Multimarket contact externalities: the effect of rival's multimarket contacts on focal firm performance

Given that firms develop their activities in a network of multiple players, interfirm rivalry is not only a matter of direct competitors, but also of indirect competition. In spite of this, the literature on competitive dynamics tends to focus on analyzing rivalry as an exclusive function of the competitive relationship between a focal firm and its direct rivals. In this article, we extend competitive dynamics literature by considering how focal firms are affected by the relationships of their rivals with third-party firms. Specifically, we study the effect that the multimarket contacts of rivals produces on the performance of the focal firm. Additionally, we incorporate the idea that there are different strategic options for operating in an industry that affect the intensity of multimarket contact externalities. Our results show that multimarket contact among firms causes externalities that indirectly affect firms that are not directly involved in this competitive relationship. We find that multimarket contact externalities differ between and within strategic groups.

Market rewards to patterns on increasing earnings: do cash flow patterns, accruals manipulation and real activities manipulation matter?

This study explores whether firms have differential price-earnings multiples associated with their means of achieving a sequential pattern of increasing positive earnings. Our main findings show that market participants assign higher price-earnings multiples to firms when their pattern of increasing earnings is supported by the same pattern of increasing cash flows. Market participants assign lower price-earnings multiples to firms suspect of having engaged in accrual-based earnings management, sales manipulation, and overproduction to achieve the earnings pattern. We find, however, that market participants do not penalize firms suspect of having achieved the earnings pattern through the opportunistic reduction of discretionary expenses.

Improving gene annotation using peptide mass spectrometry

Annotation of protein-coding genes is a key goal of genome sequencing projects. In spite of tremendous recent advances in computational gene finding, comprehensive annotation remains a challenge. Peptide mass spectrometry is a powerful tool for researching the dynamic proteome and suggests an attractive approach to discover and validate protein-coding genes. We present algorithms to construct and efficiently search spectra against a genomic database, with no prior knowledge of encoded proteins. By searching a corpus of 18.5 million tandem mass spectra (MS/MS) from human proteomic samples, we validate 39,000 exons and 11,000 introns at the level of translation. We present translation-level evidence for novel or extended exons in 16 genes, confirm translation of 224 hypothetical proteins, and discover or confirm over 40 alternative splicing events. Polymorphisms are efficiently encoded in our database, allowing us to observe variant alleles for 308 coding SNPs. Finally, we demonstrate the use of mass spectrometry to improve automated gene prediction, adding 800 correct exons to our predictions using a simple rescoring strategy. Our results demonstrate that proteomic profiling should play a role in any genome sequencing project.

Early Cretaceous radiolarians of the Northeast Indian Ocean (leg 123 - site 765, site 766 and dsdp site 261) - The Antarctic-Tethys connection

