MEG networks organization is related to white matter integrity

Many studies have assessed the characterization of anatomical or functional connectivity in mild cognitive impairment (MCI), however it is still unknown how they are related in the course of the pathology. Here we integrate the analysis of magnetoencephalographic (MEG) data with white matter (WM) integrity quantification from diffusion weighted imaging (DWI), to asses whether the damage in the WM tracts disrupt the organization of the functional networks.

Building lean thinking in a telecom software development organization: strengths and challenges.

The potential shown by Lean in different domains has aroused interest in the software industry. However, it remains unclear how Lean can be effectively applied in a domain such as software development that is fundamentally different from manufacturing. This study explores how Lean principles are implemented in software development companies and the challenges that arise when applying Lean Software Development. For that, a case study was conducted at Ericsson R&D Finland, which successfully adopted Scrum in 2009 and subsequently started a comprehensible transition to Lean in 2010. Focus groups were conducted with company representatives to help devise a questionnaire supporting the creation of a Lean mindset in the company (Team Amplifier). Afterwards, the questionnaire was used in 16 teams based in Finland, Hungary and China to evaluate the status of the transformation. By using Lean thinking, Ericsson R&D Finland has made important improvements to the quality of its products, customer satisfaction and transparency within the organization. Moreover, build times have been reduced over ten times and the number of commits per day has increased roughly five times.The study makes two main contributions to research. First, the main factors that have enabled Ericsson R&D?s achievements are analysed. Elements such as ?network of product owners?, ?continuous integration?, ?work in progress limits? and ?communities of practice? have been identified as being of fundamental importance. Second, three categories of challenges in using Lean Software Development were identified: ?achieving flow?, ?transparency? and ?creating a learning culture?

