of Library 2.0 is strongly associated with the development of the Web and social media, as well as with the public libraries and their user-centered and information technological development. The theoretical framework builds on the research within the area of Library and Information Science concerning information behavior, information practice, and information activities. Earlier research on social media and public libraries is also highlighted in this thesis. The methods survey and content analysis were applied to map the interface between social media and public libraries. A questionnaire was handed out to the users and another questionnaire was sent out to the library professionals. The results were statistically analyzed. In the content analysis public library Facebook pages were studied. All the empirical investigations were conducted in the area of Finland Proper. An integrated analysis of the results deepens the understanding of the key elements of the social media and public library context. These elements are interactivity, information activities, perceptions, and stakeholders. In this context seven information activities were distinguished: reading, seeking, creating, communicating, informing, mediating, and contributing. This thesis contributes to develop the research concerning information activities and draws a realistic picture of the challenges and opportunities in the social media and public library context. It also contributes with knowledge on library professionals and library users, and the existing differences in their perceptions of the interface between libraries and social media.

Useamman monitorin web-sovellukset: tekniset haasteet ja mahdollisuudet

Työssä tutkikaan, miten web-teknologiat soveltuvat usean monitorin sovelluksiin web-ympäristössä, ja todeta tähän liittyvät ongelmat sekä niiden mahdolliset ratkaisut teknisellä tasolla. Tutkituista teknologioista valitaan parhaiten soveltuva ratkaisu ja sen avulla luodaan usean monitorin sovellus, jonka avulla pureudutaan teknillisiin mahdollisuuksiin ja rajoitteisiin. Työn tuloksena nähdään, että usean monitorin web-sovellukset sisältävät monia ohjelmistoteknillisiä ongelmia ja ne sopivat lähinnä järjestelmiin, joiden ympäristö, esimerkiksi käyttöjärjestelmä tai selain, tiedetään. Tällöin voidaan turvautua käyttökokemusta parantaviin selaimen laajennuksiin tai ulkopuolisiin liitännäisiin, jotka toimivat kyseisessä ympäristössä.

Value co-creation in gaming the industry: A qualitative research on virtual discussion forums

This study discusses the procedures of value co-creation that persist in gaming industry. The purpose of this study was to identify the procedures that persist in current video gaming industry which answers the main research problem how value is co-created in video gaming industry followed by three sub questions: (i) What is value co-creation in gaming industry? (ii) Who participates in value co-creation in gaming industry? (iii) What are the procedures that are involved in value co-creation in gaming industry? The theoretical background of the study consists of literature relating to the theory of marketing i.e., notion of value, conventional understanding of value creation, value chain, co-creation approach, co-production approach. The research adopted qualitative research approach. As a platform of relationship researcher used web 2.0 tool interface. Data were collected from the social networks and netnography method was applied for analyzing them. Findings show that customer and company both co-create optimum level of value while they interact with each other and within the customers as well. However mostly the C2C interaction, discussions and dialogues threads that emerged around the main discussion facilitated to co-create value. In this manner, companies require exploiting and further motivating, developing and supporting the interactions between customers participating in value creation. Hierarchy of value co-creation processes is the result derived from the identified challenges of value co-creation approach and discussion forums data analysis. Overall three general sets and seven topics were found that explored the phenomenon of customer to customer (C2C) and business to customer (B2C) interaction/debating for value co-creation through user generated contents. These topics describe how gamer contributes and interacts in co-creating value along with companies. A methodical quest in current research literature acknowledged numerous evolving flows of value in this study. These are general management perspective, new product development and innovation, virtual customer environment, service science and service dominant logic. Overall the topics deliver various realistic and conceptual implications for using and handling gamers in social networks for augmenting customers’ value co-creation process.

Hacking User Experience in a Repository Service: ScholarSphere as a Case Study

Presentation at Open Repositories 2014, Helsinki, Finland, June 9-13, 2014

B2SHARE – Storing and Sharing Research Data

Poster at Open Repositories 2014, Helsinki, Finland, June 9-13, 2014

Micro Data Repositories: Increasing the Value of Research on the Web

Presentation at Open Repositories 2014, Helsinki, Finland, June 9-13, 2014