1000 resultados para Coração - Hipertrofia - Hipertensão


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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Influence of weight, volume and absolute placental density on the weight of newborns of pregnant women with arterial hypertension or Diabetes Mellitus

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The aging process involves challenges in meeting social needs, economic and health. Physiopathological changes and socio-economic predispose the elderly population at nutritional risk. The monitoring of nutritional status predict some complications of obesity or malnutrition, and is a tool for health care. The objective to know the nutritional status and risk of chronic diseases of the elderly in geriatric institutions and volunteers. The elderly population of 3 geriatric institutions (n=122) and non-institutionalized elderly (n=75) were evaluated. The body mass index was evaluated according to Nutrition Screening Initiative. For waist circumference, was used the World Health Organization criteria. For statistical analysis, chi-square was used. A high proportion of obesity (46%) was observed. The underweight affects 4% and 20% of noninstitutionalized and institutionalized, respectively. The frequency of the risk of diseases associated with obesity was higher among non-institutionalized. Hypertension affects more than 50% of the elderly. The nutritional status was different between the two situations, with high incidence of overweight and visceral adiposity, in volunteers, and wasting among institutionalized. The data emphasize that it is necessary special attention and appropriate measures to prevent morbidity and mortality and to improve quality of life.

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Pós-graduação em Fisiopatologia em Clínica Médica - FMB

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Pós-graduação em Biologia Geral e Aplicada - IBB

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Pós-graduação em Fisiopatologia em Clínica Médica - FMB

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Pós-graduação em Biologia Geral e Aplicada - IBB

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Background: Chronic stress is associated with cardiac remodeling; however the mechanisms have yet to be clarified. Objective: The purpose of this study was test the hypothesis that chronic stress promotes cardiac dysfunction associated to L-type calcium Ca2+ channel activity depression. Methods: Thirty-day-old male Wistar rats (70 - 100 g) were distributed into two groups: control (C) and chronic stress (St). The stress was consistently maintained at immobilization during 15 weeks, 5 times per week, 1h per day. The cardiac function was evaluated by left ventricular performance through echocardiography and by ventricular isolated papillary muscle. The myocardial papillary muscle activity was assessed at baseline conditions and with inotropic maneuvers such as: post-rest contraction and increases in extracellular Ca2+ concentration, in presence or absence of specific blockers L-type calcium channels. Results: The stress was characterized for adrenal glands hypertrophy, increase of systemic corticosterone level and arterial hypertension. The chronic stress provided left ventricular hypertrophy. The left ventricular and baseline myocardial function did not change with chronic stress. However, it improved the response of the papillary muscle in relation to positive inotropic stimulation. This function improvement was not associated with the L-type Ca2+ channel. Conclusion: Chronic stress produced cardiac hypertrophy; however, in the study of papillary muscle, the positive inotropic maneuvers potentiated cardiac function in stressed rats, without involvement of L-type Ca2+ channel. Thus, the responsible mechanisms remain unclear with respect to Ca2+ influx alterations. (Arq Bras Cardiol 2012;99(4):907-914)