Advanced system of planning and organization of classes at the university

This document is the result of a process of web development to create a tool that will allow to Cracow University of Technology consult, create and manage timetables. The technologies chosen for this purpose are Apache Tomcat Server, My SQL Community Server, JDBC driver, Java Servlets and JSPs for the server side. The client part counts on Javascript, jQuery, AJAX and CSS technologies to perform the dynamism. The document will justify the choice of these technologies and will explain some development tools that help in the integration and development of all this elements: specifically, NetBeans IDE and MySQL workbench have been used as helpful tools. After explaining all the elements involved in the development of the web application, the architecture and the code developed are explained through UML diagrams. Some implementation details related to security are also deeper explained through sequence diagrams. As the source code of the application is provided, an installation manual has been developed to run the project. In addition, as the platform is intended to be a beta that will be grown, some unimplemented ideas for future development are also exposed. Finally, some annexes with important files and scripts related to the initiation of the platform are attached. This project started through an existing tool that needed to be expanded. The main purpose of the project along its development has focused on setting the roots for a whole new platform that will replace the existing one. For this goal, it has been needed to make a deep inspection on the existing web technologies: a web server and a SQL database had to be chosen. Although the alternatives were a lot, Java technology for the server was finally selected because of the big community backwards, the easiness of modelling the language through UML diagrams and the fact of being free license software. Apache Tomcat is the open source server that can use Java Servlet and JSP technology. Related to the SQL database, MySQL Community Server is the most popular open-source SQL Server, with a big community after and quite a lot of tools to manage the server. JDBC is the driver needed to put in contact Java and MySQL. Once we chose the technologies that would be part of the platform, the development process started. After a detailed explanation of the development environment installation, we used UML use case diagrams to set the main tasks of the platform; UML class diagrams served to establish the existing relations between the classes generated; the architecture of the platform was represented through UML deployment diagrams; and Enhanced entity–relationship (EER) model were used to define the tables of the database and their relationships. Apart from the previous diagrams, some implementation issues were explained to make a better understanding of the developed code - UML sequence diagrams helped to explain this. Once the whole platform was properly defined and developed, the performance of the application has been shown: it has been proved that with the current state of the code, the platform covers the use cases that were set as the main target. Nevertheless, some requisites needed for the proper working of the platform have been specified. As the project is aimed to be grown, some ideas that could not be added to this beta have been explained in order not to be missed for future development. Finally, some annexes containing important configuration issues for the platform have been added after proper explanation, as well as an installation guide that will let a new developer get the project ready. In addition to this document some other files related to the project are provided: - Javadoc. The Javadoc containing the information of every Java class created is necessary for a better understanding of the source code. - database_model.mwb. This file contains the model of the database for MySQL Workbench. This model allows, among other things, generate the MySQL script for the creation of the tables. - ScheduleManager.war. The WAR file that will allow loading the developed application into Tomcat Server without using NetBeans. - ScheduleManager.zip. The source code exported from NetBeans project containing all Java packages, JSPs, Javascript files and CSS files that are part of the platform. - config.properties. The configuration file to properly get the names and credentials to use the database, also explained in Annex II. Example of config.properties file. - db_init_script.sql. The SQL query to initiate the database explained in Annex III. SQL statements for MySQL initialization. RESUMEN. Este proyecto tiene como punto de partida la necesidad de evolución de una herramienta web existente. El propósito principal del proyecto durante su desarrollo se ha centrado en establecer las bases de una completamente nueva plataforma que reemplazará a la existente. Para lograr esto, ha sido necesario realizar una profunda inspección en las tecnologías web existentes: un servidor web y una base de datos SQL debían ser elegidos. Aunque existen muchas alternativas, la tecnología Java ha resultado ser elegida debido a la gran comunidad de desarrolladores que tiene detrás, además de la facilidad que proporciona este lenguaje a la hora de modelarlo usando diagramas UML. Tampoco hay que olvidar que es una tecnología de uso libre de licencia. Apache Tomcat es el servidor de código libre que permite emplear Java Servlets y JSPs para hacer uso de la tecnología de Java. Respecto a la base de datos SQL, el servidor más popular de código libre es MySQL, y cuenta también con una gran comunidad detrás y buenas herramientas de modelado, creación y gestión de la bases de datos. JDBC es el driver que va a permitir comunicar las aplicaciones Java con MySQL. Tras elegir las tecnologías que formarían parte de esta nueva plataforma, el proceso de desarrollo tiene comienzo. Tras una extensa explicación de la instalación del entorno de desarrollo, se han usado diagramas de caso de UML para establecer cuáles son los objetivos principales de la plataforma; los diagramas de clases nos permiten realizar una organización del código java desarrollado de modo que sean fácilmente entendibles las relaciones entre las diferentes clases. La arquitectura de la plataforma queda definida a través de diagramas de despliegue. Por último, diagramas EER van a definir las relaciones entre las tablas creadas en la base de datos. Aparte de estos diagramas, algunos detalles de implementación se van a justificar para tener una mejor comprensión del código desarrollado. Diagramas de secuencia ayudarán en estas explicaciones. Una vez que toda la plataforma haya quedad debidamente definida y desarrollada, se va a realizar una demostración de la misma: se demostrará cómo los objetivos generales han sido alcanzados con el desarrollo actual del proyecto. No obstante, algunos requisitos han sido aclarados para que la plataforma trabaje adecuadamente. Como la intención del proyecto es crecer (no es una versión final), algunas ideas que se han podido llevar acabo han quedado descritas de manera que no se pierdan. Por último, algunos anexos que contienen información importante acerca de la plataforma se han añadido tras la correspondiente explicación de su utilidad, así como una guía de instalación que va a permitir a un nuevo desarrollador tener el proyecto preparado. Junto a este documento, ficheros conteniendo el proyecto desarrollado quedan adjuntos. Estos ficheros son: - Documentación Javadoc. Contiene la información de las clases Java que han sido creadas. - database_model.mwb. Este fichero contiene el modelo de la base de datos para MySQL Workbench. Esto permite, entre otras cosas, generar el script de iniciación de la base de datos para la creación de las tablas. - ScheduleManager.war. El fichero WAR que permite desplegar la plataforma en un servidor Apache Tomcat. - ScheduleManager.zip. El código fuente exportado directamente del proyecto de Netbeans. Contiene todos los paquetes de Java generados, ficheros JSPs, Javascript y CSS que forman parte de la plataforma. - config.properties. Ejemplo del fichero de configuración que permite obtener los nombres de la base de datos - db_init_script.sql. Las consultas SQL necesarias para la creación de la base de datos.