During ODP Leg 123, abundant and well-preserved Neocomian radiolarians were recovered at Site 765 (Argo Abyssal Plain) and Site 766 (lower Exmouth Plateau). Assemblages are characterized by the numerical dominance of a small number of non-tethyan forms and by the scarcity of tethyan taxa. Remarkable contrasts exist between radiolarian assemblages extracted from claystones of Site 765 and reexamined DSDP Site 26 1, and faunas recovered from radiolarian sand layers, only found at Site 765. Clay faunas are unusual in their low diversity of apparently ecologically tolerant (or solution resistant?), ubiquist species, whereas sand faunas are dominated by non-tethyan taxa. Comparisons with Sites 766 and 26 1, as well as sedimentological observations, lead to the conclusion that this faunal contrast resulted from a difference in provenance, rather than from hydraulic sorting or selective dissolution. The ranges of 27 tethyan taxa from Site 765 were compared to the tethyan radiolarian zonation by Jud (1992) by means of the Unitary Associations Method. This calculation allows to directly date the Site 765 assemblages and to estimate the amount of truncation of ranges for tethyan taxa. Over 70% of the already few tethyan species of Site 765, have truncated ranges during the Valanginian-Hauterivian. Radiolarian assemblages recovered from claystones at Sites 765 and 261 in the Argo Basin apparently reflect restricted oceanic conditions during the latest Jurassic-Barremian. Neither sedimentary facies nor faunal associations bear any resemblance to what we know from typical tethyan sequences. We conclude that the Argo Basin was paleoceanographically separated from the Tethys during the Late Jurassic and part of the Early Cretaceous by its position at higher paleolatitudes and/or by enclosing land masses. Assemblages recovered from radiolarian sand layers are dominated by non-tethyan species that are interpreted as circumantarctic. Their first appearance in the late Berriasian-early Valanginian predates the oceanization of the Indo-Australian breakup (M11, late Valanginian), but coincides with a sharp increase in margin-derived pelagic turbidites. The Indo-Australian rift zone and the adjacent margins must have been submerged deeply enough to allow an intermittent influx of circumantarctic cold water into the Argo Basin, creating increased bottom current activity. Cold-water radiolarians carried into the Argo Basin upwelled along the margin, died, and accumulated in radiolarite layers due to winnowing by bottom currents. High rates of faunal change and the sharp increase of bottom current activity are thought to be synchronous with possible pronounced late Berriasian-early Valanginian lowstands in sea level. Hypothetically, both phenomena might have been.caused by a tendency to glaciation on the Antarctic-Australian continent, which was for the first time isolated from the rest of Gondwana by oceanic seaways as a result of Jurassic-Early Cretaceous sea-floor spreading. The absence of most typical tethyan radiolarian species during the Valanginian-Hauterivian is interpreted as reflecting a time of strong influx of circumantarctic cold water following oceanization (M11) and rapid spreading between Southeast India and West Australia. The reappearance and gradual abundance/diversity increase of tethyan taxa, along with the still dominant circumantarctic species are thought to result from overall more equitable climatic conditions during the Barremian-early Aptian and from the establishment of an oceanic connection with the Tethys Ocean during the early Aptian.

La Gestió econòmico-empresarial d'un club de futbol

Hi ha records que perduraran sempre; el gol d’Iniesta contra el Chelsea, la boleia de Zidane a Hampden Park… Aquests moments memorables que queden gravats a les retines de tots nosaltres i produeixen una immensa felicitat a l’ésser humà, que l’emocionen, que el fan casi plorar. Tot això es produeix gràcies a un esport de masses molt present en les nostres vides, el futbol. Una activitat merament esportiva que s’ha convertit, amb el pas dels anys, en quelcom més que un esport, ha travessat l’àmbit purament sentimental d’una regió fins a assolir nivells d’autèntica globalització arreu del món. I és precisament el fet que el futbol porta una immensa passió a tots els racons de la societat, el que fa plantejar-nos el funcionament d’aquesta gran indústria de l’entreteniment.La realitat, tanmateix, revela l’existència de tot un món econòmico-empresarial que s’amaga darrere aquest espectacle, del qual, els veritables protagonistes són els clubs de futbol. Sense ells no es produiria mai l’espectacle. És per aquest motiu, que centrarem el nostre anàlisi sobre aquestes entitats esportives: veure el seu funcionament en la seva vessant més econòmica (1).En el present estudi s’analitzarà tot el funcionament intern d’un club, des del seu marc legal fins a l’econòmic, parant molta atenció en el que és el mercat futbolístic, el qual, al cap i a la fi, acaba relacionant la part més esportiva amb l’empresarial. A partir d’aquí intentarem extrapolar aquest entramat al que és el món futbolístic en general.Amb això, intentarem qüestionar-nos el perquè del gran moviment de divises existent, actualment, en aquest esport. Com pot ser que un club inverteixi més de 30 milions d’euros (2) només en el que seria contractar un nou treballador? Com es podengenerar tants recursos per després gastar-los en nòmines astronòmiques pels jugadors?Doncs aquest seguit de qüestions es el que pretenem respondre en aquest treball, de la forma més amena i clara possible, amb els gràfics i taules més adients.(1) Com que de clubs de futbol n’hi ha molts i no els podem analitzar tots un per un, partirem de la based’agafar-ne un com a model, en aquest cas, per la seva proximitat i facilitat d’obtenció de dades hemescollit el FC Barcelona.(2) Quantitat que equival, ni més ni menys, a 500 vegades el sou d’un treballador mitjà al llarg de tota la seva vida

Crème Noisette. What else?

