1000 resultados para administration
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1902/10 (N10).
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1900/04 (N4).
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1909/12 (N12).
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1904/06 (N6).
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1893/01 (N1).
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The analytical method developed to evaluate tamoxifen in dog plasma samples was precise, accurate, robust and linear in the range of 5-200 ng/mL. The limits of detection and quantification were 0.981 ng/mL and 2.97 ng/mL, respectively. Besides, the intra-day precision and accuracy variations were 8.78 and 10.16%, respectively. Tamoxifen concentrations were analyzed by combined reversed phase liquid chromatography and UV detection (lambda=280 nm). The study was conducted using an open randomized 2-period crossover balanced design with a 1-week washout period between the doses. This simple, rapid and selective method is suitable for pharmacokinetic, bioavailability and bioequivalence studies.
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IT outsourcing refers to the way companies focus on their core competencies and buy the supporting functions from other companies specialized in that area. Service is the total outcome of numerous of activities by employees and other resources to provide solutions to customers' problems. Outsourcing and service business have their unique characteristics. Service Level Agreements quantify the minimum acceptable service to the user. The service quality has to be objectively quantified so that its achievement or non-achievement of it can be monitored. Usually offshoring refers to the transferring of tasks to low-cost nations. Offshoring presents a lot of challenges that require special attention and they need to be assessed thoroughly. IT Infrastructure management refers to installation and basic usability assistance of operating systems, network and server tools and utilities. ITIL defines the industry best practices for organizing IT processes. This thesis did an analysis of server operations service and the customers’ perception of the quality of daily operations. The agreed workflows and processes should be followed better. Service providers’ processes are thoroughly defined but both the customer and the service provider might disobey them. Service provider should review the workflows regarding customer functions. Customer facing functions require persistent skill development, as they communicate the quality to the customer. Service provider needs to provide better organized communication and knowledge exchange methods between the specialists in different geographical locations.
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Webben är en enorm källa för information. Innehållet på webbsidorna är en synlig typ av information, men webben innehåller även information av en annan typ, en mera gömd typ i form av sambanden och nätverken som hyperlänkarna skapar mellan webbsajterna och –sidorna som de kopplar ihop. Forskningsområdet webometri ämnar, bland annat, att skapa ny kunskap ur denna gömda information som finns inbyggt i hyperlänkarna samt att skapa förståelse för hurudana fenomen och förhållanden utanför webben kan finnas representerade i hyperlänkarna. Målet med denna forskning var att öka förståelse för användningen av hyperlänkar på webben och speciellt kommunernas användning av hyperlänkar. Denna forskning undersökte hur kommunerna i Egentliga Finland skapade och mottog hyperlänkar samt hurudana nätverk formades av dessa hyperlänkar. Forskningen kartlade nätverk av direkta länkar mellan kommunerna och av samlänkar till och från kommunerna och undersökte ifall dessa nätverk kunde användas för att undersöka geopolitiska förhållanden och samarbete mellan kommunerna i Egentliga Finland. De övergripande forskningsfrågorna som har besvarats i denna forskning är: 1) Från ett webometriskt perspektiv, hur använder kommunerna i Egentliga Finland webben? 2) Kan hyperlänkar (direkta länkar och samlänkar) användas för att kartlägga geopolitiska förhållanden och samarbete mellan kommuner? 3) Vilka är de viktigaste motiveringarna för att skapa länkar mellan, till och från kommunernas webbsajter? Denna forskning kom till ovanligt tydliga resultat för en webometrisk forskning, både när det gäller upptäckta geografiska faktorer som påverkar hyperlänkningarna och de klassificerade motivationerna för att skapa länkarna. Resultaten visade att de direkta hyperlänkarna mellan kommunerna kan användas för att kartlägga geopolitiska förhållanden och samarbete mellan kommunerna för att de direkta länkarna var motiverade av officiella orsaker och de var klart påverkade av distansen mellan kommunerna och av de ekonomiska regionerna. Samlänkningarna in till kommunerna visade sig fungera som ett mått för geografisk likhet mellan kommunerna, medan samlänkningarna ut från kommunerna visade potential för att kunna användas till för att kartlägga kommunernas gemensamma intressen. Forskningen kontribuerade även till utvecklandet av forskningsområdet webometri. En del av de viktigaste kontributionerna av denna forskning var utvecklandet av nya metoder för webometrisk forskning samt att öka kunskap om hur existerande metoder från nätverksanalys kan användas effektivt för webometrisk forskning. Resultaten från denna forskning och de utvecklade metoderna kan användas för snabba kartläggningar av diverse förhållanden mellan olika organisationer och företag genom att använda information gratis tillgängligt på webben.