Cognitive reserve is associated with the functional organization of brain networks in healthy aging: a MEG study

The proportion of elderly people in the population has increased rapidly in the last century and consequently "healthy aging" is expected to become a critical area of research in neuroscience. Evidence reveals how healthy aging depends on three main behavioral factors: social lifestyle, cognitive activity and physical activity. In this study, we focused on the role of cognitive activity, concentrating specifically on educational and occupational attainment factors, which were considered two of the main pillars of cognitive reserve. 21 subjects with similar rates of social lifestyle, physical and cognitive activity were selected from a sample of 55 healthy adults. These subjects were divided into two groups according to their level of cognitive reserve; one group comprised subjects with high cognitive reserve (9 members) and the other contained those with low cognitive reserve (12 members). To evaluate the cortical brain connectivity network, all participants were recorded by Magnetoencephalography (MEG) while they performed a memory task (modified version of the Sternberg¿s Task). We then applied two algorithms (Phase Locking Value & Phase-Lag Index) to study the dynamics of functional connectivity. In response to the same task, the subjects with lower cognitive reserve presented higher functional connectivity than those with higher cognitive reserve. These results may indicate that participants with low cognitive reserve needed a greater 'effort' than those with high cognitive reserve to achieve the same level of cognitive performance. Therefore, we conclude that cognitive reserve contributes to the modulation of the functional connectivity patterns of the aging brain.

A Provenance Aware Linked Data Application for Trip Management and Organization

We present El Viajero, an application for exploiting, managing and organizing Linked Data in the domain of news and blogs about travelling. El Viajero makes use of several heterogeneous datasets to help users to plan future trips, and relies on the Open Provenance Model for modeling the provenance information of the resources

Marketing and Sales organization in a “Brand-Focused Professional” multinational

This article tests a multidimensional model of the marketing and sales organizational interface, based on a previous one tested for European companies (Homburg et al., 2008), in a specific taxonomical configuration: a brand focused professional multinational, in three successful Latin American branches. Factor reliability and hypotheses were studied through a confirmatory factor analysis. Results show the existence of a positive relationship between formalization, joint planning, teamwork, information sharing, trust and interface quality. Interface quality and business performance show also a positive relationship. This empirical study contributes to the knowledge of the organizational enhancement of interactions in emerging markets

The genera of recent Mollusca: arranged according to their organization. By Henry Adams...and Arthur Adams.

1

CONSOLIDAÇÃO OU MUDANÇA? UMA ANÁLISE FEMINISTA DA PASTORAL DA CRIANÇA

O objetivo central desta tese é investigar o potencial de transformação social da organização não-governamental, ligada a CNBB(Confederação Nacional dos Bispos do Brasil).- Pastoral da Criança - para a libertação de mulheres que lá atuam, das relações de dominação e opressões inerentes ao contexto kyriarchal. Esta pesquisa procura considerar o espaço religioso subjacente à organização em decorrência das influências das CEBs (Comunidades Eclesiais de Base) e do MRCC (Movimento de Renovação Católica Carismática). É feita pesquisa de campo na região de Curitiba com observações e entrevistas semi-estruturadas com doze mulheres atuando na Pastoral da Criança, valorizando-se a relação intersubjetiva entre pesquisadora e pessoas envolvidas na pesquisa. A análise qualitativa de dados em relação ao marco teórico feminista desenvolvido em Ciências Sociais pela sociologia, psicanálise e também a teologia, mostra o discurso das representações sociais das mulheres envolvidas, a percepção de suas próprias identidades e a importância da organização na construção de suas vidas. Nos traz a conclusão que a organização reproduz o perfil tradicional de mulheres na função materna e facilita a formação de redes comunitárias. Averigua-se que a Pastoral da Criança está vinculada ao sistema neoliberal de pensamento que reproduz os discursos de dominação do sistema kyriarchal da hierarquia da Igreja Católica e da medicina higienista. Essas instituições de apropriam da vida e dos corpos das mulheres e os reduzem às suas funções meramente biológicas, reprodutivas e de cuidados. A Pastoral da Criança é caracterizada por atividades que não consideram as causas estruturais da pobreza, mas apenas tentam amenizar os seus efeitos e conseqüências. Em suas capacitações, a organização usa a forma bancária de educação que reproduz as relações de dominação e dependência de mulheres pobres. A organização, mesmo com a estrutura da ideologia religiosa analisada, não está vinculada sistematicamente em um espaço religioso. Sugere-se em relação à situação da organização, a abertura das idéias e valores feministas nos campos da saúde e religião a fim de promover a libertação e empoderamento reais de mulheres pobres. Esta recomendação está ligada com a abertura, a necessidade de reflexão e de conhecimento, mostradas pelas mulheres entrevistadas durante a pesquisa de campo. Considera-se como limitação aos resultados da pesquisa, o local pesquisado por não ter influências de movimentos sociais.(AU)