Segurament us sonarà aquest eslògan: Nespresso, What else? Café, cuerpo y alma. Segurament, si us mencionem a l’actor George Clooney, ja no només l’identifiqueu amb una de les seves pel·lícules, sinó que directament us ve laimatge de l’anunci que protagonitza per Nespresso. I fins i tot, segurament, molts dels que esteu llegint aquest text, no us heu pogut resistir a la temptació i ja disposeu d’una màquina Nespresso a casa vostra. Nespresso s’ha convertiten un fenomen de masses i en una de les empreses que més està creixent en aquests últims anys. Per tots aquests motius, a l’hora de triar quin seria l’eix fonamental del nostre treball, vam decantar-nos per aquesta empresa.El que pretenem amb aquest treball és esbrinar tots els passos que s’han de seguir per a llençar un nou producte al mercat i analitzar la importància que té el marketing per a les empreses d’avui dia. Hem emmarcat aquests dos objectius dins de l’empresa Nespresso, i és per això que portarem a terme el llançament d’una nova càpsula d’un gust original, analitzarem com serà el seu procés productiu i dissenyarem les possibles tècniques de promoció per tal que tingui èxit. Pel que fa al segon objectiu, comprovarem mitjançant un experiment el grau d’influència que té el marketing sobre els clients.Referent a les conclusions que hem extret amb el nostre treball, aquestes són, per una part, la creació de Crème Noisette, una nova càpsula que no us deixarà indiferents; i per l’altra, que Nespresso basa el seu èxit en la qualitat, però sempre acompanyada d’una gran campanya de marketing.Voleu continuar descobrint els secrets que amaga el llançament d’una nova càpsula? Voleu saber si la gent aprecia realment totes les varietats que ofereix Nespresso? Per a descobrir-ho, us convidem a llegir el nostre treball.

La Capoeira como símbolo de los nuevos modos de representación audiovisual

Partiendo de la capacidad expresiva y reflexiva que albergan las imágenes tecnológicas para manifestar la red de implicaciones que se configuran en un sistema de representación como el que se desarrolla durante una exhibición de Capoeira, el propósito que me planteo en este trabajo consiste en abrazar el gran desafío del saber contemporáneo de educar(se) ‘en’ y ‘para’ la era planetaria, es decir, desatar un impulso de pensamiento complejo que esté animado por una tensión permanente entre la aspiración a un saber no parcelado, no dividido, no reduccionista, y el reconocimiento de lo inacabado e incompleto de todo conocimiento La aventura especulativa que se desencadena en esta investigación parte de una posición propia declarada: el análisis histórico, estético y antropológico de los fundamentos culturales que se despliegan durante una roda de Capoeira nos sirve para detectar categorías conceptuales que permiten esbozar la delimitación de un territorio metafórico donde se ilustra el carácter epistémico adscrito a la visualidad de alguno de los dispositivos y formas audiovisuales que configuran los entornos digitales comunicativos que habitamos en la actualidad

Solid pseudopapillary tumor of the pancreas in children : typical radiological findings and pathological correlation

