978 resultados para Formas farmacêuticas sólidas
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Dental plaque is the principal etiological agent of periodontal disease, one of oral diseases more prevalent in the world. Due existence of relation between periodontal disease and oral hygiene, on the point of periodontal view, it was developed a growing interesting by experimental research and by clinical investigations. The knowledge of problem, its extension, severity, hypothetic cause is so valuable to establish prevention, control and treatment acts. In this form, the use of plaque index becomes more and more often, being valuable the determination of discriminatory power of them. The aim of this work was to describe and analyze principal forms to register of dental plaque aiming to subsidize the researcher and dental surgeon on adoption of most adequate method for their case. Data bases: Medline, Lilacs and BBO were consulted without limit to identify the format of register of each index described on literature. It was observed the use of Oral Hygiene Index on diverse ways like: clinical evaluation of dental plaque, in products evaluation works and dental Office; patients monitoring; instruction about hygiene and oral hygiene technique. It was noted that dental plaque indexes are useful and allows the register of different forms point out the importance of its use on clinical and researches practice.
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The most important role played by the enzyme Glucose- 6-Phosphate Dehydrogenase (G6PD) in erythrocyte metabolism is in generating energy and reducing power used to protect the cell against oxidative attack. G6PD deficiency is the erythroenzymopathy that most frequently causes hemolytic anemia, and more than 130 molecular variants have already been identified. The aim of this study was to analyze the genetic mutations in the G6PD-deficient adult males in the population of the region of Araraquara, São Paulo State. Out of 5087 male blood donors, 89 were deficient for G6PD, as confirmed by assaying the enzyme activity and electrophoresis on cellulose acetate. Thus, a frequency of 1.75% of G6PD-deficient patients was found, this value being similar to other investigations in São Paulo state. Molecular analysis was performed by amplification of genomic DNA with specific primers and digestion with restriction enzymes. In 96.6% of the patients, the G6PD A¯ variant was observed, with mutations at residues 376(A→G) and 202(G→A). Mean G6PD specific activity among the patients was 1.31 IU.g Hb-1.min-1 at 37ºC, that is 10.8% of the normal activity of the G6PD B enzyme. The variant forms G6PD A¯ 680(G→T) and 968(T→C) were not found. In 3.4% of the deficient individuals, the G6PD Mediterranean variant was found, with a mutation at 563(C→T). In these cases, mean enzymatic activity was 0.25 IU.g Hb-1.min-1 at 37ºC, or 2.1% of the enzymatic activity of G6PD B. The use of traditional techniques, allied to the identification of the different molecular variants, is important for the understanding of the structural and functional properties and hemolytic behavior of the red blood cells of the patient.
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A invenção ora descrita revela o método de obtenção de compostos a partir do extrato de raízes, caules, cascas e folhas de espécies do gênero Arrabidaea, em especial a Arrabidaea Arachypoda. Ainda, a invenção faz referência aos compostos obtidos pelo referido método, bem como às composições farmacêuticas compreendendo os mesmos.
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This article considers the scholastic knowledge as the expression of the most developed forms of knowledge in face of the actual development stage of the mathematics. Thus, it supports that the relation between the scholastic mathematics and the mathematics produced in different social contexts, comprises a relation between the most developed (scholastic knowledge) facing the least developed (knowledge acquired from diverse social contexts). For this reason, this work comprises some specificities of the socialhistorical development of the mathematics and the implications decurrent from this, in relation to the cultural aspect for teaching mathematics.
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Given the widespread use of computers, the visual pattern recognition task has been automated in order to address the huge amount of available digital images. Many applications use image processing techniques as well as feature extraction and visual pattern recognition algorithms in order to identify people, to make the disease diagnosis process easier, to classify objects, etc. based on digital images. Among the features that can be extracted and analyzed from images is the shape of objects or regions. In some cases, shape is the unique feature that can be extracted with a relatively high accuracy from the image. In this work we present some of most important shape analysis methods and compare their performance when applied on three well-known shape image databases. Finally, we propose the development of a new shape descriptor based on the Hough Transform.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Diversas atividades nos dias atuais podem ser beneficiadas pela da análise automatizada de imagens como o reconhecimento biométrico de pessoas, a busca de imagens por conteúdo e o diagnóstico médico. Dentre as principais características que podem ser analisadas em uma imagem a fim de obter informações sobre seu conteúdo encontra-se a forma de objetos e regiões da mesma. Neste trabalho propõe-se um novo descritor de formas denominado HTS (Hough Transform Statistics) o qual se baseia no espaço de Hough para representar e reconhecer objetos em imagens por suas formas. Os resultados obtidos sobre algumas bases de imagens públicas mostram que o HTS, além de apresentar altas taxas de acerto, é muito rápido. Discute-se também uma adaptação na etapa de extração de características do descritor a qual fez com que os resultados melhorassem bastante sem deixar o método muito mais lento.
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Pós-graduação em Agronomia (Produção Vegetal) - FCAV
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Processo de obtenção de nanopartículas lipídicas sólidas, nanopartículas lipídicas sólidas e seu uso
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A presente invenção descreve um processo de obtenção de nanopartículas lipídicas sólidas com trans-resveratrol (res) por sonicação, utilizando lipídio peguilado, bem como as nanopartículas obtidas e seu uso na terapia antitumoral do melanoma.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Agronomia (Ciência do Solo) - FCAV
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)