A mulher sábia e a sabedoria mulher símbolos de co-inspiração Um estudo sobre a mulher em textos de Provérbios

Nos textos de Provérbios 1,20-23; 8 e 9, encontra-se o instigante símbolo da sabedoria mulher, que possui uma longa e controvertida história de interpretação. Ao analisar as ligações textuais entre estes textos e o poema de Pr 31, descobrimos que o símbolo da sabedoria mulher inspira-se na mulher da vida real, que participa corajosamente na reconstrução da história e das relações do povo de Judá, no período pós-exílico. Estas ligações desvelam uma grande valorização da mulher e sua proximidade com Deus ao apresentá- la com o poder de oferecer vida (Pr 8,35; 9,6) e de cuidá-la (Pr 31), vivenciando e transmitindo valores éticos fundamentais para as relações cotidianas da casa (Pr 1,8; 6,20; 31,2-9.26). Este símbolo carrega ainda a memória de antigos cultos realizados na casa para celebrar e garantir a vida. Embora estes rituais contivessem a memória de Deusas, eles não eram opostos ao culto de Javé, pois, dentro da dinâmica da casa, estavam inteiramente integrados na religião de Israel pela priorização da vida e pela prática da jus tiça. Esses textos de Provérbios atestam uma grande mudança na visão da mulher. A origem desta nova visão encontra-se na época do cativeiro, quando já não havia templo e nem um governo que canalizasse a organização do povo e sua luta pela libertação. A casa passa a ter funções de prover a subsistência e de transmitir as tradições religiosas do povo bíblico com a finalidade de obter a inspiração e a força necessárias para garantir o futuro. Na casa interiorana, a mulher tem autoridade e liderança, apesar dos preconceitos da sociedade patriarcal. É no pequeno espaço da casa judaíta que o movimento da sabedoria mulher situa-se, gerando relações de inclusão e de solidariedade, na época da dominação do 2º templo, com suas normas sobre a impureza.(AU)

A mulher sábia e a sabedoria mulher símbolos de co-inspiração Um estudo sobre a mulher em textos de Provérbios

Nos textos de Provérbios 1,20-23; 8 e 9, encontra-se o instigante símbolo da sabedoria mulher, que possui uma longa e controvertida história de interpretação. Ao analisar as ligações textuais entre estes textos e o poema de Pr 31, descobrimos que o símbolo da sabedoria mulher inspira-se na mulher da vida real, que participa corajosamente na reconstrução da história e das relações do povo de Judá, no período pós-exílico. Estas ligações desvelam uma grande valorização da mulher e sua proximidade com Deus ao apresentá- la com o poder de oferecer vida (Pr 8,35; 9,6) e de cuidá-la (Pr 31), vivenciando e transmitindo valores éticos fundamentais para as relações cotidianas da casa (Pr 1,8; 6,20; 31,2-9.26). Este símbolo carrega ainda a memória de antigos cultos realizados na casa para celebrar e garantir a vida. Embora estes rituais contivessem a memória de Deusas, eles não eram opostos ao culto de Javé, pois, dentro da dinâmica da casa, estavam inteiramente integrados na religião de Israel pela priorização da vida e pela prática da jus tiça. Esses textos de Provérbios atestam uma grande mudança na visão da mulher. A origem desta nova visão encontra-se na época do cativeiro, quando já não havia templo e nem um governo que canalizasse a organização do povo e sua luta pela libertação. A casa passa a ter funções de prover a subsistência e de transmitir as tradições religiosas do povo bíblico com a finalidade de obter a inspiração e a força necessárias para garantir o futuro. Na casa interiorana, a mulher tem autoridade e liderança, apesar dos preconceitos da sociedade patriarcal. É no pequeno espaço da casa judaíta que o movimento da sabedoria mulher situa-se, gerando relações de inclusão e de solidariedade, na época da dominação do 2º templo, com suas normas sobre a impureza.(AU)