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Probiotic bifidobacteria are used in the prevention and treatment of childhood diseases. On the other hand, these bacteria are also connected to dental caries. The purpose of the present work was to test a food supplement containing Bifidobacterium animalis subsp. lactis BB-12 (B. lactis BB-12) and xylitol, and to investigate its health effects, properties and safety when used in a novel pacifier in early childhood. In a double-blind, placebo-controlled trial, newborn infants (n=163) were assigned randomly to receive B. lactis BB-12, xylitol, or sorbitol from the age of 1– 2 monthsto 2 years with a pacifier or a spoon. Children were followed up to four years of age. A part of the parents participating in the clinical trial evaluated the feasibility of the novel administration method. The pattern of tablet release from the pouch of the pacifier was tested in adults. The food supplement tablet containing B. lactis BB-12 and xylitol could be delivered in a safe and controlled way with the novel pacifier. The early administration of B. lactis BB-12 did not result in permanent oral colonization of this probiotic or affect the colonization of mutans streptococci in early childhood. Moreover, B. lactis BB-12 did not increase the occurrence of caries. Controlled administration of B. lactis BB-12 significantly reduced the incidence of respiratory infections during the first eight months of life in a Finnish population with breastfed infants. To conclude, administration of B. lactis BB-12 in early childhood is safe with regard to the future dental health of the child. In addition, B. lactis BB-12 may add to the protection against respiratory infections provided by human breast milk in infancy.
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Alumni are considered as precious resource of the institutions, thus improving alumni adminis-tration is critical. In information era, alumni administration is assisted by widespread information technology, such as social network sites. This paper aims to discover if a self-built information sys-tem would enhance alumni connection in the IMMIT context, and what kind of attributes would be helpful applying to the special context. The current online alumni services at other universities and at the IMMIT host university are analyzed, and then social media is introduced. After illustrating the social capital existing in IM-MIT, the type of the self-built information system is suggested, following an interpretation of the prototype. Two research models are utilized in this article: TAM and intentional social action model. The second model is adjusted with proposed parameters. Afterwards, a survey and an interview protocol are designed under the guidance of the models. The results are analyzed in several groups, and the proposed parameters are tested. A conclusion is drawn to indicate how to improve alumni‟s intention to use and how to achieve a better-accepted design.
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The immunodetection of diverse cell markers was evaluated in prostatic samples from bullocks, and bullocks showing epithelial hyperplasia-metaplasia, with oestrogen-induced changes, and in experimental samples from bullocks inoculated with dietylstilbestrol (DES). Antigen-retrieval procedures allowed the use of tissues that had been fixed in formalin for long periods. Three tissue markers were chosen for the study: cytokeratins 13 and 16, vimentin and desmin. Monoclonal antibody K8.12 (specific for cytokeratins 13 and 16) stained basal cells and hyperplastic-metaplastic epithelium; monoclonal antivimentin, and desmin, allowed the definition of fibromuscular changes.
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The efficacy of a polyvalent bacterin vaccine against Aeromonas hydrophila, Pseudomonas aeroginosa and Enterococcus durans administered by different routes in Nile tilapia was assessed by analyzing hematological and immunological parameters 7 and 21 days after vaccination. Treatments consisted of: non-vaccinated tilapia; tilapia vaccinated by intraperitoneal injection with 2x10(8) formalin-inactivated bacteria·mL-1; tilapia vaccinated orally with 2x10(7) formalin-inactivated bacteria·g-1, feed for 5 days; tilapia vaccinated by immersion bath in 2x10(7) formalin-inactivated bacteria·mL-1, for 20 minutes. Vaccinated fish groups presented higher hematocrit, number of erythrocytes and leukocytes than the non-vaccinated group. Serum agglutination titer of intraperitoneally vaccinated fish was higher on both evaluation periods for the three bacteria strains. Only on day 21 post-vaccination fish from the oral and immersion vaccination groups presented higher serum agglutination titer than the non-vaccinated fish for A. hidrophyla and E. durans. Serum antimicrobial activity in vaccinated fish was higher for P. aeroginosa and E. coli than in non-vaccinated fish on both evaluation periods. The different vaccine administration routes stimulated hematological and immunological responses in Nile tilapia 21 days post-vaccination, but intraperitoneal vaccination presented higher total number of leukocytes, lymphocytes and serum agglutination titer.