Introduction : Les tumeurs solides pseudo-papillaires du pancréas (SPT) sont des tumeurs rares, d'étiopathogénie encore incertaine.Le but de notre travail était de décrire les caractéristiques radiologiques des SPT dans le groupe d'âge pédiatrique et d'étudier leur corrélation avec les études anatomopathologiques en vue d'établir un diagnostic.Patients et Méthodes : Nous avons étudié rétrospectivement trois malades pédiatriques pour lesquelles le diagnostic de tumeur solide pseudo-papillaire du pancréas a été porté à l'examen d'une pièce opératoire. Ce groupe comprenait 3 jeunes filles et femmes (âge médian: 13 ans).Résultats : La tumeur a été découverte pendant le bilan de symptômes digestifs non spécifiques. Les examens biologiques n'étaient pas informatifs. Des investigations radiologiques complètes ont été réalisées y compris les ultrasons (US), la tomodensitométrie (CT) et l'imagerie par résonance magnétique (IRM).Celles-ci ont montré de volumineuses lésions nodulaires, peu vascularisées, de compositions habituellement hétérogènes, avec des composantes kystiques et hémorragiques identifiées dans les 3 cas. Un traitement chirurgical a été pratiqué chez toute les patientes. L'étude de la pièce opératoire a montré une tumeur encapsulée dans les 3 cas. Aucune métastase n'a été mise en évidence.Conclusion : Les SPT doivent être considérées dans le diagnostic différentiel des masses pancréatiques pédiatriques, en particulier chez les adolescentes. Certaines caractéristiques radiologiques comme des masses volumineuses bien circonscrites, des lésions hétérogènes avec des zones kystiques et hémorragiques, de plus entourées d'une pseudocapsule fibreuse réactive, suggèrent fortement le diagnostic de SPT. Celui-ci devrait ensuite être confirmé par une biopsie avant que la résection chirurgicale soit effectuée. Chez les enfants, Γ écho graphie abdominale reste la méthode de première intention, suivie par l'IRM comme technique d'imagerie de choix pour évaluer les caractéristiques et l'extension de la lésion, tout en évitant l'exposition des patients aux rayonnements ionisants.

Imaging of tophaceous gout: computed tomography provides specific images compared with magnetic resonance imaging and ultrasonography.

OBJECTIVE: To determine the usefulness of computed tomography (CT), magnetic resonance imaging (MRI), and Doppler ultrasonography (US) in providing specific images of gouty tophi. METHODS: Four male patients with chronic gout with tophi affecting the knee joints (three cases) or the olecranon processes of the elbows (one case) were assessed. Crystallographic analyses of the synovial fluid or tissue aspirates of the areas of interest were made with polarising light microscopy, alizarin red staining, and x ray diffraction. CT was performed with a GE scanner, MR imaging was obtained with a 1.5 T Magneton (Siemens), and ultrasonography with colour Doppler was carried out by standard technique. RESULTS: Crystallographic analyses showed monosodium urate (MSU) crystals in the specimens of the four patients; hydroxyapatite and calcium pyrophosphate dihydrate (CPPD) crystals were not found. A diffuse soft tissue thickening was seen on plain radiographs but no calcifications or ossifications of the tophi. CT disclosed lesions containing round and oval opacities, with a mean density of about 160 Hounsfield units (HU). With MRI, lesions were of low to intermediate signal intensity on T(1) and T(2) weighting. After contrast injection in two cases, enhancement of the tophus was seen in one. Colour Doppler US showed the tophi to be hypoechogenic with peripheral increase of the blood flow in three cases. CONCLUSION: The MR and colour Doppler US images showed the tophi as masses surrounded by a hypervascular area, which cannot be considered as specific for gout. But on CT images, masses of about 160 HU density were clearly seen, which correspond to MSU crystal deposits.

Compositional Data in Biomedical Research

Modern methods of compositional data analysis are not well known in biomedical research.Moreover, there appear to be few mathematical and statistical researchersworking on compositional biomedical problems. Like the earth and environmental sciences,biomedicine has many problems in which the relevant scienti c information isencoded in the relative abundance of key species or categories. I introduce three problemsin cancer research in which analysis of compositions plays an important role. Theproblems involve 1) the classi cation of serum proteomic pro les for early detection oflung cancer, 2) inference of the relative amounts of di erent tissue types in a diagnostictumor biopsy, and 3) the subcellular localization of the BRCA1 protein, and it'srole in breast cancer patient prognosis. For each of these problems I outline a partialsolution. However, none of these problems is \solved". I attempt to identify areas inwhich additional statistical development is needed with the hope of encouraging morecompositional data analysts to become involved in biomedical research

Gestão Documental: Gestão de Processos de Aposentação usando a Plataforma IBM FileNet na Direcção Geral de Administração Pública