Chromophore-assisted light inactivation and self-organization of microtubules and motors

Chromophore-assisted light inactivation (CALI) offers the only method capable of modulating specific protein activities in localized regions and at particular times. Here, we generalize CALI so that it can be applied to a wider range of tasks. Specifically, we show that CALI can work with a genetically inserted epitope tag; we investigate the effectiveness of alternative dyes, especially fluorescein, comparing them with the standard CALI dye, malachite green; and we study the relative efficiencies of pulsed and continuous-wave illumination. We then use fluorescein-labeled hemagglutinin antibody fragments, together with relatively low-power continuous-wave illumination to examine the effectiveness of CALI targeted to kinesin. We show that CALI can destroy kinesin activity in at least two ways: it can either result in the apparent loss of motor activity, or it can cause irreversible attachment of the kinesin enzyme to its microtubule substrate. Finally, we apply this implementation of CALI to an in vitro system of motor proteins and microtubules that is capable of self-organized aster formation. In this system, CALI can effectively perturb local structure formation by blocking or reducing the degree of aster formation in chosen regions of the sample, without influencing structure formation elsewhere.

Dehydroepiandrosterone: A potential signalling molecule for neocortical organization during development

Dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEAS) are the most abundant steroids produced by the human adrenal, but no receptors have been identified for these steroids, and no function for them has been established, other than as precursors for sex steroid synthesis. DHEA and DHEAS are found in brains from many species, and we have shown that enzymes crucial for their synthesis, especially P450c17 (17α-hydroxylase/c17,20 lyase), are expressed in a developmentally regulated, region-specific fashion in the developing rodent brain. One region of embryonic expression of P450c17, the neocortical subplate, has been postulated to play a role in guiding cortical projections to their appropriate targets. We therefore determined if products of P450c17 activity, DHEA and DHEAS, regulated the motility and/or growth of neocortical neurons. In primary cultures of mouse embryonic neocortical neurons, DHEA increased the length of neurites containing the axonal marker Tau-1, and the incidence of varicosities and basket-like process formations in a dose-dependent fashion. These effects could be seen at concentrations normally found in the brain. By contrast, DHEAS had no effect on Tau-1 axonal neurites but increased the length of neurites containing the dendritic marker microtubule-associated protein-2. DHEA rapidly increased free intracellular calcium via activation of N-methyl-d-aspartate (NMDA) receptors. These studies provide evidence of mechanisms by which DHEA and DHEAS exert biological actions, show that they have specific functions other than as sex steroid precursors, mediate their effects via non-classic steroid hormone receptors, and suggest that their developmentally regulated synthesis in vivo may play crucial and different roles in organizing the neocortex.

Supramolecular organization of immature and mature murine leukemia virus revealed by electron cryo-microscopy: Implications for retroviral assembly mechanisms

We have used electron cryo-microscopy and image analysis to examine the native structure of immature, protease-deficient (PR−) and mature, wild-type (WT) Moloney murine leukemia virus (MuLV). Maturational cleavage of the Gag polyprotein by the viral protease is associated with striking morphological changes. The PR− MuLV particles exhibit a rounded central core, which has a characteristic track-like shell on its surface, whereas the WT MuLV cores display a polygonal surface with loss of the track-like feature. The pleomorphic shape and inability to refine unique orientation angles suggest that neither the PR− nor the WT MuLV adheres to strict icosahedral symmetry. Nevertheless, the PR− MuLV particles do exhibit paracrystalline order with a spacing between Gag molecules of ≈45 Å and a length of ≈200 Å. Because of the pleomorphic shape and paracrystalline packing of the Gag–RNA complexes, we raise the possibility that assembly of MuLV is driven by protein–RNA, as well as protein–protein, interactions. The maturation process involves a dramatic reorganization of the packing arrangements within the ribonucleoprotein core with disordering and loosening of the individual protein components.