Ainda, nos nossos dias, o papel como sendo base de suporte das informações, é o maior problema operacional na maioria das empresas, órgãos governamentais e instituições. A administração pública cabo-verdiana lida anualmente com um grande volume de documentos e, a dificuldade de se lidar cada vez mais com os documentos produzidos é crescente. Daí, a necessidade de estabelecer princípios de racionalidade administrativa, a partir da intervenção nas etapas do ciclo de produção, utilização, conservação e destinação dos documentos de arquivo - a Gestão Documental. Com a evolução das Tecnologias da Informação e Comunicação (TIC) é contínua, igualmente a gestão da informação precisa adaptar-se a cada nova onda de mudança. A utilização de sistemas de gestão de conteúdos e de processos constituem ferramentas indispensáveis para o desenvolvimento de modernos sistemas de informação, agilizando assim os processos críticos nas instituições, de forma a optimizar o binómio produtividade - qualidade. Este trabalho faz referência à utilização da IBM FileNet, para modelação do processo de pedido de aposentação na Administração Pública. Ficou comprovado que o sistema de gestão de Workflow - Bussiness Process Management (BPM) da IBM, é capaz de automatizar o procedimento dos processos, gerir a sequência de actividades de trabalho e chamar (ou invocar) os recursos humanos e electrónicos apropriados, associados aos vários passos de actividades numa instituição. As evidências da plataforma FileNet como solução de Gestão de Conteúdos, e Gestão de Processos na nossa Administração Pública, demonstram vantagens consideráveis em todos os níveis. Para além de dinamizar e automatizar os processos críticos, o FileNet BPM pode permitir a optimização das operações e melhorar a capacidade de tomar decisões rápidas e acertadas, capacitando a instituição, para tomar decisões atempadas, baseadas na mais rigorosa informação disponível.

La Comunicación en los gabinetes de comunicación en la Unión Europea en el siglo XXI : el uso de las TICs

El trabajo analiza la organización y funcionamiento de los gabinetes de comunicación de las instituciones europeas, poniendo especial énfasis en las nuevas tecnologías de la información. Para ello, en una primera parte se construirá un paradigma sobre los gabinetes de comunicación desde dos puntos de vista: teórico, mediante el análisis de bibliografía sobre gabinetes de comunicación y práctico, mediante el estudio del gabinete de comunicación de una empresa privada de carácter global. Este paradigma será utilizado desde una perspectiva comparativa para el análisis de los gabinetes de las instituciones europeas, objeto de la segunda parte del trabajo

La Calidad televisiva : análisis comparativo de los informativos Telenotícies Vespre y Noticias Cuatro

El treball que presentem a continuació pretén oferir una perspectiva general sobre les investigacions realitzades entorn a la qualitat televisiva per tal d'extreure una sèrie de criteris que es puguin aplicar en una anàlisi d'informatius de televisió. Per a això, presentem una panoràmica general de les investigacions que s'han dut a terme sobre qualitat televisiva i destaquem les principals valoracions del concepte "qualitat". D'aquesta manera, aplicant els criteris estudiats a la mostra seleccionada, podem extreure unes conclusions més precises sobre l'anàlisi de qualitat en els noticiaris

Two new species of Goeldichironomus Fittkau from southeast Brazil (Diptera, Chironomidae)

The adult and immature stages of two new species of Goeldichironomus are described and figured. Larvae of G. luridus sp. nov., reared in the laboratory from egg masses, are abundant on organically enriched sediments of a chicken slaughter-house effluent treatment lagoon. Larvae of G. petiolicola sp. nov., live inside petioles of aquatic macrophytes such as Eichhornia azurea and Pontederia lanceolata.

The adequacy of artificial oviposition substrates for laboratory rearing of Piezodorus guildinii (Westwood) (Heteroptera, Pentatomidae)

Studies in the laboratory tested the suitability of synthetic wool string, cotton string, cheesecloth, and commercial cotton ball as artificial oviposition substrates for the small green stink bug, Piezodorus guildinii (Westwood) (Heteroptera, Pentatomidae). In confined cages, 54% of total egg masses was laid on synthetic wool string, 31% on cotton string, and only 15% on cheesecloth. In an additional test, the best substrate selected, synthetic wool string, received 92% of egg masses compared to 8% on the commonly used substrate, cotton ball. Synthetic wool string received the most egg masses of any size, in particular those in the range 11-20 eggs/mass. Because the eggs of P. guildinii are laid in two parallel double rows, the egg masses fit the wool string perfectly.